RETINOL METABOLIC PATHWAY (PW:0000141)

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Description

Animal species cannot synthesize retinol or vitamin A. They derive it from diet as provitamin carotenoids found in plants and best exemplified by beta-carotene or as preformed vitamin such as the retinyl esters found in animal food. The provitamin carotenoid is absorbed into the small intestine by passive absorption or via transport by members of the scavenger receptor family, such as Scrba1, also known as SR-BI, and Cd36. In the lumen, retinyl esters are hydrolyzed by enzymes secreted by the pa

Pathway Diagram:

Ariadne Genomics Inc. retinal retinyl esters carotenoids carotenoids/beta-carotene re-esterifed retinol cell_retinol circ_retinol NADP+ NADPH all-trans-retinol retinyl esters ---> all-trans-retinol diet carotenoids ---> carotenoids/beta-carotene Scarb1 passive diffusion Lrat Bcmo1 Cd36 cell_retinol ---> circ_retinol Akr1b10 retinal ---> cell_retinol NADPH ---> NADP+ carotenoids/beta-carotene ---> retinal Plb1 Pnlip all-trans-retinol ---> cell_retinol cell_retinol ---> re-esterifed retinol Rbp2 cell_retinol ---- Rbp2 Abca1 Pnliprp2
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Genes in Pathway:

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retinol metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca1 ATP binding cassette subfamily A member 1 JBrowse link 5 69,857,717 69,983,042 RGD:6484679
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide JBrowse link 2 243,702,035 243,720,063 RGD:6907045
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide JBrowse link 2 243,728,500 243,740,907 RGD:6907045
G Adh6 alcohol dehydrogenase 6 (class V) JBrowse link 2 243,656,568 243,687,857 RGD:6907045
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide JBrowse link 2 243,500,540 243,516,865 RGD:6907045
G Akr1b10 aldo-keto reductase family 1 member B10 JBrowse link 4 61,813,265 61,830,371 RGD:6903952
RGD:6903957
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 JBrowse link 1 238,222,689 238,264,381 RGD:10402751
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 JBrowse link 8 77,640,234 77,719,488 RGD:1576367
RGD:10402751
RGD:6907045
G Awat1 acyl-CoA wax alcohol acyltransferase 1 JBrowse link X 70,408,124 70,414,369 RGD:10402751
G Awat2 acyl-CoA wax alcohol acyltransferase 2 JBrowse link X 70,224,761 70,233,021 RGD:6907045
G Bco1 beta-carotene oxygenase 1 JBrowse link 19 49,637,059 49,673,577 RGD:6903956
RGD:10402751
RGD:6907045
RGD:6484679
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:6484679
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6907045
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6907045
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 JBrowse link 1 256,382,861 256,386,729 RGD:6907045
RGD:10402751
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 JBrowse link 4 116,261,796 116,278,615 RGD:6907045
G Cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 JBrowse link 1 256,369,410 256,380,649 RGD:6907045
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 JBrowse link 1 83,711,223 83,725,222 RGD:6907045
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 JBrowse link 1 83,744,229 83,766,490 RGD:6907045
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 JBrowse link 1 83,653,248 83,662,118 RGD:6907045
RGD:10402751
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:6907045
G Cyp2b12 cytochrome P450, family 2, subfamily b, polypeptide 12 JBrowse link 1 83,511,167 83,522,965 RGD:6907045
