Mx1 (MX dynamin like GTPase 1) - Rat Genome Database

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Gene: Mx1 (MX dynamin like GTPase 1) Rattus norvegicus
Analyze
Symbol: Mx1
Name: MX dynamin like GTPase 1
RGD ID: 3127
Description: Predicted to have GTPase activity and microtubule binding activity. Involved in response to virus. Localizes to nucleus. Orthologous to human MX1 (MX dynamin like GTPase 1); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IFI78; interferon-induced GTP-binding protein Mx1; myxoma resistance protein 1; myxovirus (influenza virus) resistance; myxovirus (influenza virus) resistance 1; Myxovirus (influenza) resistance homolog of murine Mx (also interferon-inducible protein IFI78); Myxovirus (influenza) resistance, homolog of murine Mx (also interferon-inducible protein IFI78); myxovirus resistance protein 1
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21136,799,659 - 36,825,209 (-)NCBI
Rnor_6.0 Ensembl1137,891,156 - 37,914,983 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01137,891,150 - 37,916,775 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01141,398,737 - 41,424,277 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,438,473 - 37,462,363 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11137,496,062 - 37,517,940 (-)NCBI
Celera1136,686,487 - 36,712,040 (-)NCBICelera
Cytogenetic Map11q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aconitine  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
Actein  (EXP)
alpha-pinene  (ISO)
alvocidib  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethyl maleate  (EXP)
dimethylarsinous acid  (ISO)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
Genipin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
GW 4064  (ISO)
hydroquinone  (ISO)
iopamidol  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
metam  (ISO)
metformin  (EXP)
methotrexate  (ISO)
methylarsonic acid  (ISO)
mitomycin C  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
protein kinase inhibitor  (ISO)
rac-lactic acid  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
Soman  (EXP)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
tofacitinib  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

References

References - curated
1. Ciminski K, etal., Emerg Microbes Infect. 2019;8(1):556-563. doi: 10.1080/22221751.2019.1599301.
2. Deeg CM, etal., J Exp Med. 2017 May 1;214(5):1239-1248. doi: 10.1084/jem.20161033. Epub 2017 Apr 10.
3. García-Álvarez M, etal., Sci Rep. 2017 Jan 31;7:41516. doi: 10.1038/srep41516.
4. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Glymph S, etal., Infect Genet Evol. 2013 Jun;16:186-90. doi: 10.1016/j.meegid.2013.02.010. Epub 2013 Feb 22.
6. GOA data from the GO Consortium
7. Ivaska L, etal., J Infect. 2017 Apr;74(4):385-392. doi: 10.1016/j.jinf.2017.01.002. Epub 2017 Jan 7.
8. Jung HE, etal., Viruses. 2019 Jan 28;11(2). pii: v11020109. doi: 10.3390/v11020109.
9. Kolb E, etal., J Virol. 1992 Mar;66(3):1709-16. doi: 10.1128/JVI.66.3.1709-1716.1992.
10. Lee S, etal., Sci Immunol. 2019 Oct 25;4(40). pii: 4/40/eaau4643. doi: 10.1126/sciimmunol.aau4643.
11. Meier E, etal., J Virol 1990 Dec;64(12):6263-9.
12. MGD data from the GO Consortium
13. Murakawa M, etal., J Med Virol. 2017 Jul;89(7):1241-1247. doi: 10.1002/jmv.24763. Epub 2017 Feb 27.
14. NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. RGD automated data pipeline
16. RGD automated import pipeline for gene-chemical interactions
17. Saadeh D, etal., Clin Exp Dermatol. 2017 Dec;42(8):857-862. doi: 10.1111/ced.13187. Epub 2017 Jul 24.
18. Shaker OG, etal., Cell Biochem Biophys. 2015 Mar;71(2):617-25. doi: 10.1007/s12013-014-0241-9.
19. Tazi-Ahnini R, etal., Hum Genet. 2000 Jun;106(6):639-45. doi: 10.1007/s004390000318.
20. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. Toivonen L, etal., J Clin Virol. 2015 Jan;62:8-13. doi: 10.1016/j.jcv.2014.11.018. Epub 2014 Nov 18.
22. Zang F, etal., Epidemiol Infect. 2018 Feb;146(3):379-385. doi: 10.1017/S0950268817002928. Epub 2017 Dec 22.
23. Zhang X, etal., Hum Genet. 2014 Feb;133(2):187-97. doi: 10.1007/s00439-013-1367-3. Epub 2013 Oct 2.
Additional References at PubMed
PMID:12477932   PMID:12892903   PMID:28064310   PMID:31904090  


