1,2-dichloroethane affects expression ISO RGD:10791 6480464 ethylene dichloride affects the expression of IL1RAP mRNA CTD PMID:28960355 1,2-dimethylhydrazine decreases expression ISO RGD:10791 6480464 1, 2-Dimethylhydrazine results in decreased expression of IL1RAP mRNA CTD PMID:22206623 17beta-estradiol increases expression ISO RGD:732294 6480464 Estradiol results in increased expression of IL1RAP mRNA CTD PMID:31614463 2,3',4,4',5-Pentachlorobiphenyl increases expression ISO RGD:10791 6480464 2 more ... CTD PMID:31388691 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10791 6480464 Tetrachlorodibenzodioxin results in decreased expression of IL1RAP mRNA CTD PMID:19933214 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of IL1RAP mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:10791 6480464 Tetrachlorodibenzodioxin affects the expression of IL1RAP mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of IL1RAP mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of IL1RAP mRNA CTD PMID:21346803 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:23196670 3,3',4,4'-tetrachlorobiphenyl multiple interactions ISO RGD:10791 6480464 3 more ... CTD PMID:19467301 3,4-methylenedioxymethamphetamine increases expression ISO RGD:10791 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of IL1RAP mRNA CTD PMID:20188158 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:732294 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of IL1RAP mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IL1RAP mRNA CTD PMID:28628672 4,4'-sulfonyldiphenol multiple interactions ISO RGD:732294 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of IL1RAP mRNA CTD PMID:28628672 4,4'-sulfonyldiphenol decreases methylation ISO RGD:10791 6480464 bis(4-hydroxyphenyl)sulfone results in decreased methylation of IL1RAP exon CTD PMID:33297965 4,4'-sulfonyldiphenol increases expression ISO RGD:10791 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of IL1RAP mRNA CTD PMID:30951980 4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid decreases expression ISO RGD:732294 6480464 Am 580 results in decreased expression of IL1RAP mRNA CTD PMID:16982809 4-hydroxyphenyl retinamide decreases expression ISO RGD:10791 6480464 Fenretinide results in decreased expression of IL1RAP mRNA CTD PMID:28973697 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of IL1RAP mRNA CTD PMID:24780913 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of IL1RAP mRNA CTD PMID:31881176 aflatoxin B1 decreases expression ISO RGD:10791 6480464 Aflatoxin B1 results in decreased expression of IL1RAP mRNA CTD PMID:19770486 aflatoxin B1 increases methylation ISO RGD:732294 6480464 Aflatoxin B1 results in increased methylation of IL1RAP intron CTD PMID:30157460 aflatoxin B1 decreases methylation ISO RGD:732294 6480464 Aflatoxin B1 results in decreased methylation of IL1RAP gene CTD PMID:27153756 all-trans-retinoic acid increases expression ISO RGD:732294 6480464 Tretinoin results in increased expression of IL1RAP mRNA CTD PMID:33167477 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of IL1RAP mRNA CTD PMID:16483693 antirheumatic drug decreases expression ISO RGD:732294 6480464 Antirheumatic Agents results in decreased expression of IL1RAP mRNA CTD PMID:24449571 aripiprazole multiple interactions ISO RGD:732294 6480464 [Aripiprazole co-treated with Ozone] results in increased expression of IL1RAP mRNA CTD PMID:31476115 aristolochic acid A decreases expression ISO RGD:732294 6480464 aristolochic acid I results in decreased expression of IL1RAP mRNA CTD PMID:33212167 arsane affects expression ISO RGD:732294 6480464 Arsenic affects the expression of IL1RAP protein CTD PMID:24675094 arsane affects methylation ISO RGD:732294 6480464 Arsenic affects the methylation of IL1RAP gene CTD PMID:25304211 arsenic atom affects expression ISO RGD:732294 