Kcnc1 (potassium voltage-gated channel subfamily C member 1) - Rat Genome Database

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Gene: Kcnc1 (potassium voltage-gated channel subfamily C member 1) Rattus norvegicus
Symbol: Kcnc1
Name: potassium voltage-gated channel subfamily C member 1
RGD ID: 2955
Description: Enables delayed rectifier potassium channel activity; transmembrane transporter binding activity; and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including nervous system development; response to auditory stimulus; and response to potassium ion. Located in several cellular components, including cell surface; neuron projection membrane; and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is active in calyx of Held; postsynaptic membrane; and presynaptic membrane. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 7. Orthologous to human KCNC1 (potassium voltage-gated channel subfamily C member 1); INTERACTS WITH 6-propyl-2-thiouracil; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
Previously known as: KShIIIB; Kv3.1; KV4; NGK2; NGK2-KV4; potassium channel gene 1; Potassium channel gene 1 (alternative splicing product described in Luneau et al 1991); potassium channel, voltage gated Shaw-related subfamily C, member 1; potassium voltage gated channel, Shaw-related subfamily, member 1; RAW2; voltage-gated potassium channel subunit Kv3.1; voltage-gated potassium channel subunit Kv4
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2196,902,953 - 96,944,744 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,902,953 - 96,944,744 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1102,288,979 - 102,330,759 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,760,963 - 110,802,743 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,051,340 - 104,093,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,414,352 - 102,456,718 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,414,625 - 102,456,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,499,689 - 103,541,476 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,928,275 - 96,970,062 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1197,006,385 - 97,048,173 (+)NCBI
Celera191,151,218 - 91,193,065 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component


References - curated
# Reference Title Reference Citation
1. Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease. Boda E, etal., J Mol Neurosci. 2012 Mar;46(3):606-15. doi: 10.1007/s12031-011-9648-6. Epub 2011 Sep 13.
2. Effects of norfluoxetine, the major metabolite of fluoxetine, on the cloned neuronal potassium channel Kv3.1. Choi BH, etal., Neuropharmacology. 2001 Sep;41(4):443-53.
3. Stable expression and regulation of a rat brain K+ channel. Critz SD, etal., J Neurochem. 1993 Mar;60(3):1175-8.
4. Kv3.1b is a novel component of CNS nodes. Devaux J, etal., J Neurosci. 2003 Jun 1;23(11):4509-18.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Neuronal activity and TrkB ligands influence Kv3.1b and Kv3.2 expression in developing cortical interneurons. Grabert J and Wahle P, Neuroscience. 2008 Oct 15;156(3):618-29. doi: 10.1016/j.neuroscience.2008.08.008. Epub 2008 Aug 12.
8. Visual experience regulates Kv3.1b and Kv3.2 expression in developing rat visual cortex. Grabert J and Wahle P, Neuroscience. 2009 Jan 23;158(2):654-64. doi: 10.1016/j.neuroscience.2008.07.035. Epub 2008 Jul 25.
9. Importance of glycosylation on function of a potassium channel in neuroblastoma cells. Hall MK, etal., PLoS One. 2011 Apr 26;6(4):e19317. doi: 10.1371/journal.pone.0019317.
10. Kv3.1-Kv3.2 channels underlie a high-voltage-activating component of the delayed rectifier K+ current in projecting neurons from the globus pallidus. Hernandez-Pineda R, etal., J Neurophysiol. 1999 Sep;82(3):1512-28.
11. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. Huang CY, etal., J Comp Neurol. 2012 Nov 1;520(16):3650-72. doi: 10.1002/cne.23119.
12. Distinct roles of Kv1 and Kv3 potassium channels at the calyx of Held presynaptic terminal. Ishikawa T, etal., J Neurosci. 2003 Nov 12;23(32):10445-53.
13. KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel a-subunit composition. Kanda VA, etal., Biophys J. 2011 Sep 21;101(6):1364-75. doi: 10.1016/j.bpj.2011.08.014. Epub 2011 Sep 20.
14. Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts. Kanemasa T, etal., J Neurophysiol. 1995 Jul;74(1):207-17.
15. MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating. Lewis A, etal., J Biol Chem. 2004 Feb 27;279(9):7884-92. Epub 2003 Dec 16.
16. Localization of two high-threshold potassium channel subunits in the rat central auditory system. Li W, etal., J Comp Neurol. 2001 Aug 20;437(2):196-218.
17. The expression of two splice variants of the Kv3.1 potassium channel gene is regulated by different signaling pathways. Liu SJ and Kaczmarek LK, J Neurosci. 1998 Apr 15;18(8):2881-90.
18. Alternative splicing contributes to K+ channel diversity in the mammalian central nervous system. Luneau CJ, etal., Proc Natl Acad Sci U S A 1991 May 1;88(9):3932-6.
19. MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain. McCrossan ZA, etal., J Neurosci. 2003 Sep 3;23(22):8077-91.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Expression of the mRNAs for the Kv3.1 potassium channel gene in the adult and developing rat brain. Perney TM, etal., J Neurophysiol. 1992 Sep;68(3):756-66.
23. Precise localization of the voltage-gated potassium channel subunits Kv3.1b and Kv3.3 revealed in the molecular layer of the rat cerebellar cortex by a pre-embedding immunogold method. Puente N, etal., Histochem Cell Biol. 2010 Oct;134(4):403-9. doi: 10.1007/s00418-010-0742-6. Epub 2010 Sep 21.
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Voltage-gated potassium channel (Kv) subunits expressed in the rat cochlear nucleus. Rusznak Z, etal., J Histochem Cytochem. 2008 May;56(5):443-65. doi: 10.1369/jhc.2008.950303. Epub 2008 Feb 5.
26. Specific and rapid effects of acoustic stimulation on the tonotopic distribution of Kv3.1b potassium channels in the adult rat. Strumbos JG, etal., Neuroscience. 2010 May 19;167(3):567-72. doi: 10.1016/j.neuroscience.2010.02.046. Epub 2010 Feb 26.
27. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1378392   PMID:7526924   PMID:12000114   PMID:15240761   PMID:15528247   PMID:16413129   PMID:16595659   PMID:18094255   PMID:18187934   PMID:18682278   PMID:19213956   PMID:19387585  
PMID:21106837   PMID:21147063   PMID:22105078   PMID:22675523   PMID:23487040   PMID:23734863   PMID:24291260   PMID:26348848   PMID:28213922   PMID:28322444  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2196,902,953 - 96,944,744 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,902,953 - 96,944,744 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1102,288,979 - 102,330,759 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,760,963 - 110,802,743 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,051,340 - 104,093,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,414,352 - 102,456,718 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,414,625 - 102,456,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,499,689 - 103,541,476 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,928,275 - 96,970,062 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1197,006,385 - 97,048,173 (+)NCBI
Celera191,151,218 - 91,193,065 (+)NCBICelera
Cytogenetic Map1q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381117,734,781 - 17,783,057 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1117,734,774 - 17,856,804 (+)EnsemblGRCh38hg38GRCh38
GRCh371117,756,328 - 17,804,604 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,714,090 - 17,750,755 (+)NCBINCBI36Build 36hg18NCBI36
Build 341117,714,112 - 17,750,753NCBI
Celera1117,890,030 - 17,937,113 (+)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,441,501 - 17,487,861 (+)NCBIHuRef
CHM1_11117,757,215 - 17,804,314 (+)NCBICHM1_1
T2T-CHM13v2.01117,832,488 - 17,880,755 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39746,045,643 - 46,088,130 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,045,921 - 46,088,128 (+)EnsemblGRCm39 Ensembl
GRCm38746,396,219 - 46,438,706 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,396,497 - 46,438,704 (+)EnsemblGRCm38mm10GRCm38
MGSCv37753,651,838 - 53,694,074 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36746,265,584 - 46,306,746 (+)NCBIMGSCv36mm8
Celera741,870,004 - 41,912,217 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.1NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541432,538,938 - 32,580,370 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541432,538,968 - 32,580,370 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11120,027,491 - 20,149,375 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,788,010 - 17,936,591 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,472,061 - 17,519,214 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,472,158 - 17,517,892 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12140,273,366 - 40,315,189 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2140,273,827 - 40,315,189 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2139,773,451 - 39,814,777 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02141,377,580 - 41,419,665 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,378,304 - 41,419,665 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,391,108 - 40,432,406 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,598,959 - 40,640,287 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,937,508 - 40,978,698 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494745,317,707 - 45,359,952 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,351,689 - 1,393,932 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365281,351,687 - 1,393,926 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl241,362,347 - 41,408,127 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1241,362,208 - 41,407,935 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,432,251 - 44,438,707 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1147,189,485 - 47,237,093 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl147,190,806 - 47,236,775 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038144,582,522 - 144,631,080 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247669,359,511 - 9,400,106 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247669,360,038 - 9,400,106 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Kcnc1
76 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:101
Interacting mature miRNAs:127
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,944,542 - 96,944,727 (+)MAPPERmRatBN7.2
Rnor_6.01102,456,210 - 102,456,394NCBIRnor6.0
Rnor_5.01103,541,275 - 103,541,459UniSTSRnor5.0
RGSC_v3.4196,969,861 - 96,970,045UniSTSRGSC3.4
Celera191,192,864 - 91,193,048UniSTS
Cytogenetic Map1q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,934,428 - 96,934,506 (+)MAPPERmRatBN7.2
Rnor_6.01102,446,099 - 102,446,176NCBIRnor6.0
Rnor_5.01103,531,164 - 103,531,241UniSTSRnor5.0
RGSC_v3.4196,959,750 - 96,959,827UniSTSRGSC3.4
Celera191,182,739 - 91,182,816UniSTS
Cytogenetic Map1q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,928,701 - 96,928,867 (+)MAPPERmRatBN7.2
Rnor_6.01102,440,372 - 102,440,537NCBIRnor6.0
Rnor_5.01103,525,437 - 103,525,602UniSTSRnor5.0
RGSC_v3.4196,954,023 - 96,954,188UniSTSRGSC3.4
Celera191,177,010 - 91,177,175UniSTS
RH 3.4 Map1909.9UniSTS
Cytogenetic Map1q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,915,387 - 96,915,516 (+)MAPPERmRatBN7.2
Rnor_6.01102,427,058 - 102,427,186NCBIRnor6.0
Rnor_5.01103,512,123 - 103,512,251UniSTSRnor5.0
RGSC_v3.4196,940,709 - 96,940,837UniSTSRGSC3.4
Celera191,163,696 - 91,163,824UniSTS
RH 3.4 Map1909.6UniSTS
Cytogenetic Map1q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,933,887 - 96,934,063 (+)MAPPERmRatBN7.2
Rnor_6.01102,445,558 - 102,445,733NCBIRnor6.0
Rnor_5.01103,530,623 - 103,530,798UniSTSRnor5.0
RGSC_v3.4196,959,209 - 96,959,384UniSTSRGSC3.4
Celera191,182,198 - 91,182,373UniSTS
Cytogenetic Map1q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,933,648 - 96,934,441 (+)MAPPERmRatBN7.2
Rnor_6.01102,445,319 - 102,446,111NCBIRnor6.0
Rnor_5.01103,530,384 - 103,531,176UniSTSRnor5.0
RGSC_v3.4196,958,970 - 96,959,762UniSTSRGSC3.4
Celera191,181,959 - 91,182,751UniSTS
Cytogenetic Map1q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,933,873 - 96,934,281 (+)MAPPERmRatBN7.2
Rnor_6.01102,445,544 - 102,445,951NCBIRnor6.0
Rnor_5.01103,530,609 - 103,531,016UniSTSRnor5.0
Celera191,182,184 - 91,182,591UniSTS
Cytogenetic Map1q22UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 53
Low 1 8 11 19 8 8
Below cutoff 3 29 17 1 18 1 2 10 30 10


RefSeq Acc Id: ENSRNOT00000089488   ⟹   ENSRNOP00000074146
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,902,953 - 96,944,744 (+)Ensembl
Rnor_6.0 Ensembl1102,414,625 - 102,456,411 (+)Ensembl
RefSeq Acc Id: NM_012856   ⟹   NP_036988
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,902,953 - 96,944,744 (+)NCBI
Rnor_6.01102,414,625 - 102,456,411 (+)NCBI
Rnor_5.01103,499,689 - 103,541,476 (+)NCBI
RGSC_v3.4196,928,275 - 96,970,062 (+)RGD
Celera191,151,218 - 91,193,065 (+)RGD
Protein Sequences
Protein RefSeqs NP_036988 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41501 (Get FASTA)   NCBI Sequence Viewer  
  EDM07265 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074146
GenBank Protein P25122 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036988   ⟸   NM_012856
- UniProtKB: P25122 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074146   ⟸   ENSRNOT00000089488
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25122-F1-model_v2 AlphaFold P25122 1-585 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690061
Promoter ID:EPDNEW_R586
Type:initiation region
Description:potassium voltage-gated channel subfamily C member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01102,414,665 - 102,414,725EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2955 AgrOrtholog
BioCyc Gene G2FUF-59626 BioCyc
Ensembl Genes ENSRNOG00000055401 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055006842 UniProtKB/Swiss-Prot
  ENSRNOG00060011256 UniProtKB/Swiss-Prot
  ENSRNOG00065008751 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000089488 ENTREZGENE
  ENSRNOT00000089488.2 UniProtKB/Swiss-Prot
  ENSRNOT00055011242 UniProtKB/Swiss-Prot
  ENSRNOT00060019032 UniProtKB/Swiss-Prot
  ENSRNOT00065013925 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv3.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25327 UniProtKB/Swiss-Prot
  PTHR11537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnc1 PhenoGen
  KV31CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHAWCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055401 RatGTEx
  ENSRNOG00055006842 RatGTEx
  ENSRNOG00060011256 RatGTEx
  ENSRNOG00065008751 RatGTEx
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP POZ domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC219176

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnc1  potassium voltage-gated channel subfamily C member 1  Kcnc1  potassium channel, voltage gated Shaw-related subfamily C, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnc1  potassium channel, voltage gated Shaw-related subfamily C, member 1  Kcnc1  potassium voltage gated channel, Shaw-related subfamily, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-10-23 Kcnc1  potassium voltage gated channel, Shaw-related subfamily, member 1      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript has alternative forms arising from alternative exon usage 728931