Nr1i2 (nuclear receptor subfamily 1, group I, member 2) - Rat Genome Database

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Gene: Nr1i2 (nuclear receptor subfamily 1, group I, member 2) Rattus norvegicus
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
RGD ID: 69057
Description: Enables nuclear receptor activity. Predicted to be involved in several processes, including cellular response to type I interferon; regulation of transcription by RNA polymerase II; and xenobiotic transport. Predicted to act upstream of or within negative regulation of DNA-templated transcription and positive regulation of gene expression. Located in nucleus. Biomarker of cholestasis and epilepsy. Orthologous to human NR1I2 (nuclear receptor subfamily 1 group I member 2); INTERACTS WITH (+)-schisandrin B; (+)-trans-(S)-allethrin; (3-phenoxyphenyl)methanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC108643; nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group 1, member 2; orphan nuclear receptor PXR; pregnane X receptor (nuclear receptor sub family 1, group I, member 2); PXR
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Nr1i2em1Sage  
Genetic Models: SD-Nr1i2em1Sage SD-Nr1i2em1Sage Nr1i3em1Sage SD-Nr1i2em1Sage Nr1i3em1Sage Ahrem1Sage
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21162,460,213 - 62,496,665 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,460,213 - 62,496,658 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,272,711 - 71,309,163 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01163,934,940 - 63,971,386 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01162,985,406 - 63,021,853 (+)NCBIRnor_WKY
Rnor_6.01165,022,100 - 65,058,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,022,100 - 65,058,545 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01167,024,185 - 67,060,494 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,239,918 - 64,276,702 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11164,297,534 - 64,333,716 (+)NCBI
Celera1161,960,674 - 61,997,009 (+)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP,ISO)
(+)-trans-(S)-allethrin  (EXP,ISO)
(-)-secoisolariciresinol  (ISO)
(3-phenoxyphenyl)methanol  (EXP,ISO)
(E,E)-germacrone  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (ISO)
(Z)-ligustilide  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1-(3-chlorophenyl)piperazine  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthol  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
10H-phenothiazine  (ISO)
13-cis-retinal  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-indole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,2'-Bisphenol F  (ISO)
2,2-diphenylacetic acid 2-(diethylamino)ethyl ester  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,5-trichlorophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2,5-di-tert-butylbenzene-1,4-diol  (ISO)
2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid  (ISO)
2-(1-naphthalenylmethyl)-3-(2-oxolanyl)propanoic acid 2-(diethylamino)ethyl ester  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-methyl-1H-indole  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (ISO)
3,3'-Dimethylbenzidine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-xylenol  (ISO)
3-iodoprop-2-yn-1-yl butylcarbamate  (ISO)
3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one  (ISO)
3-oxo-5beta-cholanic acid  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
4-chloro-3,5-dimethylphenol  (ISO)
4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-chromen-2-one  (ISO)
4-hydroxy-3-[1-(4-hydroxyphenyl)-3-oxobutyl]-2H-chromen-2-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Methyl-3-penten-2-one, 9CI  (ISO)
4-nonylphenol  (EXP,ISO)
4-octylphenol  (ISO)
