Cblb (Casitas B-lineage lymphoma b) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Cblb (Casitas B-lineage lymphoma b) Mus musculus
Analyze
Symbol: Cblb
Name: Casitas B-lineage lymphoma b
RGD ID: 733799
MGI Page MGI
Description: Predicted to enable SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway. Acts upstream of or within several processes, including T cell receptor signaling pathway; positive regulation of T cell anergy; and positive regulation of protein metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in membrane raft and plasma membrane. Is expressed in brain; extrinsic ocular muscle; and incisor. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; stomach carcinoma; and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI429560; AI851073; casitas B-lineage lymphoma proto-oncogene b; Cbl-; Cbl-b; E3 ubiquitin-protein ligase CBL-B; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; signal transduction protein CBL-B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391651,851,593 - 52,028,410 (+)NCBIGRCm39mm39
GRCm39 Ensembl1651,851,588 - 52,028,411 (+)Ensembl
GRCm381652,031,230 - 52,208,047 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1652,031,225 - 52,208,048 (+)EnsemblGRCm38mm10GRCm38
MGSCv371652,031,662 - 52,208,160 (+)NCBIGRCm37mm9NCBIm37
MGSCv361651,950,573 - 52,127,397 (+)NCBImm8
Celera1652,360,484 - 52,539,724 (+)NCBICelera
Cytogenetic Map16B5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (EXP,ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
butanal  (ISO)
calcitriol  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-gluconic acid  (ISO)
deguelin  (ISO)
dexamethasone  (EXP)
dichloromethane  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
ethylbenzene  (ISO)
fenofibrate  (EXP)
folic acid  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
pyrimidifen  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
succimer  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tebufenpyrad  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)
membrane raft  (IBA,ISO)
nucleoplasm  (ISO)
plasma membrane  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Intraarticular interferon-beta gene therapy ameliorates adjuvant arthritis in rats. Adriaansen J, etal., Hum Gene Ther. 2006 Oct;17(10):985-96.
2. CBLB variants in type 1 diabetes and their genetic interaction with CTLA4. Bergholdt R, etal., J Leukoc Biol. 2005 Apr;77(4):579-85. Epub 2005 Jan 3.
3. [Expression of c-Cbl, Cbl-b, and epidermal growth factor receptor in gastric carcinoma and their clinical significance]. Dong Q, etal., Chin J Cancer. 2010 Jan;29(1):59-64.
4. Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice. Hirasaka K, etal., Diabetes. 2007 Oct;56(10):2511-22. Epub 2007 Jun 29.
5. Increased expression of the Cbl family of E3 ubiquitin ligases decreases Interleukin-2 production in a rat model of peripheral neuropathy. Jeong JS, etal., BMC Anesthesiol. 2018 Jul 18;18(1):87. doi: 10.1186/s12871-018-0555-z.
6. Polymorphic variation in the CBLB gene in human type 1 diabetes. Kosoy R, etal., Genes Immun. 2004 May;5(3):232-5.
7. Single Nucleotide Polymorphisms in CBLB, a Regulator of T-Cell Response, Predict Radiation Pneumonitis and Outcomes After Definitive Radiotherapy for Non-Small-Cell Lung Cancer. Li P, etal., Clin Lung Cancer. 2016 Jul;17(4):253-262.e5. doi: 10.1016/j.cllc.2015.11.008. Epub 2015 Nov 22.
8. Single nucleotide polymorphisms of casitas B-lineage lymphoma proto-oncogene-b predict outcomes of patients with advanced non-small cell lung cancer after first-line platinum based doublet chemotherapy. Li P, etal., J Thorac Dis. 2018 Mar;10(3):1635-1647. doi: 10.21037/jtd.2018.02.31.
9. Expression and Comparison of Cbl-b in Lung Squamous Cell Carcinoma and Adenocarcinoma. Li P, etal., Med Sci Monit. 2018 Jan 31;24:623-635. doi: 10.12659/msm.908076.