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 JBrowse link 1 83,103,925 83,119,578 RGD:6907045
G Cyp2b21 cytochrome P450, family 2, subfamily b, polypeptide 21 JBrowse link 1 83,389,783 83,418,613 RGD:6907045
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6907045
RGD:10402751
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 JBrowse link 1 257,676,172 258,004,428 RGD:6907045
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 JBrowse link 1 258,709,726 258,766,873 RGD:6907045
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 JBrowse link 1 258,796,624 258,877,023 RGD:6907045
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 JBrowse link 1 259,257,658 259,297,270 RGD:6907045
G Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 JBrowse link 1 263,778,510 263,803,166 RGD:6907045
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 JBrowse link 1 147,422,999 148,119,979 RGD:6907045
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 JBrowse link 12 10,636,294 10,684,273 RGD:6907045
RGD:10402751
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 JBrowse link 12 11,641,500 11,677,818 RGD:6907045
G Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 JBrowse link 12 11,053,888 11,082,742 RGD:6907045
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6907045
RGD:10402751
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 JBrowse link 5 134,492,734 134,507,158 RGD:6907045
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 JBrowse link 5 134,196,910 134,207,888 RGD:6907045
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 JBrowse link 5 134,468,666 134,484,851 RGD:6907045
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 JBrowse link 5 133,978,953 134,008,255 RGD:6907045
G Dgat1 diacylglycerol O-acyltransferase 1 JBrowse link 7 117,566,363 117,576,735 RGD:6907045
RGD:10402751
G Dhrs3 dehydrogenase/reductase 3 JBrowse link 5 162,809,090 162,843,385 RGD:6907045
RGD:10402751
G Dhrs4 dehydrogenase/reductase 4 JBrowse link 15 34,155,043 34,167,073 RGD:6907045
RGD:10402751
G Dhrs9 dehydrogenase/reductase 9 JBrowse link 3 55,623,671 55,645,883 RGD:6907045
RGD:10402751
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 JBrowse link 11 81,741,342 81,757,806 RGD:10402751
G Erp29 endoplasmic reticulum protein 29 JBrowse link 12 40,619,377 40,625,884 RGD:10402751
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link 7 27,226,570 27,240,533 RGD:10402751
G Hspa5 heat shock protein family A member 5 JBrowse link 3 13,838,304 13,842,763 RGD:10402751
G Hyou1 hypoxia up-regulated 1 JBrowse link 8 48,699,796 48,711,912 RGD:10402751
G Lrat lecithin retinol acyltransferase JBrowse link 2 181,896,304 181,905,366 RGD:6484679
RGD:10402751
RGD:6907045
G Pdia2 protein disulfide isomerase family A, member 2 RGD:10402751
G Pdia4 protein disulfide isomerase family A, member 4 JBrowse link 4 77,470,636 77,489,535 RGD:10402751
G Pdia6 protein disulfide isomerase family A, member 6 JBrowse link 6 42,568,269 42,585,654 RGD:10402751
G Plb1 phospholipase B1 JBrowse link 6 25,375,699 25,507,108 RGD:6903951
RGD:6484679
G Pnlip pancreatic lipase JBrowse link 1 279,798,187 279,811,372 RGD:6484679
G Pnliprp2 pancreatic lipase related protein 2 JBrowse link 1 279,896,973 279,927,600 RGD:6484679
G Pnpla4 patatin like phospholipase domain containing 4 JBrowse link X 45,519,406 45,522,988 RGD:6907045
RGD:10402751
G Ppib peptidylprolyl isomerase B JBrowse link 8 71,719,681 71,725,538 RGD:10402751
G Rbp2 retinol binding protein 2 JBrowse link 8 106,479,253 106,527,726 RGD:6484679
