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Gene: Cblb (Casitas B-lineage lymphoma b) Mus musculus
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Symbol: Cblb
Name: Casitas B-lineage lymphoma b
Description: Predicted to have SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of T cell anergy; positive regulation of protein metabolic process; and regulation of signal transduction. Predicted to localize to several cellular components, including cytosol; membrane raft; and nucleoplasm. Is expressed in brain; extrinsic ocular muscle; and incisor. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B); PARTICIPATES IN chronic myeloid leukemia pathway; endocytosis pathway; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; arsenite(3-).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI429560; AI851073; casitas B-lineage lymphoma proto-oncogene b; Cbl-b; E3 ubiquitin-protein ligase CBL-B; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; signal transduction protein CBL-B
Orthologs:
Homo sapiens (human) : CBLB (Cbl proto-oncogene B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cblb (Cbl proto-oncogene B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cblb (Cbl proto-oncogene B)
Pan paniscus (bonobo/pygmy chimpanzee) : CBLB (Cbl proto-oncogene B)
Canis lupus familiaris (dog) : CBLB (Cbl proto-oncogene B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cblb (Cbl proto-oncogene B)
Sus scrofa (pig) : CBLB (Cbl proto-oncogene B)
Chlorocebus sabaeus (African green monkey) : CBLB (Cbl proto-oncogene B)
Heterocephalus glaber (naked mole-rat) : Cblb (Cbl proto-oncogene B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1652,031,225 - 52,208,048 (+)EnsemblGRCm38mm10GRCm38
GRCm381652,031,230 - 52,208,047 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371652,031,662 - 52,208,160 (+)NCBIGRCm37mm9NCBIm37
MGSCv361651,950,573 - 52,127,397 (+)NCBImm8
Celera1652,360,484 - 52,539,724 (+)NCBICelera
Cytogenetic Map16B5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cblb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733799
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.