(+)-artemisinin increases activity ISO Cyp2a5 (Mus musculus) 6480464 artemisinin results in increased activity of CYP2A5 protein CTD PMID:16919048 (+)-artemisinin increases expression ISO Cyp2a5 (Mus musculus) 6480464 artemisinin results in increased expression of CYP2A5 mRNA CTD PMID:16919048 (+)-catechin multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2A5 mRNA CTD PMID:25663641 (+)-epicatechin-3-O-gallate multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2A5 mRNA CTD PMID:25663641 (+)-pilocarpine decreases activity EXP 6480464 Pilocarpine results in decreased activity of CYP2A6 protein CTD PMID:12464242 (-)-cotinine increases abundance EXP 6480464 CYP2A6 protein results in increased abundance of Cotinine CTD PMID:24305170 (-)-cotinine affects chemical synthesis EXP 6480464 CYP2A6 gene SNP affects the chemical synthesis of Cotinine and CYP2A6 protein affects the chemical synthesis of Cotinine CTD PMID:23371292 and PMID:29232328 (-)-cotinine multiple interactions EXP 6480464 [CYP2A6 protein affects the metabolism of Nicotine] which affects the chemical synthesis of Cotinine and [tryptamine results in decreased activity of CYP2A6 protein] which results in decreased abundance of Cotinine CTD PMID:22498344 and PMID:23371292 (-)-cotinine decreases abundance EXP 6480464 CYP2A6 gene mutant form results in decreased abundance of Cotinine CTD PMID:10668854 (-)-cotinine increases chemical synthesis EXP 6480464 CYP2A6 protein results in increased chemical synthesis of Cotinine CTD PMID:10999944 more ... (-)-cotinine increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of Cotinine CTD PMID:12024803 more ... (-)-epigallocatechin 3-gallate multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2A5 mRNA CTD PMID:25663641 (-)-trans-epsilon-viniferin decreases activity EXP 6480464 epsilon-viniferin results in decreased activity of CYP2A6 protein CTD PMID:12818727 (1->4)-beta-D-glucan multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CYP2A5 mRNA CTD PMID:36331819 (S)-nicotine affects oxidation EXP 6480464 CYP2A6 gene polymorphism affects the oxidation of Nicotine CTD PMID:10663384 and PMID:15900015 (S)-nicotine multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 CYP2A5 protein results in increased metabolism of and affects the susceptibility to Nicotine CTD PMID:16485141 (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of CYP2A6 mRNA and Nicotine results in increased expression of CYP2A6 protein CTD PMID:22498344 (S)-nicotine decreases oxidation EXP 6480464 CYP2A6 exon SNP results in decreased oxidation of Nicotine and CYP2A6 gene mutant form results in decreased oxidation of Nicotine CTD PMID:11237731 and PMID:20012030 (S)-nicotine affects metabolic processing EXP 6480464 CYP2A6 gene polymorphism affects the metabolism of Nicotine more ... CTD PMID:11180041 more ... (S)-nicotine increases oxidation EXP 6480464 CYP2A6 protein results in increased oxidation of Nicotine CTD PMID:11684323 more ... (S)-nicotine increases metabolic processing EXP 6480464 CYP2A6 gene polymorphism results in increased metabolism of Nicotine and CYP2A6 protein results in increased metabolism of Nicotine CTD PMID:10911933 more ... (S)-nicotine multiple interactions EXP 6480464 [CYP2A6 protein affects the metabolism of Nicotine] which affects the chemical synthesis of Cotinine more ... CTD PMID:10999944 more ... (S)-nicotine decreases metabolic processing EXP 6480464 CYP2A6 gene mutant form results in decreased metabolism of Nicotine and CYP2A6 gene SNP results in decreased metabolism of Nicotine CTD PMID:10448083 more ... 1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane increases chemical synthesis EXP 6480464 CYP2A6 protein results in increased chemical synthesis of 1 more ... CTD PMID:9733665 1,7-dimethyluric acid increases chemical synthesis EXP 6480464 CYP2A6 protein results in increased chemical synthesis of 1 and 7-dimethyluric acid CTD PMID:12505289 1,7-dimethyluric acid multiple interactions EXP 6480464 [CYP2A6 protein results in increased metabolism of 1 more ... CTD PMID:19215233 1,7-dimethylxanthine increases hydroxylation EXP 6480464 CYP2A6 protein polymorphism results in increased hydroxylation of 1 more ... CTD PMID:15980104 1,7-dimethylxanthine multiple interactions EXP 6480464 [CYP2A6 protein results in increased metabolism of 1 more ... CTD PMID:12505289 and PMID:19215233 1,7-dimethylxanthine increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of 1 and 7-dimethylxanthine CTD PMID:17916905 and PMID:19215233 1-naphthol multiple interactions EXP 6480464 [CYP2A6 protein results in increased oxidation of naphthalene] which results in increased abundance of 1-naphthol CTD PMID:27137136 1-naphthol increases abundance EXP 6480464 CYP2A6 protein results in increased abundance of 1-naphthol CTD PMID:16243959 and PMID:27137136 17alpha-ethynylestradiol multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYP2A5 mRNA CTD PMID:17942748 17beta-estradiol multiple interactions EXP 6480464 afimoxifene inhibits the reaction [Estradiol results in increased expression of CYP2A6 mRNA] more ... CTD PMID:17646279 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of CYP2A6 mRNA CTD PMID:17646279 and PMID:22837389 1H-pyrazole increases activity EXP 6480464 pyrazole results in increased activity of CYP2A6 protein CTD PMID:11038160 1H-pyrazole multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 G6PDX affects the reaction [pyrazole results in increased expression of and results in increased activity of CYP2A5 protein] more ... CTD PMID:11901218 more ... 1H-pyrazole increases expression ISO Cyp2a5 (Mus musculus) 6480464 pyrazole results in increased expression of CYP2A5 mRNA and pyrazole results in increased expression of CYP2A5 protein CTD PMID:11038160 more ... 1H-pyrazole increases activity ISO Cyp2a5 (Mus musculus) 6480464 pyrazole results in increased activity of CYP2A5 protein CTD PMID:11038160 and PMID:7543189 1H-pyrazole increases expression EXP 6480464 pyrazole results in increased expression of CYP2A6 mRNA CTD PMID:11038160 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CYP2A6 mRNA and [Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of CYP2A6 mRNA CTD PMID:26159488 and PMID:29162470 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Cyp2a5 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of CYP2A5 mRNA CTD PMID:18163543 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Cyp2a5 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of CYP2A5 mRNA CTD PMID:28922406 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [CYP2A5 promoter mutant form results in decreased activity of [AHR protein binds to ARNT protein]] which results in decreased susceptibility to Tetrachlorodibenzodioxin more ... CTD PMID:15657367 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of CYP2A6 mRNA CTD PMID:28571685 2,6-dichlorobenzonitrile increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of dichlobanil CTD PMID:12464242 2,6-dichlorobenzonitrile increases metabolic processing ISO Cyp2a5 (Mus musculus) 6480464 CYP2A5 protein results in increased metabolism of dichlobanil CTD PMID:20840855 2,6-dimethylaniline increases hydroxylation EXP 6480464 CYP2A6 protein results in increased hydroxylation of 2 and 6-xylidine CTD PMID:11409937 2,6-dimethylnaphthalene increases oxidation EXP 6480464 CYP2A6 protein results in increased oxidation of 2 and 6-dimethylnaphthalene CTD PMID:17156750 2-aminopurine increases expression ISO Cyp2a5 (Mus musculus) 6480464 2-Aminopurine results in increased expression of CYP2A5 CTD PMID:11853694 2-n-Propyl-4-pentenoic acid increases chemical synthesis EXP 6480464 CYP2A6 protein results in increased chemical synthesis of 2-propyl-4-pentenoic acid CTD PMID:16945988 2-tert-butylhydroquinone increases expression EXP 6480464 2-tert-butylhydroquinone results in increased expression of CYP2A6 mRNA CTD PMID:24830941 2-tert-butylhydroquinone increases expression ISO Cyp2a5 (Mus musculus) 6480464 2-tert-butylhydroquinone results in increased expression of CYP2A5 mRNA CTD PMID:29788535 3',5'-cyclic AMP increases expression ISO Cyp2a5 (Mus musculus) 6480464 Cyclic AMP results in increased expression of CYP2A5 mRNA CTD PMID:12754101 and PMID:18602936 3',5'-cyclic AMP multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 Cyclic AMP promotes the reaction [HNF4A protein binds to CYP2A5 promoter] more ... CTD PMID:12754101 and PMID:18602936 3,3',5,5'-tetrabromobisphenol A multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [CYP2A5 promoter mutant form results in decreased activity of NFE2L2 protein] which results in decreased susceptibility to tetrabromobisphenol A CTD PMID:29788535 3,3',5,5'-tetrabromobisphenol A increases expression ISO Cyp2a5 (Mus musculus) 6480464 tetrabromobisphenol A results in increased expression of CYP2A5 mRNA CTD PMID:29788535 3-methylcholanthrene increases expression ISO Cyp2a5 (Mus musculus) 6480464 