G Rdh10 retinol dehydrogenase 10 JBrowse link 5 2,605,265 2,631,905 RGD:6907045
G Rdh11 retinol dehydrogenase 11 JBrowse link 6 102,356,498 102,372,618 RGD:6907045
RGD:10402751
G Rdh12 retinol dehydrogenase 12 JBrowse link 6 102,392,828 102,405,750 RGD:6907045
RGD:10402751
G Rdh16 retinol dehydrogenase 16 JBrowse link 7 71,058,150 71,072,685 RGD:10402751
G Rdh5 retinol dehydrogenase 5 JBrowse link 7 3,335,681 3,342,573 RGD:6907045
G Rdh7 retinol dehydrogenase 7 JBrowse link 7 71,125,358 71,164,014 RGD:6907045
G Rdh8 retinol dehydrogenase 8 JBrowse link 8 21,835,065 21,842,374 RGD:6907045
RGD:10402751
G Retsat retinol saturase JBrowse link 4 100,465,365 100,474,128 RGD:6907045
RGD:10402751
G Rpe65 RPE65, retinoid isomerohydrolase JBrowse link 2 266,141,581 266,169,197 RGD:6907045
RGD:10402751
G Scarb1 scavenger receptor class B, member 1 JBrowse link 12 36,694,952 36,761,445 RGD:6484679
G Sdf2l1 stromal cell-derived factor 2-like 1 JBrowse link 11 88,122,271 88,124,513 RGD:10402751
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:6907045
RGD:10402751
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 9 95,285,592 95,302,822 RGD:6907045
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 JBrowse link 9 95,274,707 95,302,822 RGD:6907045
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 JBrowse link 9 95,256,628 95,302,822 RGD:6907045
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 JBrowse link 9 95,241,609 95,302,822 RGD:6907045
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C JBrowse link 9 95,233,957 95,302,822 RGD:6907045
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 JBrowse link 9 95,221,474 95,302,822 RGD:6907045
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:6907045
G Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 JBrowse link 14 22,192,970 22,217,094 RGD:6907045
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 JBrowse link 14 22,251,507 22,267,899 RGD:6907045
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B RGD:6907045
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 JBrowse link 14 22,724,399 22,736,148 RGD:6907045
G Ugt2b37 UDP-glucuronosyltransferase 2 family, member 37 JBrowse link 14 22,495,084 22,534,865 RGD:6907045

Pathway Gene Annotations

Disease Annotations Associated with Genes in the retinol metabolic pathway
Disease TermsGene Symbols
3MC syndrome 1Dnajb11
Abortion, SpontaneousCyp1a1 , Sdf2l1
acute kidney failureCyp1a1 , Cyp1a2 , Cyp3a23/3a1 , Ugt1a1 , Ugt1a9
Acute Lung InjuryCd36 , Cyp1a1 , Cyp2b1
acute myeloid leukemiaCyp1a1
adenocarcinomaCyp26a1 , Ugt2b17
alcohol use disorderAdh5
Alcoholic Fatty LiverCd36
alcoholic pancreatitisUgt1a7c
allergic contact dermatitisCd36 , Cyp1a1
allergic hypersensitivity diseaseCyp1a1
Alzheimer's diseaseAbca1 , Cd36
ankylosing spondylitisCyp1a1
anxiety disorderCyp3a2
ARC syndromeCyp2b3
arteriosclerosisCd36
ArteritisCyp1a1
asbestosisHspa5
asthmaAdh5 , Cyp1a1
atherosclerosisAbca1 , Cd36
atrial fibrillationCd36
AtrophyCyp1a2
autosomal recessive polycystic kidney diseaseCyp4a1 , Cyp4a2 , Cyp4a3 , Cyp4a8
Barrett's esophagusCyp26a1
basal cell carcinomaRpe65
Behcet's diseaseCyp1a1
bilirubin metabolic disorderUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a8 , Ugt1a9
Birth WeightCyp1a1
blindnessRpe65
blood platelet diseaseCd36
Bone Mineral Density Quantitative Trait Locus 12Ugt2b17
BradycardiaCyp1a1
brain ischemiaCd36
breast ductal carcinomaLrat
Breast NeoplasmsCyp1a1 , Cyp1a2 , Cyp2b1 , Cyp3a2 , Hspa5 , Ugt1a1
bronchitisCyp1a1
