Ntf4 (neurotrophin 4) - Rat Genome Database

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Gene: Ntf4 (neurotrophin 4) Rattus norvegicus
Analyze
Symbol: Ntf4
Name: neurotrophin 4
RGD ID: 3212
Description: Predicted to enable growth factor activity and nerve growth factor receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; long-term memory; and nervous system development. Predicted to act upstream of or within negative regulation of programmed cell death; nervous system development; and taste bud development. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon; dendrite; and synaptic vesicle. Orthologous to human NTF4 (neurotrophin 4); PARTICIPATES IN mitogen activated protein kinase signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neurotrophin 5; Neurotrophin 5 (neurotrophin 4/5); neurotrophin 5 (neurotrophin 4/5); neurotrophin-4; neurotrophin-5; neutrophic factor 4; NT-4; NT-5; NT4P; Ntf5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,030,035 - 105,032,866 (+)NCBIGRCr8
mRatBN7.2195,893,560 - 95,896,391 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,893,457 - 95,897,243 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,278,986 - 101,281,817 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,751,663 - 109,754,494 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,042,063 - 103,044,894 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,405,314 - 101,408,145 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,405,314 - 101,408,145 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,484,724 - 102,487,555 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,885,577 - 95,888,408 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,963,687 - 95,966,519 (+)NCBI
Celera190,149,153 - 90,151,984 (+)NCBICelera
RH 3.4 Map1909.3RGD
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Berkemeier LR, etal., Neuron 1991 Nov;7(5):857-66.
2. A new role for neurotrophins: involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control. Botchkarev VA, etal., FASEB J. 1999 Feb;13(2):395-410.
3. Dissociation equilibrium constant of beta nerve growth factor. Bothwell MA and Shooter EM, J Biol Chem. 1977 Dec 10;252(23):8532-6.
4. Increased neurotrophin production in a Penicillium chrysogenum-induced allergic asthma model in mice. Chung YJ, etal., J Toxicol Environ Health A. 2007 Jun;70(12):1020-6.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Levels of brain-derived neurotrophic factor and neurotrophin-4 in lumbar motoneurons after low-thoracic spinal cord hemisection. Gulino R, etal., Brain Res 2004 Jul 9;1013(2):174-81.
8. Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. Ip NY, etal., Proc Natl Acad Sci U S A 1992 Apr 1;89(7):3060-4.
9. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
10. NT4/5 mutant mice have deficiency in gustatory papillae and taste bud formation. Liebl DJ, etal., Dev Biol. 1999 Sep 15;213(2):378-89.
11. Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice. Liebl DJ, etal., Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2297-302.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene. Xie CW, etal., Proc Natl Acad Sci U S A 2000 Jul 5;97(14):8116-21.
Additional References at PubMed
PMID:10908605   PMID:12376548   PMID:12970359   PMID:14519521   PMID:14622146   PMID:15376326   PMID:15703301   PMID:18045880   PMID:18957307   PMID:21273656   PMID:21767604   PMID:23526925  
PMID:24378336   PMID:35086088  


Genomics

Comparative Map Data
Ntf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,030,035 - 105,032,866 (+)NCBIGRCr8
mRatBN7.2195,893,560 - 95,896,391 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,893,457 - 95,897,243 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,278,986 - 101,281,817 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,751,663 - 109,754,494 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,042,063 - 103,044,894 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,405,314 - 101,408,145 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,405,314 - 101,408,145 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,484,724 - 102,487,555 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,885,577 - 95,888,408 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,963,687 - 95,966,519 (+)NCBI
Celera190,149,153 - 90,151,984 (+)NCBICelera
RH 3.4 Map1909.3RGD
Cytogenetic Map1q22NCBI
NTF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,058,284 - 49,065,035 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,061,066 - 49,065,076 (-)EnsemblGRCh38hg38GRCh38
GRCh371949,564,385 - 49,568,292 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,256,209 - 54,260,047 (-)NCBINCBI36Build 36hg18NCBI36
Build 341954,256,210 - 54,258,937NCBI
Celera1946,431,605 - 46,435,443 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,941,069 - 45,943,797 (-)NCBIHuRef
CHM1_11949,566,638 - 49,569,366 (-)NCBICHM1_1
T2T-CHM13v2.01952,053,068 - 52,059,823 (-)NCBIT2T-CHM13v2.0
Ntf5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,063,119 - 45,066,603 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,063,119 - 45,066,603 (+)EnsemblGRCm39 Ensembl
GRCm38745,413,695 - 45,417,179 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,413,695 - 45,417,179 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,669,065 - 52,672,549 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,281,737 - 45,285,221 (+)NCBIMGSCv36mm8
Celera740,869,726 - 40,873,213 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.3NCBI
Ntf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,647,685 - 1,650,553 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,647,685 - 1,650,553 (+)NCBIChiLan1.0ChiLan1.0
NTF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,175,303 - 55,179,596 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,094,760 - 57,099,077 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl1954,995,009 - 54,995,641 (-)Ensemblpanpan1.1panPan2
NTF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,371,335 - 107,377,238 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,371,335 - 107,376,987 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.01107,895,849 - 107,901,840 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,895,849 - 107,901,548 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,563,703 - 107,569,398 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,209,908 - 107,215,558 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,045,520 - 108,051,170 (+)NCBIUU_Cfam_GSD_1.0
Ntf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,398,887 - 21,401,144 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366643,017,108 - 3,017,955 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,271,246 - 54,274,092 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,271,244 - 54,288,846 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,039,657 - 50,057,398 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NTF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,254,693 - 42,284,899 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,279,190 - 42,279,822 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607322,170,689 - 22,171,841 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ntf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,007,801 - 5,008,451 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,005,935 - 5,008,694 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ntf4
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:61
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000028194
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat

Markers in Region
Ntf5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,895,659 - 95,895,908 (+)MAPPERmRatBN7.2
Rnor_6.01101,407,414 - 101,407,662NCBIRnor6.0
Rnor_5.01102,486,824 - 102,487,072UniSTSRnor5.0
RGSC_v3.4195,887,677 - 95,887,925UniSTSRGSC3.4
Celera190,151,253 - 90,151,501UniSTS
Cytogenetic Map1q22UniSTS
RH94573  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,895,910 - 95,895,992 (+)MAPPERmRatBN7.2
Rnor_6.01101,407,665 - 101,407,746NCBIRnor6.0
Rnor_5.01102,487,075 - 102,487,156UniSTSRnor5.0
RGSC_v3.4195,887,928 - 95,888,009UniSTSRGSC3.4
Celera190,151,504 - 90,151,585UniSTS
RH 3.4 Map1909.3UniSTS
Cytogenetic Map1q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6
Low 1 28 26 18 12 18 8 11 4 29 32 11 8
Below cutoff 2 13 25 21 7 21 63 6 3

Sequence


RefSeq Acc Id: ENSRNOT00000028194   ⟹   ENSRNOP00000028195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,893,915 - 95,896,146 (+)Ensembl
Rnor_6.0 Ensembl1101,405,314 - 101,408,145 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095694   ⟹   ENSRNOP00000093109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,893,457 - 95,897,243 (+)Ensembl
RefSeq Acc Id: NM_013184   ⟹   NP_037316
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,030,035 - 105,032,866 (+)NCBI
mRatBN7.2195,893,560 - 95,896,391 (+)NCBI
Rnor_6.01101,405,314 - 101,408,145 (+)NCBI
Rnor_5.01102,484,724 - 102,487,555 (+)NCBI
RGSC_v3.4195,885,577 - 95,888,408 (+)RGD
Celera190,149,153 - 90,151,984 (+)RGD
Sequence:
RefSeq Acc Id: XM_039102250   ⟹   XP_038958178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,030,168 - 105,032,627 (+)NCBI
mRatBN7.2195,893,679 - 95,896,152 (+)NCBI
RefSeq Acc Id: NP_037316   ⟸   NM_013184
- Peptide Label: precursor
- UniProtKB: P34131 (UniProtKB/Swiss-Prot),   A6JB25 (UniProtKB/TrEMBL),   A6JB26 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028195   ⟸   ENSRNOT00000028194
RefSeq Acc Id: XP_038958178   ⟸   XM_039102250
- Peptide Label: isoform X1
- UniProtKB: P34131 (UniProtKB/Swiss-Prot),   A6JB25 (UniProtKB/TrEMBL),   A6JB26 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093109   ⟸   ENSRNOT00000095694
Protein Domains
Nerve growth factor-related

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P34131-F1-model_v2 AlphaFold P34131 1-209 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690037
Promoter ID:EPDNEW_R561
Type:multiple initiation site
Name:Ntf4_1
Description:neurotrophin 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,405,279 - 101,405,339EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3212 AgrOrtholog
BioCyc Gene G2FUF-59687 BioCyc
Ensembl Genes ENSRNOG00000020783 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055005881 UniProtKB/Swiss-Prot
  ENSRNOG00060008911 UniProtKB/Swiss-Prot
  ENSRNOG00065029767 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028194.3 UniProtKB/Swiss-Prot
  ENSRNOT00000095694 ENTREZGENE
  ENSRNOT00000095694.1 UniProtKB/Swiss-Prot
  ENSRNOT00055009507 UniProtKB/Swiss-Prot
  ENSRNOT00060014924 UniProtKB/Swiss-Prot
  ENSRNOT00065051421 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nerve_growth_factor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nerve_growth_factor-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nerve_growth_factor_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrophin-4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25730 UniProtKB/Swiss-Prot
NCBI Gene 25730 ENTREZGENE
PANTHER NERVE GROWTH FACTOR NGF -RELATED UniProtKB/TrEMBL
  NEUROTROPHIN-4 UniProtKB/TrEMBL
  PTHR11589 UniProtKB/Swiss-Prot
  PTHR11589:SF8 UniProtKB/Swiss-Prot
Pfam NGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ntf4 PhenoGen
PIRSF NGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS NEUROTROPHN4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020783 RatGTEx
  ENSRNOG00055005881 RatGTEx
  ENSRNOG00060008911 RatGTEx
  ENSRNOG00065029767 RatGTEx
SMART NGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Cystine-knot cytokines UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC202021
UniProt A6JB25 ENTREZGENE, UniProtKB/TrEMBL
  A6JB26 ENTREZGENE, UniProtKB/TrEMBL
  NTF4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-12 Ntf4  neurotrophin 4  Ntf5  neurotrophin 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ntf5  Neurotrophin 5 (neurotrophin 4/5)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process activates two trk-related tyrosine kinase receptors 729138