Methylcholanthrene results in increased expression of CYP2A5 mRNA CTD PMID:30503582 3-phenylprop-2-enal decreases activity EXP 6480464 cinnamaldehyde results in decreased activity of CYP2A6 protein CTD PMID:32496054 3-phenylprop-2-enal multiple interactions EXP 6480464 [[cinnamaldehyde results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin and [cinnamaldehyde results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin CTD PMID:32496054 4,4'-methanol-bisbenzonitrile affects chemical synthesis EXP 6480464 CYP2A6 gene polymorphism affects the chemical synthesis of 4 and 4'-methanol-bisbenzonitrile CTD PMID:19845430 4,4'-methanol-bisbenzonitrile increases chemical synthesis EXP 6480464 CYP2A6 protein results in increased chemical synthesis of 4 and 4'-methanol-bisbenzonitrile CTD PMID:19845430 4,4'-methylene-bis-(2-chloroaniline) increases oxidation EXP 6480464 CYP2A6 protein results in increased oxidation of Methylenebis(chloroaniline) CTD PMID:1740010 4,6-dioxoheptanoic acid multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 NFE2L2 gene mutant form affects the reaction [succinylacetone results in increased expression of CYP2A5 mRNA] CTD PMID:22859313 4,6-dioxoheptanoic acid increases expression ISO Cyp2a5 (Mus musculus) 6480464 succinylacetone results in increased expression of CYP2A5 mRNA CTD PMID:22859313 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile affects metabolic processing EXP 6480464 CYP2A6 protein affects the metabolism of Fadrozole CTD PMID:15980104 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of Fadrozole CTD PMID:12464242 and PMID:12487152 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one multiple interactions EXP 6480464 CYB5A protein promotes the reaction [CYP2A6 protein results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] more ... CTD PMID:11259349 more ... 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases hydroxylation EXP 6480464 CYP2A6 results in increased hydroxylation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:21473878 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:12115524 more ... 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases activity EXP 6480464 CYP2A6 protein results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and CYP2A6 results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:15728263 and PMID:21473878 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one affects metabolic processing EXP 6480464 CYP2A6 protein affects the metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:12920169 4-hydroxyphenyl retinamide increases expression ISO Cyp2a5 (Mus musculus) 6480464 Fenretinide results in increased expression of CYP2A6 mRNA CTD PMID:28973697 4-Hydroxyvalproic acid increases chemical synthesis EXP 6480464 CYP2A6 protein results in increased chemical synthesis of 4-hydroxyvalproate CTD PMID:16945988 4-nitroanisole increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of 4-nitroanisole CTD PMID:12464242 4-nitrophenol increases hydroxylation EXP 6480464 CYP2A6 protein results in increased hydroxylation of 4-nitrophenol CTD PMID:15135088 5-(2-chloroethyl)-4-methylthiazole multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 Chlormethiazole inhibits the reaction [Ethanol results in increased activity of CYP2A5 protein] CTD PMID:22552773 5-aminolevulinic acid increases expression ISO Cyp2a5 (Mus musculus) 6480464 Aminolevulinic Acid results in increased expression of CYP2A5 mRNA CTD PMID:22859313 5-aminolevulinic acid multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 NFE2L2 gene mutant form inhibits the reaction [Aminolevulinic Acid results in increased expression of CYP2A5 mRNA] CTD PMID:22859313 5-aza-2'-deoxycytidine increases expression ISO Cyp2a5 (Mus musculus) 6480464 Decitabine results in increased expression of CYP2A5 mRNA CTD PMID:30503582 5-fluorouracil increases chemical synthesis EXP 6480464 CYP2A6 protein results in increased chemical synthesis of Fluorouracil CTD PMID:11376561 and PMID:18212800 5-Hydroxyflavone multiple interactions EXP 6480464 [CYP2A6 protein co-treated with POR protein] results in increased oxidation of 5-hydroxyflavone CTD PMID:30964977 5-Hydroxyvalproic acid increases chemical synthesis EXP 6480464 CYP2A6 protein results in increased chemical synthesis of 5-hydroxyvalproate CTD PMID:16945988 5-methyltryptamine multiple interactions EXP 6480464 [5-methyltryptamine analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin CTD PMID:26599973 5-methyltryptamine decreases activity EXP 6480464 5-methyltryptamine analog results in decreased activity of CYP2A6 protein CTD PMID:26599973 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime increases expression EXP 6480464 6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:16857725 acenaphthene multiple interactions EXP 6480464 [CYP2A6 protein results in increased oxidation of acenaphthene] which results in increased chemical synthesis of acenaphthene-1-ol CTD PMID:25642975 acenaphthene increases oxidation EXP 6480464 CYP2A6 protein results in increased oxidation of acenaphthene CTD PMID:25642975 acenaphthylene increases oxidation EXP 6480464 CYP2A6 protein results in increased oxidation of acenaphthylene and CYP2A6 protein results in increased oxidation of acenaphthylene metabolite CTD PMID:25642975 acifluorfen increases activity ISO Cyp2a5 (Mus musculus) 6480464 acifluorfen results in increased activity of CYP2A5 protein CTD PMID:9007836 actinomycin D increases stability ISO Cyp2a5 (Mus musculus) 6480464 Dactinomycin results in increased stability of CYP2A5 mRNA CTD PMID:12754101 actinomycin D multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 Dactinomycin affects the reaction [HNRNPA1 protein binds to CYP2A5 mRNA] more ... CTD PMID:12754101 afimoxifene multiple interactions EXP 6480464 afimoxifene inhibits the reaction [Estradiol results in increased expression of CYP2A6 mRNA] CTD PMID:17646279 afimoxifene decreases expression EXP 6480464 afimoxifene results in decreased expression of CYP2A6 mRNA CTD PMID:29285606 aflatoxin B1 increases response to substance EXP 6480464 CYP2A6 protein results in increased susceptibility to Aflatoxin B1 CTD PMID:11189750 aflatoxin B1 decreases expression ISO Cyp2a5 (Mus musculus) 6480464 Aflatoxin B1 results in decreased expression of CYP2A5 mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation EXP 6480464 Aflatoxin B1 results in decreased methylation of CYP2A6 gene CTD PMID:27153756 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of CYP2A6 mRNA CTD PMID:27153756 aflatoxin B1 affects expression EXP 6480464 Aflatoxin B1 affects the expression of CYP2A6 protein CTD PMID:20106945 Aflatoxin G1 increases expression EXP 6480464 aflatoxin G1 results in increased expression of CYP2A6 protein CTD PMID:36997055 aldehydo-D-glucose multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in decreased expression of CYP2A5 mRNA CTD PMID:37567420 alizarin decreases activity EXP 6480464 alizarin results in decreased activity of CYP2A6 protein CTD PMID:12379470 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of CYP2A6 mRNA CTD PMID:21376804 alpha-linolenic acid increases expression EXP 6480464 alpha-Linolenic Acid results in increased expression of CYP2A6 mRNA and alpha-Linolenic Acid results in increased expression of CYP2A6 protein CTD PMID:28555106 alpha-linolenic acid multiple interactions EXP 6480464 NFE2L2 protein promotes the reaction [alpha-Linolenic Acid results in increased expression of CYP2A6 mRNA] and NFE2L2 protein promotes the reaction [alpha-Linolenic Acid results in increased expression of CYP2A6 protein] CTD PMID:28555106 alpha-methyltryptamine decreases activity EXP 6480464 indopan analog results in decreased activity of CYP2A6 protein and indopan results in decreased activity of CYP2A6 protein CTD PMID:26599973 alpha-methyltryptamine multiple interactions EXP 6480464 [indopan analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin and [indopan results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin CTD PMID:26599973 amiodarone decreases response to substance EXP 6480464 CYP2A6 protein results in decreased susceptibility to Amiodarone CTD PMID:26477383 amitrole increases expression ISO Cyp2a5 (Mus musculus) 6480464 Amitrole results in increased expression of CYP2A5 mRNA and Amitrole results in increased expression of CYP2A5 protein CTD PMID:7543189 and PMID:9698299 amitrole multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 heme arginate inhibits the reaction [Amitrole results in increased activity of CYP2A5 protein] CTD PMID:7543189 amitrole increases activity ISO Cyp2a5 (Mus musculus) 6480464 Amitrole results in increased activity of CYP2A5 protein CTD PMID:7543189 amodiaquine increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of Amodiaquine CTD PMID:31629065 amodiaquine multiple interactions EXP 6480464 [CYP2A6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine CTD PMID:31629065 Aroclor 1254 increases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of CYP2A6 mRNA CTD PMID:17851650 artesunate affects metabolic processing EXP 6480464 CYP2A6 protein affects the metabolism of artesunate CTD PMID:12920490 atazanavir sulfate multiple interactions EXP 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of CYP2A6 mRNA CTD PMID:33819548 atrazine increases expression EXP 6480464 Atrazine results in increased expression of CYP2A6 mRNA CTD PMID:22310298 atrazine multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP2A5 mRNA CTD PMID:22515965 benidipine increases expression EXP 6480464 benidipine results in increased expression of CYP2A6 mRNA and benidipine results in increased expression of CYP2A6 protein CTD PMID:27732883 benzaldehyde decreases activity EXP 6480464 benzaldehyde results in decreased activity of CYP2A6 protein CTD PMID:32496054 benzaldehyde multiple interactions EXP 6480464 [[benzaldehyde results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin and [benzaldehyde results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin CTD PMID:32496054 benzaldehyde increases chemical synthesis EXP 6480464 CYP2A6 protein results in increased chemical synthesis of benzaldehyde CTD PMID:10616189 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of CYP2A6 mRNA CTD PMID:20106945 and PMID:32234424 benzo[a]pyrene decreases expression ISO Cyp2a5 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of CYP2A5 mRNA CTD PMID:22228805 benzo[a]pyrene increases expression ISO Cyp2a5 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of CYP2A5 mRNA and Benzo(a)pyrene results in increased expression of CYP2A5 protein CTD PMID:19770486 more ... benzo[a]pyrene multiple interactions EXP 6480464 Benzo(a)pyrene promotes the reaction [TP53 protein results in increased expression of CYP2A6 mRNA] CTD PMID:26343999 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of CYP2A6 mRNA and Benzo(a)pyrene results in increased expression of CYP2A6 protein CTD PMID:26343999 benzoic acid increases chemical synthesis EXP 6480464 CYP2A6 protein results in increased chemical synthesis of Benzoic Acid CTD PMID:10616189 benzyl alcohol increases chemical synthesis EXP 6480464 CYP2A6 protein results in increased chemical synthesis of Benzyl Alcohol CTD PMID:10616189 beta-naphthoflavone increases expression EXP 6480464 beta-Naphthoflavone results in increased expression of CYP2A6 mRNA CTD PMID:19118567 beta-naphthoflavone increases expression ISO Cyp2a5 (Mus musculus) 6480464 beta-Naphthoflavone results in increased expression of CYP2A5 mRNA CTD PMID:29788535 bilirubin IXalpha increases oxidation EXP 6480464 CYP2A6 protein results in increased oxidation of Bilirubin CTD PMID:22465937 bilirubin IXalpha increases stability ISO Cyp2a5 (Mus musculus) 6480464 Bilirubin results in increased stability of CYP2A5 protein CTD PMID:21871474 bilirubin IXalpha multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [CYP2A5 protein results in increased oxidation of Bilirubin] which results in increased chemical synthesis of Biliverdine more ... CTD PMID:21871474 and PMID:23628428 bilirubin IXalpha affects degradation ISO Cyp2a5 (Mus musculus) 6480464 CYP2A5 protein affects the degradation of Bilirubin CTD PMID:25478736 bilirubin IXalpha increases degradation ISO Cyp2a5 (Mus musculus) 6480464 CYP2A5 protein results in increased degradation of Bilirubin CTD PMID:16183037 more ... bilirubin IXalpha increases expression ISO Cyp2a5 (Mus musculus) 6480464 Bilirubin results in increased expression of CYP2A5 mRNA and Bilirubin results in increased expression of CYP2A5 protein CTD PMID:23628428 bilirubin IXalpha increases oxidation ISO Cyp2a5 (Mus musculus) 6480464 CYP2A5 protein results in increased oxidation of Bilirubin CTD PMID:21871474 and PMID:22465937 bilirubin IXalpha decreases activity ISO Cyp2a5 (Mus musculus) 6480464 Bilirubin results in decreased activity of CYP2A5 protein CTD PMID:16183037 bilirubin IXalpha increases stability EXP 6480464 Bilirubin results in increased stability of CYP2A6 protein CTD PMID:22465937 bilirubin IXalpha decreases activity EXP 6480464 Bilirubin results in decreased activity of CYP2A6 protein CTD PMID:22465937 bilirubin IXalpha multiple interactions EXP 6480464 [CYP2A6 protein results in increased oxidation of Bilirubin] which results in increased chemical synthesis of Biliverdine more ... CTD PMID:22465937 biliverdin multiple interactions EXP 6480464 [CYP2A6 protein results in increased oxidation of Bilirubin] which results in increased chemical synthesis of Biliverdine CTD PMID:22465937 biliverdin increases chemical synthesis ISO Cyp2a5 (Mus musculus) 6480464 CYP2A5 protein results in increased chemical synthesis of Biliverdine CTD PMID:21871474 biliverdin multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [CYP2A5 protein results in increased oxidation of Bilirubin] which results in increased chemical synthesis of Biliverdine CTD PMID:21871474 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of CYP2A6 mRNA CTD PMID:26196221 bromodichloromethane increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of bromodichloromethane CTD PMID:12076521 bucladesine multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 NFE2L2 gene mutant form promotes the reaction [Bucladesine results in increased expression of CYP2A5 mRNA] CTD PMID:22859313 bucladesine increases expression ISO Cyp2a5 (Mus musculus) 6480464 Bucladesine results in increased expression of CYP2A5 mRNA CTD PMID:11162586 and PMID:22859313 butylated hydroxyanisole increases expression EXP 6480464 Butylated Hydroxyanisole results in increased expression of CYP2A6 mRNA and Butylated Hydroxyanisole results in increased expression of CYP2A6 protein CTD PMID:22530035 cadmium atom increases expression ISO Cyp2a5 (Mus musculus) 6480464 Cadmium results in increased expression of CYP2A5 mRNA CTD PMID:15041070 and PMID:16183037 cadmium atom multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 Cadmium results in increased expression of and results in increased activity of CYP2A5 protein and NFE2L2 protein promotes the reaction [Cadmium results in increased expression of CYP2A5 mRNA] CTD PMID:15041070 and PMID:16183037 cadmium dichloride multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [CYP2A5 promoter mutant form results in decreased activity of NFE2L2 protein] which results in decreased susceptibility to Cadmium Chloride more ... CTD PMID:15041070 more ... cadmium dichloride increases expression ISO Cyp2a5 (Mus musculus) 6480464 Cadmium Chloride results in increased expression of CYP2A5 mRNA CTD PMID:15041070 more ... caffeine multiple interactions EXP 6480464 CYP2A6 protein affects the metabolism of and results in increased activity of Caffeine metabolite CTD PMID:12505289 caffeine increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of Caffeine CTD PMID:17916905 calcitriol increases expression EXP 6480464 Calcitriol results in increased expression of CYP2A6 mRNA CTD PMID:21592394 calcitriol multiple interactions EXP 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of CYP2A6 mRNA CTD PMID:21592394 captan increases expression ISO Cyp2a5 (Mus musculus) 6480464 Captan results in increased expression of CYP2A5 mRNA CTD PMID:31558096 carbamazepine increases expression EXP 6480464 Carbamazepine results in increased expression of CYP2A6 mRNA CTD PMID:17112801 carbendazim increases expression EXP 6480464 carbendazim results in increased expression of CYP2A6 mRNA CTD PMID:22310298 carbosulfan increases expression EXP 6480464 carbosulfan results in increased expression of CYP2A6 mRNA CTD PMID:22310298 Chalepensin increases expression ISO Cyp2a5 (Mus musculus) 6480464 3-(alpha and alpha-dimethylallyl)psoralen results in increased expression of CYP2A5 protein CTD PMID:22790670 chenodeoxycholic acid multiple interactions EXP 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of CYP2A6 mRNA more ... CTD PMID:33819548 chlorfluazuron increases expression EXP 6480464 chlorfluazuron results in increased expression of CYP2A6 mRNA CTD PMID:22310298 chlorpromazine decreases activity EXP 6480464 Chlorpromazine results in decreased activity of CYP2A6 protein CTD PMID:15135088 chlorpromazine decreases response to substance EXP 6480464 CYP2A6 protein results in decreased susceptibility to Chlorpromazine CTD PMID:26477383 chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of CYP2A6 mRNA CTD PMID:22310298 chlorpyrifos multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP2A5 mRNA CTD PMID:22515965 chrysin multiple interactions EXP 6480464 [CYP2A6 protein co-treated with POR protein] results in increased oxidation of chrysin CTD PMID:30964977 cisplatin multiple interactions EXP 6480464 CYP2A6 gene polymorphism results in decreased susceptibility to [Cisplatin co-treated with S 1 (combination)] CTD PMID:21364592 clofibric acid decreases activity EXP 6480464 