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. MGD IEA MGD IEA
12. Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes. Payne F, etal., J Leukoc Biol. 2007 Mar;81(3):581-3. Epub 2007 Jan 5.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. E3 Ubiquitin Ligase Cbl-b Prevents Tumor Metastasis by Maintaining the Epithelial Phenotype in Multiple Drug-Resistant Gastric and Breast Cancer Cells. Xu L, etal., Neoplasia. 2017 Apr;19(4):374-382. doi: 10.1016/j.neo.2017.01.011. Epub 2017 Mar 20.
18. Identification and functional analysis of CBLB mutations in type 1 diabetes. Yokoi N, etal., Biochem Biophys Res Commun. 2008 Mar 28;368(1):37-42. Epub 2008 Jan 15.
19. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Yokoi N, etal., Nat Genet 2002 Aug;31(4):391-4.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10646608   PMID:10646609   PMID:10922068   PMID:11042159   PMID:11070165   PMID:11076861   PMID:11217851   PMID:11526404   PMID:11826757   PMID:12102152  
PMID:12193687   PMID:12415267   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12697763   PMID:12771181   PMID:12842890   PMID:14610273   PMID:14738763   PMID:14973438   PMID:15102471  
PMID:15240694   PMID:15265912   PMID:15308098   PMID:15315962   PMID:15467726   PMID:15585834   PMID:15589167   PMID:15592455   PMID:15596523   PMID:15661906   PMID:16141072   PMID:16141073  
PMID:16313364   PMID:16424156   PMID:16549761   PMID:16713970   PMID:16734387   PMID:16892055   PMID:17045823   PMID:17056522   PMID:17182860   PMID:17235393   PMID:17364027   PMID:17403934  
PMID:17493844   PMID:17618294   PMID:17868870   PMID:17878343   PMID:18025165   PMID:18199651   PMID:18227156   PMID:18239087   PMID:18832689   PMID:19009524   PMID:19017948   PMID:19257814  
PMID:19396174   PMID:19494812   PMID:19546233   PMID:19549983   PMID:19549985   PMID:19641021   PMID:19741161   PMID:19801520   PMID:19815501   PMID:20037154   PMID:20395198   PMID:20400514  
PMID:20439537   PMID:20578243   PMID:20624942   PMID:20637659   PMID:20639876   PMID:20668237   PMID:20738317   PMID:20805496   PMID:20890046   PMID:20951942   PMID:21248249   PMID:21248250  
PMID:21254087   PMID:21267068   PMID:21273399   PMID:21383769   PMID:21677750   PMID:21725061   PMID:21768087   PMID:21873635   PMID:22763434   PMID:22884358   PMID:23160449   PMID:23310953  
PMID:23349502   PMID:23709694   PMID:23749633   PMID:23762309   PMID:24457600   PMID:24470255   PMID:24508458   PMID:24553136   PMID:24631539   PMID:24651487   PMID:24994594   PMID:25000980  
PMID:25249301   PMID:25560411   PMID:25744063   PMID:25762784   PMID:25829233   PMID:25871390   PMID:26173181   PMID:26177294   PMID:26342078   PMID:26416283   PMID:26811477   PMID:27276677  
PMID:27325702   PMID:27428899   PMID:27428901   PMID:27432944   PMID:27449297   PMID:27474268   PMID:27773928   PMID:27841348   PMID:27926878   PMID:28100467   PMID:28190767   PMID:29109121  
PMID:29237719   PMID:29562201   PMID:30054317   PMID:30082827   PMID:30349541   PMID:31282857   PMID:31591574   PMID:31999304   PMID:32325033   PMID:32584413   PMID:32606037   PMID:33378226  
PMID:33462140   PMID:33974042   PMID:34048740   PMID:34630435   PMID:35181779   PMID:35288194  


Genomics

Comparative Map Data
Cblb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391651,851,593 - 52,028,410 (+)NCBIGRCm39mm39
GRCm39 Ensembl1651,851,588 - 52,028,411 (+)Ensembl
GRCm381652,031,230 - 52,208,047 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1652,031,225 - 52,208,048 (+)EnsemblGRCm38mm10GRCm38
MGSCv371652,031,662 - 52,208,160 (+)NCBIGRCm37mm9NCBIm37
MGSCv361651,950,573 - 52,127,397 (+)NCBImm8
Celera1652,360,484 - 52,539,724 (+)NCBICelera
Cytogenetic Map16B5NCBI
CBLB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383105,655,461 - 105,869,449 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3105,655,461 - 105,869,552 (-)EnsemblGRCh38hg38GRCh38
GRCh373105,374,305 - 105,588,245 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363106,859,799 - 107,070,577 (-)NCBINCBI36hg18NCBI36
Build 343106,859,798 - 107,070,577NCBI
Celera3103,775,519 - 103,986,437 (-)NCBI
Cytogenetic Map3q13.11NCBI
HuRef3102,751,829 - 102,962,841 (-)NCBIHuRef
