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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Bbx | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | BBX (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BBX mRNA | CTD | PMID:22079256 | Bbx | Rat | 1,2-dichloroethane | decreases expression | ISO | Bbx (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of BBX mRNA | CTD | PMID:28960355 | Bbx | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Bbx (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of BBX mRNA | CTD | PMID:22206623 | Bbx | Rat | 17beta-estradiol | increases expression | ISO | BBX (Homo sapiens) | 6480464 | Estradiol results in increased expression of BBX mRNA | CTD | PMID:21185374 | Bbx | Rat | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | BBX (Homo sapiens) | 6480464 | Dihydrotestosterone results in increased expression of BBX mRNA | CTD | PMID:29581250 | Bbx | Rat | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Bbx (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Bbx | Rat | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Bbx (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Bbx | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Bbx (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of BBX mRNA | CTD | PMID:21570461 | Bbx | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of BBX mRNA | CTD | PMID:33387578 | Bbx | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of BBX mRNA | CTD | PMID:21346803 | Bbx | Rat | 2-methylcholine | affects expression | ISO | BBX (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of BBX mRNA | CTD | PMID:21179406 | Bbx | Rat | 2-palmitoylglycerol | increases expression | ISO | BBX (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of BBX mRNA | CTD | PMID:37199045 | Bbx | Rat | 3-methylcholanthrene | multiple interactions | ISO | BBX (Homo sapiens) | 6480464 | Methylcholanthrene promotes the reaction [AHR protein binds to BBX promoter] | CTD | PMID:20348232 | Bbx | Rat | 4,4'-diaminodiphenylmethane | increases expression | ISO | Bbx (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of BBX mRNA | CTD | PMID:18648102 | Bbx | Rat | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2 and 6-dinitrotoluene affects the expression of BBX mRNA | CTD | PMID:21346803 | Bbx | Rat | 4-hydroxynon-2-enal | increases expression | ISO | Bbx (Mus musculus) | 6480464 | 4-hydroxy-2-nonenal results in increased expression of BBX mRNA | CTD | PMID:19191707 | Bbx | Rat | 5-fluorouracil | affects response to substance | ISO | BBX (Homo sapiens) | 6480464 | BBX protein affects the susceptibility to Fluorouracil | CTD | PMID:16217747 | Bbx | Rat | acrolein | multiple interactions | ISO | BBX (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of BBX mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of BBX mRNA | CTD | PMID:32699268 | Bbx | Rat | aflatoxin B1 | decreases methylation | ISO | BBX (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of BBX intron | CTD | PMID:30157460 | Bbx | Rat | alpha-pinene | multiple interactions | ISO | BBX (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of BBX mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of BBX mRNA | CTD | PMID:32699268 | Bbx | Rat | aristolochic acid A | decreases expression | ISO | BBX (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of BBX mRNA | CTD | PMID:33212167 | Bbx | Rat | Aroclor 1254 | decreases expression | ISO | Bbx (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of BBX mRNA | CTD | PMID:23650126 | Bbx | Rat | benzo[a]pyrene | decreases expression | ISO | BBX (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of BBX mRNA | CTD | PMID:20064835 | Bbx | Rat | benzo[a]pyrene | affects methylation | ISO | BBX (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of BBX 5' UTR and Benzo(a)pyrene affects the methylation of BBX intron | CTD | PMID:27901495 and PMID:30157460 | Bbx | Rat | benzo[a]pyrene | decreases expression | ISO | Bbx (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of BBX mRNA | CTD | PMID:19770486 | Bbx | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | BBX (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20018196 | Bbx | Rat | benzo[e]pyrene | increases methylation | ISO | BBX (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of BBX intron | CTD | PMID:30157460 | Bbx | Rat | bisphenol