Clofibric Acid results in decreased activity of CYP2A6 protein CTD PMID:11038160 clofibric acid decreases activity ISO Cyp2a5 (Mus musculus) 6480464 Clofibric Acid results in decreased activity of CYP2A5 protein CTD PMID:11038160 clofibric acid decreases expression ISO Cyp2a5 (Mus musculus) 6480464 Clofibric Acid results in decreased expression of CYP2A5 mRNA CTD PMID:11038160 clofibric acid decreases expression EXP 6480464 Clofibric Acid results in decreased expression of CYP2A6 mRNA CTD PMID:11038160 clothianidin multiple interactions EXP 6480464 [clothianidin co-treated with enilconazole] results in decreased expression of CYP2A6 protein and [clothianidin co-treated with thiacloprid] results in increased expression of CYP2A6 protein CTD PMID:32201337 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of CYP2A6 mRNA CTD PMID:11038160 cobalt dichloride increases expression ISO Cyp2a5 (Mus musculus) 6480464 cobaltous chloride results in increased expression of CYP2A5 mRNA and cobaltous chloride results in increased expression of CYP2A5 protein CTD PMID:11038160 and PMID:9698299 cobalt dichloride increases activity EXP 6480464 cobaltous chloride results in increased activity of CYP2A6 protein CTD PMID:11038160 colforsin daropate hydrochloride increases expression ISO Cyp2a5 (Mus musculus) 6480464 Colforsin results in increased expression of CYP2A5 mRNA CTD PMID:11162586 corticosterone increases expression EXP 6480464 Corticosterone results in increased expression of CYP2A6 mRNA CTD PMID:35301062 coumarin affects binding EXP 6480464 coumarin binds to CYP2A6 protein CTD PMID:24924949 coumarin affects metabolic processing ISO Cyp2a5 (Mus musculus) 6480464 CYP2A5 protein affects the metabolism of coumarin CTD PMID:10646973 coumarin increases hydroxylation EXP 6480464 CYP2A6 protein polymorphism results in increased hydroxylation of coumarin and CYP2A6 protein results in increased hydroxylation of coumarin CTD PMID:10616189 more ... coumarin multiple interactions EXP 6480464 [5-chlorotryptamine analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin more ... CTD PMID:10616189 more ... coumarin affects metabolic processing EXP 6480464 CYP2A6 promoter SNP affects the metabolism of coumarin more ... CTD PMID:12818727 more ... coumarin increases metabolic processing EXP 6480464 CYP2A6 exon SNP results in increased metabolism of coumarin and CYP2A6 protein results in increased metabolism of coumarin CTD PMID:11237731 more ... coumarin decreases metabolic processing EXP 6480464 CYP2A6 exon SNP results in decreased metabolism of coumarin CTD PMID:15618666 coumarin decreases activity EXP 6480464 coumarin results in decreased activity of CYP2A6 protein CTD PMID:16035375 cycloheximide multiple interactions EXP 6480464 Bilirubin inhibits the reaction [Cycloheximide results in decreased expression of CYP2A6 protein] CTD PMID:22465937 cycloheximide increases expression ISO Cyp2a5 (Mus musculus) 6480464 Cycloheximide results in increased expression of CYP2A5 mRNA CTD PMID:9007836 cycloheximide decreases expression EXP 6480464 Cycloheximide results in decreased expression of CYP2A6 protein CTD PMID:22465937 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of CYP2A6 mRNA CTD PMID:20106945 cyclosporin A multiple interactions EXP 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine] results in decreased expression of CYP2A6 mRNA CTD PMID:33819548 cyclosporin A affects expression ISO Cyp2a5 (Mus musculus) 6480464 Cyclosporine affects the expression of CYP2A5 mRNA CTD PMID:19770486 cyhalothrin increases expression EXP 6480464 cyhalothrin results in increased expression of CYP2A6 mRNA CTD PMID:22310298 cylindrospermopsin decreases expression EXP 6480464 cylindrospermopsin results in decreased expression of CYP2A6 mRNA CTD PMID:23726867 cypermethrin increases expression EXP 6480464 cypermethrin results in increased expression of CYP2A6 mRNA CTD PMID:22310298 cyproconazole decreases expression EXP 6480464 cyproconazole results in decreased expression of CYP2A6 protein CTD PMID:29995386 D-glucose multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in decreased expression of CYP2A5 mRNA CTD PMID:37567420 deoxycholic acid multiple interactions EXP 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of CYP2A6 mRNA more ... CTD PMID:33819548 desipramine decreases activity EXP 6480464 Desipramine results in decreased activity of CYP2A6 protein CTD PMID:15135088 dexamethasone multiple interactions EXP 6480464 Dexamethasone promotes the reaction [HNF4A protein binds to CYP2A6 promoter] more ... CTD PMID:17978169 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of CYP2A6 mRNA and Dexamethasone results in increased expression of CYP2A6 protein CTD PMID:17978169 dexamethasone increases activity EXP 6480464 Dexamethasone results in increased activity of CYP2A6 protein CTD PMID:10923861 diallyl disulfide decreases activity EXP 6480464 diallyl disulfide results in decreased activity of CYP2A6 protein CTD PMID:18339364 Diallyl sulfide decreases activity EXP 6480464 allyl sulfide results in decreased activity of CYP2A6 protein CTD PMID:18339364 Diallyl sulfide multiple interactions EXP 6480464 allyl sulfide inhibits the reaction [Ethanol results in increased expression of CYP2A6 mRNA] and allyl sulfide inhibits the reaction [Ethanol results in increased expression of CYP2A6 protein] CTD PMID:22530035 dichloroacetic acid increases expression ISO Cyp2a5 (Mus musculus) 6480464 Dichloroacetic Acid results in increased expression of CYP2A5 mRNA CTD PMID:28962523 diclofenac affects expression ISO Cyp2a5 (Mus musculus) 6480464 Diclofenac affects the expression of CYP2A5 mRNA CTD PMID:26934552 diethyldithiocarbamic acid decreases activity EXP 6480464 Ditiocarb results in decreased activity of CYP2A6 protein CTD PMID:8819299 difenoconazole increases expression ISO Cyp2a5 (Mus musculus) 6480464 difenoconazole results in increased expression of CYP2A5 mRNA CTD PMID:34425431 dimethyl sulfoxide affects expression EXP 6480464 Dimethyl Sulfoxide affects the expression of CYP2A6 mRNA CTD PMID:12843640 dipropyl disulfide decreases activity EXP 6480464 n-propyl disulfide results in decreased activity of CYP2A6 protein CTD PMID:18339364 Dipropyl sulfide decreases activity EXP 6480464 dipropyl sulfide results in decreased activity of CYP2A6 protein CTD PMID:18339364 diquat increases expression ISO Cyp2a5 (Mus musculus) 6480464 Diquat results in increased expression of CYP2A5 mRNA CTD PMID:36851058 diuron increases expression EXP 6480464 Diuron results in increased expression of CYP2A6 mRNA CTD PMID:22310298 doramapimod increases expression ISO Cyp2a5 (Mus musculus) 6480464 doramapimod results in increased expression of CYP2A5 mRNA CTD PMID:21328587 elemental selenium increases expression ISO Cyp2a5 (Mus musculus) 6480464 Selenium deficiency results in increased expression of CYP2A5 mRNA CTD PMID:16170372 endosulfan multiple interactions EXP 6480464 [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CYP2A6 mRNA CTD PMID:26159488 endosulfan multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP2A5 mRNA CTD PMID:22515965 enilconazole multiple interactions EXP 6480464 [clothianidin co-treated with enilconazole] results in decreased expression of CYP2A6 protein and [enilconazole co-treated with thiacloprid] results in decreased expression of CYP2A6 protein CTD PMID:32201337 enilconazole decreases expression EXP 6480464 enilconazole results in decreased expression of CYP2A6 mRNA and enilconazole results in decreased expression of CYP2A6 protein CTD PMID:32201337 estragole increases hydroxylation EXP 6480464 CYP2A6 protein results in increased hydroxylation of estragole CTD PMID:19920071 ethanol increases expression EXP 6480464 Ethanol results in increased expression of CYP2A6 mRNA and Ethanol results in increased expression of CYP2A6 protein CTD PMID:22530035 and PMID:35301062 ethanol increases oxidation ISO Cyp2a5 (Mus musculus) 6480464 CYP2A5 protein results in increased oxidation of Ethanol CTD PMID:22552773 ethanol multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [[PPARA protein co-treated with CYP2A5 protein] affects the susceptibility to Ethanol] which affects the expression of FGF21 protein more ... CTD PMID:22552773 and PMID:28131861 ethanol increases expression ISO Cyp2a5 (Mus musculus) 6480464 Ethanol results in increased expression of CYP2A5 mRNA CTD PMID:19167417 ethanol decreases response to substance ISO Cyp2a5 (Mus musculus) 6480464 CYP2A5 protein results in decreased susceptibility to Ethanol CTD PMID:22552773 and PMID:28131861 ethanol multiple interactions EXP 6480464 [[Ethanol affects the activity of CYP2E1 protein] which affects the localization of NFE2L2 protein] which results in increased expression of CYP2A6 more ... CTD PMID:22530035 ethyl vanillin decreases activity EXP 6480464 ethyl vanillin results in decreased activity of CYP2A6 protein CTD PMID:32496054 ethyl vanillin