Bp27 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Bp27 (Blood pressure QTL 27) Rattus norvegicus

Symbol: Bp27
Name: Blood pressure QTL 27
RGD ID: 61342
Trait: arterial blood pressure trait   (VT:2000000)    
Measurement Type: systolic blood pressure   (CMO:0000004)    
LOD Score: 3.4
P Value: 6.0E-4
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8165,405,637 - 96,805,205RGD_MAPPER_PIPELINE
mRatBN7.2156,732,668 - 98,773,277RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0157,761,301 - 104,391,981RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0158,687,835 - 77,717,707RGDRnor5.0
Cross Type: F2
Strains Crossed: SS/Jr LEW 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp27Rathypertension  IDA 61049 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp27Ratincreased systemic arterial blood pressure  QTM 61049 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp27Ratsystolic blood pressure  IDA 61049 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp27Ratcontrolled sodium content diet  IDA 61049 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp27Rattail cuff plethysmography  IDA 61049 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp27RatLEW  IEA 61049 RGD 
Bp27RatSS/Jr  IEA 61049 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp27Ratarterial blood pressure trait  IDA 61049 RGD 


#
Reference Title
Reference Citation
1. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
2. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. Gu L, etal., J Clin Invest 1996 Feb 1;97(3):777-88
3. Multiple blood pressure QTL on rat chromosome 1 defined by Dahl rat congenic strains. Saad Y, etal., Physiol Genomics 2001 Jan 19;4(3):201-14.
4. Closely linked non-additive blood pressure quantitative trait loci. Toland EJ, etal., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7.

Related QTL Description Reference
Bp93 interacts with RGD:2291850
Bp94 interacts with RGD:2291850
Bp95 interacts with RGD:68885



1 to 20 of 1319 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1595392Rgmbrepulsive guidance molecule BMP co-receptor b15676659856792396Rat
2324378Mtfr2-ps2mitochondrial fission regulator 2, pseudogene 215687145256872588Rat
41243157LOC120100349small nucleolar RNA SNORA6715731786157318000Rat
40963993Trnaa-agc40transfer RNA alanine (anticodon AGC) 4015752508757525161Rat
41387258LOC120100130U6 spliceosomal RNA15775597957756085Rat
1584940Tpi1-ps1triosephosphate isomerase 1, pseudogene 115782019357820963Rat
11417311LOC10834983640S ribosomal protein S2 pseudogene15809496758095887Rat
1311588Riok2RIO kinase 215810313258119397Rat
1309454Lix1limb and CNS expressed 115812896158187554Rat
41260575Chchd2l2-ps6coiled-coil-helix-coiled-coil-helix domain containing protein 2-like 2, pseudogene 615823687958237403Rat
621752Lnpepleucyl and cystinyl aminopeptidase15825864258355532Rat
41070194Ppp2cb-ps1protein phosphatase 2 catalytic subunit beta, pseudogene 115840464858411052Rat
7535253Znf431l-ps7zinc finger protein 431 like, pseudogene 715840809858425715Rat
7716102Zfp950l13zinc finger protein 950 like 1315845544858482226Rat
41225682Tuba1b-ps6tubulin, alpha 1B, pseudogene 615848237258484437Rat
1626024Vom2r-ps19vomeronasal 2 receptor, pseudogene 1915852331058523375Rat
1584045Vom2r-ps20vomeronasal 2 receptor, pseudogene 2015856064158561032Rat
7703204LOC102553133uncharacterized LOC10255313315856644658574216Rat
1588836Spaca6sperm acrosome associated 615867212858689309Rat
2325431Mir99bmicroRNA 99b15867701558677084Rat

1 to 20 of 1319 rows
1 to 20 of 1129 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10279D1Wox1214717759307977593226Ratregion
10280D1Arb3525017759298477593234Ratregion
10281D1Mgh2719517759876677598961Ratregion
10332D1Arb3229317786449677864789Ratregion
10333D1Arb3324617787625477876500Ratregion
10334D1Wox1420617843047178430669Ratregion
10334D1Wox1420617844904778449238Ratregion
10335D1Arb3632717843042478430754Ratregion
10337D1Mgh514217843053678430678Ratregion
10442D1Wox1620218217474382174945Ratregion
10444D1Wox178318159422681594309Ratregion
10646D1Wox3011517880456978804684Ratregion
10839D1Wox1812019464443594644553Ratregion
11047D2Mit1320915679441956794475Ratregion
11144D1Wox1114716583292965833076Ratregion
11145D1Arb3130216583290165833203Ratregion
33872D1Mit3321516474374564743958Ratregion
33872D1Mit3321516487235364872485Ratregion
33931D1Mit108515683509656835181Ratregion
34258D1Mgh3510719846236998462476Ratregion
1 to 20 of 1129 rows

Flank 1: (D1M7Mit69)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2198,773,277 - 98,773,511 (+)MAPPER
Rnor_6.01104,391,981 - 104,392,214RGD
Peak: (D1Mco1)
Rat AssemblyChrPosition (strand)Source
GRCr8181,105,347 - 81,105,495 (+)Marker Load Pipeline
mRatBN7.2172,033,151 - 72,033,299 (-)MAPPER
Rnor_6.0167,412,099 - 67,412,246NCBI
Rnor_5.0168,202,698 - 68,202,845UniSTS
Celera161,757,214 - 61,757,361UniSTS
Cytogenetic Map1 RGD
Flank 2: (D1Mco2)
Rat AssemblyChrPosition (strand)Source
GRCr8165,405,637 - 65,405,819 (+)Marker Load Pipeline
mRatBN7.2156,732,484 - 56,732,668 (+)MAPPER
Rnor_6.0157,761,120 - 57,761,301NCBI
Rnor_5.0158,687,835 - 58,688,016UniSTS
Celera152,934,777 - 52,934,936UniSTS
Cytogenetic Map1 RGD


1 to 10 of 77 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat

1 to 10 of 77 rows


Database
Acc Id
Source(s)
NCBI Gene Bp27

Note Type Note Reference
qtl_general In contrast to evidence for Bp27 observed in F2(LEW/NCrl x SS/Jr), no evidence for a similarly located Bp QTL was detected in other F2 populations tested; F2(WKY x SS/Jr), F2(SR/Jr x SS/Jr) , F2 (BN x SS/Jr), F2 (SS/Jr x MNS) 61049