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Gene: Cyp2a3 (cytochrome P450, family 2, subfamily a, polypeptide 3) Rattus norvegicus
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Symbol: Cyp2a3
Name: cytochrome P450, family 2, subfamily a, polypeptide 3
Description: Predicted to have heme binding activity and monooxygenase activity. Predicted to be involved in several processes, including cellular response to cadmium ion; epoxygenase P450 pathway; and exogenous drug catabolic process. Predicted to localize to the cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human CYP2A13 (cytochrome P450 family 2 subfamily A member 13); CYP2A6 (cytochrome P450 family 2 subfamily A member 6); and CYP2A7 (cytochrome P450 family 2 subfamily A member 7); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; retinol metabolic pathway; vitamin A deficiency pathway; INTERACTS WITH (2-trans,6-trans)-farnesol; (S)-nicotine; 1H-pyrazole.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: coumarin 7-hydroxylase; Cyp2a3a; CYPIIA3; cytochrome P450 2A3; cytochrome P450, family 2, subfamily A, polypeptide 3a; Cytochrome P450, subfamily IIA (phenobarbital-inducble)/ (Cytochrome P450 IIA3); RATCYP2A3A
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0183,653,248 - 83,662,118 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0184,869,280 - 84,876,600 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,944,896 - 81,953,007 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1182,023,006 - 82,030,923 (+)NCBI
Celera176,591,113 - 76,599,123 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cyp2a3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2465
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.