multiple interactions EXP 6480464 [[ethyl vanillin results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin and [ethyl vanillin results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin CTD PMID:32496054 felodipine increases expression EXP 6480464 Felodipine results in increased expression of CYP2A6 mRNA and Felodipine results in increased expression of CYP2A6 protein CTD PMID:27732883 fenitrothion increases expression EXP 6480464 Fenitrothion results in increased expression of CYP2A6 mRNA CTD PMID:22310298 fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of CYP2A6 mRNA CTD PMID:22310298 fipronil multiple interactions EXP 6480464 [fipronil co-treated with DEET] results in increased expression of CYP2A6 mRNA CTD PMID:27091632 fipronil increases expression EXP 6480464 fipronil results in increased expression of CYP2A6 mRNA CTD PMID:27091632 fluphenazine decreases activity EXP 6480464 Fluphenazine results in decreased activity of CYP2A6 protein CTD PMID:15135088 folpet increases expression ISO Cyp2a5 (Mus musculus) 6480464 folpet results in increased expression of CYP2A5 mRNA CTD PMID:31558096 fructose multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in decreased expression of CYP2A5 mRNA CTD PMID:37567420 fulvestrant multiple interactions EXP 6480464 fulvestrant inhibits the reaction [Estradiol results in increased expression of CYP2A6 mRNA] CTD PMID:17646279 furan increases expression ISO Cyp2a5 (Mus musculus) 6480464 furan results in increased expression of CYP2A5 mRNA CTD PMID:20194422 gallocatechin multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2A5 mRNA CTD PMID:25663641 glucose multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in decreased expression of CYP2A5 mRNA CTD PMID:37567420 glutathione multiple interactions EXP 6480464 [CYP2A6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac CTD PMID:24246759 glycochenodeoxycholic acid multiple interactions EXP 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of CYP2A6 mRNA more ... CTD PMID:33819548 glycocholic acid multiple interactions EXP 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of CYP2A6 mRNA more ... CTD PMID:33819548 glycodeoxycholic acid multiple interactions EXP 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of CYP2A6 mRNA more ... CTD PMID:33819548 griseofulvin increases expression ISO Cyp2a5 (Mus musculus) 6480464 Griseofulvin results in increased expression of CYP2A5 mRNA and Griseofulvin results in increased expression of CYP2A5 protein CTD PMID:11038160 more ... griseofulvin increases activity ISO Cyp2a5 (Mus musculus) 6480464 Griseofulvin results in increased activity of CYP2A5 protein CTD PMID:11038160 more ... halothane increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of Halothane CTD PMID:12487152 and PMID:8886607 halothane affects metabolic processing EXP 6480464 CYP2A6 protein affects the metabolism of Halothane CTD PMID:9103523 hemin multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [tin protoporphyrin IX co-treated with Hemin] affects the localization of CYP2A5 protein more ... CTD PMID:22859313 hemin increases expression ISO Cyp2a5 (Mus musculus) 6480464 Hemin results in increased expression of CYP2A5 mRNA and Hemin results in increased expression of CYP2A5 protein CTD PMID:22859313 hexaflumuron increases expression EXP 6480464 hexafluoron results in increased expression of CYP2A6 mRNA CTD PMID:22310298 hexamethylphosphoric triamide increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of Hempa CTD PMID:9007030 hydrogen chloride multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of CYP2A5 mRNA] CTD PMID:29618784 hydrogen chloride increases expression ISO Cyp2a5 (Mus musculus) 6480464 Hydrochloric Acid results in increased expression of CYP2A5 mRNA CTD PMID:29618784 ifosfamide affects hydroxylation EXP 6480464 CYP2A6 protein affects the hydroxylation of Ifosfamide CTD PMID:12136253 indole-3-methanol decreases activity EXP 6480464 indole-3-carbinol results in decreased activity of CYP2A6 protein CTD PMID:17582584 inulin multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of CYP2A5 mRNA CTD PMID:36331819 irinotecan decreases activity EXP 6480464 Irinotecan metabolite results in decreased activity of CYP2A6 protein CTD PMID:11901092 iron atom increases expression EXP 6480464 Iron results in increased expression of CYP2A6 protein CTD PMID:11927840 iron(0) increases expression EXP 6480464 Iron results in increased expression of CYP2A6 protein CTD PMID:11927840 isatin increases expression EXP 6480464 Isatin results in increased expression of CYP2A6 mRNA CTD PMID:15056799 isoprenaline increases activity ISO Cyp2a5 (Mus musculus) 6480464 Isoproterenol results in increased activity of CYP2A5 protein CTD PMID:11162586 isoproturon increases expression EXP 6480464 isoproturon results in increased expression of CYP2A6 mRNA CTD PMID:22310298 Isradipine increases expression EXP 6480464 Isradipine results in increased expression of CYP2A6 mRNA and Isradipine results in increased expression of CYP2A6 protein CTD PMID:27732883 ketoconazole increases expression ISO Cyp2a5 (Mus musculus) 6480464 Ketoconazole results in increased expression of CYP2A5 mRNA and Ketoconazole results in increased expression of CYP2A5 protein CTD PMID:17966066 kojic acid multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CYP2A5 mRNA CTD PMID:17917374 L-ascorbic acid decreases activity EXP 6480464 Ascorbic Acid results in decreased activity of CYP2A6 protein CTD PMID:17512695 L-ascorbic acid multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CYP2A5 mRNA and Ascorbic Acid inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2A5 protein] CTD PMID:17917374 and PMID:22552773 L-ascorbic acid multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [Ethanol results in increased expression of CYP2A6 mRNA] and Ascorbic Acid inhibits the reaction [Ethanol results in increased expression of CYP2A6 protein] CTD PMID:22530035 lamotrigine multiple interactions EXP 6480464 coumarin inhibits the reaction [CYP2A6 protein results in increased glutathionylation of lamotrigine] and Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased glutathionylation of lamotrigine] CTD PMID:19961160 lamotrigine increases activity EXP 6480464 CYP2A6 protein results in increased activity of lamotrigine CTD PMID:19961160 lamotrigine increases glutathionylation EXP 6480464 CYP2A6 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 lead diacetate increases expression ISO Cyp2a5 (Mus musculus) 6480464 lead acetate results in increased expression of CYP2A5 mRNA CTD PMID:30623991 lead diacetate affects expression ISO Cyp2a5 (Mus musculus) 6480464 lead acetate affects the expression of CYP2A5 mRNA CTD PMID:26229098 lead(II) chloride multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [lead chloride affects the localization of NFE2L2 protein] promotes the reaction [NFE2L2 protein binds to CYP2A5 promoter] and NFE2L2 protein affects the reaction [lead chloride results in increased expression of CYP2A5 mRNA] CTD PMID:20402460 lead(II) chloride increases expression ISO Cyp2a5 (Mus musculus) 6480464 lead chloride results in increased expression of CYP2A5 mRNA CTD PMID:20402460 letrozole increases oxidation EXP 6480464 CYP2A6 protein results in increased oxidation of letrozole CTD PMID:19845430 letrozole affects oxidation EXP 6480464 CYP2A6 gene polymorphism affects the oxidation of letrozole CTD PMID:19845430 linoleic acid multiple interactions EXP 6480464 NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of CYP2A6 mRNA] and NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of CYP2A6 protein] CTD PMID:28555106 linoleic acid increases expression EXP 6480464 Linoleic Acid results in increased expression of CYP2A6 mRNA and Linoleic Acid results in increased expression of CYP2A6 protein CTD PMID:28555106 lipopolysaccharide decreases expression ISO Cyp2a5 (Mus musculus) 6480464 Lipopolysaccharides results in decreased expression of CYP2A5 mRNA CTD PMID:30942577 m-xylene increases oxidation EXP 6480464 CYP2A6 protein results in increased oxidation of 3-xylene CTD PMID:17156750 malathion increases expression EXP 6480464 Malathion results in increased expression of CYP2A6 mRNA CTD PMID:22310298 mangiferin decreases activity EXP 6480464 mangiferin results in decreased activity of CYP2A6 protein CTD PMID:22815239 menadione increases expression ISO Cyp2a5 (Mus musculus) 6480464 Vitamin K 3 results in increased expression of CYP2A5 mRNA CTD PMID:14610226 mercaptoethanol increases expression ISO Cyp2a5 (Mus musculus) 6480464 Mercaptoethanol results in increased expression of CYP2A5 protein CTD PMID:35341795 methimazole multiple interactions EXP 6480464 [CYP2A6 protein results in increased metabolism of Methimazole] which results in increased abundance of N-methylthiourea and Tranylcypromine inhibits the reaction [[CYP2A6 protein results in increased metabolism of