Il1rap (interleukin 1 receptor accessory protein) - Rat Genome Database

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Gene: Il1rap (interleukin 1 receptor accessory protein) Rattus norvegicus
Analyze
Symbol: Il1rap
Name: interleukin 1 receptor accessory protein
RGD ID: 2893
Description: Enables interleukin-1 receptor binding activity. Predicted to be involved in several processes, including interleukin-33-mediated signaling pathway; positive regulation of cytokine production; and regulation of synapse assembly. Predicted to act upstream of or within cytokine-mediated signaling pathway and positive regulation of dendrite development. Located in cytoplasm. Part of protein-containing complex. Orthologous to human IL1RAP (interleukin 1 receptor accessory protein); PARTICIPATES IN interleukin-1 signaling pathway; apoptotic cell death pathway; cytokine mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IL-1 receptor accessory protein; IL-1RAcp; Il1racpb; interleukin-1 receptor accessory protein; MGC114349
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21174,062,999 - 74,199,530 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1174,070,304 - 74,199,530 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1182,878,646 - 83,008,143 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01175,513,692 - 75,643,189 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01174,567,675 - 74,697,315 (-)NCBIRnor_WKY
Rnor_6.01177,456,648 - 77,593,208 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1177,463,954 - 77,593,207 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01183,123,891 - 83,260,450 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41176,092,252 - 76,222,576 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11176,157,597 - 76,280,084 (-)NCBI
Celera1172,986,798 - 73,116,646 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium selenide  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
dexamethasone  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
febuxostat  (ISO)
fenamidone  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
gentamycin  (EXP)
imiquimod  (ISO)
indometacin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nitrobenzenes  (EXP)
omega-6 fatty acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pinosylvin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trans-pinosylvin  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1beta and NMDA stimulation. Gardoni F, etal., J Neuroinflammation. 2011 Feb 11;8(1):14.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat homolog of mouse interleukin-1 receptor accessory protein: cloning, localization and modulation studies. Liu C, etal., J Neuroimmunol 1996 May;66(1-2):41-8.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. The IL-1 family: regulators of immunity. Sims JE and Smith DE, Nat Rev Immunol. 2010 Feb;10(2):89-102. Epub 2010 Jan 18.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:11880380   PMID:12477932   PMID:15030977   PMID:17675517   PMID:18003919   PMID:19198660   PMID:19946888   PMID:22357843   PMID:22871113   PMID:24006456   PMID:25908590   PMID:27440742  


Genomics

Comparative Map Data
Il1rap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21174,062,999 - 74,199,530 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1174,070,304 - 74,199,530 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1182,878,646 - 83,008,143 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01175,513,692 - 75,643,189 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01174,567,675 - 74,697,315 (-)NCBIRnor_WKY
Rnor_6.01177,456,648 - 77,593,208 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1177,463,954 - 77,593,207 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01183,123,891 - 83,260,450 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41176,092,252 - 76,222,576 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11176,157,597 - 76,280,084 (-)NCBI
Celera1172,986,798 - 73,116,646 (-)NCBICelera
Cytogenetic Map11q22NCBI
IL1RAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383190,514,085 - 190,659,750 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3190,514,051 - 190,659,750 (+)EnsemblGRCh38hg38GRCh38
GRCh373190,231,874 - 190,377,539 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363191,714,585 - 191,851,995 (+)NCBINCBI36Build 36hg18NCBI36
Build 343191,714,592 - 191,830,773NCBI
Celera3188,662,339 - 188,805,268 (+)NCBICelera
Cytogenetic Map3q28NCBI
HuRef3187,631,658 - 187,775,020 (+)NCBIHuRef
CHM1_13190,195,381 - 190,338,509 (+)NCBICHM1_1
T2T-CHM13v2.03193,330,399 - 193,476,092 (+)NCBIT2T-CHM13v2.0
Il1rap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391626,400,259 - 26,548,878 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1626,400,454 - 26,548,867 (+)EnsemblGRCm39 Ensembl