A | increases expression | ISO | Bbx (Mus musculus) | 6480464 | bisphenol A results in increased expression of BBX mRNA | CTD | PMID:26063408 | Bbx | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of BBX mRNA | CTD | PMID:30816183 and PMID:34947998 | Bbx | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of BBX protein | CTD | PMID:24552547 | Bbx | Rat | C60 fullerene | affects expression | EXP | | 6480464 | fullerene C60 affects the expression of BBX mRNA | CTD | PMID:19167457 | Bbx | Rat | cadmium dichloride | increases expression | ISO | Bbx (Mus musculus) | 6480464 | Cadmium Chloride results in increased expression of BBX mRNA | CTD | PMID:18974090 | Bbx | Rat | cadmium dichloride | increases expression | ISO | BBX (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of BBX mRNA | CTD | PMID:26472689 | Bbx | Rat | caffeine | affects phosphorylation | ISO | BBX (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of BBX protein | CTD | PMID:35688186 | Bbx | Rat | CGP 52608 | multiple interactions | ISO | BBX (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to BBX gene] | CTD | PMID:28238834 | Bbx | Rat | chloroprene | increases expression | EXP | | 6480464 | Chloroprene results in increased expression of BBX mRNA | CTD | PMID:23125180 | Bbx | Rat | cisplatin | increases phosphorylation | ISO | Bbx (Mus musculus) | 6480464 | Cisplatin results in increased phosphorylation of BBX protein | CTD | PMID:22006019 | Bbx | Rat | copper(II) sulfate | increases expression | ISO | BBX (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of BBX mRNA | CTD | PMID:19549813 | Bbx | Rat | coumarin | affects phosphorylation | ISO | BBX (Homo sapiens) | 6480464 | coumarin affects the phosphorylation of BBX protein | CTD | PMID:35688186 | Bbx | Rat | Dibutyl phosphate | affects expression | ISO | BBX (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of BBX mRNA | CTD | PMID:37042841 | Bbx | Rat | dibutyl phthalate | decreases expression | ISO | Bbx (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of BBX mRNA | CTD | PMID:21266533 | Bbx | Rat | dorsomorphin | multiple interactions | ISO | BBX (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BBX mRNA | CTD | PMID:27188386 | Bbx | Rat | doxorubicin | decreases expression | ISO | BBX (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of BBX mRNA | CTD | PMID:29803840 | Bbx | Rat | elemental selenium | multiple interactions | ISO | BBX (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of BBX mRNA | CTD | PMID:19244175 | Bbx | Rat | elemental selenium | decreases expression | ISO | BBX (Homo sapiens) | 6480464 | Selenium results in decreased expression of BBX mRNA | CTD | PMID:19244175 | Bbx | Rat | enzyme inhibitor | multiple interactions | ISO | BBX (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of BBX protein | CTD | PMID:23301498 | Bbx | Rat | folic acid | decreases expression | ISO | Bbx (Mus musculus) | 6480464 | Folic Acid results in decreased expression of BBX mRNA | CTD | PMID:25629700 | Bbx | Rat | FR900359 | affects phosphorylation | ISO | BBX (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of BBX protein | CTD | PMID:37730182 | Bbx | Rat | geraniol | increases expression | ISO | BBX (Homo sapiens) | 6480464 | geraniol results in increased expression of BBX mRNA | CTD | PMID:27683099 | Bbx | Rat | lead diacetate | decreases methylation | EXP | | 6480464 | lead acetate results in decreased methylation of BBX gene | CTD | PMID:29571894 | Bbx | Rat | lead(0) | affects splicing | ISO | BBX (Homo sapiens) | 6480464 | Lead affects the splicing of BBX mRNA | CTD | PMID:28903495 | Bbx | Rat | levonorgestrel | multiple interactions | ISO | BBX (Homo sapiens) | 6480464 | [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of BBX mRNA | CTD | PMID:19074003 | Bbx | Rat | methapyrilene | increases methylation | ISO | BBX (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of BBX intron | CTD | PMID:30157460 | Bbx | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of BBX gene | CTD | PMID:35440735 | Bbx | Rat | methylmercury chloride | decreases expression | ISO | BBX (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of BBX mRNA | CTD | PMID:28001369 | Bbx | Rat | mitoxantrone | affects response to substance | ISO | BBX (Homo sapiens) | 6480464 | BBX protein affects the susceptibility to Mitoxantrone | CTD | PMID:16217747 | Bbx | Rat | N(4)-hydroxycytidine | decreases expression | ISO | Bbx (Mus musculus) | 6480464 | N(4)-hydroxycytidine results in decreased expression of BBX mRNA | CTD | PMID:37748715 | Bbx | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of BBX mRNA | CTD | PMID:25729387 | Bbx | Rat | ozone | multiple interactions | ISO | BBX (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of BBX mRNA more ... | CTD | PMID:32699268 | Bbx | Rat | paracetamol | decreases expression | ISO | BBX (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of BBX mRNA | CTD | PMID:21420995 | Bbx | Rat | PCB138 | multiple interactions | ISO | Bbx (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Bbx | Rat | pirinixic acid | multiple interactions | ISO | Bbx (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BBX mRNA | CTD | PMID:19710929 | Bbx | Rat | potassium chromate | decreases expression | ISO | BBX (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of BBX mRNA | CTD | PMID:22079256 | Bbx | Rat | potassium chromate | multiple interactions | ISO | BBX (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BBX mRNA | CTD | PMID:22079256 | Bbx | Rat | propiconazole | decreases expression | ISO | Bbx (Mus musculus) | 6480464 | propiconazole results in decreased expression of BBX mRNA | CTD | PMID:21278054 | Bbx | Rat | SB 431542 | multiple interactions | ISO | BBX (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BBX mRNA | CTD | PMID:27188386 | Bbx | Rat | selenium atom | multiple interactions | ISO | BBX (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of BBX mRNA | CTD | PMID:19244175 | Bbx | Rat | selenium atom | decreases expression | ISO | BBX (Homo sapiens) | 6480464 | Selenium results in decreased expression of BBX mRNA | CTD | PMID:19244175 | Bbx | Rat | sodium arsenate | increases expression | ISO | Bbx (Mus musculus) | 6480464 | sodium arsenate results in increased expression of BBX mRNA | CTD | PMID:21795629 | Bbx | Rat | testosterone enanthate | affects expression | ISO | BBX (Homo sapiens) | 6480464 | testosterone enanthate affects the expression of BBX mRNA | CTD | PMID:17440010 | Bbx | Rat | testosterone undecanoate | multiple interactions | ISO | BBX (Homo sapiens) | 6480464 | [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of BBX mRNA | CTD | PMID:19074003 | Bbx | Rat | tetrachloromethane | increases expression | ISO | Bbx (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of BBX mRNA | CTD | PMID:31919559 | Bbx | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of BBX mRNA | CTD | PMID:25729387 | Bbx | Rat | trichostatin A | increases expression | ISO | BBX (Homo sapiens) | 6480464 | trichostatin A results in increased expression of BBX mRNA | CTD | PMID:24935251 and PMID:26272509 | Bbx | Rat | trichostatin A | multiple interactions | ISO | BBX (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BBX mRNA | CTD | PMID:27188386 | Bbx | Rat | triphenyl phosphate | affects expression | ISO | BBX (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of BBX mRNA | CTD | PMID:37042841 | Bbx | Rat | urethane | increases expression | ISO | BBX (Homo sapiens) | 6480464 | Urethane results in increased expression of BBX mRNA | CTD | PMID:28818685 | Bbx | Rat | valproic acid | decreases expression | ISO | BBX (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of BBX mRNA | CTD | PMID:23179753 and PMID:28001369 | Bbx | Rat | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of BBX mRNA | CTD | PMID:29427782 | Bbx | Rat | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of BBX mRNA | CTD | PMID:29427782 | Bbx | Rat | valproic acid | affects expression | ISO | BBX (Homo sapiens) | 6480464 | Valproic Acid affects the expression of BBX mRNA | CTD | PMID:25979313 | Bbx | Rat | valproic acid | increases expression | ISO | BBX (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of BBX mRNA | CTD | PMID:19101580 and PMID:26272509 | Bbx | Rat | vitamin E | multiple interactions | ISO | BBX (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of BBX mRNA | CTD | PMID:19244175 | Bbx | Rat | vitamin E | decreases expression | ISO | BBX (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of BBX mRNA | CTD | PMID:19244175 | Bbx | Rat | zoledronic acid | decreases expression | ISO | BBX (Homo sapiens) | 6480464 | zoledronic acid results in decreased expression of BBX mRNA | CTD | PMID:20977926 | |