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Gene: Rnf168 (ring finger protein 168) Rattus norvegicus
Symbol: Rnf168
Name: ring finger protein 168
Description: Predicted to have several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; histone binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including DNA metabolic process; histone H2A ubiquitination; and regulation of nucleobase-containing compound metabolic process. Predicted to localize to several cellular components, including the cytosol; nucleoplasm; and site of double-strand break. Human ortholog(s) of this gene implicated in RIDDLE syndrome. Orthologous to human RNF168 (ring finger protein 168); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,2',4,4'-Tetrabromodiphenyl ether; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E3 ubiquitin-protein ligase RNF168; LOC690043; MGC188789; ring finger protein 168, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF168; similar to ring finger protein 168
Homo sapiens (human) : RNF168 (ring finger protein 168)  HGNC  Alliance
Mus musculus (house mouse) : Rnf168 (ring finger protein 168)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rnf168 (ring finger protein 168)
Pan paniscus (bonobo/pygmy chimpanzee) : RNF168 (ring finger protein 168)
Canis lupus familiaris (dog) : RNF168 (ring finger protein 168)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rnf168 (ring finger protein 168)
Sus scrofa (pig) : RNF168 (ring finger protein 168)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01171,721,242 - 71,743,421 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01174,805,354 - 74,827,533 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,304,917 - 70,328,010 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1167,918,463 - 67,940,284 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Rnf168
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1585168
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.