Tomm70 (translocase of outer mitochondrial membrane 70)

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Gene: Tomm70 (translocase of outer mitochondrial membrane 70) Rattus norvegicus

Analyze

Symbol:

Tomm70

Name:

translocase of outer mitochondrial membrane 70

RGD ID:

1303049

Description:

Predicted to enable mitochondrion targeting sequence binding activity. Predicted to contribute to protein transmembrane transporter activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; positive regulation of protein import; and response to thyroxine. Part of mitochondrial outer membrane translocase complex. Used to study congestive heart failure. Biomarker of hypothyroidism. Orthologous to human TOMM70 (translocase of outer mitochondrial membrane 70); PARTICIPATES IN alpha-helical insertion pathway of mitochondrial protein import; beta-barrel pathway of mitochondrial protein import; carrier pathway of mitochondrial protein import; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC112570; mitochondrial import receptor subunit TOM70; mitochondrial precursor proteins import receptor; TOM70; Tomm70a; translocase of outer membrane 70 kDa subunit; translocase of outer mitochondrial membrane 70 homolog A; translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae); translocase of outer mitochondrial membrane 70 homolog A (yeast); translocase of outer mitochondrial membrane protein 70

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Related Pseudogenes:

Tomm70-ps1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	43,378,719 - 43,417,166 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	43,377,216 - 43,417,202 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	52,153,913 - 52,192,339 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	11	44,815,517 - 44,853,943 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	11	43,939,611 - 43,978,037 (-)	NCBI	Rnor_WKY
Rnor_6.0	11	45,477,053 - 45,511,409 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	45,480,250 - 45,510,961 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	48,669,804 - 48,706,365 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	44,302,535 - 44,341,250 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	44,360,417 - 44,398,702 (-)	NCBI
Celera	11	43,168,344 - 43,206,551 (-)	NCBI		Celera
Cytogenetic Map	11	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cardiomegaly (IEP,ISO)

congestive heart failure (IDA,ISO)

Experimental Diabetes Mellitus (IEP)

hypothyroidism (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3-chloropropane-1,2-diol (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

CGP 52608 (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

deoxynivalenol (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

dioxygen (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

isotretinoin (ISO)

ivermectin (ISO)

morphine (ISO)

nefazodone (EXP)

nicotine (ISO)

ochratoxin A (ISO)

paracetamol (ISO)

paraquat (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

rotenone (ISO)

Soman (EXP)

tebufenpyrad (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

trimellitic anhydride (ISO)

triphenyl phosphate (EXP)

trovafloxacin (EXP)

valproic acid (EXP,ISO)

vincristine (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of innate immune response (IEA,ISO,ISS)

cellular response to virus (IEA,ISO,ISS)

negative regulation of cell growth involved in cardiac muscle cell development (IMP)

positive regulation of defense response to virus by host (IEA,ISO,ISS)

positive regulation of interferon-beta production (IEA,ISO,ISS)

positive regulation of protein targeting to mitochondrion (IMP)

protein import into mitochondrial matrix (IBA)

protein insertion into mitochondrial inner membrane (IBA)

protein targeting to mitochondrion (IMP)

regulation of apoptotic process (IEA,ISO,ISS)

response to thyroxine (IEP)

Cellular Component

mitochondrial outer membrane (IBA,IDA)

mitochondrion (IEA,ISO)

Molecular Function

mitochondrion targeting sequence binding (IBA)

protein binding (IPI,ISO)

protein transmembrane transporter activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

alpha-helical insertion pathway of mitochondrial protein import (ISO)

beta-barrel pathway of mitochondrial protein import (ISO)

carrier pathway of mitochondrial protein import (ISO)