Methimazole] which results in increased abundance of N-methylthiourea] CTD PMID:34788025 methimazole increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of Methimazole CTD PMID:34788025 methotrexate affects expression ISO Cyp2a5 (Mus musculus) 6480464 Methotrexate affects the expression of CYP2A5 mRNA CTD PMID:18502557 methoxsalen decreases activity EXP 6480464 Methoxsalen results in decreased activity of CYP2A6 protein CTD PMID:10911933 more ... methoxsalen multiple interactions EXP 6480464 Methoxsalen inhibits the reaction [CYP2A6 protein results in increased chemical synthesis of 7-hydroxycoumarin] and Methoxsalen inhibits the reaction [CYP2A6 protein results in increased metabolism of coumarin] CTD PMID:21915887 methoxychlor decreases methylation EXP 6480464 CYP2A6 protein results in decreased methylation of Methoxychlor CTD PMID:12167570 more ... methoxyflurane increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of Methoxyflurane CTD PMID:12464242 and PMID:7879937 methyl tert-butyl ether increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of methyl tert-butyl ether CTD PMID:11504148 methylmercury chloride increases expression ISO Cyp2a5 (Mus musculus) 6480464 methylmercuric chloride results in increased expression of CYP2A5 mRNA CTD PMID:20402460 mifepristone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Dexamethasone results in increased expression of CYP2A6 mRNA] and Mifepristone inhibits the reaction [Dexamethasone results in increased expression of CYP2A6 protein] CTD PMID:17978169 monocrotaline multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA CTD PMID:21224054 monosodium L-glutamate multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2A5 mRNA and [Sodium Glutamate co-treated with Tea] affects the expression of CYP2A5 mRNA CTD PMID:25663641 myricetin decreases activity EXP 6480464 myricetin results in decreased activity of CYP2A6 protein CTD PMID:29753067 N'-Nitrosoanabasine multiple interactions EXP 6480464 CYP2A6 protein affects the metabolism of and results in increased activity of N'-nitrosoanabasine CTD PMID:11774366 N'-Nitrosoanabasine increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of N'-nitrosoanabasine CTD PMID:12214673 N'-Nitrosoanatabine multiple interactions EXP 6480464 CYP2A6 protein affects the metabolism of and results in increased activity of N'-nitrosoanatabine CTD PMID:11774366 N'-Nitrosoanatabine increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of N'-nitrosoanatabine CTD PMID:12214673 N'-Nitrosonornicotine multiple interactions EXP 6480464 CYP2A6 protein affects the metabolism of and results in increased activity of N'-nitrosonornicotine CTD PMID:11774366 N'-Nitrosonornicotine increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of N'-nitrosonornicotine CTD PMID:12214673 more ... N'-Nitrosonornicotine increases hydroxylation EXP 6480464 CYP2A6 protein results in increased hydroxylation of N'-nitrosonornicotine CTD PMID:9029045 N,N-diethyl-m-toluamide increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of DEET CTD PMID:11854147 N,N-diethyl-m-toluamide increases expression EXP 6480464 DEET results in increased expression of CYP2A6 mRNA CTD PMID:19326769 and PMID:27091632 N,N-diethyl-m-toluamide multiple interactions EXP 6480464 [fipronil co-treated with DEET] results in increased expression of CYP2A6 mRNA CTD PMID:27091632 N,N-diisopropyltryptamine decreases activity EXP 6480464 N and N-diisopropyltryptamine analog results in decreased activity of CYP2A6 protein CTD PMID:26599973 N,N-diisopropyltryptamine multiple interactions EXP 6480464 [N and N-diisopropyltryptamine analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin CTD PMID:26599973 N-acetyl-L-cysteine multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2A5 protein] CTD PMID:22552773 N-methylthiourea multiple interactions EXP 6480464 [CYP2A6 protein results in increased metabolism of Methimazole] which results in increased abundance of N-methylthiourea more ... CTD PMID:34788025 N-methylthiourea increases abundance EXP 6480464 CYP2A6 protein results in increased abundance of N-methylthiourea CTD PMID:34788025 N-nitroso-N-methyl-4-aminobutyric acid multiple interactions EXP 6480464 [CYP2A6 protein results in increased metabolism of 4-(N-nitroso-N-methylamino)butyric acid] which results in increased expression of H2AX protein CTD PMID:35882637 N-nitroso-N-methyl-4-aminobutyric acid increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of 4-(N-nitroso-N-methylamino)butyric acid CTD PMID:35882637 N-Nitrosodi-n-propylamine affects metabolic processing EXP 6480464 CYP2A6 protein affects the metabolism of N-nitroso(di-n-propyl)amine CTD PMID:10910959 N-Nitrosodi-n-propylamine multiple interactions EXP 6480464 CYB5A protein promotes the reaction [CYP2A6 protein results in increased activity of N-nitroso(di-n-propyl)amine] and CYP2A6 protein affects the metabolism of and results in increased activity of N-nitroso(di-n-propyl)amine CTD PMID:11600130 and PMID:15728263 N-Nitrosodi-n-propylamine increases activity EXP 6480464 CYP2A6 protein results in increased activity of N-nitroso(di-n-propyl)amine CTD PMID:15728263 N-nitrosodiethylamine multiple interactions EXP 6480464 [CYP2A6 protein results in increased metabolism of Diethylnitrosamine] which affects the localization of TP53 protein more ... CTD PMID:11600130 more ... N-nitrosodiethylamine multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CYP2A5 mRNA more ... CTD PMID:17917374 more ... N-nitrosodiethylamine increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of Diethylnitrosamine CTD PMID:12214673 and PMID:35882637 N-nitrosodiethylamine increases activity EXP 6480464 CYP2A6 protein results in increased activity of Diethylnitrosamine CTD PMID:15728263 N-nitrosodimethylamine multiple interactions EXP 6480464 CYP2A6 protein results in increased metabolism of and results in increased activity of Dimethylnitrosamine CTD PMID:11960914 N-Nitrosoguvacoline increases activity EXP 6480464 CYP2A6 protein results in increased activity of N-nitrosoguvacoline CTD PMID:15725615 N-nitrosomorpholine multiple interactions EXP 6480464 CYP2A6 protein affects the metabolism of and results in increased activity of N-nitrosomorpholine CTD PMID:11774366 N-nitrosopiperidine increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of N-nitrosopiperidine CTD PMID:12214673 N-nitrosopiperidine multiple interactions EXP 6480464 CYP2A6 protein affects the metabolism of and results in increased activity of N-nitrosopiperidine CTD PMID:11774366 N-Nitrosopyrrolidine multiple interactions EXP 6480464 CYP2A6 protein affects the metabolism of and results in increased activity of N-Nitrosopyrrolidine CTD PMID:11774366 N-Nitrosopyrrolidine decreases expression EXP 6480464 N-Nitrosopyrrolidine results in decreased expression of CYP2A6 mRNA CTD PMID:32234424 N-Nitrosopyrrolidine increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of N-Nitrosopyrrolidine CTD PMID:12214673 naphthalene multiple interactions EXP 6480464 [CYP2A6 protein results in increased oxidation of naphthalene] which results in increased abundance of 1-naphthol CTD PMID:27137136 naphthalene increases oxidation EXP 6480464 CYP2A6 protein results in increased oxidation of naphthalene CTD PMID:27137136 nefazodone multiple interactions EXP 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with nefazodone] results in decreased expression of CYP2A6 mRNA CTD PMID:33819548 nicardipine decreases activity EXP 6480464 Nicardipine results in decreased activity of CYP2A6 protein CTD PMID:15863898 nicotine decreases oxidation EXP 6480464 CYP2A6 exon SNP results in decreased oxidation of Nicotine and CYP2A6 gene mutant form results in decreased oxidation of Nicotine CTD PMID:11237731 and PMID:20012030 nicotine multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 CYP2A5 protein results in increased metabolism of and affects the susceptibility to Nicotine CTD PMID:16485141 nicotine increases expression EXP 6480464 Nicotine results in increased expression of CYP2A6 mRNA and Nicotine results in increased expression of CYP2A6 protein CTD PMID:22498344 nicotine affects metabolic processing EXP 6480464 CYP2A6 gene polymorphism affects the metabolism of Nicotine more ... CTD PMID:11180041 more ... nicotine affects oxidation EXP 6480464 CYP2A6 gene polymorphism affects the oxidation of Nicotine CTD PMID:10663384 and PMID:15900015 nicotine increases oxidation EXP 6480464 CYP2A6 protein results in increased oxidation of Nicotine CTD PMID:11684323 more ... nicotine increases metabolic processing EXP 6480464 CYP2A6 gene polymorphism results in increased metabolism of Nicotine and CYP2A6 protein results in increased metabolism of Nicotine CTD PMID:10911933 more ... nicotine multiple interactions EXP 6480464 [CYP2A6 protein affects the metabolism of Nicotine] which affects the chemical synthesis of Cotinine more ... CTD PMID:10999944 