Hpn (hepsin) - Rat Genome Database

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Gene: Hpn (hepsin) Rattus norvegicus
Analyze
Symbol: Hpn
Name: hepsin
RGD ID: 61982
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including cochlea morphogenesis; positive regulation of nitrogen compound metabolic process; and regulation of epithelial cell proliferation. Predicted to act upstream of or within several processes, including cholesterol homeostasis; negative regulation of alkaline phosphatase activity; and sensory perception of sound. Predicted to be located in several cellular components, including cell surface; endoplasmic reticulum membrane; and neuronal cell body. Predicted to be integral component of plasma membrane. Predicted to colocalize with nuclear membrane. Orthologous to human HPN (hepsin); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: hepsin (transmembrane protease, serine 1); serine protease hepsin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2186,337,085 - 86,352,785 (-)NCBI
Rnor_6.0 Ensembl189,534,106 - 89,543,967 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0189,534,112 - 89,549,575 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0190,688,659 - 90,704,122 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,145,615 - 86,161,091 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1186,223,725 - 86,239,202 (-)NCBI
Celera180,705,987 - 80,721,634 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
amiodarone  (ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
calcitriol  (ISO)
chlorpromazine  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clomipramine  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP,ISO)
disodium selenite  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
erythromycin A  (ISO)
flecainide  (ISO)
fluoxetine  (ISO)
imipramine  (ISO)
ketoconazole  (ISO)
Loratadine  (ISO)
methapyrilene  (EXP)
N-Nitrosopyrrolidine  (ISO)
nitroglycerin  (EXP)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
pentamidine  (ISO)
perhexiline  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
selenium atom  (ISO)
selenomethionine  (ISO)
sertraline  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioridazine  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
zimeldine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1885621   PMID:8346233   PMID:12744720   PMID:15614436   PMID:16908524   PMID:17620368   PMID:17918732   PMID:18784072   PMID:19843851   PMID:19911255   PMID:20683358   PMID:21734266  
PMID:22912808   PMID:23376485   PMID:23533145   PMID:24227843  


Genomics

Comparative Map Data
Hpn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2186,337,085 - 86,352,785 (-)NCBI
Rnor_6.0 Ensembl189,534,106 - 89,543,967 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0189,534,112 - 89,549,575 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0190,688,659 - 90,704,122 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,145,615 - 86,161,091 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1186,223,725 - 86,239,202 (-)NCBI
Celera180,705,987 - 80,721,634 (-)NCBICelera
Cytogenetic Map1q21NCBI
HPN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1935,040,506 - 35,066,573 (+)EnsemblGRCh38hg38GRCh38
GRCh381935,040,506 - 35,066,573 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371935,531,410 - 35,557,477 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,223,250 - 40,249,315 (+)NCBINCBI36hg18NCBI36
Build 341940,223,249 - 40,249,315NCBI
Celera1932,245,008 - 32,271,054 (+)NCBI
Cytogenetic Map19q13.11NCBI
HuRef1932,039,443 - 32,065,498 (+)NCBIHuRef
CHM1_11935,533,351 - 35,559,397 (+)NCBICHM1_1
Hpn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,798,150 - 30,814,751 (-)NCBIGRCm39mm39
GRCm39 Ensembl730,798,150 - 30,814,715 (-)Ensembl
GRCm38731,098,725 - 31,115,326 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl731,098,725 - 31,115,290 (-)EnsemblGRCm38mm10GRCm38
MGSCv37731,883,744 - 31,900,309 (-)NCBIGRCm37mm9NCBIm37
MGSCv36730,807,485 - 30,824,034 (-)NCBImm8
Celera725,667,468 - 25,684,520 (-)NCBICelera
Cytogenetic Map7B1NCBI
Hpn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554684,384,630 - 4,400,379 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554684,384,630 - 4,399,881 (+)NCBIChiLan1.0ChiLan1.0
HPN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11940,725,315 - 40,750,628 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1940,725,319 - 40,750,628 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01931,985,761 - 32,012,841 (+)NCBIMhudiblu_PPA_v0panPan3
HPN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11117,486,308 - 117,503,127 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1117,486,340 - 117,502,583 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1116,886,860 - 116,903,191 (-)NCBI
ROS_Cfam_1.01118,083,712 - 118,100,079 (-)NCBI
UMICH_Zoey_3.11117,646,333 - 117,662,660 (-)NCBI
UNSW_CanFamBas_1.01117,271,725 - 117,288,073 (-)NCBI
UU_Cfam_GSD_1.01118,328,288 - 118,344,658 (-)NCBI
Hpn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934910,458,113 - 10,474,937 (+)NCBI
SpeTri2.0NW_0049365701,170,951 - 1,186,501 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HPN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl644,608,071 - 44,628,049 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1644,608,076 - 44,628,044 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,033,553 - 40,101,145 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HPN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1629,973,743 - 29,998,701 (+)NCBI
ChlSab1.1 Ensembl629,973,867 - 29,998,855 (+)Ensembl
Vero_WHO_p1.0NW_0236660737,743,680 - 7,768,279 (+)NCBI
Hpn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247948,426,005 - 8,439,758 (-)NCBI

