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Gene: Lyn (LYN proto-oncogene, Src family tyrosine kinase) Rattus norvegicus
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Symbol: Lyn
Name: LYN proto-oncogene, Src family tyrosine kinase
Description: Exhibits several functions, including gamma-tubulin binding activity; signaling receptor binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of Fc receptor mediated stimulatory signaling pathway; positive regulation of gliogenesis; and secretion by cell. Localizes to several cellular components, including the integrin alpha2-beta1 complex; mitochondrion; and postsynaptic specialization, intracellular component. Biomarker of endometriosis. Orthologous to human LYN (LYN proto-oncogene, Src family tyrosine kinase); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; erythropoietin signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: lyn protein non-receptor kinase; p53Lyn; p56Lyn; tyrosine-protein kinase Lyn; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
Orthologs:
Homo sapiens (human) : LYN (LYN proto-oncogene, Src family tyrosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Lyn (LYN proto-oncogene, Src family tyrosine kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lyn (LYN proto-oncogene, Src family tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : LYN (LYN proto-oncogene, Src family tyrosine kinase)
Canis lupus familiaris (dog) : LYN (LYN proto-oncogene, Src family tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lyn (LYN proto-oncogene, Src family tyrosine kinase)
Sus scrofa (pig) : LYN (LYN proto-oncogene, Src family tyrosine kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0516,526,058 - 16,642,648 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0521,307,094 - 21,422,842 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4516,933,111 - 17,054,564 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1516,933,105 - 17,054,560 (+)NCBI
Celera516,004,013 - 16,119,589 (+)NCBICelera
Cytogenetic Map5q12NCBI
RH 3.4 Map586.9RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Lyn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621017
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.