Cyp2a3 (cytochrome P450, family 2, subfamily a, polypeptide 3) - Rat Genome Database

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Gene: Cyp2a3 (cytochrome P450, family 2, subfamily a, polypeptide 3) Rattus norvegicus
Analyze
Symbol: Cyp2a3
Name: cytochrome P450, family 2, subfamily a, polypeptide 3
RGD ID: 2465
Description: Predicted to enable arachidonic acid epoxygenase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in coumarin metabolic process; epoxygenase P450 pathway; and xenobiotic metabolic process. Predicted to act upstream of or within cellular response to cadmium ion; heme metabolic process; and response to stilbenoid. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in nicotine dependence and warfarin resistance. Orthologous to human CYP2A13 (cytochrome P450 family 2 subfamily A member 13); CYP2A6 (cytochrome P450 family 2 subfamily A member 6); and CYP2A7 (cytochrome P450 family 2 subfamily A member 7); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; retinol metabolic pathway; vitamin A deficiency pathway; INTERACTS WITH (S)-nicotine; 1H-pyrazole; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: coumarin 7-hydroxylase; Cyp2a3a; CYPIIA3; cytochrome P450 2A3; cytochrome P450, family 2, subfamily A, polypeptide 3a; Cytochrome P450, subfamily IIA (phenobarbital-inducble)/ (Cytochrome P450 IIA3); RATCYP2A3A
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2182,171,914 - 82,179,980 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,169,949 - 82,179,979 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx187,588,938 - 87,597,006 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0196,075,221 - 96,083,279 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0189,344,793 - 89,352,861 (+)NCBIRnor_WKY
Rnor_6.0183,653,248 - 83,662,118 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,653,234 - 83,766,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,869,280 - 84,876,600 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,944,896 - 81,953,007 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1182,023,006 - 82,030,923 (+)NCBI
Celera176,591,113 - 76,599,123 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxyindole  (ISO)
aflatoxin B1  (ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorohydrocarbon  (EXP)
cholesterol  (ISO)
cholic acid  (ISO)
cobalt atom  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
daidzein  (ISO)
dextromethorphan  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dihydroergotamine  (ISO)
doramapimod  (ISO)
endosulfan  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
farnesol  (EXP)
fenofibrate  (EXP)
fipronil  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
griseofulvin  (ISO)
hexachlorobenzene  (EXP)
hydralazine  (ISO)
isoproturon  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
Lasiocarpine  (ISO)
lithocholic acid  (ISO)
lycopene  (ISO)
MeIQx  (EXP)
mephenytoin  (ISO)
methotrexate  (ISO)
methoxsalen  (EXP,ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
midazolam  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (EXP)
nicotine  (EXP)
nifedipine  (ISO)
O-methyleugenol  (ISO)
paraquat  (EXP)
parathion  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
quinidine  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
Testosterone propionate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
triclosan  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tungsten  (EXP)
valproic acid  (EXP,ISO)
verapamil  (ISO)
warfarin  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Functional role of cytochrome p-450 2a3 in N-nitrosomethylbenzylamine metabolism in rat esophagus. Gopalakrishnan R, etal., J Toxicol Environ Health A 2002 Aug 9;65(15):1077-91.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
12. Complete sequence of the rat CYP2A3 gene specifically transcribed in lung. Ueno T and Gonzalez FJ, Nucleic Acids Res 1990 Aug 11;18(15):4623-4.
Additional References at PubMed
PMID:2751996   PMID:8889548   PMID:15123731   PMID:16183037   PMID:17086191  


Genomics

Comparative Map Data
Cyp2a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2182,171,914 - 82,179,980 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,169,949 - 82,179,979 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx187,588,938 - 87,597,006 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0196,075,221 - 96,083,279 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0189,344,793 - 89,352,861 (+)NCBIRnor_WKY
Rnor_6.0183,653,248 - 83,662,118 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,653,234 - 83,766,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,869,280 - 84,876,600 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,944,896 - 81,953,007 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1182,023,006 - 82,030,923 (+)NCBI
Celera176,591,113 - 76,599,123 (+)NCBICelera
Cytogenetic Map1q21NCBI
CYP2A7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381940,875,439 - 40,882,231 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1940,875,439 - 40,882,752 (-)EnsemblGRCh38hg38GRCh38
GRCh371941,381,344 - 41,388,136 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,073,184 - 46,080,497 (-)NCBINCBI36Build 36hg18NCBI36
Build 341946,073,183 - 46,080,497NCBI
Celera1938,181,466 - 38,188,779 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1937,814,479 - 37,821,742 (-)NCBIHuRef
CHM1_11941,381,111 - 41,388,380 (-)NCBICHM1_1
T2T-CHM13v2.01943,696,148 - 43,702,882 (-)NCBIT2T-CHM13v2.0
Cyp2a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39726,006,617 - 26,014,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl726,006,594 - 26,014,513 (+)EnsemblGRCm39 Ensembl
GRCm38726,307,192 - 26,315,088 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl726,307,169 - 26,315,088 (+)EnsemblGRCm38mm10GRCm38
MGSCv37727,092,211 - 27,100,107 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36726,015,952 - 26,023,848 (+)NCBIMGSCv36mm8
Celera720,896,679 - 20,902,855 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.39NCBI