4-tert-butylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-iodo-2'-deoxyuridine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5alpha-pregnane-3,20-dione  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinal  (ISO)
9-cis-retinoic acid  (ISO)
9-phenanthrol  (ISO)
acetamide  (EXP)
acetochlor  (ISO)
Acetyl tributyl citrate  (EXP,ISO)
actinomycin D  (EXP,ISO)
adenine arabinoside  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
Aflatoxin G1  (ISO)
aflatoxin M1  (ISO)
alachlor  (EXP,ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
allyl isothiocyanate  (EXP,ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-santonin  (ISO)
alpha-tocotrienol  (ISO)
aminoglutethimide  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP,ISO)
amphetamine  (ISO)
amprenavir  (ISO)
androst-4-ene-3,17-dione  (ISO)
androstane  (ISO)
Anilofos  (ISO)
apazone  (ISO)
apigenin  (ISO)
arsenite(3-)  (EXP)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
azinphos-methyl  (ISO)
azoxystrobin  (ISO)
beclomethasone  (ISO)
Benfuresate  (ISO)
benidipine  (ISO)
bensulfuron-methyl  (ISO)
Bensulide  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[c]phenanthrene  (ISO)
benzophenone  (EXP)
Benzyl parahydroxybenzoate  (ISO)
berberine  (ISO)
bergomottin  (ISO)
Besigomsin  (ISO)
beta-carotene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP,ISO)
beta-tocotrienol  (ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bifenthrin  (EXP,ISO)
bilirubin IXalpha  (ISO)
biochanin A  (ISO)
bioresmethrin  (EXP,ISO)
biphenyl-2-ol  (ISO)
biphenyl-4-ol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol A dimethacrylate  (ISO)
Bisphenol B  (ISO)
bitertanol  (ISO)
brefeldin A  (ISO)
Bromadiolone  (ISO)
bromocresol purple  (ISO)
Bromophos-ethyl  (ISO)
bromothymol blue  (ISO)
Bromperidol  (ISO)
bromuconazole  (EXP,ISO)
budesonide  (EXP,ISO)
bupirimate  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butafenacil  (ISO)
Butamifos  (ISO)
butein  (ISO)
butoconazole  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP,ISO)
cafenstrole  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbamazepine-10,11-epoxide  (ISO)
carbaryl  (EXP,ISO)
carbon nanotube  (ISO)
cerivastatin  (ISO)
cetylpyridinium  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
Chlomethoxyfen  (ISO)
chlordecone  (ISO)
chlorfenvinfos  (ISO)
chlornitrofen  (ISO)
Chlorobenzilate  (ISO)
Chloromethyl methyl ether  (ISO)
chloropropylate  (ISO)
chlorothalonil  (ISO)
chlorpromazine  (ISO)
chlorpropham  (ISO)
chlorpyrifos  (ISO)
chlorpyrifos-methyl  (ISO)
cholesterol  (ISO)
cholic acid  (ISO)
choline  (ISO)
chrysin  (ISO)
ciguatoxin CTX1B  (ISO)
cimetidine  (ISO)
cinchocaine  (ISO)
cisplatin  (ISO)
clemizole  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clomiphene  (ISO)
clonazepam  (ISO)
clorgyline  (ISO)
clotrimazole  (EXP,ISO)
clozapine  (ISO)
cobicistat  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
coumaphos  (ISO)
coumestrol  (ISO)
Cryptotanshinone  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
Cyanofenphos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (EXP,ISO)
cyhalothrin  (EXP,ISO)
cypermethrin  (EXP,ISO)
cyproconazole  (ISO)
cyprodinil  (ISO)
cyproterone acetate  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
decabromodiphenyl ether  (EXP,ISO)
Decamethylcyclopentasiloxane  (ISO)
dehydroepiandrosterone  (ISO)
delta-hexachlorocyclohexane  (ISO)
delta-tocotrienol  (ISO)
deoxycholic acid  (ISO)
Deoxyschizandrin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diazepam  (ISO)
diazinon  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
Dichlofenthion  (ISO)
diclofenac  (ISO)
dicloxacillin  (ISO)
dicofol  (ISO)
Dicyclohexyl phthalate  (ISO)
dieldrin  (EXP,ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
difenoconazole  (ISO)
diflubenzuron  (ISO)
dihydroergotamine  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dilazep  (ISO)