presequence pathway of mitochondrial protein import (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions.	Alvarez-Dolado M, etal., J Neurochem. 1999 Dec;73(6):2240-9.
2.	Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism.	Anandatheerthavarada HK, etal., J Biol Chem. 2009 Jun 19;284(25):17352-63. doi: 10.1074/jbc.M109.007492. Epub 2009 Apr 28.
3.	Biogenesis of mitochondrial outer membrane proteins, problems and diseases.	Ellenrieder L, etal., Biol Chem. 2015 Oct 1;396(11):1199-213. doi: 10.1515/hsz-2015-0170.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Phosphoproteome mapping of cardiomyocyte mitochondria in a rat model of heart failure.	Giorgianni F, etal., Mol Cell Biochem. 2014 Apr;389(1-2):159-67. doi: 10.1007/s11010-013-1937-7. Epub 2014 Jan 7.
6.	Assembly of beta-barrel proteins in the mitochondrial outer membrane.	Hohr AI, etal., Biochim Biophys Acta. 2015 Jan;1853(1):74-88. doi: 10.1016/j.bbamcr.2014.10.006. Epub 2014 Oct 8.
7.	Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy.	Li J, etal., Cell Res. 2014 Aug;24(8):977-93. doi: 10.1038/cr.2014.94. Epub 2014 Jul 15.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	GOA pipeline	RGD automated data pipeline
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy.	Santos JM and Kowluru RA, Diabetes Metab Res Rev. 2013 Mar;29(3):204-13. doi: 10.1002/dmrr.2384.
12.	Unlocking the presequence import pathway.	Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.
13.	Characterization of rat TOM70 as a receptor of the preprotein translocase of the mitochondrial outer membrane.	Suzuki H, etal., J Cell Sci 2002 May 1;115(Pt 9):1895-905.
14.	Cooperation of protein machineries in mitochondrial protein sorting.	Wenz LS, etal., Biochim Biophys Acta. 2015 May;1853(5):1119-29. doi: 10.1016/j.bbamcr.2015.01.012. Epub 2015 Jan 26.

Additional References at PubMed

PMID:12477932	PMID:14651853	PMID:18570454	PMID:18614015	PMID:19946888	PMID:20531390	PMID:22871113	PMID:23303939	PMID:27919679	PMID:31505169	PMID:32357304

Genomics

Comparative Map Data

Tomm70
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	43,378,719 - 43,417,166 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	43,377,216 - 43,417,202 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	52,153,913 - 52,192,339 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	11	44,815,517 - 44,853,943 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	11	43,939,611 - 43,978,037 (-)	NCBI	Rnor_WKY
Rnor_6.0	11	45,477,053 - 45,511,409 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	45,480,250 - 45,510,961 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	48,669,804 - 48,706,365 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	44,302,535 - 44,341,250 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	44,360,417 - 44,398,702 (-)	NCBI
Celera	11	43,168,344 - 43,206,551 (-)	NCBI		Celera
Cytogenetic Map	11	q12	NCBI

TOMM70
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	100,363,431 - 100,401,089 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	3	100,363,431 - 100,401,089 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	100,082,275 - 100,119,933 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	101,564,997 - 101,602,915 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	101,564,998 - 101,602,915	NCBI
Celera	3	98,473,164 - 98,511,084 (-)	NCBI		Celera
Cytogenetic Map	3	q12.2	NCBI
HuRef	3	97,450,096 - 97,488,049 (-)	NCBI		HuRef
CHM1_1	3	100,045,331 - 100,083,272 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	103,068,774 - 103,106,448 (-)	NCBI		T2T-CHM13v2.0

Tomm70a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	56,942,077 - 56,974,893 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	56,942,066 - 56,977,068 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	57,121,714 - 57,154,530 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	57,121,703 - 57,156,705 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	57,121,827 - 57,154,643 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	57,043,073 - 57,075,889 (+)	NCBI		MGSCv36	mm8
Celera	16	57,455,013 - 57,487,868 (+)	NCBI		Celera
Cytogenetic Map	16	C1.1	NCBI
cM Map	16	34.22	NCBI

Tomm70
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955427	1,876,222 - 1,908,737 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955427	1,874,277 - 1,908,245 (-)	NCBI	ChiLan1.0	ChiLan1.0

TOMM70
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	3	104,139,473 - 104,177,061 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	104,139,473 - 104,178,074 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	3	97,459,180 - 97,497,175 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