CHM1_13105,340,227 - 105,551,366 (-)NCBICHM1_1
T2T-CHM13v2.03108,373,636 - 108,587,703 (-)NCBI
Cblb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21148,589,878 - 48,756,940 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1148,592,703 - 48,756,839 (-)Ensembl
Rnor_6.01151,037,383 - 51,202,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,037,393 - 51,202,820 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01154,218,260 - 54,383,403 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41149,690,402 - 49,856,762 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11149,747,990 - 49,914,351 (-)NCBI
Celera1148,274,821 - 48,438,836 (-)NCBICelera
Cytogenetic Map11q21NCBI
Cblb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554276,604,820 - 6,812,882 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554276,601,651 - 6,812,896 (-)NCBIChiLan1.0ChiLan1.0
CBLB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13109,690,120 - 109,905,306 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3109,690,120 - 109,905,191 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03102,752,406 - 102,966,414 (-)NCBIMhudiblu_PPA_v0panPan3
CBLB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13311,255,453 - 11,665,755 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3311,199,863 - 11,530,810 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3311,363,164 - 11,770,049 (-)NCBI
ROS_Cfam_1.03311,418,045 - 11,825,614 (-)NCBI
ROS_Cfam_1.0 Ensembl3311,418,236 - 11,631,415 (-)Ensembl
UMICH_Zoey_3.13311,285,163 - 11,691,897 (-)NCBI
UNSW_CanFamBas_1.03311,352,619 - 11,761,772 (-)NCBI
UU_Cfam_GSD_1.03311,761,341 - 12,168,419 (-)NCBI
Cblb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602145,313,740 - 145,509,343 (+)NCBI
SpeTri2.0NW_0049367011,157,790 - 1,353,375 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBLB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13153,395,978 - 153,700,064 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113153,480,525 - 153,700,115 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213162,675,952 - 162,892,734 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CBLB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12274,961,831 - 75,181,307 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2274,961,859 - 75,178,548 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604191,314,990 - 91,530,969 (-)NCBIVero_WHO_p1.0
Cblb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473143,803,768 - 44,015,870 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473143,803,743 - 44,018,682 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AI851073  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381652,207,582 - 52,207,684UniSTSGRCm38
MGSCv371652,207,695 - 52,207,797UniSTSGRCm37
Celera1652,539,259 - 52,539,361UniSTS
Cytogenetic Map16B5UniSTS
Whitehead/MRC_RH16492.76UniSTS
AI429560  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381652,205,041 - 52,205,187UniSTSGRCm38
MGSCv371652,205,154 - 52,205,300UniSTSGRCm37
Celera1652,536,718 - 52,536,864UniSTS
Cytogenetic Map16B5UniSTS
Whitehead/MRC_RH16492.99UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162193838355938574Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2277525257594076Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162879281362792952Mouse
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162879281362792952Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162879281362792952Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162879281362792952Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163231279566312933Mouse
4142187Arrd3_mage-related retinal degeneration 3 (mouse)Not determined3252290965466552Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse
26884416Bzwq5_mbi-zygomatic width QTL 5, 5 week (mouse)163732036284696888Mouse
4142112Skts-fp3_mskin tumor susceptibility in FVB and PWK 3 (mouse)Not determined164005388172924385Mouse
11522747Eae41_mexperimental allergic encephalomyelitis susceptibility 41 (mouse)164039913478015472Mouse
1301138Pcd4ts3_mp-glycoprotein positive CD4 T cell subset 3 (mouse)Not determined164059392374594076Mouse