more ... nicotine decreases metabolic processing EXP 6480464 CYP2A6 gene mutant form results in decreased metabolism of Nicotine and CYP2A6 gene SNP results in decreased metabolism of Nicotine CTD PMID:10448083 more ... o-anisidine increases oxidation EXP 6480464 CYP2A6 protein results in increased oxidation of 2-anisidine CTD PMID:15828049 O-methyleugenol decreases expression EXP 6480464 methyleugenol results in decreased expression of CYP2A6 mRNA CTD PMID:32234424 o-xylene increases oxidation EXP 6480464 CYP2A6 protein results in increased oxidation of 2-xylene CTD PMID:17156750 obeticholic acid increases expression EXP 6480464 obeticholic acid results in increased expression of CYP2A6 mRNA CTD PMID:27939613 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of CYP2A6 mRNA CTD PMID:26505656 octadecanoic acid increases expression EXP 6480464 stearic acid results in increased expression of CYP2A6 mRNA and stearic acid results in increased expression of CYP2A6 protein CTD PMID:28555106 oleic acid increases expression EXP 6480464 Oleic Acid results in increased expression of CYP2A6 mRNA and Oleic Acid results in increased expression of CYP2A6 protein CTD PMID:28555106 organoselenium compound multiple interactions EXP 6480464 Organoselenium Compounds binds to and results in decreased activity of CYP2A6 protein CTD PMID:21732699 ozone decreases expression ISO Cyp2a5 (Mus musculus) 6480464 Ozone results in decreased expression of CYP2A5 mRNA CTD PMID:12763052 more ... p-xylene increases oxidation EXP 6480464 CYP2A6 protein results in increased oxidation of 4-xylene CTD PMID:17156750 paracetamol increases metabolic processing EXP 6480464 CYP2A6 results in increased metabolism of Acetaminophen CTD PMID:20566340 paracetamol multiple interactions EXP 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of CYP2A6 mRNA CTD PMID:33819548 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of CYP2A6 mRNA CTD PMID:29067470 paracetamol increases response to substance ISO Cyp2a5 (Mus musculus) 6480464 CYP2A5 results in increased susceptibility to Acetaminophen CTD PMID:21252290 paracetamol affects expression ISO Cyp2a5 (Mus musculus) 6480464 Acetaminophen affects the expression of CYP2A5 mRNA CTD PMID:15606129 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of CYP2A6 mRNA CTD PMID:26690555 parathion increases expression EXP 6480464 Parathion results in increased expression of CYP2A6 mRNA and Parathion results in increased expression of CYP2A6 protein CTD PMID:26196221 parathion increases expression ISO Cyp2a5 (Mus musculus) 6480464 Parathion results in increased expression of CYP2A5 mRNA CTD PMID:34813904 perfluorononanoic acid increases expression EXP 6480464 perfluoro-n-nonanoic acid results in increased expression of CYP2A6 mRNA CTD PMID:32588087 perfluorooctane-1-sulfonic acid multiple interactions EXP 6480464 perfluorooctane sulfonic acid inhibits the reaction [CYP2A6 protein results in increased hydroxylation of coumarin] CTD PMID:21964418 perfluorooctane-1-sulfonic acid increases expression EXP 6480464 perfluorooctane sulfonic acid results in increased expression of CYP2A6 mRNA CTD PMID:33772556 perfluorooctane-1-sulfonic acid multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CYP2A5 mRNA more ... CTD PMID:36331819 perfluorooctane-1-sulfonic acid increases expression ISO Cyp2a5 (Mus musculus) 6480464 perfluorooctane sulfonic acid results in increased expression of CYP2A5 mRNA CTD PMID:20936131 perfluorooctanoic acid increases expression ISO Cyp2a5 (Mus musculus) 6480464 perfluorooctanoic acid results in increased expression of CYP2A5 mRNA CTD PMID:18467677 more ... perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of CYP2A6 mRNA CTD PMID:33772556 and PMID:37302725 perfluorooctanoic acid multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [CYP2A5 promoter mutant form results in decreased activity of NFE2L2 protein] which results in decreased susceptibility to perfluorooctanoic acid and PPARA protein inhibits the reaction [perfluorooctanoic acid results in increased expression of CYP2A5 mRNA] CTD PMID:18467677 more ... permethrin increases expression EXP 6480464 Permethrin results in increased expression of CYP2A6 mRNA CTD PMID:19326768 phenethyl isothiocyanate decreases activity EXP 6480464 phenethyl isothiocyanate results in decreased activity of CYP2A6 protein CTD PMID:10616189 and PMID:17582584 phenethyl isothiocyanate multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 NFE2L2 protein affects the reaction [phenethyl isothiocyanate results in increased expression of CYP2A5 mRNA] CTD PMID:20402460 phenethyl isothiocyanate increases expression ISO Cyp2a5 (Mus musculus) 6480464 phenethyl isothiocyanate results in increased expression of CYP2A5 mRNA CTD PMID:20402460 phenobarbital multiple interactions EXP 6480464 [Celsior co-treated with Phenobarbital] results in increased expression of CYP2A6 mRNA CTD PMID:15448115 phenobarbital increases expression ISO Cyp2a5 (Mus musculus) 6480464 Phenobarbital results in increased expression of CYP2A5 mRNA CTD PMID:11038160 more ... phenobarbital increases activity ISO Cyp2a5 (Mus musculus) 6480464 Phenobarbital results in increased activity of CYP2A5 protein CTD PMID:11038160 more ... phenobarbital multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 Dactinomycin inhibits the reaction [Phenobarbital results in increased expression of CYP2A5 mRNA] more ... CTD PMID:12754101 more ... phenobarbital increases activity EXP 6480464 Phenobarbital results in increased activity of CYP2A6 protein CTD PMID:11038160 and PMID:22310298 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of CYP2A6 mRNA and Phenobarbital results in increased expression of CYP2A6 protein CTD PMID:11038160 more ... phenthoate increases expression EXP 6480464 phenthoate results in increased expression of CYP2A6 mRNA CTD PMID:22310298 phenytoin multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA CTD PMID:21224054 phorone multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 NFE2L2 gene mutant form inhibits the reaction [phorone results in increased expression of CYP2A5 mRNA] CTD PMID:24494203 phorone increases expression ISO Cyp2a5 (Mus musculus) 6480464 phorone results in increased expression of CYP2A5 mRNA CTD PMID:24494203 piperonyl butoxide multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of CYP2A5 mRNA and [Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of CYP2A5 gene CTD PMID:19690152 more ... piperonyl butoxide increases expression ISO Cyp2a5 (Mus musculus) 6480464 Piperonyl Butoxide results in increased expression of CYP2A5 mRNA CTD PMID:17014948 and PMID:19690152 pirinixic acid decreases expression ISO Cyp2a5 (Mus musculus) 6480464 pirinixic acid results in decreased expression of CYP2A5 mRNA CTD PMID:18467677 more ... pirinixic acid multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 PPARA protein promotes the reaction [pirinixic acid results in decreased expression of CYP2A5 mRNA] CTD PMID:18467677 potassium dichromate affects expression ISO Cyp2a5 (Mus musculus) 6480464 Potassium Dichromate affects the expression of CYP2A5 mRNA CTD PMID:23608068 pregnenolone 16alpha-carbonitrile increases expression ISO Cyp2a5 (Mus musculus) 6480464 Pregnenolone Carbonitrile results in increased expression of CYP2A5 mRNA CTD PMID:27413110 profenofos increases expression EXP 6480464 profenofos results in increased expression of CYP2A6 mRNA CTD PMID:22310298 progesterone increases expression EXP 6480464 Progesterone results in increased expression of CYP2A6 mRNA CTD PMID:22837389 quercetin increases activity EXP 6480464 Quercetin results in increased activity of CYP2A6 protein CTD PMID:19215233 quinoline increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of quinoline CTD PMID:8824525 resveratrol multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 Resveratrol inhibits the reaction [Dietary Fats affects the expression of CYP2A5 mRNA] CTD PMID:17086191 rifampicin multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of CYP2A6 mRNA more ... CTD PMID:16857725 and PMID:29162470 rifampicin multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA CTD PMID:21224054 rifampicin increases expression ISO Cyp2a5 (Mus musculus) 6480464 Rifampin results in increased expression of CYP2A5 mRNA CTD PMID:11038160 and PMID:30503582 rifampicin increases activity ISO Cyp2a5 (Mus musculus) 6480464 Rifampin results in increased activity of CYP2A5 protein CTD PMID:11038160 rifampicin increases expression EXP 6480464 Rifampin results in increased expression of CYP2A6 mRNA and Rifampin results in increased expression of CYP2A6 protein CTD PMID:14709624 more ... safrole decreases activity EXP 6480464 Safrole results in decreased activity of CYP2A6 protein CTD PMID:15778010 selenium atom increases expression ISO Cyp2a5 (Mus musculus) 6480464 Selenium deficiency results in increased expression of CYP2A5 mRNA CTD PMID:16170372 