TOMM70
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	6,976,322 - 7,009,618 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	6,976,934 - 7,009,594 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	7,130,612 - 7,165,083 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	7,114,093 - 7,148,576 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	33	7,114,753 - 7,148,568 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	33	7,001,694 - 7,036,139 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	7,050,040 - 7,084,498 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	7,379,916 - 7,414,382 (-)	NCBI		UU_Cfam_GSD_1.0

Tomm70
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	150,008,687 - 150,042,592 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936630	2,906,581 - 2,940,608 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936630	2,906,573 - 2,938,837 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TOMM70
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	158,577,379 - 158,628,262 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	158,577,026 - 158,629,878 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	168,193,917 - 168,218,856 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TOMM70
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	80,477,429 - 80,516,536 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	80,477,872 - 80,516,670 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	86,056,352 - 86,094,501 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tomm70
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624789	13,792,049 - 13,829,104 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624789	13,792,434 - 13,828,403 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tomm70
94 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	167
Count of miRNA genes:	119
Interacting mature miRNAs:	127
Transcripts:	ENSRNOT00000002238
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	1	69446234	Rat
1558659	Tescar1	Testicular tumor resistance QTL 1	3.9		testis integrity trait (VT:0010572)	percentage of study population developing testis tumors during a period of time (CMO:0001261)	11	1041931	66113562	Rat
1641927	Alcrsp10	Alcohol response QTL 10			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	11	8436674	53436674	Rat
724517	Uae18	Urinary albumin excretion QTL 18	3.7		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	16472047	44285911	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
10058952	Gmadr6	Adrenal mass QTL 6	2.29	0.0072	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	22959403	67959403	Rat
8694376	Bw156	Body weight QTL 156	2.25	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
9590313	Scort20	Serum corticosterone level QTL 20	6.51	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	11	23280456	68280456	Rat
9589032	Epfw10	Epididymal fat weight QTL 10	9.29	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	11	23280456	68280456	Rat
8694424	Bw162	Body weight QTL 162	3.8	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	27672410	82846715	Rat
1300130	Rf20	Renal function QTL 20	4.44		kidney glomerulus integrity trait (VT:0010546)	kidney glomerulus diameter (CMO:0001166)	11	29528418	60324829	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	29528418	82566702	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	31239134	78851519	Rat
70180	BpQTLcluster10	Blood pressure QTL cluster 10	3.19		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	11	34918041	79918041	Rat
1300135	Rf19	Renal function QTL 19	3.38		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	11	40946188	82566702	Rat

Markers in Region

BF410432

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	43,417,853 - 43,418,071 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	45,511,794 - 45,512,011	NCBI	Rnor6.0
Rnor_5.0	11	48,707,061 - 48,707,278	UniSTS	Rnor5.0
RGSC_v3.4	11	44,341,946 - 44,342,163	UniSTS	RGSC3.4
Celera	11	43,207,247 - 43,207,464	UniSTS
RH 3.4 Map	11	325.3	UniSTS
Cytogenetic Map	11	q12	UniSTS

RH125842

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	50,124,978 - 50,125,223 (+)	MAPPER	mRatBN7.2
mRatBN7.2	11	43,378,778 - 43,379,023 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	52,822,334 - 52,822,578	NCBI	Rnor6.0
Rnor_6.0	11	45,477,113 - 45,477,358	NCBI	Rnor6.0
Rnor_5.0	6	62,442,457 - 62,442,701	UniSTS	Rnor5.0
RGSC_v3.4	11	44,302,595 - 44,302,839	UniSTS	RGSC3.4
Celera	6	49,307,483 - 49,307,727	UniSTS
Celera	11	43,168,404 - 43,168,648	UniSTS
Cytogenetic Map	6	q16	UniSTS
Cytogenetic Map	11	q12	UniSTS

AI029154

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	43,377,273 - 43,377,477 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	45,475,608 - 45,475,811	NCBI	Rnor6.0
Rnor_5.0	11	48,668,359 - 48,668,562	UniSTS	Rnor5.0
RGSC_v3.4	11	44,301,090 - 44,301,293	UniSTS	RGSC3.4
Celera	11	43,166,899 - 43,167,102	UniSTS
RH 3.4 Map	11	325.3	UniSTS
Cytogenetic Map	11	q12	UniSTS