dimethomorph  (ISO)
dimethylarsinous acid  (ISO)
diniconazole  (ISO)
diosgenin  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (ISO)
Diphenolic acid  (ISO)
diphenylamine  (ISO)
disopyramide  (ISO)
disulfiram  (ISO)
disulfoton  (ISO)
Dithiopyr  (ISO)
diuron  (ISO)
dodecylamine  (ISO)
doxorubicin  (ISO)
econazole  (ISO)
efavirenz  (EXP)
endosulfan  (EXP,ISO)
endrin  (ISO)
enilconazole  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
equilin  (ISO)
erlotinib hydrochloride  (ISO)
estriol  (ISO)
estrone  (ISO)
Ethalfluralin  (ISO)
ethanol  (EXP,ISO)
ethion  (ISO)
ethoprophos  (ISO)
ethotoin  (ISO)
ethoxyquin  (ISO)
ethylparaben  (EXP,ISO)
eticlopride(1+)  (ISO)
etidronic acid  (ISO)
etofenprox  (ISO)
etoposide  (ISO)
eugenol  (ISO)
felodipine  (EXP,ISO)
fenamiphos  (ISO)
fenarimol  (ISO)
fenbuconazole  (ISO)
fenhexamid  (ISO)
fenitrothion  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
fentin chloride  (ISO)
fenvalerate  (EXP,ISO)
Fexofenadine hydrochloride  (ISO)
finasteride  (ISO)
fipronil  (ISO)
fisetin  (ISO)
flavonol  (EXP,ISO)
fluconazole  (ISO)
flucythrinate  (ISO)
fludioxonil  (ISO)
flufenacet  (ISO)
Flumetralin  (ISO)
flunisolide  (ISO)
fluoranthene  (ISO)
flutamide  (EXP,ISO)
fluticasone  (ISO)
flutolanil  (ISO)
fluvalinate  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
galangin  (ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
genistein  (EXP,ISO)
Ginkgolide A  (ISO)
ginkgolide B  (ISO)
glimepiride  (ISO)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhizinic acid  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
heptachlor  (ISO)
Heptachlor epoxide  (ISO)
hesperetin  (ISO)
hexestrol  (ISO)
hycanthone  (ISO)
Hydrastine  (ISO)
hydroxyflutamide  (ISO)
hydroxyitraconazole  (ISO)
hyperforin  (ISO)
ifosfamide  (ISO)
imazamox  (ISO)
imipenem hydrate  (ISO)
Indanofan  (ISO)
indole-3-acetamide  (ISO)
indoprofen  (ISO)
iprobenfos  (ISO)
iprodione  (ISO)
Isobutylparaben  (EXP,ISO)
Isoetharine  (ISO)
isofenphos  (ISO)
isoliquiritigenin  (ISO)
isopimpinellin  (ISO)
isoprothiolane  (ISO)
isoproturon  (ISO)
isorhamnetin  (ISO)
isotretinoin  (ISO)
isoxaben  (ISO)
isoxazoles  (ISO)
Isradipine  (ISO)
itraconazole  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
kojic acid  (EXP)
L-methionine  (ISO)
lansoprazole  (ISO)
leflunomide  (ISO)
leptophos  (ISO)
levonorgestrel  (ISO)
lidocaine  (ISO)
lignan  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (EXP,ISO)
loperamide  (ISO)
lovastatin  (ISO)
Maleic hydrazide  (ISO)
MC-4379  (ISO)
mecarbam  (ISO)
Medazepam  (ISO)
medroxyprogesterone acetate  (ISO)
mefenacet  (ISO)
mefenamic acid  (ISO)
megestrol  (ISO)
melatonin  (ISO)
Melengestrol acetate  (ISO)
menaquinone  (ISO)
menaquinone-4  (ISO)
mephenytoin  (ISO)
mephobarbital  (ISO)
mercury dichloride  (EXP)
mestranol  (ISO)
metconazole  (ISO)
metformin  (EXP,ISO)
methacholine chloride  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methiocarb  (EXP)
methotrexate  (EXP)
methoxsalen  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyltestosterone  (ISO)
metolachlor  (ISO)
metolazone  (ISO)
metyrapone  (ISO)
mevastatin  (ISO)
miconazole  (EXP,ISO)
midazolam  (ISO)
mifepristone  (EXP,ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzone  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (EXP)
monocrotaline  (ISO)
monocrotophos  (ISO)
mycophenolic acid  (ISO)
N-nitrosodiethylamine  (EXP)
nabumetone  (ISO)
nafcillin  (ISO)
napropamide  (ISO)
nefazodone  (ISO)
nelfinavir  (ISO)
nicardipine  (ISO)
nifedipine  (ISO)
nilutamide  (ISO)
nimodipine  (ISO)
nitrofen  (ISO)
Nonylphenol  (EXP,ISO)
norethisterone  (ISO)
norgestrel  (ISO)
notoginsenoside R1  (ISO)
ochratoxin A  (ISO)
octamethylcyclotetrasiloxane  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP,ISO)
orlistat  (ISO)