senecionine increases expression ISO Cyp2a5 (Mus musculus) 6480464 senecionine results in increased expression of CYP2A5 protein CTD PMID:35357534 sevoflurane increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of sevoflurane CTD PMID:7879937 silicon dioxide decreases expression ISO Cyp2a5 (Mus musculus) 6480464 Silicon Dioxide results in decreased expression of CYP2A5 mRNA CTD PMID:29341224 sirolimus decreases expression EXP 6480464 Sirolimus results in decreased expression of CYP2A6 protein CTD PMID:25929522 skatole decreases expression EXP 6480464 Skatole results in decreased expression of CYP2A6 mRNA CTD PMID:28571685 sodium arsenite increases expression ISO Cyp2a5 (Mus musculus) 6480464 sodium arsenite results in increased expression of CYP2A5 mRNA CTD PMID:11979426 and PMID:33933676 sodium arsenite multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of CYP2A5 mRNA] and SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of CYP2A5 mRNA] CTD PMID:33933676 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of CYP2A6 mRNA CTD PMID:29301061 sodium arsenite increases activity ISO Cyp2a5 (Mus musculus) 6480464 sodium arsenite results in increased activity of CYP2A5 protein CTD PMID:11979426 sodium arsenite decreases expression ISO Cyp2a5 (Mus musculus) 6480464 sodium arsenite results in decreased expression of CYP2A6 mRNA CTD PMID:31532247 staurosporine multiple interactions EXP 6480464 Staurosporine inhibits the reaction [Ethanol results in increased expression of CYP2A6 mRNA] and Staurosporine inhibits the reaction [Ethanol results in increased expression of CYP2A6 protein] CTD PMID:22530035 Sudan I multiple interactions EXP 6480464 CYB5A protein promotes the reaction [CYP2A6 protein results in increased oxidation of 1-phenylazo-2-naphthol] CTD PMID:17159775 Sudan I increases oxidation EXP 6480464 CYP2A6 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 sulfasalazine increases expression ISO Cyp2a5 (Mus musculus) 6480464 Sulfasalazine results in increased expression of CYP2A5 mRNA CTD PMID:31830553 sulforaphane multiple interactions EXP 6480464 [sulforaphane results in increased activity of NFE2L2 protein] which results in increased expression of CYP2A6 mRNA CTD PMID:20887713 Sunset Yellow FCF multiple interactions EXP 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of CYP2A6 mRNA CTD PMID:33819548 tamoxifen increases expression EXP 6480464 Tamoxifen results in increased expression of CYP2A6 protein CTD PMID:19812351 tartrazine multiple interactions EXP 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine] results in decreased expression of CYP2A6 mRNA CTD PMID:33819548 tebufenozide increases expression EXP 6480464 tebufenozide results in increased expression of CYP2A6 mRNA CTD PMID:22310298 Tegafur multiple interactions EXP 6480464 CYP2A6 protein affects the metabolism of and results in increased activity of Tegafur CTD PMID:15980104 Tegafur increases response to substance EXP 6480464 CYP2A6 protein results in increased susceptibility to Tegafur CTD PMID:11376561 Tegafur increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of Tegafur CTD PMID:11376561 more ... Tegafur decreases activity EXP 6480464 CYP2A6 protein mutant form results in decreased activity of Tegafur CTD PMID:15980104 Tegafur affects metabolic processing EXP 6480464 CYP2A6 gene polymorphism affects the metabolism of Tegafur and CYP2A6 protein mutant form affects the metabolism of Tegafur CTD PMID:15980104 and PMID:18212800 tert-butyl ethyl ether increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of ethyl tert-butyl ether CTD PMID:11504148 testosterone multiple interactions EXP 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of CYP2A6 mRNA CTD PMID:21592394 testosterone increases expression EXP 6480464 Testosterone results in increased expression of CYP2A6 mRNA CTD PMID:21592394 tetrachloroethene increases expression ISO Cyp2a5 (Mus musculus) 6480464 Tetrachloroethylene results in increased expression of CYP2A5 mRNA CTD PMID:28973375 tetracycline decreases expression ISO Cyp2a5 (Mus musculus) 6480464 Tetracycline results in decreased expression of CYP2A5 mRNA CTD PMID:16917069 thapsigargin increases expression ISO Cyp2a5 (Mus musculus) 6480464 Thapsigargin results in increased expression of CYP2A5 mRNA CTD PMID:35341795 thiacloprid decreases expression EXP 6480464 thiacloprid results in decreased expression of CYP2A6 protein CTD PMID:32201337 thiacloprid increases expression EXP 6480464 thiacloprid results in increased expression of CYP2A6 mRNA CTD PMID:32201337 thiacloprid multiple interactions EXP 6480464 [clothianidin co-treated with thiacloprid] results in increased expression of CYP2A6 protein and [enilconazole co-treated with thiacloprid] results in decreased expression of CYP2A6 protein CTD PMID:32201337 thioacetamide increases activity ISO Cyp2a5 (Mus musculus) 6480464 Thioacetamide results in increased activity of CYP2A5 protein CTD PMID:7543189 thioacetamide increases expression ISO Cyp2a5 (Mus musculus) 6480464 Thioacetamide results in increased expression of CYP2A5 mRNA and Thioacetamide results in increased expression of CYP2A5 protein CTD PMID:7543189 and PMID:9698299 thioacetamide multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 heme arginate inhibits the reaction [Thioacetamide results in increased activity of CYP2A5 protein] CTD PMID:7543189 thioridazine decreases activity EXP 6480464 Thioridazine results in decreased activity of CYP2A6 protein CTD PMID:15135088 tin(II) chloride (anhydrous) increases expression ISO Cyp2a5 (Mus musculus) 6480464 stannous chloride results in increased expression of CYP2A5 protein CTD PMID:9698299 titanium dioxide decreases expression ISO Cyp2a5 (Mus musculus) 6480464 titanium dioxide results in decreased expression of CYP2A5 mRNA CTD PMID:23131501 and PMID:23557971 trans-cinnamic acid decreases activity EXP 6480464 cinnamic acid analog results in decreased activity of CYP2A6 protein CTD PMID:15072549 tranylcypromine decreases activity EXP 6480464 Tranylcypromine results in decreased activity of CYP2A6 protein CTD PMID:10911933 more ... tranylcypromine multiple interactions EXP 6480464 [[Tranylcypromine results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin more ... CTD PMID:11353760 more ... trichloroethene increases expression ISO Cyp2a5 (Mus musculus) 6480464 Trichloroethylene results in increased expression of CYP2A5 mRNA CTD PMID:19448997 triflumuron increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of triflumuron CTD PMID:31082524 tryptamine decreases activity EXP 6480464 tryptamine results in decreased activity of CYP2A6 protein CTD PMID:11353760 tryptamine multiple interactions EXP 6480464 [tryptamine results in decreased activity of CYP2A6 protein] which results in decreased abundance of Cotinine and [tryptamine results in decreased activity of CYP2A6 protein] which results in decreased abundance of Nicotine metabolite CTD PMID:22498344 tryptamines decreases activity EXP 6480464 Tryptamines analog results in decreased activity of CYP2A6 protein CTD PMID:26599973 tryptamines multiple interactions EXP 6480464 [Tryptamines analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin CTD PMID:26599973 tunicamycin increases expression ISO Cyp2a5 (Mus musculus) 6480464 Tunicamycin results in increased expression of CYP2A5 mRNA CTD PMID:35341795 umbelliferone increases chemical synthesis EXP 6480464 CYP2A6 protein results in increased chemical synthesis of 7-hydroxycoumarin CTD PMID:10616189 more ... umbelliferone multiple interactions EXP 6480464 [CYP2A6 protein results in increased metabolism of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin more ... CTD PMID:10616189 more ... valproic acid increases metabolic processing EXP 6480464 CYP2A6 protein results in increased metabolism of Valproic Acid CTD PMID:12487152 and PMID:16945988 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of CYP2A6 mRNA CTD PMID:29501571 valproic acid decreases methylation EXP 6480464 Valproic Acid results in decreased methylation of CYP2A6 gene CTD PMID:29501571 valproic acid affects expression ISO Cyp2a5 (Mus musculus) 6480464 Valproic Acid affects the expression of CYP2A5 mRNA CTD PMID:17963808 vanillin decreases activity EXP 6480464 vanillin results in decreased activity of CYP2A6 protein CTD PMID:32496054 vanillin multiple interactions EXP 6480464 [[vanillin results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin and [vanillin results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin CTD PMID:32496054 vitamin E multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 Vitamin E inhibits the reaction [pyrazole results in increased expression of CYP2A5 mRNA] CTD PMID:12499123 and PMID:14610226 zinc protoporphyrin multiple interactions ISO Cyp2a5 (Mus musculus) 6480464 [zinc protoporphyrin co-treated with Hemin] results in increased expression of CYP2A5 mRNA CTD PMID:22859313