Tomm70a

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	50,125,428 - 50,126,335 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	52,822,784 - 52,823,690	NCBI	Rnor6.0
Rnor_5.0	6	62,442,907 - 62,443,813	UniSTS	Rnor5.0
RGSC_v3.4	6	51,873,209 - 51,874,115	UniSTS	RGSC3.4
Celera	6	49,307,933 - 49,308,839	UniSTS
Cytogenetic Map	6	q16	UniSTS
Cytogenetic Map	11	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	42	57	41	19	41	8	10	74	35	41	11	8
Low		1						1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_212519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008768643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008768644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008768645	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB162856	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ243368	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000002238 ⟹ ENSRNOP00000002238

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	43,377,216 - 43,417,202 (-)	Ensembl
Rnor_6.0 Ensembl	11	45,480,250 - 45,510,961 (-)	Ensembl

RefSeq Acc Id:

NM_212519 ⟹ NP_997684

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	43,378,719 - 43,417,158 (-)	NCBI
Rnor_6.0	11	45,477,053 - 45,511,098 (-)	NCBI
Rnor_5.0	11	48,669,804 - 48,706,365 (-)	NCBI
RGSC_v3.4	11	44,302,535 - 44,341,250 (-)	RGD
Celera	11	43,168,344 - 43,206,551 (-)	RGD

Sequence:

show sequence

CCTTTTCTGTCGTCCGCTCCTGCTGCTTAGCGTGCTCGCTCGCGCGTTGCTTTCCTCCACGCTC
CCGGCTTCCTCTCCACGCTGCCCGGTGACCGTGGCGCCCGCGACCGGCGCGGCGGCGGCGGAGG
ACAGTCGTCATGGCCGCCTCTAAGCCCGTAGAGGCGGCGATGGCGGCGGCTGCTGCGCCCGCTT
CTGGAAATGGAGTGGGCAGTAGCGGTGGGACTGCGGCCCCCGGCTCGGGCGCGGGGACCCTGCC
GCGATGGCACGTGGCGCTGGCCATCGGGGCGCCCCTGTTGCTGGGTGCTGGGGCCATGTACCTG
TGGAGCCGAAGACGGAGGCGCCGGGAAGCCGGAGGCCGGGGCGACGCCAGCGGCCTGAAGCGCA
ACAGCGAACGAAAGACCCCAGAGGGCAGGGCCAGTCCGGCCCTGGGCAGTGGCCCCGACGGTTC
TGGTGACTCCCTGGAAATGAGCTCTCTGGATAGAGCCCAAGCAGCCAAAAATAAAGGCAACAAA
