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Gene: Cdc45 (cell division cycle 45) Rattus norvegicus
Symbol: Cdc45
Name: cell division cycle 45
Description: Predicted to have 3'-5' DNA helicase activity; DNA binding activity; and chromatin binding activity. Predicted to be involved in several processes, including DNA metabolic process; mitotic DNA replication preinitiation complex assembly; and positive regulation of G1/S transition of mitotic cell cycle. Predicted to localize to the centrosome and nucleus. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Orthologous to human CDC45 (cell division cycle 45); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: CDC45 cell division cycle 45-like; CDC45 cell division cycle 45-like (S. cerevisiae); CDC45-related protein; Cdc45l; cell division control protein 45 homolog; cell division cycle 45 homolog; cell division cycle 45 homolog (S. cerevisiae); cell division cycle 45 homolog (S. cerevisiae)-like; cell division cycle 45 homolog-like; LOC287961; similar to cell division cycle 45 homolog (S. cerevisiae)-like
Homo sapiens (human) : CDC45 (cell division cycle 45)  HGNC  Alliance
Mus musculus (house mouse) : Cdc45 (cell division cycle 45)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdc45 (cell division cycle 45)
Pan paniscus (bonobo/pygmy chimpanzee) : CDC45 (cell division cycle 45)
Canis lupus familiaris (dog) : CDC45 (cell division cycle 45)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdc45 (cell division cycle 45)
Sus scrofa (pig) : CDC45 (cell division cycle 45)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01186,328,785 - 86,354,099 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01189,431,161 - 89,456,065 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1180,966,334 - 80,990,943 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Cdc45
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1590928
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.