6480464 Arsenic affects the expression of IL1RAP protein CTD PMID:24675094 arsenic atom affects methylation ISO RGD:732294 6480464 Arsenic affects the methylation of IL1RAP gene CTD PMID:25304211 arsenite(3-) multiple interactions ISO RGD:10791 6480464 [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of IL1RAP mRNA CTD PMID:15894712 arsenite(3-) decreases expression ISO RGD:10791 6480464 arsenite results in decreased expression of IL1RAP mRNA CTD PMID:15894712 benzene increases expression ISO RGD:732294 6480464 Benzene results in increased expression of IL1RAP mRNA CTD PMID:33064461 benzo[a]pyrene decreases expression ISO RGD:10791 6480464 Benzo(a)pyrene results in decreased expression of IL1RAP mRNA CTD PMID:15894712 , PMID:19770486 benzo[a]pyrene decreases methylation ISO RGD:732294 6480464 Benzo(a)pyrene results in decreased methylation of IL1RAP 5' UTR CTD PMID:27901495 benzo[a]pyrene multiple interactions ISO RGD:10791 6480464 [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of IL1RAP mRNA CTD PMID:15894712 benzo[e]pyrene increases methylation ISO RGD:732294 6480464 benzo(e)pyrene results in increased methylation of IL1RAP intron CTD PMID:30157460 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:10791 6480464 Diethylhexyl Phthalate results in decreased expression of IL1RAP mRNA CTD PMID:19850644 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:10791 6480464 PPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of IL1RAP mRNA] CTD PMID:19850644 bisphenol A decreases expression ISO RGD:732294 6480464 bisphenol A results in decreased expression of IL1RAP mRNA CTD PMID:20678512 bisphenol A increases expression ISO RGD:10791 6480464 bisphenol A results in increased expression of IL1RAP mRNA CTD PMID:30951980 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of IL1RAP gene CTD PMID:28505145 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of IL1RAP mRNA CTD PMID:25181051 bisphenol F multiple interactions ISO RGD:732294 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IL1RAP mRNA CTD PMID:28628672 bisphenol F increases expression ISO RGD:10791 6480464 bisphenol F results in increased expression of IL1RAP mRNA CTD PMID:30951980 cadmium atom increases expression ISO RGD:732294 6480464 Cadmium results in increased expression of IL1RAP mRNA CTD PMID:22562489 cadmium selenide multiple interactions ISO RGD:732294 6480464 [cadmium selenide co-treated with zinc sulfide] results in increased expression of IL1RAP mRNA CTD PMID:22342292 calcitriol increases expression ISO RGD:732294 6480464 Calcitriol results in increased expression of IL1RAP mRNA CTD PMID:26485663 CGP 52608 multiple interactions ISO RGD:732294 6480464 CGP 52608 promotes the reaction [RORA protein binds to IL1RAP gene] CTD PMID:28238834 ciprofibrate decreases expression ISO RGD:10791 6480464 ciprofibrate results in decreased expression of IL1RAP mRNA CTD PMID:12771043 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of IL1RAP mRNA CTD PMID:22023808 cisplatin increases expression ISO RGD:732294 6480464 Cisplatin results in increased expression of IL1RAP mRNA CTD PMID:27392435 copper atom multiple interactions ISO RGD:732294 6480464 [Chelating Agents binds to Copper] which results in increased expression of IL1RAP mRNA CTD PMID:30911355 copper(0) multiple interactions ISO RGD:732294 6480464 [Chelating Agents binds to Copper] which results in increased expression of IL1RAP mRNA CTD PMID:30911355 copper(II) sulfate decreases expression ISO RGD:732294 6480464 Copper Sulfate results in decreased expression of IL1RAP mRNA CTD PMID:19549813 coumarin affects phosphorylation ISO RGD:732294 6480464 coumarin affects the phosphorylation of IL1RAP protein CTD PMID:35688186 crocidolite asbestos increases expression ISO RGD:10791 6480464 Asbestos, Crocidolite results in increased expression of IL1RAP mRNA CTD PMID:19446018 , PMID:29279043 crocidolite asbestos decreases expression ISO RGD:732294 6480464 Asbestos, Crocidolite results in decreased expression of IL1RAP mRNA CTD PMID:29523930 Cuprizon decreases expression EXP 6480464 Cuprizone results in decreased expression of IL1RAP mRNA CTD PMID:26577399 cyclosporin A decreases expression ISO RGD:732294 6480464 Cyclosporine results in decreased expression of IL1RAP mRNA CTD PMID:27989131 cyproconazole decreases expression ISO RGD:10791 6480464 cyproconazole results in decreased expression of IL1RAP mRNA CTD PMID:22334560 dexamethasone multiple interactions ISO RGD:732294 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of IL1RAP mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IL1RAP mRNA CTD PMID:28628672 dorsomorphin multiple interactions ISO RGD:732294 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of IL1RAP mRNA CTD PMID:27181935 doxorubicin multiple interactions EXP 6480464 Fungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of IL1RAP mRNA] CTD PMID:27181935 epoxiconazole decreases expression ISO RGD:10791 6480464 epoxiconazole results in decreased expression of IL1RAP mRNA CTD PMID:22334560 erlotinib hydrochloride multiple interactions ISO RGD:732294 6480464 [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of IL1RAP mRNA CTD PMID:27738319 ethanol affects splicing ISO RGD:10791 6480464 Ethanol affects the splicing of IL1RAP mRNA CTD PMID:30319688 ethyl methanesulfonate increases expression ISO RGD:732294 6480464 Ethyl Methanesulfonate results in increased expression of IL1RAP mRNA CTD PMID:23649840 febuxostat increases expression ISO RGD:732294 6480464 Febuxostat results in increased expression of IL1RAP mRNA CTD PMID:35866629 fenamidone increases expression ISO RGD:10791 6480464 fenamidone results in increased expression of IL1RAP mRNA CTD PMID:27029645 fipronil decreases expression EXP 6480464 fipronil results in decreased expression of IL1RAP mRNA CTD PMID:34044035 flavonoids increases expression EXP 6480464 Flavonoids results in increased expression of IL1RAP mRNA CTD PMID:18035473 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of IL1RAP mRNA CTD PMID:24136188 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of IL1RAP mRNA CTD PMID:33387578 imiquimod increases expression ISO RGD:10791 6480464 Imiquimod results in increased expression of IL1RAP mRNA CTD PMID:31054998 indometacin multiple interactions ISO RGD:732294 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of IL1RAP mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IL1RAP mRNA CTD PMID:28628672 lead(0) affects expression ISO RGD:732294 6480464 Lead affects the expression of IL1RAP mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:732294 6480464 Lead affects the expression of IL1RAP mRNA CTD PMID:28903495 leflunomide increases expression EXP 6480464 leflunomide results in increased expression of IL1RAP mRNA CTD PMID:24136188 lidocaine increases expression EXP 6480464 Lidocaine results in increased expression of IL1RAP mRNA CTD PMID:35283115 lipopolysaccharide increases expression ISO RGD:10791 6480464 Lipopolysaccharides results in increased expression of IL1RAP mRNA CTD PMID:17321000 lipopolysaccharide increases expression ISO RGD:732294 6480464 Lipopolysaccharides results in increased expression of IL1RAP mRNA CTD PMID:35811015 lipopolysaccharide decreases expression ISO RGD:732294 6480464 Lipopolysaccharides results in decreased expression of IL1RAP mRNA CTD PMID:31059760 lipopolysaccharide multiple interactions ISO RGD:732294 6480464 [Acetaminophen co-treated with Lipopolysaccharides] results in decreased expression of IL1RAP mRNA more ... CTD PMID:31059760 , PMID:35811015 mercury dibromide multiple interactions ISO RGD:732294 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IL1RAP mRNA CTD PMID:27188386 methapyrilene increases methylation ISO RGD:732294 