GRCm381626,581,509 - 26,730,128 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1626,581,704 - 26,730,117 (+)EnsemblGRCm38mm10GRCm38
MGSCv371626,581,791 - 26,725,233 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361626,497,122 - 26,631,799 (+)NCBIMGSCv36mm8
Celera1627,124,937 - 27,269,259 (+)NCBICelera
Cytogenetic Map16B2NCBI
Il1rap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542017,463,852 - 17,591,023 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542017,463,493 - 17,591,054 (-)NCBIChiLan1.0ChiLan1.0
IL1RAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13196,089,340 - 196,232,236 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3196,089,208 - 196,231,379 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03187,535,880 - 187,680,628 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IL1RAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13422,547,422 - 22,628,628 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3422,546,899 - 22,623,544 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3426,593,650 - 26,721,856 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03422,434,081 - 22,562,566 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3422,434,042 - 22,557,836 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13422,455,737 - 22,584,041 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03422,442,654 - 22,570,368 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03422,684,947 - 22,812,908 (+)NCBIUU_Cfam_GSD_1.0
Il1rap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602113,537,247 - 113,675,115 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493704948,274 - 181,281 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493704948,267 - 185,766 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1RAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13127,933,693 - 128,043,480 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113127,933,239 - 128,071,984 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213137,204,766 - 137,370,308 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL1RAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11584,728,594 - 84,876,098 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1584,728,517 - 84,866,263 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604158,314,327 - 58,465,943 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il1rap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473066,491,230 - 66,625,642 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il1rap
857 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:195
Count of miRNA genes:134
Interacting mature miRNAs:159
Transcripts:ENSRNOT00000002645, ENSRNOT00000043498
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat

Markers in Region
D11Rat92  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21174,106,772 - 74,106,899 (+)MAPPERmRatBN7.2
Rnor_6.01177,500,524 - 77,500,650NCBIRnor6.0
Rnor_5.01183,216,448 - 83,216,574UniSTSRnor5.0
RGSC_v3.41176,129,617 - 76,129,984RGDRGSC3.4
RGSC_v3.41176,129,817 - 76,129,943UniSTSRGSC3.4
RGSC_v3.11176,187,406 - 76,187,532RGD
Celera1173,023,951 - 73,024,077UniSTS
RH 3.4 Map11601.3RGD
RH 3.4 Map11601.3UniSTS
RH 2.0 Map1190.0RGD
SHRSP x BN Map1135.6998RGD
Cytogenetic Map11q22UniSTS
RH133894  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21174,081,027 - 74,082,650 (+)MAPPERmRatBN7.2
Rnor_6.01177,474,781 - 77,476,403NCBIRnor6.0
Rnor_5.01183,240,695 - 83,242,317UniSTSRnor5.0
RGSC_v3.41176,103,304 - 76,104,926UniSTSRGSC3.4
Celera1172,998,211 - 72,999,833UniSTS
RH 3.4 Map11601.9UniSTS
Cytogenetic Map11q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 34 29 29 25 10 1 10
Low 3 43 23 12 19 12 8 11 49 25 40 1 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001167840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001840406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005490978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005490979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005490980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005490981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB079119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC097339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU123169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U48592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000002645   ⟹   ENSRNOP00000002645
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1174,078,061 - 74,199,449 (-)Ensembl
Rnor_6.0 Ensembl1177,471,558 - 77,593,171 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000043498   ⟹   ENSRNOP00000051260
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1174,070,305 - 74,199,530 (-)Ensembl