TATTTCAAAGCAGGAAAATATGAGCAAGCTATTCAGTGCTATACCGAGGCTATTAGTCTGTGCC
CTACTGAGAAGAATGCAGACCTCTCTACATTTTATCAGAACAGAGCTGCTGCCTTTGAACAGTT
GCAAAAATGGAAAGAAGTGGCCCAAGATTGTACAAAGGCCGTTGAACTTAATCCCAAATATGTG
AAAGCTCTCTTTAGACGTGCAAAAGCCCATGAGAAGCTAGACAATAAGAAGGAGTGTTTAGAAG
ATGTCACTGCTGTGTGTATATTAGAAGGGTTTCAAAATGAGCAGAGCATGCTGTTAGCTGATAA
AGTTCTTAAACTTCTCGGGAAAGAGAATGCCAAAGAAAAATATAAGAACCGGGAACCTCTGATG
CCATCTCCACAGTTTATTAAATCTTACTTCAGTTCTTTCACGGATGACATAATTTCTCAGCCAA
TGCTTAAAGGAGAGAAGTCTGACGAAGATAAGGACAAGGAGGGAGAAGCGTTAGAAGTAAAAGA
AAATTCTGGATATTTAAAAGCTAAACAATATATGGAAGAAGAAAACTATGACAAAATCATAAGT
GAATGCTCAAAGGAAATAGATGCTCAAGGCAAATACATGGCAGAGGCATTACTACTACGAGCCA
CCTTCTACTTGCTTATTGGCAGTGCCAACGCGGCCAAGCCTGACTTAGATAAGGTCATCAGTTT
GAAGGAAGCTAACGTGAAGCTTCGAGCAAATGCCCTTATCAAAAGAGGCACCATGTGCATGCAG
CAGCAGCAGCCTATGCTGTCTACTCAGGACTTCAACATGGCTGCTGAGATTGACCCTATGAACT
CGGATGTTTATCACCACCGAGGACAGCTGAAAATCCTGCTGGATCTAGTTGAAGAAGCAGTGGC
AGATTTTGATGCATGTATCAGACTAAGACCGAAGTTTGCTTTGGCACAGGCTCAGAAGTGTTTT
GCATTGTATCGGCAGGCATATACAGCAAACAATTCTTCGCAAGTCCAGGCAGCTATGAAAGGTT
TTGAAGAAGTCATAAAGAAATTTCCAAGGTGTGCTGAAGGCTATGCACTTTATGCCCAGGCATT
AACAGATCAACAACAATTTGGTAAAGCTGATGAAATGTATGATAAATGTATTGATTTGGAACCA
GATAATGCTACAACTTATGTTCATAAAGGTTTACTTCAACTTCAGTGGAAGCAAGATTTGGATA
AAGGTTTGGAGCTTATCAGCAAAGCTATTGAAATTGACAACAAATGTGACTTTGCGTATGAGAC
CATGGGGACTATTGAAGTGCAGAGAGGAAACATGGAGAAAGCCATTGACATGTTCAACAAAGCT
ATCAACCTGGCCAAGTCGGAAATGGAGATGGCTCATCTGTACTCACTTTGTGATGCTGCCCATG
CCCAGACAGAAGTAGCAAAGAAATACGGATTAAAACCACCGACATTATAAGCACCAGGGGAAAC
AGACTGACTCTTTTAAAAGAAGTTTACCCCCTCTTCAACTGAATCCTGAAGACACTGTCATGAA
TTGTTGAATGGTGGAACTCAGTATTCCCTTTGTGATGTTGTCATTACATCTGTTTCATGTTTAG
GTGTAGTGGGCGTGGCCTTCAAGGAAGTTTGCAGTCTTGCAGCTTTTATTCCCTGTGCAACAAA
AGCTTAGAACCTGTTAAAGGGATATTAAAACAAAGTTGTAGAATACAAACAGTAATTGGCCATG
CAAATAAAAACTTTGATTTGTTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_008768645 ⟹ XP_008766867

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	43,385,372 - 43,417,166 (-)	NCBI
Rnor_6.0	11	45,483,825 - 45,511,408 (-)	NCBI

Sequence:

show sequence

GCCTACTCACAAAGCTACTGGGAGCTGTCCCTCTGCACTCGCTGTATACAACAACCCCGTCCAC
GCTGCACTGGCAACAGTGCCACCGGCCCTTCCATCCTGGAGAAGAGGTCTACTATCACGCAAGG
CCCAAGACCTCCCAAGAGATTCTAAGCAACTGCCTGCTAAAGGAAAGGGGAAAGCAACCCGAAA
CGCCAGACGCACATCCATCCTTCTGACCCCGGAAGTGGTTCTCCCCTGTTCACTCGATAGGGGC
GGGCACAACCGCAGGTCTAGCCCGGCATGCTCCGGGCTTCCGGTGACCTCTGGCCCTTTTCTGT
CGTCCGCTCCTGCTGCTTAGCGTGCTCGCTCGCGCGTTGCTTTCCTCCACGCTCCCGGCTTCCT
CTCCACGCTGCCCGGTGACCGTGGCGCCCGCGACCGGCGCGGCGGCGGCGGAGGACAGTCGTCA
TGGCCGCCTCTAAGCCCGTAGAGGCGGCGATGGCGGCGGCTGCTGCGCCCGCTTCTGGAAATGG
AGTGGGCAGTAGCGGTGGGACTGCGGCCCCCGGCTCGGGCGCGGGGACCCTGCCGCGATGGCAC
GTGGCGCTGGCCATCGGGGCGCCCCTGTTGCTGGGTGCTGGGGCCATGTACCTGTGGAGCCGAA
GACGGAGGCGCCGGGAAGCCGGAGGCCGGGGCGACGCCAGCGGCCTGAAGCGCAACAGCGAACG
AAAGACCCCAGAGGGCAGGGCCAGTCCGGCCCTGGGCAGTGGCCCCGACGGTTCTGGTGACTCC
CTGGAAATGAGCTCTCTGGATAGAGCCCAAGCAGCCAAAAATAAAGGCAACAAATATTTCAAAG
CAGGAAAATATGAGCAAGCTATTCAGTGCTATACCGAGGCTATTAGTCTGTGCCCTACTGAGAA
GAATGCAGACCTCTCTACATTTTATCAGAACAGAGCTGCTGCCTTTGAACAGTTGCAAAAATGG
AAAGAAGTGGCCCAAGATTGTACAAAGGCCGTTGAACTTAATCCCAAATATGTGAAAGCTCTCT
TTAGACGTGCAAAAGCCCATGAGAAGCTAGACAATAAGAAGGAGTGTTTAGAAGATGTCACTGC
TGTGTGTATATTAGAAGGGTTTCAAAATGAGCAGAGCATGCTGTTAGCTGATAAAGTTCTTAAA
CTTCTCGGGAAAGAGAATGCCAAAGAAAAATATAAGAACCGGGAACCTCTGATGCCATCTCCAC
AGTTTATTAAATCTTACTTCAGTTCTTTCACGGATGACATAATTTCTCAGCCAATGCTTAAAGG
AGAGAAGTCTGACGAAGATAAGGACAAGGAGGGAGAAGCGTTAGAAGTAAAAGAAAATTCTGGA
TATTTAAAAGCTAAACAATATATGGAAGAAGAAAACTATGACAAAATCATAAGTGAATGCTCAA
AGGAAATAGATGCTCAAGGCAAATACATGGCAGAGGCATTACTACTACGAGCCACCTTCTACTT
GCTTATTGGCAGTGCCAACGCGGCCAAGCCTGACTTAGATAAGGTCATCAGTTTGAAGGAAGCT
AACGTGAAGCTTCGAGCAAATGCCCTTATCAAAAGAGGCACCATGTGCATGCAGCAGCAGCAGC
CTATGCTGTCTACTCAGGACTTCAACATGGCTGCTGAGATTGACCCTATGAACTCGGATGTTTA
TCACCACCGAGGACAGCTGAAAATCCTGCTGGATCTAGTTGAAGAAGCAGTGGCAGATTTTGAT
GCATGTATCAGACTAAGACCGAAGTTTGCTTTGGCACAGGCTCAGAAGTGTTTTGCATTGAACA
GTGAACTCAAGAAGGAAGCATCTGAAAGCATGTGTCACTGTGCGATTGGCCTGGACTCACAGCC
CTCTTGCCCCAGCCTCCTGCTGGTGCTATCATAGCTGTGCATTGCACACCCCGCTCCTGAGTTT
ACAGCAGAATTATATCTCTACCAGAACCTAGTATGAAAGTGTCAAAAATAATTTGAGGAAATAA
GTCATAGTAATGACAAGACTTAACTGCTTTTGCTTTCCTATGGCCAACCCTAAAATAATTTTCC
CTCTAAAGAAAGTTGTATCATAAGTATTATAGGTTTAAGATGAAAATGAAATTACTACATTAAA
AAGTCTATAGGTGGGATGTATCTTGGTGATAGAGCATGTGGAGGCCTAACATGTGTAAAGTCTT
GTTTTGAATTCTGGCACTACAGAAAAGTACATCAAAATTATGACATCTATGTGCTCAGTTAACA
TGTCTTAGTTTTCTATCGCTGTGGAGAGACAACATAACTAGGGCAGCTTATAAAAGGAAACATT
TACTTGGTGAACACATTATCATTGTGTCCGAGTATGTCAAAGGTCAGGTAGGCATGAAGCTAGA
GCAGTGGCTAAGAACTTACCTAAGTAGGAGATCCTAAGTAGGAGAAAGCGGGCCTAGCCTCAAA
GCCCACCCCAGGAACATACCATTTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_997684	(Get FASTA)	NCBI Sequence Viewer
	XP_008766867	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98640	(Get FASTA)	NCBI Sequence Viewer
	BAD11366	(Get FASTA)	NCBI Sequence Viewer
	EDM11035	(Get FASTA)	NCBI Sequence Viewer
	EDM11036	(Get FASTA)	NCBI Sequence Viewer
	EDM11037	(Get FASTA)	NCBI Sequence Viewer
	Q75Q39	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_997684 ⟸ NM_212519