Genomics

Comparative Map Data
Mx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21136,799,659 - 36,825,209 (-)NCBI
Rnor_6.0 Ensembl1137,891,156 - 37,914,983 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01137,891,150 - 37,916,775 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01141,398,737 - 41,424,277 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,438,473 - 37,462,363 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11137,496,062 - 37,517,940 (-)NCBI
Celera1136,686,487 - 36,712,040 (-)NCBICelera
Cytogenetic Map11q12NCBI
MX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2141,420,020 - 41,470,071 (+)EnsemblGRCh38hg38GRCh38
GRCh382141,420,329 - 41,459,214 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372142,792,485 - 42,831,141 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362141,720,024 - 41,753,008 (+)NCBINCBI36hg18NCBI36
Build 342141,720,023 - 41,753,008NCBI
Celera2127,990,716 - 28,029,320 (+)NCBI
Cytogenetic Map21q22.3NCBI
HuRef2128,261,373 - 28,300,013 (+)NCBIHuRef
CHM1_12142,353,308 - 42,391,928 (+)NCBICHM1_1
Mx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391697,248,235 - 97,264,106 (-)NCBIGRCm39mm39
GRCm39 Ensembl1697,248,235 - 97,264,107 (-)Ensembl
GRCm381697,447,035 - 97,462,906 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1697,447,035 - 97,462,907 (-)EnsemblGRCm38mm10GRCm38
MGSCv371697,668,642 - 97,684,513 (-)NCBIGRCm37mm9NCBIm37
MGSCv361697,551,947 - 97,567,815 (-)NCBImm8
Celera1698,507,376 - 98,523,260 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1657.46NCBI

Position Markers
AA997168  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map11261.71UniSTS
Cytogenetic Map11q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11172720192Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)1132503169342559Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11935127454351274Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)111136730644444347Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111632197346583360Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111947517979734728Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)112194422966944229Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)112194422966944229Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)112204314944444112Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112540112970401129Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112572003870720038Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112572003870720038Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112572003870720038Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112572003870720038Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112831466586994795Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113043533963186373Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)113043533986714631Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113215552082443118Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113590063480900634Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:393
Count of miRNA genes:189
Interacting mature miRNAs:213
Transcripts:ENSRNOT00000039876
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 8 19 3 4 9
Low 17 47 39 39 8 9 41 16 28 2 8
Below cutoff 24 2 2 2 2 33 16 9