6480464 Methapyrilene results in increased methylation of IL1RAP intron CTD PMID:30157460 methidathion decreases expression ISO RGD:10791 6480464 methidathion results in decreased expression of IL1RAP mRNA CTD PMID:34813904 methyl methanesulfonate increases expression ISO RGD:732294 6480464 Methyl Methanesulfonate results in increased expression of IL1RAP mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO RGD:732294 6480464 methylmercuric chloride results in decreased expression of IL1RAP mRNA CTD PMID:28001369 N,N-diethyl-m-toluamide multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in decreased methylation of IL1RAP gene CTD PMID:33148267 N-methylformamide decreases expression ISO RGD:10791 6480464 methylformamide analog results in decreased expression of IL1RAP mRNA, methylformamide results in decreased expression of IL1RAP mRNA CTD PMID:17040096 N-nitrosodiethylamine decreases expression ISO RGD:10791 6480464 Diethylnitrosamine results in decreased expression of IL1RAP mRNA CTD PMID:12771043 nickel atom increases expression ISO RGD:732294 6480464 Nickel results in increased expression of IL1RAP mRNA CTD PMID:25583101 nitrobenzenes decreases expression EXP 6480464 Nitrobenzenes analog results in decreased expression of IL1RAP mRNA CTD PMID:19784758 omega-6 fatty acid increases expression ISO RGD:732294 6480464 Fatty Acids, Omega-6 results in increased expression of IL1RAP mRNA CTD PMID:16823509 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of IL1RAP mRNA CTD PMID:25729387 ozone increases expression ISO RGD:732294 6480464 Ozone results in increased expression of IL1RAP mRNA CTD PMID:31476115 ozone multiple interactions ISO RGD:732294 6480464 [Aripiprazole co-treated with Ozone] results in increased expression of IL1RAP mRNA CTD PMID:31476115 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of IL1RAP mRNA CTD PMID:19784758 paracetamol multiple interactions ISO RGD:732294 6480464 [Acetaminophen co-treated with Lipopolysaccharides] results in decreased expression of IL1RAP mRNA CTD PMID:31059760 paracetamol increases expression ISO RGD:732294 6480464 Acetaminophen results in increased expression of IL1RAP mRNA CTD PMID:29067470 paracetamol decreases expression ISO RGD:732294 6480464 Acetaminophen results in decreased expression of IL1RAP mRNA CTD PMID:31059760 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of IL1RAP mRNA CTD PMID:19784758 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of IL1RAP mRNA CTD PMID:19784758 , PMID:33387578 permethrin multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in decreased methylation of IL1RAP gene CTD PMID:33148267 phenobarbital affects expression ISO RGD:10791 6480464 Phenobarbital affects the expression of IL1RAP mRNA CTD PMID:23091169 phenylmercury acetate multiple interactions ISO RGD:732294 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IL1RAP mRNA CTD PMID:27188386 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:732294 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL1RAP mRNA CTD PMID:16979875 pinosylvin decreases expression ISO RGD:732294 6480464 pinosylvin results in decreased expression of IL1RAP mRNA CTD PMID:23333577 pirinixic acid multiple interactions ISO RGD:10791 6480464 [pirinixic acid co-treated with PPARA] results in decreased expression of IL1RAP mRNA, PPARA protein affects the reaction [pirinixic acid results in decreased expression of IL1RAP mRNA] CTD PMID:17321000 , PMID:20813756 pirinixic acid decreases expression ISO RGD:10791 6480464 pirinixic acid results in decreased expression of IL1RAP mRNA CTD PMID:17321000 more ... potassium chromate decreases expression ISO RGD:732294 6480464 potassium chromate(VI) results in decreased expression of IL1RAP mRNA CTD PMID:22714537 pregnenolone 16alpha-carbonitrile decreases expression ISO RGD:10791 6480464 Pregnenolone Carbonitrile results