Zfp324 (zinc finger protein 324) - Rat Genome Database

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Gene: Zfp324 (zinc finger protein 324) Rattus norvegicus
Analyze
Symbol: Zfp324
Name: zinc finger protein 324
RGD ID: 1306631
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF324B (zinc finger protein 324B); INTERACTS WITH 17beta-estradiol (ortholog); arsane (ortholog); arsenic atom (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC365192; zinc finger protein 324A; Znf324
RGD Orthologs
Human
Bonobo
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2173,591,411 - 73,600,601 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl173,591,491 - 73,597,894 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx178,971,864 - 78,981,006 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0187,536,204 - 87,545,344 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0180,726,937 - 80,736,082 (+)NCBIRnor_WKY
Rnor_6.0165,604,342 - 65,612,196 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl165,606,520 - 65,611,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,414,380 - 66,423,065 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4172,953,866 - 72,961,550 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1173,031,980 - 73,034,113 (-)NCBI
Celera160,239,920 - 60,247,748 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Zfp324
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2173,591,411 - 73,600,601 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl173,591,491 - 73,597,894 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx178,971,864 - 78,981,006 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0187,536,204 - 87,545,344 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0180,726,937 - 80,736,082 (+)NCBIRnor_WKY
Rnor_6.0165,604,342 - 65,612,196 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl165,606,520 - 65,611,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,414,380 - 66,423,065 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4172,953,866 - 72,961,550 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1173,031,980 - 73,034,113 (-)NCBI
Celera160,239,920 - 60,247,748 (-)NCBICelera
Cytogenetic Map1q12NCBI
ZNF324B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381958,418,396 - 58,457,833 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1958,451,611 - 58,457,833 (+)EnsemblGRCh38hg38GRCh38
GRCh371958,962,989 - 58,969,200 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361963,654,783 - 63,661,011 (+)NCBINCBI36Build 36hg18NCBI36
Celera1956,006,972 - 56,013,201 (+)NCBICelera
Cytogenetic Map19q13.43NCBI
HuRef1955,271,912 - 55,278,141 (+)NCBIHuRef
CHM1_11958,956,843 - 58,963,072 (+)NCBICHM1_1
T2T-CHM13v2.01961,547,594 - 61,553,798 (+)NCBIT2T-CHM13v2.0
ZNF324B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11964,283,432 - 64,289,592 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1964,285,509 - 64,288,340 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01955,458,533 - 55,464,744 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC119870868
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.01100,090,151 - 100,096,115 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1100,080,264 - 100,096,063 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1199,735,256 - 99,741,438 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0199,448,085 - 99,454,052 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01100,202,736 - 100,208,918 (-)NCBIUU_Cfam_GSD_1.0
LOC110261334
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1663,043,264 - 63,049,273 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Zfp324
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:44
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000036874
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 9 3 6 3 59 18 25 5
Low 3 41 48 38 13 38 8 11 15 17 16 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000036874   ⟹   ENSRNOP00000036344
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl173,591,491 - 73,597,894 (+)Ensembl
Rnor_6.0 Ensembl165,606,520 - 65,611,815 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102855   ⟹   ENSRNOP00000093845
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl173,591,491 - 73,596,239 (+)Ensembl
RefSeq Acc Id: XM_039100790   ⟹   XP_038956718
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2173,591,411 - 73,600,601 (+)NCBI
RefSeq Acc Id: XM_344862   ⟹   XP_344863
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2173,591,427 - 73,600,601 (+)NCBI
Rnor_6.0165,604,342 - 65,612,196 (-)NCBI
Rnor_5.0166,414,380 - 66,423,065 (-)NCBI
RGSC_v3.4172,953,866 - 72,961,550 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001387852 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956718 (Get FASTA)   NCBI Sequence Viewer  
  XP_344863 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75775 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_344863   ⟸   XM_344862
- Peptide Label: isoform X1
- UniProtKB: D3ZB44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000036344   ⟸   ENSRNOT00000036874
RefSeq Acc Id: XP_038956718   ⟸   XM_039100790
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000093845   ⟸   ENSRNOT00000102855
Protein Domains
C2H2-type   KRAB   KRAB-related

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZB44-F1-model_v2 AlphaFold D3ZB44 1-581 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306631 AgrOrtholog
BioCyc Gene G2FUF-60711 BioCyc
Ensembl Genes ENSRNOG00000027436 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000036344 ENTREZGENE
  ENSRNOP00000036344.4 UniProtKB/TrEMBL
  ENSRNOP00000093845.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036874 ENTREZGENE
  ENSRNOT00000036874.6 UniProtKB/TrEMBL
  ENSRNOT00000102855.1 UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Krueppel-associated_box-rel UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:365192 UniProtKB/TrEMBL
NCBI Gene 365192 ENTREZGENE
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp324 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  KRAB_RELATED UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8I6GKG8_RAT UniProtKB/TrEMBL
  D3ZB44 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-03 Zfp324  zinc finger protein 324  Znf324_predicted  zinc finger protein 324 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Znf324_predicted  zinc finger protein 324 (predicted)      Symbol and Name status set to approved 70820 APPROVED