oryzalin  (ISO)
Oxadiazon  (ISO)
oxiconazole  (ISO)
oxolane  (ISO)
oxybenzone  (ISO)
oxybuprocaine  (ISO)
oxycodone  (EXP)
Oxyfluorfen  (ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
parathion-methyl  (ISO)
parthenolide  (ISO)
pazopanib  (ISO)
penconazole  (ISO)
pencycuron  (ISO)
pendimethalin  (ISO)
pentachloronitrobenzene  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (EXP,ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP,ISO)
phenanthrene  (ISO)
phenobarbital  (EXP,ISO)
phenolphthalein  (ISO)
phenothrin  (EXP)
Phenoxybenzamine  (ISO)
phenthoate  (ISO)
phenylephrine  (ISO)
phenytoin  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosalone  (ISO)
phoxim  (ISO)
phthalic acid  (ISO)
picoxystrobin  (ISO)
pimecrolimus  (ISO)
pioglitazone  (ISO)
piperine  (ISO)
piperonyl butoxide  (ISO)
Piperophos  (ISO)
pirimiphos-methyl  (ISO)
pirinixic acid  (ISO)
PK-11195  (ISO)
prallethrin  (ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
Pretilachlor  (ISO)
procaine  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
prometryn  (ISO)
propanil  (ISO)
propaphos  (ISO)
propargite  (ISO)
propiconazole  (ISO)
propranolol  (ISO)
propylparaben  (EXP,ISO)
propyzamide  (ISO)
prothiofos  (ISO)
pterostilbene  (ISO)
pyrene  (ISO)
pyrethrins  (ISO)
pyridaben  (ISO)
pyridaphenthion  (ISO)
pyrimethanil  (ISO)
quercetin  (ISO)
quinalphos  (ISO)
quinoxyfen  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
rifampicin  (EXP,ISO)
rifaximin  (ISO)
Riluzole  (ISO)
risperidone  (ISO)
ritonavir  (EXP,ISO)
saquinavir  (ISO)
secobarbital  (ISO)
sevoflurane  (EXP)
silibinin  (ISO)
simvastatin  (ISO)
skatole  (ISO)
sodium arsenite  (EXP,ISO)
spironolactone  (EXP,ISO)
steviol  (ISO)
stilbene oxide  (ISO)
sulconazole  (ISO)
sulfamethazine  (ISO)
sulfinpyrazone  (ISO)
sulfluramid  (ISO)
sulforaphane  (EXP,ISO)
sulfoxaflor  (ISO)
tamarixetin  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tartrazine  (ISO)
taurocholic acid  (ISO)
tebuconazole  (ISO)
terbufos  (ISO)
terbutryn  (ISO)
terbutylazine  (ISO)
testosterone  (EXP,ISO)
Testosterone propionate  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
tetrachlorvinphos  (ISO)
tetramethrin  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thiabendazole  (ISO)
Thiazopyr  (ISO)
thioacetamide  (EXP)
Thiobencarb  (ISO)
Thymophthalein  (ISO)
thyroxine  (ISO)
tiaprofenic acid  (ISO)
tiracizine  (ISO)
titanium dioxide  (ISO)
tolclofos-methyl  (ISO)
tolylfluanid  (ISO)
topiramate  (ISO)
toxaphene  (ISO)
tralomethrin  (ISO)
TRAM-34  (ISO)
trans-cinnamic acid  (ISO)
trenbolone  (ISO)
Tri-2-ethylhexyl trimellitate  (ISO)
triadimefon  (ISO)
Tributyl citrate  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triflumizole  (ISO)
trifluralin  (EXP,ISO)
trifluridine  (ISO)
triforine  (ISO)
trimethobenzamide  (ISO)
triphenyl phosphate  (ISO)
Triphenylethylene  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
Tris(2-ethylhexyl) phosphate  (ISO)
triticonazole  (ISO)
troglitazone  (ISO)
troleandomycin  (ISO)
tryptamine  (ISO)
tryptophol  (ISO)
uranium atom  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP,ISO)
vincristine  (ISO)
vitamin D  (ISO)
voriconazole  (ISO)
warfarin  (ISO)
zearalenone  (EXP,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Creation and Preliminary Characterization of Pregnane X Receptor and Constitutive Androstane Receptor Knockout Rats. Forbes KP, etal., Drug Metab Dispos. 2017 Oct;45(10):1068-1076. doi: 10.1124/dmd.117.075788. Epub 2017 Jul 17.
2. Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis. Gabbia D, etal., World J Gastroenterol. 2017 Nov 14;23(42):7519-7530. doi: 10.3748/wjg.v23.i42.7519.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats. Haines C, etal., Toxicology. 2018 May 1;400-401:20-27. doi: 10.1016/j.tox.2018.03.002. Epub 2018 Mar 13.
6. Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase. Hunter SR, etal., Drug Metab Dispos. 2017 Feb;45(2):118-129. doi: 10.1124/dmd.116.073833. Epub 2016 Nov 16.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. Pregnane X Receptor Not Nuclear Factor-kappa B Up-regulates P-glycoprotein Expression in the Brain of Chronic Epileptic Rats Induced by Kainic Acid. Yu N, etal., Neurochem Res. 2017 Aug;42(8):2167-2177. doi: 10.1007/s11064-017-2224-x. Epub 2017 Mar 16.
15. Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation. Zhang H, etal., Arch Biochem Biophys 1999 Aug 1;368(1):14-22.
16. Genetic polymorphisms in PXR and NF-κB1 influence susceptibility to anti-tuberculosis drug-induced liver injury. Zhang J, etal., PLoS One. 2019 Sep 6;14(9):e0222033. doi: 10.1371/journal.pone.0222033. eCollection 2019.
Additional References at PubMed
PMID:11114890   PMID:11891224   PMID:12477932   PMID:12578355   PMID:16085054   PMID:17919779   PMID:18794335   PMID:19141612   PMID:19162173   PMID:19435144   PMID:20599767   PMID:21311750  
PMID:21402137   PMID:22066269   PMID:22166712   PMID:23331901   PMID:23634744   PMID:23878263   PMID:24090815   PMID:24525126   PMID:26302150   PMID:27665777   PMID:28825834   PMID:30132884  
PMID:31955533   PMID:32205367   PMID:34226610  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21162,460,213 - 62,496,665 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,460,213 - 62,496,658 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,272,711 - 71,309,163 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01163,934,940 - 63,971,386 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01162,985,406 - 63,021,853 (+)NCBIRnor_WKY
Rnor_6.01165,022,100 - 65,058,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,022,100 - 65,058,545 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01167,024,185 - 67,060,494 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,239,918 - 64,276,702 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11164,297,534 - 64,333,716 (+)NCBI
Celera1161,960,674 - 61,997,009 (+)NCBICelera
Cytogenetic Map11q21NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh383119,782,101 - 119,818,487 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3119,780,484 - 119,818,487 (+)EnsemblGRCh38hg38GRCh38
GRCh373119,500,948 - 119,537,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363120,982,021 - 121,020,022 (+)NCBINCBI36Build 36hg18NCBI36
Build 343120,982,020 - 121,020,021NCBI
Celera3117,908,432 - 117,946,438 (+)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3116,874,950 - 116,913,074 (+)NCBIHuRef
CHM1_13119,462,845 - 119,500,855 (+)NCBICHM1_1
T2T-CHM13v2.03122,501,838 - 122,538,215 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391638,068,711 - 38,115,211 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1638,068,685 - 38,115,186 (-)EnsemblGRCm39 Ensembl
GRCm381638,248,349 - 38,294,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,248,323 - 38,294,824 (-)EnsemblGRCm38mm10GRCm38
MGSCv371638,248,435 - 38,294,910 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361638,167,590 - 38,214,062 (-)NCBIMGSCv36mm8
Celera1638,657,356 - 38,703,953 (-)NCBICelera
Cytogenetic Map16B3NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542719,459,936 - 19,487,276 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542719,459,936 - 19,487,276 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.13123,815,135 - 123,853,129 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3123,815,135 - 123,853,129 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03116,901,579 - 116,940,366 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13323,444,367 - 23,456,405 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3323,432,690 - 23,455,347 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3323,474,457 - 23,486,487 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03323,682,177 - 23,694,192 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3323,669,760 - 23,694,177 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13323,486,165 - 23,498,350 (+)NCBIUMICH_Zoey_3.1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405602130,794,594 - 130,830,392 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365366,691,590 - 6,726,704 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365366,691,590 - 6,726,421 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl13140,364,075 - 140,406,112 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113140,373,571 - 140,406,129 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213149,710,912 - 149,743,466 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12261,005,404 - 61,043,016 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2261,006,667 - 61,040,832 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041105,267,620 - 105,304,705 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473128,371,707 - 28,381,357 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473128,371,707 - 28,405,327 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Nr1i2
234 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:69
Interacting mature miRNAs:79
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat

Genetic Models
This gene Nr1i2 is modified in the following models/strains


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 37 37 37 11
Low 4 6 4 1 4 1 1 2 18 13 11 1
Below cutoff 17 14 16 7 8 40 2 22 7


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003934   ⟹   ENSRNOP00000003934
RefSeq Status: