GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2a3 | increases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of CYP2A3 mRNA | PMID:21215274 | Cyp2a3 | affects expression | ISO | Cyp2a4 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of CYP2A4 mRNA | PMID:28922406 | Cyp2a3 | increases expression | ISO | Cyp2a4 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of CYP2A4 mRNA | PMID:28213091 | Cyp2a3 | multiple interactions | ISO | CYP2A7 (Homo sapiens) | 6480464 | CTD | [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CYP2A7 mRNA | PMID:26159488 | Cyp2a3 | multiple interactions | ISO | Cyp2a4 (Mus musculus) | 6480464 | CTD | [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CYP2A4 mRNA; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of CYP2A4 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP2A4 gene]; TIPARP gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP2A4 mRNA] | PMID:16214954 PMID:28213091 PMID:28433925 PMID:34129049 | | ||||||||||||||||||||||
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