Variants

.
Variants in Cyp2a3
31 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir126brno-miR-126a-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18780894

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:110
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000028231
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat

Markers in Region
D1Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,174,743 - 82,174,945 (+)MAPPERmRatBN7.2
Rnor_6.0183,656,882 - 83,657,083NCBIRnor6.0
Rnor_5.0184,871,364 - 84,871,565UniSTSRnor5.0
RGSC_v3.4181,947,770 - 81,947,972RGDRGSC3.4
RGSC_v3.4181,947,771 - 81,947,972UniSTSRGSC3.4
RGSC_v3.1182,025,881 - 82,026,083RGD
Celera176,593,887 - 76,594,088UniSTS
RH 3.4 Map1826.1UniSTS
RH 3.4 Map1826.1RGD
RH 2.0 Map1515.9RGD
Cytogenetic Map1q21UniSTS
D1Mgh28  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map1826.4UniSTS
RH 3.4 Map1826.4RGD
RH 2.0 Map1514.3RGD
Cytogenetic Map1q21UniSTS
RH127774  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,179,627 - 82,179,808 (+)MAPPERmRatBN7.2
Rnor_6.0183,661,766 - 83,661,946NCBIRnor6.0
Rnor_5.0184,876,248 - 84,876,428UniSTSRnor5.0
RGSC_v3.4181,952,655 - 81,952,835UniSTSRGSC3.4
Celera176,598,771 - 76,598,951UniSTS
RH 3.4 Map1840.5UniSTS
Cytogenetic Map1q21UniSTS
Cyp2a4  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0184,870,605 - 84,872,088UniSTSRnor5.0
Cytogenetic Map1q21UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028237   ⟹   ENSRNOP00000028237
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl182,231,611 - 82,244,887 (+)Ensembl
Rnor_6.0 Ensembl183,711,251 - 83,724,936 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000028249   ⟹   ENSRNOP00000028249
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,744,238 - 83,765,719 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084230   ⟹   ENSRNOP00000074544
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,653,248 - 83,661,920 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085008   ⟹   ENSRNOP00000075563
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,653,234 - 83,766,484 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085245   ⟹   ENSRNOP00000071749
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,714,347 - 83,766,230 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090071   ⟹   ENSRNOP00000070405
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl182,169,949 - 82,179,979 (+)Ensembl
Rnor_6.0 Ensembl183,653,248 - 83,662,117 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092008   ⟹   ENSRNOP00000068901
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,711,270 - 83,765,716 (+)Ensembl
RefSeq Acc Id: NM_012542   ⟹   NP_036674
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,171,914 - 82,179,980 (+)NCBI
Rnor_6.0183,653,248 - 83,662,118 (+)NCBI
Rnor_5.0184,869,280 - 84,876,600 (+)NCBI
RGSC_v3.4181,944,896 - 81,953,007 (+)RGD
Celera176,591,113 - 76,599,123 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036674 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41022 (Get FASTA)   NCBI Sequence Viewer  
  AAA88511 (Get FASTA)   NCBI Sequence Viewer  
  EDM07980 (Get FASTA)   NCBI Sequence Viewer  
  P20812 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036674   ⟸   NM_012542
- UniProtKB: P20812 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068901   ⟸   ENSRNOT00000092008
RefSeq Acc Id: ENSRNOP00000070405   ⟸   ENSRNOT00000090071
RefSeq Acc Id: ENSRNOP00000028237   ⟸   ENSRNOT00000028237
RefSeq Acc Id: ENSRNOP00000028249   ⟸   ENSRNOT00000028249
RefSeq Acc Id: ENSRNOP00000071749   ⟸   ENSRNOT00000085245
RefSeq Acc Id: ENSRNOP00000075563   ⟸   ENSRNOT00000085008
RefSeq Acc Id: ENSRNOP00000074544   ⟸   ENSRNOT00000084230

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20812-F1-model_v2 AlphaFold P20812 1-494 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2465 AgrOrtholog
BioCyc Gene G2FUF-60333 BioCyc
Ensembl Genes ENSRNOG00000020817 Ensembl
  ENSRNOG00000068556 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070405 ENTREZGENE
  ENSRNOP00000070405.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090071 ENTREZGENE
  ENSRNOT00000090071.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2A-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24299 UniProtKB/Swiss-Prot
NCBI Gene 24299 ENTREZGENE
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYP2A7 RGD
PhenoGen Cyp2a3 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450ICYP2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC234666
UniProt A0A0G2JXU4_RAT UniProtKB/TrEMBL
  CP2A3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp2a3    Cyp2a3a  cytochrome P450, family 2, subfamily A, polypeptide 3a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cyp2a3a  cytochrome P450, family 2, subfamily A, polypeptide 3a    Cytochrome P450, subfamily IIA (phenobarbital-inducble)/ (Cytochrome P450 IIA3)  Name updated 1299863 APPROVED
2002-06-10 Cyp2a3a  Cytochrome P450, subfamily IIA (phenobarbital-inducble)/ (Cytochrome P450 IIA3)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process activates NMBA metabolism in the esophagus 1298847