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC099784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000039876   ⟹   ENSRNOP00000043001
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1137,891,156 - 37,914,983 (-)Ensembl
RefSeq Acc Id: NM_001271058   ⟹   NP_001257987
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21136,799,659 - 36,825,209 (-)NCBI
Rnor_6.01137,891,150 - 37,916,690 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Celera1136,686,487 - 36,712,040 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271059   ⟹   NP_001257988
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21136,799,659 - 36,825,209 (-)NCBI
Rnor_6.01137,891,150 - 37,916,690 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Celera1136,686,487 - 36,712,040 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271060   ⟹   NP_001257989
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21136,799,659 - 36,823,507 (-)NCBI
Rnor_6.01137,891,150 - 37,914,983 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Celera1136,686,487 - 36,710,338 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271061   ⟹   NP_001257990
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21136,799,659 - 36,823,507 (-)NCBI
Rnor_6.01137,891,150 - 37,914,983 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Celera1136,686,487 - 36,710,338 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271062   ⟹   NP_001257991
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21136,799,659 - 36,823,507 (-)NCBI
Rnor_6.01137,891,150 - 37,914,983 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Celera1136,686,487 - 36,710,338 (-)NCBI
Sequence:
RefSeq Acc Id: NM_173096   ⟹   NP_775119
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21136,799,659 - 36,823,507 (-)NCBI
Rnor_6.01137,891,150 - 37,914,983 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
RGSC_v3.41137,438,473 - 37,462,363 (-)RGD
Celera1136,686,487 - 36,710,338 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248146   ⟹   XP_006248208
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21136,799,659 - 36,825,171 (-)NCBI
Rnor_6.01137,891,150 - 37,916,775 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248149   ⟹   XP_006248211
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01137,891,150 - 37,916,775 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597876   ⟹   XP_017453365
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01137,891,150 - 37,916,775 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597877   ⟹   XP_017453366
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21136,799,659 - 36,825,170 (-)NCBI
Rnor_6.01137,891,150 - 37,916,775 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597878   ⟹   XP_017453367
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21136,799,659 - 36,824,041 (-)NCBI
Rnor_6.01137,891,150 - 37,915,203 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039087955   ⟹   XP_038943883
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21136,799,659 - 36,824,040 (-)NCBI
RefSeq Acc Id: XM_039087956   ⟹   XP_038943884
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21136,799,659 - 36,824,041 (-)NCBI
RefSeq Acc Id: XM_039087958   ⟹   XP_038943886
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21136,799,659 - 36,823,244 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_775119   ⟸   NM_173096
- UniProtKB: Q499S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257988   ⟸   NM_001271059
- UniProtKB: Q499S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257987   ⟸   NM_001271058
- UniProtKB: Q499S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257990   ⟸   NM_001271061
- UniProtKB: Q499S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257989   ⟸   NM_001271060
- UniProtKB: Q499S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257991   ⟸   NM_001271062
- UniProtKB: Q499S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248208   ⟸   XM_006248146
- Peptide Label: isoform X1
- UniProtKB: Q499S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248211   ⟸   XM_006248149
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017453366   ⟸   XM_017597877
- Peptide Label: isoform X1
- UniProtKB: Q499S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453365   ⟸   XM_017597876
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017453367   ⟸   XM_017597878
- Peptide Label: isoform X1
- UniProtKB: Q499S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043001   ⟸   ENSRNOT00000039876
RefSeq Acc Id: XP_038943884   ⟸   XM_039087956
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038943883   ⟸   XM_039087955
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038943886   ⟸   XM_039087958
- Peptide Label: isoform X1
Protein Domains
Dynamin-type G   GED

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698092
Promoter ID:EPDNEW_R8616
Type:single initiation site
Name:Mx1_1
Description:myxovirus resistance 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01137,914,983 - 37,915,043EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3127 AgrOrtholog
Ensembl Genes ENSRNOG00000001959 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000043001 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039876 ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7933587 IMAGE-MGC_LOAD
InterPro Dynamin_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_GTPase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24575 UniProtKB/TrEMBL
MGC_CLONE MGC:124551 IMAGE-MGC_LOAD
NCBI Gene 24575 ENTREZGENE
PANTHER PTHR11566 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Dynamin_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mx1 PhenoGen
PRINTS DYNAMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_DYNAMIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_DYNAMIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DYNc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216795
UniProt MX1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q499S4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-18 Mx1  MX dynamin like GTPase 1  Mx1  myxovirus (influenza virus) resistance 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Mx1  myxovirus (influenza virus) resistance 1    myxovirus (influenza virus) resistance  Name updated 1299863 APPROVED
2003-04-09 Mx1  myxovirus (influenza virus) resistance    Myxovirus (influenza) resistance, homolog of murine Mx (also interferon-inducible protein IFI78)  Name updated 629478 APPROVED
2002-06-10 Mx1  Myxovirus (influenza) resistance, homolog of murine Mx (also interferon-inducible protein IFI78)      Symbol and Name status set to approved 70586 APPROVED