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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of ECE2 mRNA] | CTD | PMID:31150632 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:1550450 | 6480464 | Ethinyl Estradiol affects the expression of ECE2 mRNA | CTD | PMID:17555576 | 17beta-estradiol | multiple interactions | ISO | RGD:1349338 | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of ECE2 mRNA | CTD | PMID:21453500 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | RGD:1550450 | 6480464 | 2 more ... | CTD | PMID:31388691 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:1550450 | 6480464 | N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of ECE2 mRNA | CTD | PMID:20188158 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of ECE2 mRNA | CTD | PMID:24780913 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of ECE2 mRNA | CTD | PMID:31881176 | afimoxifene | multiple interactions | ISO | RGD:1349338 | 6480464 | afimoxifene inhibits the reaction [Estrogens results in increased expression of ECE2 mRNA] | CTD | PMID:21233418 | aflatoxin B1 | increases methylation | ISO | RGD:1349338 | 6480464 | Aflatoxin B1 results in increased methylation of ECE2 gene | CTD | PMID:27153756 | all-trans-retinoic acid | decreases expression | ISO | RGD:1349338 | 6480464 | Tretinoin results in decreased expression of ECE2 mRNA | CTD | PMID:23724009 | atrazine | decreases expression | ISO | RGD:1349338 | 6480464 | Atrazine results in decreased expression of ECE2 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | increases methylation | ISO | RGD:1349338 | 6480464 | Benzoapyrene results in increased methylation of ECE2 3' UTR | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | RGD:1349338 | 6480464 | Benzoapyrene affects the methylation of ECE2 promoter | CTD | PMID:27901495 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | RGD:1349338 | 6480464 | Diethylhexyl Phthalate results in decreased expression of ECE2 mRNA | CTD | PMID:31163220 | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of ECE2 mRNA | CTD | PMID:31199487 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of ECE2 mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of ECE2 gene | CTD | PMID:28505145 | Butylbenzyl phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of ECE2 mRNA | CTD | PMID:31199487 | carbon nanotube | increases expression | ISO | RGD:1550450 | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | choline | multiple interactions | ISO | RGD:1550450 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ECE2 gene | CTD | PMID:20938992 | cisplatin | decreases expression | ISO | RGD:1349338 | 6480464 | Cisplatin results in decreased expression of ECE2 mRNA | CTD | PMID:19561079, PMID:27594783 | clothianidin | increases expression | ISO | RGD:1349338 | 6480464 | clothianidin results in increased expression of ECE2 mRNA | CTD | PMID:31626844 | copper(II) sulfate | decreases expression | ISO | RGD:1349338 | 6480464 | Copper Sulfate results in decreased expression of ECE2 mRNA | CTD | PMID:19549813 | dibutyl phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of ECE2 mRNA | CTD | PMID:31199487 | diethyl phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of ECE2 mRNA | CTD | PMID:31199487 | diisobutyl phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of ECE2 mRNA | CTD | PMID:31199487 | diisononyl phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of ECE2 mRNA | CTD | PMID:31199487 | dioxygen | multiple interactions | ISO | RGD:1550450 | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of ECE2 mRNA | CTD | PMID:30529165 | dorsomorphin | multiple interactions | ISO | RGD:1349338 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of ECE2 mRNA | CTD | PMID:27188386 | ethyl methanesulfonate | decreases expression | ISO | RGD:1349338 | 6480464 | Ethyl Methanesulfonate results in decreased expression of ECE2 mRNA | CTD | PMID:23649840 | folic acid | multiple interactions | ISO | RGD:1550450 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ECE2 gene | CTD | PMID:20938992 | formaldehyde | decreases expression | ISO | RGD:1349338 | 6480464 | Formaldehyde results in decreased expression of ECE2 mRNA | CTD | PMID:23649840 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of ECE2 gene | CTD | PMID:22079235 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of ECE2 mRNA | CTD | PMID:22061828 | L-methionine | multiple interactions | ISO | RGD:1550450 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ECE2 gene | CTD | PMID:20938992 | methotrexate | increases expression | ISO | RGD:1349338 | 6480464 | Methotrexate results in increased expression of ECE2 mRNA | CTD | PMID:24449571 | methyl methanesulfonate | decreases expression | ISO | RGD:1349338 | 6480464 | Methyl Methanesulfonate results in decreased expression of ECE2 mRNA | CTD | PMID:23649840 | nickel atom | increases expression | ISO | RGD:1349338 | 6480464 | Nickel results in increased expression of ECE2 mRNA | CTD | PMID:25583101 | paracetamol | affects expression | ISO | RGD:1550450 | 6480464 | Acetaminophen affects the expression of ECE2 mRNA | CTD | PMID:17562736 | potassium dichromate | decreases expression | ISO | RGD:1550450 | 6480464 | Potassium Dichromate results in decreased expression of ECE2 mRNA | CTD | PMID:23608068 | progesterone | multiple interactions | ISO | RGD:1349338 | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of ECE2 mRNA | CTD | PMID:21453500 | SB 431542 | multiple interactions | ISO | RGD:1349338 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of ECE2 mRNA | CTD | PMID:27188386 | selenomethionine | affects expression | ISO | RGD:1349338 | 6480464 | Selenomethionine affects the expression of ECE2 mRNA | CTD | PMID:17222674 | tamoxifen | affects expression | ISO | RGD:1550450 | 6480464 | Tamoxifen affects the expression of ECE2 mRNA | CTD | PMID:17555576 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of ECE2 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of ECE2 mRNA] | CTD | PMID:31150632 | titanium dioxide | increases expression | ISO | RGD:1550450 | 6480464 | titanium dioxide results in increased expression of ECE2 mRNA | CTD | PMID:27760801 | valproic acid | increases methylation | ISO | RGD:1349338 | 6480464 | Valproic Acid results in increased methylation of ECE2 gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | RGD:1349338 | 6480464 | Valproic Acid results in increased expression of ECE2 mRNA | CTD | PMID:23179753, PMID:26272509 | valproic acid | multiple interactions | ISO | RGD:1349338 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of ECE2 mRNA | CTD | PMID:27188386 | |