in decreased expression of IL1RAP mRNA CTD PMID:28903501 propiconazole decreases expression ISO RGD:10791 6480464 propiconazole results in decreased expression of IL1RAP mRNA CTD PMID:22334560 quercetin increases expression ISO RGD:732294 6480464 Quercetin results in increased expression of IL1RAP mRNA CTD PMID:30152185 raloxifene affects expression ISO RGD:732294 6480464 Raloxifene Hydrochloride affects the expression of IL1RAP mRNA CTD PMID:14699072 rotenone increases expression ISO RGD:10791 6480464 Rotenone results in increased expression of IL1RAP mRNA CTD PMID:23186747 S-(1,2-dichlorovinyl)-L-cysteine multiple interactions ISO RGD:732294 6480464 [S-(1, 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of IL1RAP mRNA CTD PMID:35811015 SB 431542 multiple interactions ISO RGD:732294 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silver atom increases expression ISO RGD:732294 6480464 Silver results in increased expression of IL1RAP mRNA CTD PMID:22342292 silver atom decreases expression ISO RGD:10791 6480464 Silver results in decreased expression of IL1RAP mRNA CTD PMID:27131904 silver(0) increases expression ISO RGD:732294 6480464 Silver results in increased expression of IL1RAP mRNA CTD PMID:22342292 silver(0) decreases expression ISO RGD:10791 6480464 Silver results in decreased expression of IL1RAP mRNA CTD PMID:27131904 Soman increases expression EXP 6480464 Soman results in increased expression of IL1RAP mRNA CTD PMID:19281266 sunitinib decreases expression ISO RGD:732294 6480464 Sunitinib results in decreased expression of IL1RAP mRNA CTD PMID:31533062 tetrachloromethane decreases expression ISO RGD:10791 6480464 Carbon Tetrachloride results in decreased expression of IL1RAP mRNA CTD PMID:17084009 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of IL1RAP mRNA CTD PMID:19784758 tetrachloromethane multiple interactions ISO RGD:10791 6480464 CYP2E1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL1RAP mRNA] CTD PMID:17084009 tetrachloromethane affects expression ISO RGD:10791 6480464 Carbon Tetrachloride affects the expression of IL1RAP mRNA CTD PMID:17484886 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of IL1RAP mRNA CTD PMID:19784758 more ... titanium dioxide increases expression ISO RGD:732294 6480464 titanium dioxide results in increased expression of IL1RAP mRNA CTD PMID:22342292 topotecan increases expression EXP 6480464 Topotecan results in increased expression of IL1RAP mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of IL1RAP mRNA CTD PMID:25729387 trans-pinosylvin decreases expression ISO RGD:732294 6480464 pinosylvin results in decreased expression of IL1RAP mRNA CTD PMID:23333577 trichloroethene affects expression ISO RGD:10791 6480464 Trichloroethylene affects the expression of IL1RAP mRNA CTD PMID:21135412 triptonide increases expression ISO RGD:10791 6480464 triptonide results in increased expression of IL1RAP mRNA CTD PMID:33045310 troglitazone decreases expression ISO RGD:10791 6480464 troglitazone results in decreased expression of IL1RAP mRNA CTD PMID:28973697 valproic acid increases expression ISO RGD:732294 6480464 Valproic Acid results in increased expression of IL1RAP mRNA CTD PMID:23179753 more ... valproic acid decreases methylation ISO RGD:732294 6480464 Valproic Acid results in decreased methylation of IL1RAP gene CTD PMID:29154799 valproic acid affects expression ISO RGD:732294 6480464 Valproic Acid affects the expression of IL1RAP mRNA CTD PMID:25979313 vorinostat increases expression ISO RGD:732294 6480464 vorinostat results in increased expression of IL1RAP mRNA CTD PMID:27188386 zinc atom multiple interactions ISO RGD:732294 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL1RAP mRNA CTD PMID:16979875 zinc(0) multiple interactions ISO RGD:732294 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL1RAP mRNA CTD PMID:16979875