Bronchitis, ChronicCyp1a1
cannabis abuseScarb1
carcinomaScarb1
Cardiac ArrhythmiasCd36
CardiomegalyCd36 , Cyp1a1 , Cyp2c11 , Cyp4a3
cardiomyopathyCd36 , Dgat1
Cerebral HemorrhageCd36
cerebral infarctionCd36
cerebral malariaCd36
Chemical and Drug Induced Liver InjuryCyp1a2 , Cyp2a3 , Cyp2b3 , Cyp2c11 , Cyp3a23/3a1 , Cyp4a3 , Hspa5 , Lrat , Ugt1a9
Chemotherapy-Induced Febrile NeutropeniaCyp3a9
cholangiocarcinomaUgt1a9
cholecystolithiasisUgt1a1
cholelithiasisUgt1a1
cholestasisAdh5 , Cyp1a2 , Cyp2b1
chronic kidney diseaseDgat1
chronic myeloid leukemiaCd36 , Cyp1a1 , Cyp3a9 , Hspa5
chronic obstructive pulmonary diseaseCyp1a1 , Cyp1a2
clubfootCyp1a1
Cocaine-Related DisordersScarb1
colitisCd36 , Cyp1a1
Colonic NeoplasmsCyp26a1
Colorectal NeoplasmsAbca1 , Akr1b10 , Cyp1a2
Congenital AbnormalitiesRdh5
congenital diarrhea 7 with exudative enteropathyDgat1
contact dermatitisAkr1b10 , Cyp1a1 , Ugt1a1 , Ugt1a6
corneal neovascularizationCd36
coronary artery diseaseAbca1 , Cd36
Coronary DiseaseAbca1 , Cd36 , Scarb1
Coumarin ResistanceCyp2a3
Coumarin SensitivityCyp2a3
Craniofacial AbnormalitiesRdh10
Creutzfeldt-Jakob diseaseAldh1a1
Crigler Najjar Syndrome, Type 2Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a8 , Ugt1a9
Crigler-Najjar syndromeUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a8 , Ugt1a9
Crohn's diseaseUgt1a1
cystic fibrosisCyp1a1
dermatomyositisCd36
Diabetes ComplicationsCyp2c11
diabetes mellitusCd36 , Cyp1a1
Diabetic NephropathiesCd36 , Hspa5
diarrheaDgat1
Diarrhea 7Dgat1
DiGeorge syndromeAldh1a2
Digestive System NeoplasmsCyp1a1
dilated cardiomyopathyCd36
disease of cellular proliferationAkr1b10
dopamine beta-hydroxylase deficiencyHspa5
Drug EruptionsCyp1a1
Drug-Induced LeukopeniaCyp3a9
Drug-induced NeutropeniaCyp3a9 , Ugt1a1
Drug-Related Side Effects and Adverse ReactionsCyp1a2 , Cyp2b3 , Ugt1a1
EFAVIRENZ, POOR METABOLISM OFCyp2b3
end stage renal failureAbca1 , Cyp1a1 , Cyp2b3 , Cyp2c11 , Cyp3a2 , Scarb1
Endometrial NeoplasmsAkr1b10 , Cyp1a1 , Ugt1a1
endometriosisCd36 , Cyp1a1 , Cyp26a1
Esophageal NeoplasmsAdh7 , Cyp26a1
esophagus squamous cell carcinomaCyp26b1 , Hspa5
essential hypertensionCyp3a9
essential thrombocythemiaCd36
Experimental Autoimmune MyocarditisHspa5
Experimental Autoimmune UveitisRpe65
Experimental Diabetes MellitusCd36 , Cyp1a1 , Cyp2b1 , Cyp2b3 , Rpe65 , Ugt2b17
Experimental Liver CirrhosisAdh4 , Aldh1a1 , Cd36 , Cyp1a2 , Cyp26a1 , Cyp2a2 , Cyp2c11 , Cyp3a9 , Dhrs3 , Lrat , Rdh10 , Ugt2b
eye diseaseRdh12
familial adenomatous polyposisCyp26a1
Familial HDL DeficiencyAbca1
familial hypercholesterolemiaAbca1
familial hyperlipidemiaAbca1
Familial Prostate CancerCyp3a2
fatty liver diseaseAbca1 , Cd36 , Hspa5
Female Genital NeoplasmsUgt1a1
Female InfertilityHspa5
Fetal DeathRdh10
Fetal Growth RetardationCyp1a1
Focal Facial Dermal DysplasiaCyp26c1
Focal Facial Dermal Dysplasia 4Cyp26c1
Follicular CystScarb1
fundus albipunctatusRdh5
fundus dystrophyLrat , Rdh12 , Rdh5 , Rpe65
Gallbladder NeoplasmsCyp1a1
GallstonesUgt1a1
genetic diseaseAbca1 , Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a8 , Ugt1a9
Gilbert syndromeUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a8 , Ugt1a9
gliosarcomaCyp2b3
glucose intoleranceCd36
Graft vs Host DiseaseUgt2b17
Gram-Negative Bacterial InfectionsUgt1a1
Graves' diseaseCyp1a1
Growth DisordersCyp1a2
HamartomaCyp1a1
heart diseaseCyp1a1
Hematologic NeoplasmsHspa5
HematomaCd36
hematopoietic system diseaseUgt1a1
hemolytic-uremic syndromeCd36
hepatitis CCyp2b1 , Scarb1
hepatocellular adenomaCyp3a23/3a1
