Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Strain Registration

Strain: KDP/Tky

Symbol: KDP/Tky
Strain: KDP
Substrain: Tky
Full Name: Komeda diabetes-prone rat
RGD ID: 724576
Citation ID: RRID:RGD_724576
Ontology ID: RS:0000433
Alleles: Cblb
Also Known As: Komeda Diabetes Prone Rat; MDC-02-76; NBRP Rat No: 0026
Type: inbred
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: This is a diabetic-prone substrain of LETL where only diabetic males were used for the backcross.
Coat Color: a, B, C, h
Inbred Generations: F27
Last Known Status: Live Animals; Cryopreserved Embryo
Research Usage Diabetes Obesity; Immunology






  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
KDP/TkyRattype 1 diabetes mellitus MODEL: spontaneousIAGP 634732compared to KND/TkyRGD 
KDP/TkyRattype 1 diabetes mellitus MODEL: spontaneousIAGP 41412159compared to KND/TkyRGD 


Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
KDP/TkyRatKDP/Tky  IEA 7241799 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
KDP/TkyRatblood glucose amount  EXP 634732 RGD 


#
Reference Title
Reference Citation
1. Establishment of two substrains, diabetes-prone and non-diabetic, from Long-Evans Tokushima Lean (LETL) rats. Komeda K, etal., Endocr J. 1998 Dec;45(6):737-44. doi: 10.1507/endocrj.45.737.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
5. A non-MHC locus essential for autoimmune type I diabetes in the Komeda Diabetes-Prone rat. Yokoi N, etal., J Clin Invest 1997 Oct 15;100(8):2015-21.
6. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Yokoi N, etal., Nat Genet 2002 Aug;31(4):391-4.


1 to 1 of 1 rows
Symbol
Name
Trait
Iddm17 Insulin dependent diabetes mellitus QTL 17 blood glucose amount   (VT:0000188)    
1 to 1 of 1 rows


Note Type Note Reference
strain_life_disease These rats develop moderate to severe insulitis within 220 days of age. The cumulative frequency of IDDM was 70% at 120 days of age, and reached 82% within 220 days of age 634732
strain_reproduction These are maintained in heterozygous condition. 625457

Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-07 KDP/Tky  Komeda diabetes-prone rat  KDP/Tky  Komeda diabetes-prone rat  Name updated 68913 APPROVED