Rnor_6.0 Ensembl1177,463,954 - 77,593,207 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105096   ⟹   ENSRNOP00000090112
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1174,070,304 - 74,199,530 (-)Ensembl
RefSeq Acc Id: NM_001167840   ⟹   NP_001161312
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,070,304 - 74,199,530 (-)NCBI
Rnor_6.01177,463,953 - 77,593,207 (-)NCBI
Rnor_5.01183,123,891 - 83,260,450 (+)NCBI
RGSC_v3.41176,092,252 - 76,222,576 (-)RGD
Celera1172,986,798 - 73,116,646 (-)RGD
Sequence:
RefSeq Acc Id: NM_012968   ⟹   NP_037100
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,078,061 - 74,199,449 (-)NCBI
Rnor_6.01177,471,710 - 77,593,126 (-)NCBI
Rnor_5.01183,123,891 - 83,260,450 (+)NCBI
RGSC_v3.41176,092,252 - 76,222,576 (-)RGD
Celera1172,994,555 - 73,116,565 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088037   ⟹   XP_038943965
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,062,999 - 74,156,842 (-)NCBI
RefSeq Acc Id: XM_039088038   ⟹   XP_038943966
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,062,999 - 74,199,526 (-)NCBI
RefSeq Acc Id: XM_039088039   ⟹   XP_038943967
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,062,999 - 74,156,840 (-)NCBI
RefSeq Acc Id: XM_039088040   ⟹   XP_038943968
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,075,385 - 74,156,834 (-)NCBI
RefSeq Acc Id: XR_005490978
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,062,999 - 74,156,842 (-)NCBI
RefSeq Acc Id: XR_005490979
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,062,999 - 74,156,842 (-)NCBI
RefSeq Acc Id: XR_005490980
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,062,999 - 74,156,840 (-)NCBI
RefSeq Acc Id: XR_005490981
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,062,999 - 74,156,840 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_037100   ⟸   NM_012968
- Peptide Label: precursor
- UniProtKB: Q63621 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001161312   ⟸   NM_001167840
- Peptide Label: isoform b precursor
- UniProtKB: D1M8S3 (UniProtKB/TrEMBL),   F1LRE8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000051260   ⟸   ENSRNOT00000043498
RefSeq Acc Id: ENSRNOP00000002645   ⟸   ENSRNOT00000002645
RefSeq Acc Id: XP_038943966   ⟸   XM_039088038
- Peptide Label: isoform X2
- UniProtKB: F1LRE8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943965   ⟸   XM_039088037
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038943967   ⟸   XM_039088039
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038943968   ⟸   XM_039088040
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000090112   ⟸   ENSRNOT00000105096
Protein Domains
Ig-like   Ig-like C2-type   TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63621-F1-model_v2 AlphaFold Q63621 1-570 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698235
Promoter ID:EPDNEW_R8760
Type:single initiation site
Name:Il1rap_1
Description:interleukin 1 receptor accessory protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01177,593,155 - 77,593,215EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2893 AgrOrtholog
BioCyc Gene G2FUF-20943 BioCyc
Ensembl Genes ENSRNOG00000001928 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002645 ENTREZGENE
  ENSRNOP00000002645.3 UniProtKB/TrEMBL
  ENSRNOP00000051260 ENTREZGENE
  ENSRNOP00000051260.4 UniProtKB/TrEMBL
  ENSRNOP00000090112.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002645 ENTREZGENE
  ENSRNOT00000002645.5 UniProtKB/TrEMBL
  ENSRNOT00000043498 ENTREZGENE
  ENSRNOT00000043498.7 UniProtKB/TrEMBL
  ENSRNOT00000105096.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.10140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7442849 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_rcpt_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_rcpt_I/II-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25466 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114349 IMAGE-MGC_LOAD
NCBI Gene 25466 ENTREZGENE
PANTHER PTHR11890 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il1rap PhenoGen
PRINTS INTRLKN1R12F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC213055
UniProt A0A8I6ACY6_RAT UniProtKB/TrEMBL
  D1M8S3 ENTREZGENE, UniProtKB/TrEMBL
  F1LRE8 ENTREZGENE
  F1M9B9_RAT UniProtKB/TrEMBL
  IL1AP_RAT UniProtKB/Swiss-Prot
  Q4V8K9_RAT UniProtKB/TrEMBL
  Q63621 ENTREZGENE
UniProt Secondary F1LRE8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Il1rap  Interleukin 1 receptor accessory protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a extracellular domain with three immunoglobulin-like loops, a single transmembrane domain and a long intracellular domain 633114
gene_homology has > 95% sequence identity to mouse gene 633114