hepatocellular carcinomaAbca1 , Akr1b10 , Cyp1a1 , Erp29 , Hspa5
HepatomegalyCyp1a1 , Cyp1a2 , Cyp2b1
Hereditary Eye DiseasesLrat , Rpe65
High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6Scarb1
Hodgkin's lymphomaUgt1a1
human immunodeficiency virus infectious diseasePpib
Hyperbilirubinemia, NeonatalUgt1a1
Hyperbilirubinemia, Transient Familial NeonatalUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a8 , Ugt1a9
Hypercarotenemia and Vitamin A Deficiency, Autosomal DominantBco1
HypercholesterolemiaAbca1 , Cd36 , Scarb1
Hyperlipoproteinemia Type IIAbca1
HyperoxiaCyp1a1
Hyperoxic Lung InjuryCyp1a1
hypertensionCd36 , Cyp1a1 , Cyp2c11 , Cyp4a1 , Cyp4a8
hyperthyroidismUgt1a1
HypertriglyceridemiaDgat1
hypertrophic cardiomyopathyCd36
HypoalphalipoproteinemiasAbca1
hypolipoproteinemiaAbca1
hypospadiasCyp1a1
inclusion body myositisCd36
InflammationCd36 , Cyp1a1 , Cyp2b1 , Cyp2b2 , Cyp3a2 , Cyp3a23/3a1 , Ugt1a1
inflammatory bowel diseaseHspa5
Insulin ResistanceCd36
JaundiceCyp1a1 , Cyp1a2 , Ugt1a1
kernicterusUgt1a1
kidney diseaseCyp3a9
Kidney NeoplasmsCyp1a1
Laryngeal NeoplasmsAdh7
Leber congenital amaurosisLrat , Rdh12 , Rpe65
Leber congenital amaurosis 13Rdh12
Leber congenital amaurosis 14Lrat
Leber congenital amaurosis 2Rpe65
Leber congenital amaurosis 3Rdh12
Leber hereditary optic neuropathyLrat , Rdh12 , Rpe65
Leukemia, Myeloid, Chronic-PhaseCyp3a9
liver cirrhosisCd36 , Cyp1a2 , Dgat1
liver diseaseCyp1a2
Liver InjuryCyp1a2
Liver Neoplasms, ExperimentalCyp1a1 , Cyp1a2
Liver Reperfusion InjuryCyp1a1
long QT syndromeCyp1a1
lung adenocarcinomaErp29
Lung InjuryCyp1a1 , Cyp1a2
Lung NeoplasmsCyp1a1 , Cyp1a2 , Ugt2b17
Lynch syndromeCyp2a3
macular degenerationCd36
malariaCd36
male infertilityCyp1a1
Malformations of Cortical Development, Group IIPnpla4
malignant gliomaCyp2b1 , Hspa5
Mammary Neoplasms, AnimalScarb1
Mammary Neoplasms, ExperimentalScarb1
melanomaAkr1b10
membranous glomerulonephritisAbca1
mental depressionCyp1a2 , Cyp2b1 , Cyp2c11 , Cyp3a23/3a1
Metabolic SyndromeAbca1 , Cd36 , Dgat1
methemoglobinemiaCyp1a2
Micronuclei, Chromosome-DefectiveCyp1a1
Microphthalmia, Syndromic 1Cyp26c1
middle cerebral artery infarctionCd36
mouth diseaseCyp26b1
Mouth NeoplasmsAdh7
multiple myelomaCyp1a1
Mycobacterium InfectionsCd36
myeloid leukemiaUgt1a1
myeloid neoplasmCd36 , Hspa5
myelomeningoceleAldh1a2
myocardial infarctionCd36 , Hspa5
Myocardial IschemiaCd36
Myocardial Reperfusion InjuryHspa5
myopiaRdh5
NecrosisCyp2b1
Nematode InfectionsCyp1a1
Neoplasm InvasivenessAkr1b10
Neoplasm MetastasisErp29
nephritisCyp1a1
nephrosisCd36 , Cyp3a18 , Cyp3a9
nephrotic syndromeDgat1
Nerve DegenerationHspa5
neural tube defectCyp1a2
neuronal ceroid lipofuscinosisHspa5
neutropeniaUgt1a1
night blindnessRdh5
non-small cell lung carcinomaUgt1a1
nonalcoholic fatty liver diseaseCd36 , Cyp1a2 , Scarb1
obesityAbca1 , Cd36 , Cyp26b1 , Cyp2b1 , Dgat1 , Hspa5 , Pnlip
Occupational DiseasesCyp1a1
osteoarthritisAldh1a2 , Cd36
Osteoarthritis, KneeCd36
osteogenesis imperfectaPpib
osteogenesis imperfecta type 9Ppib
Ovarian NeoplasmsCyp1a2 , Ugt1a1
pancreatic cancerAldh1a1 , Cyp2b1 , Ugt1a7c
Pancreatic Lipase DeficiencyPnlip
Pancreatitis, Experimental, Acute Hspa5
Parkinson's diseaseAdh7 , Cyp1a1
Parkinsonian DisordersAldh1a1 , Aldh1a2 , Cyp1a1
pemphigusCd36
Peripheral Nerve InjuriesHspa5
peripheral nervous system diseaseAbca1
peripheral vascular diseaseCyp1a1
Pharyngeal NeoplasmsAdh7
phencyclidine abuseScarb1
platelet-type bleeding disorder 10Cd36
pleomorphic xanthoastrocytomaAkr1b10 , Cd36 , Cyp3a18 , Cyp3a9
pneumoniaCyp1a1
