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Gene: Cblb (Cbl proto-oncogene B) Rattus norvegicus
Symbol: Cblb
Name: Cbl proto-oncogene B
Description: Exhibits protein kinase binding activity. Involved in response to gravity; response to hormone; and signal transduction. Localizes to membrane raft. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B); PARTICIPATES IN chronic myeloid leukemia pathway; endocytosis pathway; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
Also known as: Cas-Br-M (murine) ecotropic retroviral transforming sequence b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Casitas B-lineage lymphoma B; casitas B-lineage lymphoma proto-oncogene b; Cbl proto-oncogene B, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase B; E3 ubiquitin-protein ligase CBL-B; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; signal transduction protein CBL-B
Homo sapiens (human) : CBLB (Cbl proto-oncogene B)  HGNC  Alliance
Mus musculus (house mouse) : Cblb (Casitas B-lineage lymphoma b)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cblb (Cbl proto-oncogene B)
Pan paniscus (bonobo/pygmy chimpanzee) : CBLB (Cbl proto-oncogene B)
Canis lupus familiaris (dog) : CBLB (Cbl proto-oncogene B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cblb (Cbl proto-oncogene B)
Sus scrofa (pig) : CBLB (Cbl proto-oncogene B)
Chlorocebus sabaeus (African green monkey) : CBLB (Cbl proto-oncogene B)
Heterocephalus glaber (naked mole-rat) : Cblb (Cbl proto-oncogene B)
more info ...
Is Marker For: Strains:   KDP/Tky   KDP-Tg(H2Kd-Cblb)2Nyo   KDP-Tg(H2Kd-Cblb)1Nyo   KDP-Tg(INS-Cblb)1Nyo   KDP-Tg(CAG-Cblb)1Nyo   TM.KDP-Cblb/Nyo   PVG.KDP-Cblb/Nyo   TM.KDP-Cblb(D9Rat13-D9Rat4)(D12Rat5-D12Rat45)(D18Mit9-D18Rat44)/Nyo  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01151,037,383 - 51,202,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,037,393 - 51,202,820 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01154,218,260 - 54,383,403 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41149,690,402 - 49,856,762 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11149,747,990 - 49,914,351 (-)NCBI
Celera1148,274,821 - 48,438,836 (-)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cblb
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620535
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.