- UniProtKB:

Q75Q39 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAASKPVEAAMAAAAAPASGNGVGSSGGTAAPGSGAGTLPRWHVALAIGAPLLLGAGAMYLWSR
RRRRREAGGRGDASGLKRNSERKTPEGRASPALGSGPDGSGDSLEMSSLDRAQAAKNKGNKYFK
AGKYEQAIQCYTEAISLCPTEKNADLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKAL
FRRAKAHEKLDNKKECLEDVTAVCILEGFQNEQSMLLADKVLKLLGKENAKEKYKNREPLMPSP
QFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECS
KEIDAQGKYMAEALLLRATFYLLIGSANAAKPDLDKVISLKEANVKLRANALIKRGTMCMQQQQ
PMLSTQDFNMAAEIDPMNSDVYHHRGQLKILLDLVEEAVADFDACIRLRPKFALAQAQKCFALY
RQAYTANNSSQVQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNA
TTYVHKGLLQLQWKQDLDKGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINL
AKSEMEMAHLYSLCDAAHAQTEVAKKYGLKPPTL

hide sequence

RefSeq Acc Id:

XP_008766867 ⟸ XM_008768645

- Peptide Label:

isoform X1

- Sequence:

show sequence

MAASKPVEAAMAAAAAPASGNGVGSSGGTAAPGSGAGTLPRWHVALAIGAPLLLGAGAMYLWSR
RRRRREAGGRGDASGLKRNSERKTPEGRASPALGSGPDGSGDSLEMSSLDRAQAAKNKGNKYFK
AGKYEQAIQCYTEAISLCPTEKNADLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKAL
FRRAKAHEKLDNKKECLEDVTAVCILEGFQNEQSMLLADKVLKLLGKENAKEKYKNREPLMPSP
QFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECS
KEIDAQGKYMAEALLLRATFYLLIGSANAAKPDLDKVISLKEANVKLRANALIKRGTMCMQQQQ
PMLSTQDFNMAAEIDPMNSDVYHHRGQLKILLDLVEEAVADFDACIRLRPKFALAQAQKCFALN
SELKKEASESMCHCAIGLDSQPSCPSLLLVLS

hide sequence

RefSeq Acc Id:

ENSRNOP00000002238 ⟸ ENSRNOT00000002238

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q75Q39-F1-model_v2	AlphaFold	Q75Q39	1-610	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303049	AgrOrtholog
BioCyc Gene	G2FUF-21537	BioCyc
Ensembl Genes	ENSRNOG00000001640	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000002238	ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002238	ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7099109	IMAGE-MGC_LOAD
InterPro	TPR-like_helical_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR_repeat	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:304017	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112570	IMAGE-MGC_LOAD
NCBI Gene	304017	ENTREZGENE
Pfam	TPR_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR_6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR_8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Tomm70	PhenoGen
PROSITE	TPR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR_REGION	UniProtKB/Swiss-Prot
SMART	TPR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48452	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	Q75Q39	ENTREZGENE
	R9PXR4_RAT	UniProtKB/TrEMBL
	TOM70_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-01	Tomm70	translocase of outer mitochondrial membrane 70	Tomm70a	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-12-15	Tomm70a	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)	Tomm70a	translocase of outer mitochondrial membrane 70 homolog A (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Tomm70a	translocase of outer mitochondrial membrane 70 homolog A (yeast)		translocase of outer mitochondrial membrane 70 homolog A	Name updated	1299863	APPROVED
2005-01-06	Tomm70a	translocase of outer mitochondrial membrane 70 homolog A	TOM70	TOM70 protein	Symbol and Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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