polycystic ovary syndromeCd36 , Cyp1a1
polycythemia veraCd36
porphyria cutanea tardaCyp1a1 , Cyp1a2
precursor B lymphoblastic lymphoma/leukemiaCyp3a9
precursor lymphoblastic lymphoma/leukemiaCyp1a1 , Cyp1a2 , Cyp3a9
primary immunodeficiency diseaseCd36 , Cyp3a9
prostate cancerPlb1
Prostatic NeoplasmsAldh1a2 , Cyp1a1 , Cyp3a18 , Cyp3a9 , Erp29 , Hsp90b1 , Sdf2l1 , Ugt2b17
psoriasisCyp1a1
psoriatic arthritisCyp1a1
pulmonary fibrosisCd36 , Hspa5
pulmonary hypertensionAdh5
Radiohumeral Fusions with Other Skeletal and Craniofacial AnomaliesCyp26b1
reactive arthritisCyp1a1
relapsing-remitting multiple sclerosisCd36
renal cell carcinomaAldh1a1 , Cyp1a1 , Scarb1
Reperfusion InjuryCd36 , Cyp3a9 , Hspa5
respiratory allergyHspa5
retinal degenerationRdh12 , Rpe65
Retinal Dystrophy, Juvenile Cataracts, and Short Stature SyndromeRdh11
retinitis pigmentosaLrat , Rdh12 , Rpe65
retinitis pigmentosa 20Rpe65
Retroperitoneal FibrosisCd36
rheumatic heart diseaseCd36
rheumatoid arthritisHspa5 , Plb1
schizophreniaAbca1 , Pnpla4 , Ugt1a2
SepsisCd36 , Cyp1a1 , Cyp1a2 , Cyp2b1
sickle cell anemiaCd36
silicosisCd36
Simpson-Golabi-Behmel syndromeRetsat
Sjogren's syndromeCyp1a1
small cell carcinomaUgt1a1
spina bifidaCyp26a1
Spinal Cord InjuriesHspa5
Spinal Cord Reperfusion InjuryHspa5
spinocerebellar ataxia type 17Hspa5 , Hyou1
splenic diseaseCyp1a2
SplenomegalyCyp1a2
squamous cell carcinomaCyp1a2 , Rpe65
Staphylococcal InfectionsCd36
StarvationUgt1a1
systemic lupus erythematosusCyp1a1
TachycardiaCd36
Tachycardia, SinusCyp1a1
Tangier diseaseAbca1
Tardive DyskinesiaCyp1a2
thrombosisCyp3a9
thrombotic thrombocytopenic purpuraCd36
Tobacco Addiction, Susceptibility ToCyp2b3
toxic encephalopathyCyp3a9
transient cerebral ischemiaHspa5
type 1 diabetes mellitusCd36 , Ugt1a1
type 2 diabetes mellitusAbca1 , Cd36 , Cyp1a1 , Cyp1a2 , Cyp3a2 , Cyp3a23/3a1 , Sdf2l1 , Ugt1a1 , Ugt1a6 , Ugt1a7c
urinary bladder cancerCyp1a1 , Cyp2c11
visual epilepsyCd36 , Hspa5
Vitamin A DeficiencyLrat
Warfarin SensitivityCyp2a3
Wegener's granulomatosisCd36
Weight GainCd36
Wounds, PenetratingCd36
X-linked ichthyosisPnpla4
Pathway Annotations Associated with Genes in the retinol metabolic pathway
Pathway TermsGene Symbols
acetylsalicylic acid pharmacodynamics pathwayCyp2b3
alpha-linoleic acid metabolic pathwayPlb1
altered retinoid cycle metabolic pathwayLrat , Rdh12 , Rpe65
altered reverse cholesterol transport pathwayAbca1
antigen processing and presentation pathwayHspa5
antipyrine drug pathwayCyp2b3
arachidonic acid metabolic pathwayCyp2b1 , Cyp2b12 , Cyp2b2 , Cyp2b21 , Cyp2b3 , Cyp2c11 , Cyp2c12 , Cyp2c13 , Cyp2c22 , Cyp2c23 , Cyp2c7 , Cyp4a1 , Cyp4a2 , Cyp4a3 , Cyp4a8 , Plb1
arginine and proline metabolic pathwayAldh1a1
artemether pharmacokinetics pathwayCyp3a9 , Ugt1a9
ascorbate and aldarate metabolic pathwayAldh1a1 , Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
beta-alanine metabolic pathwayAldh1a1
bile acid transport pathwayScarb1
caffeine metabolic pathwayCyp1a2 , Cyp2a1 , Cyp2a2 , Cyp2a3
caffeine pharmacokinetics pathwayCyp1a2
carbamazepine pharmacokinetics pathwayCyp2b3 , Cyp3a9
celecoxib pharmacodynamics pathwayCyp2b3
cell-extracellular matrix signaling pathwayCd36
clomipramine pharmacokinetics pathwayCyp1a2
clopidogrel pharmacodynamics pathwayCyp1a2 , Cyp2b3 , Cyp3a9
clopidogrel pharmacokinetics pathwayCyp1a2 , Cyp2b3 , Cyp3a9
codeine and morphine pharmacodynamics pathwayDnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a2 , Ugt1a8
codeine and morphine pharmacokinetics pathwayDnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a2 , Ugt1a8
cyclophosphamide pharmacodynamics pathwayAldh1a1 , Cyp2b3
cyclophosphamide pharmacokinetics pathwayAldh1a1 , Cyp2b3
cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolismCyp2b12 , Cyp4a1 , Cyp4a2 , Cyp4a3
diclofenac pharmacodynamics pathwayCyp2b3
diflunisal pharmacodynamics pathwayCyp2b3
doxepin pharmacokinetics pathwayCyp1a2
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaCd36 , Cyp4a1 , Cyp4a2 , Cyp4a3 , Cyp4a8
Endoplasmic Reticulum-associated degradation pathwayDnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia4 , Pdia6
ether lipid metabolic pathwayPlb1
ether lipid metabolic pathwayPlb1
etodolac pharmacodynamics pathwayCyp2b3
etoposide pharmacodynamics pathwayCyp3a9 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
etoposide pharmacokinetics pathwayCyp3a9 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
fatty acid metabolic pathwayAdh4 , Adh5 , Adh6 , Adh7 , Aldh1a1 , Cyp4a1 , Cyp4a2 , Cyp4a3 , Cyp4a8
fenoprofen pharmacodynamics pathwayCyp2b3
fluoxetine pharmacodynamics pathwayCyp3a9
fluoxetine pharmacokinetics pathwayCyp3a9
flurbiprofen pharmacodynamics pathwayCyp2b3
gluconeogenesis pathwayAdh4 , Adh5 , Adh6 , Adh7 , Aldh1a1
glycerolipid metabolic pathwayAldh1a1 , Dgat1 , Pnlip , Pnliprp2
glycerophospholipid metabolic pathwayPlb1
glycolysis pathwayAdh4 , Adh5 , Adh6 , Adh7 , Aldh1a1
glycolysis/gluconeogenesis pathwayAdh4 , Adh5 , Adh6 , Adh7 , Aldh1a1
hepatitis C pathwayScarb1
histidine metabolic pathwayAldh1a1
ibuprofen pharmacodynamics pathwayCyp2b3 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a2 , Ugt1a9
ibuprofen pharmacokinetics pathwayDnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a2 , Ugt1a9
ifosfamide pharmacodynamics pathwayAldh1a1 , Cyp2b3 , Cyp3a9
ifosfamide pharmacokinetics pathwayAldh1a1 , Cyp2b3 , Cyp3a9
imipramine pharmacodynamics pathwayCyp1a2
imipramine pharmacokinetics pathwayCyp1a2
indometacin pharmacodynamics pathwayCyp2b3
indometacin pharmacodynamics pathwayCyp2b3
interleukin-6 signaling pathwayHsp90b1
irinotecan pharmacodynamics pathwayCyp3a9 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
irinotecan pharmacokinetics pathwayCyp3a9 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
ketoprofen pharmacodynamics pathwayCyp2b3
ketorolac pharmacodynamics pathwayCyp2b3
leukotriene C4 synthase deficiency pathwayCyp2b3
lidocaine pharmacodynamics pathwayCyp1a2
lidocaine pharmacokinetics pathwayCyp1a2
linoleic acid metabolic pathwayCyp1a2 , Cyp2c11 , Cyp2c12 , Cyp2c13 , Cyp2c22 , Cyp2c23 , Cyp2c7 , Cyp3a18 , Cyp3a2 , Cyp3a23/3a1 , Cyp3a9 , Cyp4a1 , Cyp4a2 , Cyp4a3 , Plb1
lornoxicam pharmacodynamics pathwayCyp2b3
lysine degradation pathwayAldh1a1
magnesium salicylate pharmacodynamics pathwayCyp2b3
malaria pathwayCd36
mefenamic acid pharmacodynamics pathwayCyp2b3
meloxicam pharmacodynamics pathwayCyp2b3
methadone pharmacodynamics pathwayCyp2b3
methadone pharmacokinetics pathwayCyp2b3
mycophenolic acid pharmacokinetics pathwayCyp3a9 , Ugt1a8 , Ugt1a9
nabumetone pharmacodynamics pathwayCyp2b3
naproxen pharmacodynamics pathwayCyp2b3
neviparine pharmacokinetics pathwayAldh1a1 , Cyp2b3 , Cyp3a9
nicotine pharmacodynamics pathwayCyp2b3 , Ugt1a5 , Ugt1a9
nicotine pharmacokinetics pathwayCyp2b3 , Ugt1a5 , Ugt1a9
NOD-like receptor signaling pathwayHsp90b1
O-linked glycan biosynthetic pathwayUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
paracetamol drug pathwayCyp2b3
paracetamol pharmacokinetics pathwayCyp1a2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a6 , Ugt1a9
pentose and glucuronate interconversion pathwayAldh1a1 , Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
phagocytosis pathwayCd36 , Scarb1
phase I biotransformation pathway via cytochrome P450Adh4 , Adh5 , Adh6 , Adh7 , Cyp1a1 , Cyp1a2 , Cyp2a1 , Cyp2a2 , Cyp2a3 , Cyp2b1 , Cyp2b12 , Cyp2b2 , Cyp2b21 , Cyp2b3 , Cyp2c11 , Cyp2c12 , Cyp2c13 , Cyp2c22 , Cyp2c23 , Cyp2c7 , Cyp3a18 , Cyp3a2 , Cyp3a23/3a1 , Cyp3a9 , Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
phenytoin pharmacodynamics pathwayCyp1a2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a5 , Ugt1a6 , Ugt1a9
piroxicam pharmacodynamics pathwayCyp2b3
porphyrin and chlorophyll metabolic pathwayUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
prion disease pathwayHspa5
propanoate metabolic pathwayAldh1a1
prostate cancer pathwayHsp90b1
pyruvate metabolic pathwayAldh1a1
retinitis pigmentosa pathwayLrat , Rdh12 , Rpe65
retinoic acid metabolic pathwayAldh1a1 , Aldh1a2 , Cyp26a1 , Cyp26b1 , Cyp26c1 , Dhrs9 , Lrat , Rdh10 , Rdh16 , Rdh7
retinoid cycle metabolic pathwayLrat , Rdh10 , Rdh11 , Rdh12 , Rdh5 , Rdh8 , Rpe65
retinol metabolic pathwayAbca1 , Adh4 , Adh5 , Adh6 , Adh7 , Akr1b10 , Aldh1a1 , Aldh1a2 , Awat1 , Awat2 , Bco1 , Cd36 , Cyp1a1 , Cyp1a2 , Cyp26a1 , Cyp26b1 , Cyp26c1 , Cyp2a1 , Cyp2a2 , Cyp2a3 , Cyp2b1 , Cyp2b12 , Cyp2b2 , Cyp2b21 , Cyp2b3 , Cyp2c11 , Cyp2c12 , Cyp2c13 , Cyp2c22 , Cyp2c23 , Cyp2c7 , Cyp3a18 , Cyp3a2 , Cyp3a23/3a1 , Cyp3a9 , Cyp4a1 , Cyp4a2 , Cyp4a3 , Cyp4a8 , Dgat1 , Dhrs3 , Dhrs4 , Dhrs9 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Lrat , Pdia2 , Pdia4 , Pdia6 , Plb1 , Pnlip , Pnliprp2 , Pnpla4 , Ppib , Rbp2 , Rdh10 , Rdh11 , Rdh12 , Rdh16 , Rdh5 , Rdh7 , Rdh8 , Retsat , Rpe65 , Scarb1 , Sdf2l1 , Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
reverse cholesterol transport pathwayAbca1 , Scarb1
salicylic acid pharmacodynamics pathwayCyp2b3
sodium salicylate pharmacodynamics pathwayCyp2b3
sorafenib pharmacokinetics pathwayCyp2b3 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
starch and sucrose metabolic pathwayUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
steroid hormone biosynthetic pathwayCyp1a1 , Cyp3a18 , Cyp3a2 , Cyp3a23/3a1 , Cyp3a9 , Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
sulindac pharmacodynamics pathwayCyp2b3
syndecan signaling pathwayPpib
tamoxifen pharmacodynamics pathwayCyp2b3 , Cyp3a9 , Ugt1a5
tamoxifen pharmacokinetics pathwayCyp2b3 , Cyp3a2 , Cyp3a23/3a1 , Cyp3a9 , Ugt1a5
teniposide pharmacodynamics pathwayCyp3a9
teniposide pharmacokinetics pathwayCyp3a9
tenoxicam pharmacodynamics pathwayCyp2b3
tiaprofenic acid pharmacodynamics pathwayCyp2b3
tolmetin pharmacodynamics pathwayCyp2b3
tramadol pharmacokinetics pathwayCyp2b3 , Ugt1a8
triacylglycerol metabolic pathwayDgat1
tryptophan metabolic pathwayAldh1a1 , Cyp1a1 , Cyp1a2
tyrosine metabolic pathwayAdh4 , Adh5 , Adh6 , Adh7
valdecoxib pharmacodynamics pathwayCyp2b3
valine, leucine and isoleucine degradation pathwayAldh1a1
valproic acid pharmacokinetics pathwayCyp2b3 , Ugt1a2
vitamin A deficiency pathwayAldh1a1 , Aldh1a2 , Awat1 , Bco1 , Cyp26a1 , Cyp2a3 , Cyp2b3 , Cyp3a18 , Cyp3a9 , Dgat1 , Dhrs3 , Dhrs4 , Dhrs9 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Lrat , Pdia2 , Pdia4 , Pdia6 , Pnpla4 , Ppib , Rdh11 , Rdh12 , Rdh16 , Rdh8 , Retsat , Rpe65 , Sdf2l1 , Ugt1a1
Phenotype Annotations Associated with Genes in the retinol metabolic pathway

References Associated with the retinol metabolic pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: