Kcne2 (potassium voltage-gated channel subfamily E regulatory subunit 2) - Rat Genome Database

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Gene: Kcne2 (potassium voltage-gated channel subfamily E regulatory subunit 2) Rattus norvegicus
Analyze
Symbol: Kcne2
Name: potassium voltage-gated channel subfamily E regulatory subunit 2
RGD ID: 621383
Description: Enables several functions, including identical protein binding activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Contributes to delayed rectifier potassium channel activity and inward rectifier potassium channel activity. Involved in several processes, including potassium ion transmembrane transport; regulation of monoatomic ion transmembrane transporter activity; and tongue development. Located in cell surface and plasma membrane. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in atrial fibrillation; familial atrial fibrillation; long QT syndrome; and long QT syndrome 6. Orthologous to human KCNE2 (potassium voltage-gated channel subfamily E regulatory subunit 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC108602; minimum potassium ion channel-related peptide 1; minK-related peptide 1; Mirp1; potassium channel subunit beta MiRP1; potassium channel, voltage gated subfamily E regulatory beta subunit 2; potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 2; potassium voltage-gated channel subfamily E member 2; potassium voltage-gated channel, Isk-related family, member 2; potassium voltage-gated channel, Isk-related subfamily, gene 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81145,003,468 - 45,015,942 (+)NCBIGRCr8
mRatBN7.21131,517,176 - 31,530,026 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1131,295,614 - 31,530,043 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,212,209 - 40,224,677 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01132,883,668 - 32,896,136 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01132,047,012 - 32,054,013 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01132,434,786 - 32,447,264 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1132,440,237 - 32,447,259 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01136,038,539 - 36,051,121 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41132,277,711 - 32,290,828 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11132,339,411 - 32,347,070 (+)NCBI
Celera1131,171,793 - 31,183,884 (+)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Abbott GW, etal., Cell 1999 Apr 16;97(2):175-87.
2. Expression of the IKr components KCNH2 (rERG) and KCNE2 (rMiRP1) during late rat heart development. Chun KR, etal., Exp Mol Med. 2004 Aug 31;36(4):367-71.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Altered gene expression may underlie prolonged duration of the QT interval and ventricular action potential in streptozotocin-induced diabetic rat heart. Howarth FC, etal., Mol Cell Biochem. 2009 Aug;328(1-2):57-65. doi: 10.1007/s11010-009-0074-9. Epub 2009 Mar 8.
6. KCNE2 protein is expressed in ventricles of different species, and changes in its expression contribute to electrical remodeling in diseased hearts. Jiang M, etal., Circulation. 2004 Apr 13;109(14):1783-8. Epub 2004 Apr 5.
7. KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels. Kanda VA, etal., Biophys J. 2011 Sep 21;101(6):1354-63. doi: 10.1016/j.bpj.2011.08.015. Epub 2011 Sep 20.
8. The stoichiometric relationship between KCNH-2 and KCNE-2 in I(Kr) channel formation. Kim DG, etal., Int J Cardiol. 2010 Nov 19;145(2):272-4. doi: 10.1016/j.ijcard.2009.09.552. Epub 2009 Nov 13.
9. MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating. Lewis A, etal., J Biol Chem. 2004 Feb 27;279(9):7884-92. Epub 2003 Dec 16.
10. Regulation of the Kv2.1 potassium channel by MinK and MiRP1. McCrossan ZA, etal., J Membr Biol. 2009 Mar;228(1):1-14. doi: 10.1007/s00232-009-9154-8. Epub 2009 Feb 14.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Ohya S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G277-87.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. MiRP1 modulates HCN2 channel expression and gating in cardiac myocytes. Qu J, etal., J Biol Chem. 2004 Oct 15;279(42):43497-502. Epub 2004 Aug 2.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing. Tester DJ, etal., Heart Rhythm. 2005 May;2(5):507-17.
21. Dynamic changes in HCN2, HCN4, KCNE1, and KCNE2 expression in ventricular cells from acute myocardial infarction rat hearts. Xia S, etal., Biochem Biophys Res Commun. 2010 May 7;395(3):330-5. doi: 10.1016/j.bbrc.2010.04.003. Epub 2010 Apr 8.
22. Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation. Yang Y, etal., Am J Hum Genet. 2004 Nov;75(5):899-905. Epub 2004 Sep 13.
23. MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation. Yu H, etal., Circ Res. 2001 Jun 22;88(12):E84-7.
Additional References at PubMed
PMID:12477932   PMID:16780588   PMID:18603586   PMID:20533308   PMID:21943417   PMID:22180649   PMID:23504710   PMID:24681347   PMID:26297229  


Genomics

Comparative Map Data
Kcne2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81145,003,468 - 45,015,942 (+)NCBIGRCr8
mRatBN7.21131,517,176 - 31,530,026 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1131,295,614 - 31,530,043 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,212,209 - 40,224,677 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01132,883,668 - 32,896,136 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01132,047,012 - 32,054,013 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01132,434,786 - 32,447,264 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1132,440,237 - 32,447,259 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01136,038,539 - 36,051,121 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41132,277,711 - 32,290,828 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11132,339,411 - 32,347,070 (+)NCBI
Celera1131,171,793 - 31,183,884 (+)NCBICelera
Cytogenetic Map11q11NCBI
KCNE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382134,364,006 - 34,371,381 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2134,180,729 - 34,371,381 (+)EnsemblGRCh38hg38GRCh38
GRCh372135,736,305 - 35,743,680 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362134,658,193 - 34,665,310 (+)NCBINCBI36Build 36hg18NCBI36
Build 342134,658,192 - 34,665,310NCBI
Celera2120,935,893 - 20,943,010 (+)NCBICelera
Cytogenetic Map21q22.11NCBI
HuRef2121,214,794 - 21,221,877 (+)NCBIHuRef
CHM1_12135,298,575 - 35,305,689 (+)NCBICHM1_1
T2T-CHM13v2.02132,746,055 - 32,753,431 (+)NCBIT2T-CHM13v2.0
Kcne2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391692,089,277 - 92,095,021 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1692,089,277 - 92,095,017 (+)EnsemblGRCm39 Ensembl
GRCm381692,292,389 - 92,298,133 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1692,292,389 - 92,298,129 (+)EnsemblGRCm38mm10GRCm38
MGSCv371692,292,634 - 92,298,374 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361692,181,248 - 92,186,988 (+)NCBIMGSCv36mm8
Celera1693,375,548 - 93,381,246 (+)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1653.55NCBI
Kcne2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540733,735,148 - 33,735,513 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540733,734,969 - 33,736,609 (+)NCBIChiLan1.0ChiLan1.0
LOC106634235
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22230,299,137 - 30,446,379 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12125,157,322 - 25,304,548 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02120,548,631 - 20,739,999 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12134,000,211 - 34,063,718 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2134,107,443 - 34,107,814 (+)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl2134,107,443 - 34,107,814 (+)NCBIpanpan1.1panPan2
KCNE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13129,777,154 - 29,777,839 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3129,581,658 - 29,777,525 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3128,876,722 - 28,877,407 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03129,070,854 - 29,078,555 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13128,944,202 - 28,944,887 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03128,958,946 - 28,959,631 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03129,458,093 - 29,458,778 (+)NCBIUU_Cfam_GSD_1.0
Kcne2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497129,395,302 - 29,399,661 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365008,068,188 - 8,068,553 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365008,067,009 - 8,072,383 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13197,980,145 - 197,980,516 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113197,979,749 - 197,980,974 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213207,798,714 - 207,809,529 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1257,833,459 - 57,841,052 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl257,833,629 - 57,834,000 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666071335,337 - 336,729 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcne2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474522,525,037 - 22,556,000 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474522,552,809 - 22,553,321 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcne2
102 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:68
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000040844
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat

Markers in Region
Kcne2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,528,523 - 31,528,771 (+)MAPPERmRatBN7.2
Rnor_6.01132,445,766 - 32,446,013NCBIRnor6.0
Rnor_5.01136,049,623 - 36,049,870UniSTSRnor5.0
RGSC_v3.41132,289,334 - 32,289,581UniSTSRGSC3.4
Celera1131,182,390 - 31,182,637UniSTS
Cytogenetic Map11q11UniSTS
RH139863  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,529,744 - 31,529,941 (+)MAPPERmRatBN7.2
Rnor_6.01132,446,987 - 32,447,183NCBIRnor6.0
Rnor_5.01136,050,844 - 36,051,040UniSTSRnor5.0
RGSC_v3.41132,290,555 - 32,290,751UniSTSRGSC3.4
Celera1131,183,611 - 31,183,807UniSTS
RH 3.4 Map11204.5UniSTS
Cytogenetic Map11q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 86 85 54 25 54 6 213 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000040844   ⟹   ENSRNOP00000045279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,469,632 - 31,530,043 (+)Ensembl
Rnor_6.0 Ensembl1132,440,237 - 32,447,259 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093948   ⟹   ENSRNOP00000081079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,295,614 - 31,530,022 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094999   ⟹   ENSRNOP00000078157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,522,449 - 31,530,024 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099713   ⟹   ENSRNOP00000080461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,523,332 - 31,530,043 (+)Ensembl
RefSeq Acc Id: NM_133603   ⟹   NP_598287
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81145,003,468 - 45,015,942 (+)NCBI
mRatBN7.21131,517,544 - 31,530,018 (+)NCBI
Rnor_6.01132,434,786 - 32,447,260 (+)NCBI
Rnor_5.01136,038,539 - 36,051,121 (+)NCBI
RGSC_v3.41132,277,711 - 32,290,828 (+)RGD
Celera1131,171,793 - 31,183,884 (+)RGD
Sequence:
RefSeq Acc Id: NP_598287   ⟸   NM_133603
- UniProtKB: Q5FVT9 (UniProtKB/Swiss-Prot),   P63161 (UniProtKB/Swiss-Prot),   A6JLI9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045279   ⟸   ENSRNOT00000040844
Ensembl Acc Id: ENSRNOP00000078157   ⟸   ENSRNOT00000094999
Ensembl Acc Id: ENSRNOP00000081079   ⟸   ENSRNOT00000093948
Ensembl Acc Id: ENSRNOP00000080461   ⟸   ENSRNOT00000099713

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63161-F1-model_v2 AlphaFold P63161 1-123 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621383 AgrOrtholog
BioCyc Gene G2FUF-21841 BioCyc
Ensembl Genes ENSRNOG00000029811 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055017442 UniProtKB/Swiss-Prot
  ENSRNOG00060018583 UniProtKB/Swiss-Prot
  ENSRNOG00065013379 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000040844.5 UniProtKB/Swiss-Prot
  ENSRNOT00000093948.1 UniProtKB/Swiss-Prot
  ENSRNOT00000094999.1 UniProtKB/Swiss-Prot
  ENSRNOT00000099713.1 UniProtKB/Swiss-Prot
  ENSRNOT00055029513 UniProtKB/Swiss-Prot
  ENSRNOT00055029515 UniProtKB/Swiss-Prot
  ENSRNOT00055029516 UniProtKB/Swiss-Prot
  ENSRNOT00060031926 UniProtKB/Swiss-Prot
  ENSRNOT00060031935 UniProtKB/Swiss-Prot
  ENSRNOT00060031964 UniProtKB/Swiss-Prot
  ENSRNOT00065021999 UniProtKB/Swiss-Prot
  ENSRNOT00065022005 UniProtKB/Swiss-Prot
  ENSRNOT00065022008 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7301610 IMAGE-MGC_LOAD
InterPro K_chnl_KCNE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_bsu_KCNE2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171138 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108602 IMAGE-MGC_LOAD
NCBI Gene 171138 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1, 3 UniProtKB/TrEMBL
  POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15282 UniProtKB/Swiss-Prot
Pfam ISK_Channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB KCNE2 RGD
PhenoGen Kcne2 PhenoGen
PRINTS KCNE2CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029811 RatGTEx
  ENSRNOG00055017442 RatGTEx
  ENSRNOG00060018583 RatGTEx
  ENSRNOG00065013379 RatGTEx
UniProt A6JLI9 ENTREZGENE, UniProtKB/TrEMBL
  KCNE2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5FVT9 ENTREZGENE
UniProt Secondary Q5FVT9 UniProtKB/Swiss-Prot
  Q9WTW0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcne2  potassium voltage-gated channel subfamily E regulatory subunit 2  Kcne2  potassium channel, voltage gated subfamily E regulatory beta subunit 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-27 Kcne2  potassium channel, voltage gated subfamily E regulatory beta subunit 2  Kcne2  potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcne2  potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 2  Kcne2  potassium voltage-gated channel, Isk-related family, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-04-29 Kcne2  potassium voltage-gated channel, Isk-related family, member 2  Kcne2  potassium voltage-gated channel, Isk-related subfamily, gene 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Kcne2  potassium voltage-gated channel, Isk-related subfamily, gene 2  Kcne2  potassium voltage-gated channel, Isk-related family, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Kcne2  potassium voltage-gated channel, Isk-related family, member 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kcne2  potassium voltage-gated channel, Isk-related family, member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease gene associated to cardiac arrhythmia 633041
gene_domains contains two N-linked glycosylation sites, single transmembrane segment and two PKC-mediated phosphorylation sites 633041
gene_function ion channel subunit, effects the channels formed by HERG subunits 633041
gene_protein 123 amino acids protein 633041