1357778Diobq_mdiet-induced obesity QTL (mouse)Not determined164219781782331174Mouse
4141212Imraq3_mimmune response to AAV2 QTL 3 (mouse)Not determined164438335078383506Mouse
1301719Remslp3_mrapid eye movement sleep 3 (mouse)Not determined164438335078383506Mouse
1558836Dice1b_mdetermination of interleukin 4 commitment 1b (mouse)Not determined164551100072274485Mouse
14928310Manh80_mmandible shape 80 (mouse)164821984182219841Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1171
Count of miRNA genes:600
Interacting mature miRNAs:763
Transcripts:ENSMUST00000114471
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001033238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ102432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ110973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ244362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF442243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000114471   ⟹   ENSMUSP00000110115
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1651,851,588 - 52,028,411 (+)Ensembl
GRCm38.p6 Ensembl1652,031,225 - 52,208,048 (+)Ensembl
RefSeq Acc Id: ENSMUST00000226253
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1651,852,008 - 51,871,268 (+)Ensembl
GRCm38.p6 Ensembl1652,031,645 - 52,050,905 (+)Ensembl
RefSeq Acc Id: ENSMUST00000226593   ⟹   ENSMUSP00000154755
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1651,851,969 - 52,025,876 (+)Ensembl
GRCm38.p6 Ensembl1652,031,606 - 52,205,513 (+)Ensembl
RefSeq Acc Id: ENSMUST00000227062   ⟹   ENSMUSP00000154583
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1651,851,926 - 52,025,747 (+)Ensembl
GRCm38.p6 Ensembl1652,031,563 - 52,205,384 (+)Ensembl
RefSeq Acc Id: ENSMUST00000227756   ⟹   ENSMUSP00000153753
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1651,870,016 - 52,025,748 (+)Ensembl
GRCm38.p6 Ensembl1652,049,653 - 52,205,385 (+)Ensembl
RefSeq Acc Id: ENSMUST00000227879   ⟹   ENSMUSP00000153787
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1651,852,580 - 52,025,876 (+)Ensembl
GRCm38.p6 Ensembl1652,032,217 - 52,205,513 (+)Ensembl
RefSeq Acc Id: ENSMUST00000228247
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1651,972,889 - 51,977,024 (+)Ensembl
GRCm38.p6 Ensembl1652,152,526 - 52,156,661 (+)Ensembl
RefSeq Acc Id: NM_001033238   ⟹   NP_001028410
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391651,851,912 - 52,028,410 (+)NCBI
GRCm381652,031,549 - 52,208,047 (+)NCBI
MGSCv371652,031,662 - 52,208,160 (+)RGD
Celera1652,360,484 - 52,539,724 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521947   ⟹   XP_006522010
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391651,851,593 - 52,028,410 (+)NCBI
GRCm381652,031,230 - 52,208,047 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006521948   ⟹   XP_006522011
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391651,851,593 - 52,028,410 (+)NCBI
GRCm381652,031,230 - 52,208,047 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006521949   ⟹   XP_006522012
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391651,851,593 - 52,028,410 (+)NCBI
GRCm381652,031,230 - 52,208,047 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006521950   ⟹   XP_006522013
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391651,851,593 - 52,028,410 (+)NCBI
GRCm381652,031,712 - 52,208,047 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006521951   ⟹   XP_006522014
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391651,851,593 - 52,028,410 (+)NCBI
GRCm381652,031,230 - 52,208,047 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006521952   ⟹   XP_006522015
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391651,867,858 - 52,028,410 (+)NCBI
GRCm381652,047,489 - 52,208,047 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036159858   ⟹   XP_036015751
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391651,851,593 - 52,028,410 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036159859   ⟹   XP_036015752
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391651,851,593 - 52,028,410 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001028410   ⟸   NM_001033238
- UniProtKB: Q3TTA7 (UniProtKB/Swiss-Prot),   B9EKI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006522012   ⟸   XM_006521949
- Peptide Label: isoform X1
- UniProtKB: Q3TTA7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006522011   ⟸   XM_006521948
- Peptide Label: isoform X1
- UniProtKB: Q3TTA7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006522014   ⟸   XM_006521951
- Peptide Label: isoform X3
- UniProtKB: B9EKI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006522010   ⟸   XM_006521947
- Peptide Label: isoform X1
- UniProtKB: Q3TTA7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006522013   ⟸   XM_006521950
- Peptide Label: isoform X1
- UniProtKB: Q3TTA7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006522015   ⟸   XM_006521952
- Peptide Label: isoform X4
- UniProtKB: Q3TTA7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000153787   ⟸   ENSMUST00000227879
RefSeq Acc Id: ENSMUSP00000153753   ⟸   ENSMUST00000227756
RefSeq Acc Id: ENSMUSP00000154583   ⟸   ENSMUST00000227062
RefSeq Acc Id: ENSMUSP00000154755   ⟸   ENSMUST00000226593
RefSeq Acc Id: ENSMUSP00000110115   ⟸   ENSMUST00000114471
RefSeq Acc Id: XP_036015752   ⟸   XM_036159859
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036015751   ⟸   XM_036159858
- Peptide Label: isoform X2
Protein Domains
Cbl-PTB   RING-type   UBA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3TTA7-F1-model_v2 AlphaFold Q3TTA7 1-982 view protein structure

Promoters
RGD ID:6826878
Promoter ID:MM_KWN:21214
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   Liver,   Lung,   MEF_B4,   Spleen
Transcripts:ENSMUST00000114471,   UC007ZLD.1,   UC007ZLF.1,   UC007ZLG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361652,031,126 - 52,031,797 (+)MPROMDB
RGD ID:6826879
Promoter ID:MM_KWN:21215
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   Brain,   ES_Cell,   Kidney,   MEF_B6
Transcripts:UC007ZLH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361652,031,446 - 52,032,727 (+)MPROMDB
RGD ID:8686360
Promoter ID:EPDNEW_M21210
Type:initiation region
Name:Cblb_1
Description:Mus musculus Casitas B-lineage lymphoma b , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381652,031,598 - 52,031,658EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2146430 AgrOrtholog
Ensembl Genes ENSMUSG00000022637 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000110115 ENTREZGENE
  ENSMUSP00000110115.2 UniProtKB/TrEMBL
  ENSMUSP00000153753 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000153787 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000154583 ENTREZGENE
  ENSMUSP00000154583.2 UniProtKB/TrEMBL
  ENSMUSP00000154755 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000114471 ENTREZGENE
  ENSMUST00000114471.3 UniProtKB/TrEMBL
  ENSMUST00000226593 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000227062 ENTREZGENE
  ENSMUST00000227062.2 UniProtKB/TrEMBL
  ENSMUST00000227756 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000227879 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.930.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Adaptor_Cbl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adaptor_Cbl_EF_hand-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adaptor_Cbl_N_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adaptor_Cbl_N_hlx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adaptor_Cbl_SH2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBL-B_RING-HC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cbl_PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:208650 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2146430 ENTREZGENE
NCBI Gene 208650 ENTREZGENE
PANTHER PTHR23007 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cbl_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cbl_N2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cbl_N3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cblb PhenoGen
PROSITE CBL_PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47668 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B1NE43_MOUSE UniProtKB/TrEMBL
  B9EKI5 ENTREZGENE, UniProtKB/TrEMBL
  CBLB_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary E9QMY2 UniProtKB/Swiss-Prot