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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | increases expression | ISO | RGD:1551718 | 6480464 | Nicotine results in increased expression of TOMM70A mRNA | CTD | PMID:21955143 | 1,2-dichloroethane | decreases expression | ISO | RGD:1551718 | 6480464 | ethylene dichloride results in decreased expression of TOMM70A mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | multiple interactions | ISO | RGD:1551718 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TOMM70A mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | decreases expression | ISO | RGD:1551718 | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of TOMM70A mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:1551718 | 6480464 | Ethinyl Estradiol results in increased expression of TOMM70A mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1551718 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TOMM70A mRNA | CTD | PMID:17942748 | 17beta-estradiol | multiple interactions | ISO | RGD:1343038 | 6480464 | Estradiol promotes the reaction [TOMM70A protein binds to ESR1 protein] | CTD | PMID:27156127 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1551718 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TOMM70A mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1551718 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TOMM70A mRNA | CTD | PMID:17942748 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2, 4-dinitrotoluene affects the expression of TOMM70 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2, 6-dinitrotoluene affects the expression of TOMM70 mRNA | CTD | PMID:21346803 | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of TOMM70 protein | CTD | PMID:34915118 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of TOMM70 mRNA | CTD | PMID:31881176 | aflatoxin B1 | decreases expression | ISO | RGD:1551718 | 6480464 | Aflatoxin B1 results in decreased expression of TOMM70A mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases methylation | ISO | RGD:1343038 | 6480464 | Aflatoxin B1 results in decreased methylation of TOMM70A gene | CTD | PMID:27153756 | all-trans-retinoic acid | decreases expression | ISO | RGD:1551718 | 6480464 | Tretinoin results in decreased expression of TOMM70A mRNA | CTD | PMID:16169686 | all-trans-retinoic acid | decreases expression | ISO | RGD:1343038 | 6480464 | Tretinoin results in decreased expression of TOMM70A mRNA | CTD | PMID:33167477 | atrazine | increases expression | ISO | RGD:1343038 | 6480464 | Atrazine results in increased expression of TOMM70 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | multiple interactions | ISO | RGD:1551718 | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to TOMM70A promoter] | CTD | PMID:19654925 | benzo[a]pyrene | affects methylation | ISO | RGD:1343038 | 6480464 | Benzo(a)pyrene affects the methylation of TOMM70A intron | CTD | PMID:30157460 | benzo[a]pyrene | increases expression | ISO | RGD:1551718 | 6480464 | Benzo(a)pyrene results in increased expression of TOMM70A mRNA | CTD | PMID:19770486, PMID:22228805 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RGD:1343038 | 6480464 | 7 more ... | CTD | PMID:19150397 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of TOMM70 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | RGD:1551718 | 6480464 | bisphenol A results in decreased expression of TOMM70A mRNA | CTD | PMID:33221593 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of TOMM70 mRNA | CTD | PMID:30816183, PMID:34947998 | bisphenol A | affects methylation | ISO | RGD:1551718 | 6480464 | bisphenol A affects the methylation of TOMM70A promoter | CTD | PMID:27334623 | cadmium atom | multiple interactions | ISO | RGD:1343038 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TOMM70 mRNA | CTD | PMID:35301059 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of TOMM70 mRNA | CTD | PMID:33453195 | cadmium dichloride | multiple interactions | ISO | RGD:1343038 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TOMM70 mRNA | CTD | PMID:35301059 | caffeine | affects phosphorylation | ISO | RGD:1343038 | 6480464 | Caffeine affects the phosphorylation of TOMM70 protein | CTD | PMID:35688186 | CGP 52608 | multiple interactions | ISO | RGD:1343038 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to TOMM70A gene] | CTD | PMID:28238834 | clofibrate | multiple interactions | ISO | RGD:1551718 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of TOMM70A mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TOMM70A mRNA] | CTD | PMID:17585979 | clofibrate | increases expression | ISO | RGD:1551718 | 6480464 | Clofibrate results in increased expression of TOMM70A mRNA | CTD | PMID:17585979 | cobalt dichloride | increases expression | ISO | RGD:1343038 | 6480464 | cobaltous chloride results in increased expression of TOMM70 mRNA | CTD | PMID:19376846 | copper(II) sulfate | decreases expression | ISO | RGD:1343038 | 6480464 | Copper Sulfate results in decreased expression of TOMM70 mRNA | CTD | PMID:19549813 | coumarin | increases phosphorylation | ISO | RGD:1343038 | 6480464 | coumarin results in increased phosphorylation of TOMM70 protein | CTD | PMID:35688186 | deoxynivalenol | increases phosphorylation | ISO | RGD:1551718 | 6480464 | deoxynivalenol results in increased phosphorylation of TOMM70A protein | CTD | PMID:23352502 | deoxynivalenol | decreases expression | ISO | RGD:1343038 | 6480464 | deoxynivalenol results in decreased expression of TOMM70A protein | CTD | PMID:33890134 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of TOMM70 mRNA | CTD | PMID:21266533 | dicrotophos | decreases expression | ISO | RGD:1343038 | 6480464 | dicrotophos results in decreased expression of TOMM70A mRNA | CTD | PMID:28302478 | dioxygen | multiple interactions | ISO | RGD:1551718 | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of TOMM70A mRNA | CTD | PMID:30529165 | enzyme inhibitor | multiple interactions | ISO | RGD:1343038 | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TOMM70 protein | CTD | PMID:23301498 | ethanol | decreases expression | ISO | RGD:1551718 | 6480464 | Ethanol results in decreased expression of TOMM70A mRNA | CTD | PMID:21955143 | ethanol | affects splicing | ISO | RGD:1551718 | 6480464 | Ethanol affects the splicing of TOMM70A mRNA | CTD | PMID:30319688 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of TOMM70A mRNA | CTD | PMID:24136188 | folic acid | decreases expression | ISO | RGD:1551718 | 6480464 | Folic Acid results in decreased expression of TOMM70A mRNA | CTD | PMID:25629700 | folic acid | multiple interactions | ISO | RGD:1551718 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TOMM70A mRNA | CTD | PMID:22206623 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of TOM70 mRNA | CTD | PMID:22061828 | isotretinoin | decreases expression | ISO | RGD:1343038 | 6480464 | Isotretinoin results in decreased expression of TOMM70 mRNA | CTD | PMID:20436886 | ivermectin | decreases expression | ISO | RGD:1343038 | 6480464 | Ivermectin results in decreased expression of TOMM70 protein | CTD | PMID:32959892 | morphine | decreases expression | ISO | RGD:1551718 | 6480464 | Morphine results in decreased expression of TOMM70A mRNA | CTD | PMID:21955143 | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of TOMM70A mRNA | CTD | PMID:24136188 | nicotine | increases expression | ISO | RGD:1551718 | 6480464 | Nicotine results in increased expression of TOMM70A mRNA | CTD | PMID:21955143 | ochratoxin A | decreases expression | ISO | RGD:1343038 | 6480464 | ochratoxin A results in decreased expression of TOMM70 protein | CTD | PMID:26861962 | paracetamol | affects expression | ISO | RGD:1551718 | 6480464 | Acetaminophen affects the expression of TOMM70A mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | RGD:1343038 | 6480464 | Acetaminophen results in decreased expression of TOMM70 mRNA | CTD | PMID:25704631 | paracetamol | multiple interactions | ISO | RGD:1551718 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of TOMM70A mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TOMM70A mRNA] | CTD | PMID:17585979 | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of TOMM70 mRNA | CTD | PMID:32680482 | phenobarbital | decreases expression | ISO | RGD:1551718 | 6480464 | Phenobarbital results in decreased expression of TOMM70A mRNA | CTD | PMID:19363144 | pirinixic acid | increases expression | ISO | RGD:1551718 | 6480464 | pirinixic acid results in increased expression of TOMM70A mRNA | CTD | PMID:17426115 more ... | resveratrol | increases expression | ISO | RGD:1551718 | 6480464 | resveratrol results in increased expression of TOMM70A protein | CTD | PMID:25505154 | resveratrol | multiple interactions | ISO | RGD:1343038 | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of TOMM70 mRNA | CTD | PMID:23557933 | rotenone | decreases expression | ISO | RGD:1551718 | 6480464 | Rotenone results in decreased expression of TOMM70A mRNA | CTD | PMID:23186747 | rotenone | decreases expression | ISO | RGD:1343038 | 6480464 | Rotenone results in decreased expression of TOMM70 mRNA | CTD | PMID:33512557 | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of TOMM70 mRNA | CTD | PMID:19281266 | tebufenpyrad | decreases expression | ISO | RGD:1343038 | 6480464 | 4-chloro-N-((4-(1, 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in decreased expression of TOMM70 mRNA | CTD | PMID:33512557 | tetrachloromethane | increases expression | ISO | RGD:1551718 | 6480464 | Carbon Tetrachloride results in increased expression of TOMM70A mRNA | CTD | PMID:31919559 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of TOMM70 mRNA | CTD | PMID:34492290 | trimellitic anhydride | increases expression | ISO | RGD:1551718 | 6480464 | trimellitic anhydride results in increased expression of TOMM70A mRNA | CTD | PMID:19042947 | triphenyl phosphate | affects expression | EXP | | 6480464 | triphenyl phosphate affects the expression of TOMM70A mRNA | CTD | PMID:30589522 | trovafloxacin | decreases expression | EXP | | 6480464 | trovafloxacin results in decreased expression of TOMM70A mRNA | CTD | PMID:24136188 | valproic acid | decreases expression | ISO | RGD:1343038 | 6480464 | Valproic Acid results in decreased expression of TOMM70 mRNA, Valproic Acid results in decreased expression of TOMM70A mRNA | CTD | PMID:23179753, PMID:27188386 | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of TOMM70A mRNA | CTD | PMID:29427782 | vincristine | decreases expression | ISO | RGD:1343038 | 6480464 | Vincristine results in decreased expression of TOMM70 mRNA | CTD | PMID:23649840 | zearalenone | increases expression | ISO | RGD:1551718 | 6480464 | Zearalenone results in increased expression of TOMM70A protein | CTD | PMID:25058043 | |