Cblb (Cbl proto-oncogene B) - Rat Genome Database

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Gene: Cblb (Cbl proto-oncogene B) Rattus norvegicus
Analyze
Symbol: Cblb
Name: Cbl proto-oncogene B
RGD ID: 620535
Description: Enables protein kinase binding activity. Involved in several processes, including cellular response to hydrogen peroxide; response to gravity; and response to hormone. Located in membrane raft. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; stomach carcinoma; and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B); PARTICIPATES IN chronic myeloid leukemia pathway; endocytosis pathway; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cas-Br-M (murine) ecotropic retroviral transforming sequence b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Casitas B-lineage lymphoma B; casitas B-lineage lymphoma proto-oncogene b; Cbl proto-oncogene B, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase B; E3 ubiquitin-protein ligase CBL-B; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; signal transduction protein CBL-B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   KDP/Tky   KDP-Tg(H2Kd-Cblb)2Nyo   KDP-Tg(H2Kd-Cblb)1Nyo   KDP-Tg(INS-Cblb)1Nyo   KDP-Tg(CAG-Cblb)1Nyo   TM.KDP-Cblb/Nyo   PVG.KDP-Cblb/Nyo   TM.KDP-Cblb(D9Rat13-D9Rat4)(D12Rat5-D12Rat45)(D18Mit9-D18Rat44)/Nyo  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21148,589,878 - 48,756,940 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1148,592,703 - 48,756,839 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1157,366,338 - 57,530,452 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01150,028,005 - 50,192,131 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01149,152,080 - 49,316,208 (-)NCBIRnor_WKY
Rnor_6.01151,037,383 - 51,202,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,037,393 - 51,202,820 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01154,218,260 - 54,383,403 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41149,690,402 - 49,856,762 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11149,747,990 - 49,914,351 (-)NCBI
Celera1148,274,821 - 48,438,836 (-)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-gluconic acid  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
dichloromethane  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
ethylbenzene  (EXP)
fenofibrate  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
isoprenaline  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pyrimidifen  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)
membrane raft  (IBA)
membrane raft  (IDA)
nucleoplasm  (IEA,ISO)
plasma membrane  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Intraarticular interferon-beta gene therapy ameliorates adjuvant arthritis in rats. Adriaansen J, etal., Hum Gene Ther. 2006 Oct;17(10):985-96.
2. CBLB variants in type 1 diabetes and their genetic interaction with CTLA4. Bergholdt R, etal., J Leukoc Biol. 2005 Apr;77(4):579-85. Epub 2005 Jan 3.
3. [Expression of c-Cbl, Cbl-b, and epidermal growth factor receptor in gastric carcinoma and their clinical significance]. Dong Q, etal., Chin J Cancer. 2010 Jan;29(1):59-64.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice. Hirasaka K, etal., Diabetes. 2007 Oct;56(10):2511-22. Epub 2007 Jun 29.
7. Increased expression of the Cbl family of E3 ubiquitin ligases decreases Interleukin-2 production in a rat model of peripheral neuropathy. Jeong JS, etal., BMC Anesthesiol. 2018 Jul 18;18(1):87. doi: 10.1186/s12871-018-0555-z.
8. Polymorphic variation in the CBLB gene in human type 1 diabetes. Kosoy R, etal., Genes Immun. 2004 May;5(3):232-5.
9. Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation. Kyo S, etal., Genes Cells. 2003 Oct;8(10):825-36.
10. Single Nucleotide Polymorphisms in CBLB, a Regulator of T-Cell Response, Predict Radiation Pneumonitis and Outcomes After Definitive Radiotherapy for Non-Small-Cell Lung Cancer. Li P, etal., Clin Lung Cancer. 2016 Jul;17(4):253-262.e5. doi: 10.1016/j.cllc.2015.11.008. Epub 2015 Nov 22.
11. Single nucleotide polymorphisms of casitas B-lineage lymphoma proto-oncogene-b predict outcomes of patients with advanced non-small cell lung cancer after first-line platinum based doublet chemotherapy. Li P, etal., J Thorac Dis. 2018 Mar;10(3):1635-1647. doi: 10.21037/jtd.2018.02.31.
12. Expression and Comparison of Cbl-b in Lung Squamous Cell Carcinoma and Adenocarcinoma. Li P, etal., Med Sci Monit. 2018 Jan 31;24:623-635. doi: 10.12659/msm.908076.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Skeletal muscle gene expression in space-flown rats. Nikawa T, etal., FASEB J. 2004 Mar;18(3):522-4. Epub 2004 Jan 8.
16. Phosphorylation of c-Cbl protooncogene product following ethanol administration in rat cerebellum: possible involvement of Fyn kinase. Nishio H, etal., Brain Res 2002 Sep 20;950(1-2):203-9.
17. Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes. Payne F, etal., J Leukoc Biol. 2007 Mar;81(3):581-3. Epub 2007 Jan 5.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Negative regulation of FcepsilonRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b. Qu X, etal., Blood. 2004 Mar 1;103(5):1779-86. Epub 2003 Nov 6.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Cbl negatively regulates JNK activation and cell death. Sproul AA, etal., Cell Res. 2009 Aug;19(8):950-61. doi: 10.1038/cr.2009.74.
24. E3 Ubiquitin Ligase Cbl-b Prevents Tumor Metastasis by Maintaining the Epithelial Phenotype in Multiple Drug-Resistant Gastric and Breast Cancer Cells. Xu L, etal., Neoplasia. 2017 Apr;19(4):374-382. doi: 10.1016/j.neo.2017.01.011. Epub 2017 Mar 20.
25. CD28 activation does not down-regulate Cbl-b expression in aged rat T-lymphocytes. Xu Z, etal., Mech Ageing Dev. 2004 Sep;125(9):595-602.
26. Identification and functional analysis of CBLB mutations in type 1 diabetes. Yokoi N, etal., Biochem Biophys Res Commun. 2008 Mar 28;368(1):37-42. Epub 2008 Jan 15.
27. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Yokoi N, etal., Nat Genet 2002 Aug;31(4):391-4.
Additional References at PubMed
PMID:11070165   PMID:12697763   PMID:14525909   PMID:14738763   PMID:14747305   PMID:14973438   PMID:15337528   PMID:16002993   PMID:19546233   PMID:20177738   PMID:29237719   PMID:29513566  
PMID:32606037  


Genomics

Comparative Map Data
Cblb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21148,589,878 - 48,756,940 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1148,592,703 - 48,756,839 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1157,366,338 - 57,530,452 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01150,028,005 - 50,192,131 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01149,152,080 - 49,316,208 (-)NCBIRnor_WKY
Rnor_6.01151,037,383 - 51,202,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,037,393 - 51,202,820 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01154,218,260 - 54,383,403 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41149,690,402 - 49,856,762 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11149,747,990 - 49,914,351 (-)NCBI
Celera1148,274,821 - 48,438,836 (-)NCBICelera
Cytogenetic Map11q21NCBI
CBLB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383105,655,461 - 105,869,449 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3105,655,461 - 105,869,552 (-)EnsemblGRCh38hg38GRCh38
GRCh373105,374,305 - 105,588,245 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363106,859,799 - 107,070,577 (-)NCBINCBI36Build 36hg18NCBI36
Build 343106,859,798 - 107,070,577NCBI
Celera3103,775,519 - 103,986,437 (-)NCBICelera
Cytogenetic Map3q13.11NCBI
HuRef3102,751,829 - 102,962,841 (-)NCBIHuRef
CHM1_13105,340,227 - 105,551,366 (-)NCBICHM1_1
T2T-CHM13v2.03108,373,636 - 108,587,703 (-)NCBIT2T-CHM13v2.0
Cblb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391651,851,593 - 52,028,410 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1651,851,588 - 52,028,411 (+)EnsemblGRCm39 Ensembl
GRCm381652,031,230 - 52,208,047 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1652,031,225 - 52,208,048 (+)EnsemblGRCm38mm10GRCm38
MGSCv371652,031,662 - 52,208,160 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361651,950,573 - 52,127,397 (+)NCBIMGSCv36mm8
Celera1652,360,484 - 52,539,724 (+)NCBICelera
Cytogenetic Map16B5NCBI
Cblb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554276,604,820 - 6,812,882 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554276,601,651 - 6,812,896 (-)NCBIChiLan1.0ChiLan1.0
CBLB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13109,690,120 - 109,905,306 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3109,690,120 - 109,905,191 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03102,752,406 - 102,966,414 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CBLB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13311,255,453 - 11,665,755 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3311,199,863 - 11,530,810 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3311,363,164 - 11,770,049 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03311,418,045 - 11,825,614 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3311,418,236 - 11,631,415 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13311,285,163 - 11,691,897 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03311,352,619 - 11,761,772 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03311,761,341 - 12,168,419 (-)NCBIUU_Cfam_GSD_1.0
Cblb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602145,313,740 - 145,509,343 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367011,157,797 - 1,353,388 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049367011,157,790 - 1,353,375 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBLB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13153,395,978 - 153,700,056 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113153,480,525 - 153,700,115 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213162,675,952 - 162,892,734 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CBLB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12274,961,831 - 75,181,307 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2274,961,859 - 75,178,548 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604191,314,990 - 91,530,969 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cblb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473143,803,768 - 44,015,870 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473143,803,743 - 44,018,682 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cblb
749 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:208
Count of miRNA genes:145
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000002719
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat

Markers in Region
RH142540  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21148,592,737 - 48,592,935 (+)MAPPERmRatBN7.2
Rnor_6.01151,040,242 - 51,040,439NCBIRnor6.0
Rnor_5.01154,221,119 - 54,221,316UniSTSRnor5.0
RGSC_v3.41149,690,437 - 49,690,634UniSTSRGSC3.4
Celera1148,274,856 - 48,275,053UniSTS
Cytogenetic Map11q21UniSTS


Related Rat Strains
The following Strains have been annotated to Cblb


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 22 23 7 19 7 1 1 65 23 34 11 1
Low 1 21 34 34 34 7 10 9 12 7 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002719   ⟹   ENSRNOP00000002719
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1148,592,703 - 48,756,839 (-)Ensembl
Rnor_6.0 Ensembl1151,040,207 - 51,202,703 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077220   ⟹   ENSRNOP00000074638
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1148,592,703 - 48,756,839 (-)Ensembl
Rnor_6.0 Ensembl1151,037,393 - 51,202,820 (-)Ensembl
RefSeq Acc Id: NM_133601   ⟹   NP_598285
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21148,592,703 - 48,756,839 (-)NCBI
Rnor_6.01151,040,207 - 51,202,703 (-)NCBI
Rnor_5.01154,218,260 - 54,383,403 (-)NCBI
RGSC_v3.41149,690,402 - 49,856,762 (-)RGD
Celera1148,274,821 - 48,438,836 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248258   ⟹   XP_006248320
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21148,589,878 - 48,756,940 (-)NCBI
Rnor_6.01151,037,383 - 51,202,761 (-)NCBI
Rnor_5.01154,218,260 - 54,383,403 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248259   ⟹   XP_006248321
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21148,593,215 - 48,756,358 (-)NCBI
Rnor_6.01151,040,719 - 51,202,222 (-)NCBI
Rnor_5.01154,218,260 - 54,383,403 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248260   ⟹   XP_006248322
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21148,589,878 - 48,756,940 (-)NCBI
Rnor_6.01151,037,383 - 51,202,761 (-)NCBI
Rnor_5.01154,218,260 - 54,383,403 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768626   ⟹   XP_008766848
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21148,593,215 - 48,756,426 (-)NCBI
Rnor_6.01151,040,719 - 51,202,349 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598285   ⟸   NM_133601
- UniProtKB: Q9QZ69 (UniProtKB/Swiss-Prot),   Q8K4S7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006248320   ⟸   XM_006248258
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K8K2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248322   ⟸   XM_006248260
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006248321   ⟸   XM_006248259
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K8K2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766848   ⟸   XM_008768626
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K8K2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074638   ⟸   ENSRNOT00000077220
RefSeq Acc Id: ENSRNOP00000002719   ⟸   ENSRNOT00000002719
Protein Domains
Cbl-PTB   RING-type   UBA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K4S7-F1-model_v2 AlphaFold Q8K4S7 1-938 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698119
Promoter ID:EPDNEW_R8644
Type:initiation region
Name:Cblb_1
Description:Cbl proto-oncogene B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01151,202,765 - 51,202,825EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620535 AgrOrtholog
BioCyc Gene G2FUF-21473 BioCyc
Ensembl Genes ENSRNOG00000001982 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002719 ENTREZGENE
  ENSRNOP00000002719.3 UniProtKB/TrEMBL
  ENSRNOP00000074638 ENTREZGENE
  ENSRNOP00000074638.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002719 ENTREZGENE
  ENSRNOT00000002719.5 UniProtKB/TrEMBL
  ENSRNOT00000077220 ENTREZGENE
  ENSRNOT00000077220.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.930.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Adaptor_Cbl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adaptor_Cbl_EF_hand-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adaptor_Cbl_N_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adaptor_Cbl_N_hlx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adaptor_Cbl_SH2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBL-B_RING-HC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cbl_PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171136 UniProtKB/Swiss-Prot
NCBI Gene 171136 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE CBL-B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23007 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cbl_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cbl_N2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cbl_N3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prok-RING_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cblb PhenoGen
PROSITE CBL_PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47668 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K8K2 ENTREZGENE, UniProtKB/TrEMBL
  CBLB_RAT UniProtKB/Swiss-Prot
  G3V689_RAT UniProtKB/TrEMBL
  Q8K4S7 ENTREZGENE
  Q9QZ69 ENTREZGENE
UniProt Secondary Q9QZ69 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-05 Cblb  Cbl proto-oncogene B  Cblb  Casitas B-lineage lymphoma B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-04 Cblb  Casitas B-lineage lymphoma B  Cblb  Cbl proto-oncogene B, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-18 Cblb  Cbl proto-oncogene B, E3 ubiquitin protein ligase  Cblb  Cbl proto-oncogene, E3 ubiquitin protein ligase B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-13 Cblb  Cbl proto-oncogene, E3 ubiquitin protein ligase B  Cblb  Cas-Br-M (murine) ecotropic retroviral transforming sequence b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Cblb  Cas-Br-M (murine) ecotropic retroviral transforming sequence b  Cblb  Casitas B-lineage lymphoma b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cblb  Casitas B-lineage lymphoma b    Cas-Br-M (murine) ectropic retroviral transforming sequence b  Name updated 1299863 APPROVED
2002-08-07 Cblb  Cas-Br-M (murine) ectropic retroviral transforming sequence b      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease major susceptibility gene for type 1 diabetes characterized by KDP diabetes-prone rat substrain 625457
gene_mutations_overexpression KDP rat contains a CT homozygous nonsense mutation (Arg455X) that removes 484 amino acids including the proline-rich region and leucine zipper domain 625457
gene_process negative regulator of autoimmunity 625457
gene_product 938 amino acid protein 625457