Position Markers
U85786  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2186,353,982 - 86,354,124 (+)MAPPER
Rnor_6.0189,550,804 - 89,550,945NCBIRnor6.0
Rnor_5.0190,705,351 - 90,705,492UniSTSRnor5.0
RGSC_v3.4186,162,320 - 86,162,461UniSTSRGSC3.4
Celera180,722,863 - 80,723,004UniSTS
Cytogenetic Map1q21UniSTS
PMC15797P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2186,354,090 - 86,354,306 (+)MAPPER
Rnor_6.0189,550,912 - 89,551,127NCBIRnor6.0
Rnor_5.0190,705,459 - 90,705,674UniSTSRnor5.0
RGSC_v3.4186,162,428 - 86,162,643UniSTSRGSC3.4
Celera180,722,971 - 80,723,186UniSTS
Cytogenetic Map1q21UniSTS
RH131311  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2186,337,107 - 86,337,310 (+)MAPPER
Rnor_6.0189,534,133 - 89,534,335NCBIRnor6.0
Rnor_5.0190,688,680 - 90,688,882UniSTSRnor5.0
RGSC_v3.4186,145,636 - 86,145,838UniSTSRGSC3.4
Celera180,706,008 - 80,706,210UniSTS
RH 3.4 Map1843.2UniSTS
Cytogenetic Map1q21UniSTS
D1Bda14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2186,337,109 - 86,337,305 (+)MAPPER
Rnor_6.0189,534,135 - 89,534,330NCBIRnor6.0
Rnor_5.0190,688,682 - 90,688,877UniSTSRnor5.0
RGSC_v3.4186,145,638 - 86,145,833UniSTSRGSC3.4
Celera180,706,010 - 80,706,205UniSTS
Cytogenetic Map1q21UniSTS
Hpn  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2186,337,336 - 86,337,410 (+)MAPPER
Rnor_6.0189,534,362 - 89,534,435NCBIRnor6.0
Rnor_5.0190,688,909 - 90,688,982UniSTSRnor5.0
Celera180,706,237 - 80,706,310UniSTS
Cytogenetic Map1q21UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15655769122614963Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123406428108057505Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)125951907130917265Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13537750894364229Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143579208126240667Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143579208126240667Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143579208126240667Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143579208126240667Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143579208126240667Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)149147799156446783Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14957857794578577Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149578577169852184Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15052271494225616Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157761301104391981Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)158209327103209327Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)158354072161711996Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)164588516125875986Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)166113339122614963Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)16722768394201552Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)179134941113593716Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)179689548124689548Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17968976594909507Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)182788437239853971Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)183502376128502376Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)183656882126240667Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185779320130779320Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185917265130917265Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)186776571131776571Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)188634585106002500Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:50
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000028644
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 41 41 41 35 2 1
Low 2 38 6 13 8 11 24 33 10 8
Below cutoff 1 5 10 6 36 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X70900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000028644   ⟹   ENSRNOP00000028644
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl189,534,112 - 89,539,210 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077462   ⟹   ENSRNOP00000074136
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl189,534,106 - 89,539,210 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079631   ⟹   ENSRNOP00000075632
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl189,534,416 - 89,543,967 (-)Ensembl
RefSeq Acc Id: NM_017112   ⟹   NP_058808
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,337,087 - 86,352,754 (-)NCBI
Rnor_6.0189,534,112 - 89,549,575 (-)NCBI
Rnor_5.0190,688,659 - 90,704,122 (-)NCBI
RGSC_v3.4186,145,615 - 86,161,091 (-)RGD
Celera180,705,987 - 80,721,634 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102952   ⟹   XP_038958880
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,337,085 - 86,352,782 (-)NCBI
RefSeq Acc Id: XM_039102956   ⟹   XP_038958884
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,337,085 - 86,352,123 (-)NCBI
RefSeq Acc Id: XM_039102958   ⟹   XP_038958886
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,337,085 - 86,352,780 (-)NCBI
RefSeq Acc Id: XM_039102963   ⟹   XP_038958891
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,337,085 - 86,352,785 (-)NCBI
RefSeq Acc Id: XM_039102966   ⟹   XP_038958894
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,337,085 - 86,352,121 (-)NCBI
RefSeq Acc Id: XM_039102969   ⟹   XP_038958897
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,337,085 - 86,352,785 (-)NCBI
RefSeq Acc Id: XM_039102973   ⟹   XP_038958901
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,337,085 - 86,352,775 (-)NCBI
RefSeq Acc Id: XM_039102979   ⟹   XP_038958907
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,337,085 - 86,352,785 (-)NCBI
RefSeq Acc Id: XM_039102984   ⟹   XP_038958912
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,337,085 - 86,352,780 (-)NCBI
RefSeq Acc Id: XM_039102990   ⟹   XP_038958918
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,337,490 - 86,352,782 (-)NCBI
RefSeq Acc Id: XM_039102995   ⟹   XP_038958923
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,337,328 - 86,352,782 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058808   ⟸   NM_017112
- Peptide Label: precursor
- UniProtKB: Q05511 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075632   ⟸   ENSRNOT00000079631
RefSeq Acc Id: ENSRNOP00000028644   ⟸   ENSRNOT00000028644
RefSeq Acc Id: ENSRNOP00000074136   ⟸   ENSRNOT00000077462
RefSeq Acc Id: XP_038958897   ⟸   XM_039102969
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038958907   ⟸   XM_039102979
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038958891   ⟸   XM_039102963
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038958880   ⟸   XM_039102952
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038958912   ⟸   XM_039102984
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038958886   ⟸   XM_039102958
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038958901   ⟸   XM_039102973
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038958884   ⟸   XM_039102956
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038958894   ⟸   XM_039102966
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038958923   ⟸   XM_039102995
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038958918   ⟸   XM_039102990
- Peptide Label: isoform X8
Protein Domains
Peptidase S1   SRCR

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61982 AgrOrtholog
Ensembl Genes ENSRNOG00000021097 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028644 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000074136 UniProtKB/TrEMBL
  ENSRNOP00000075632 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028644 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000077462 UniProtKB/TrEMBL
  ENSRNOT00000079631 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7098661 IMAGE-MGC_LOAD
InterPro Hepsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hepsin-SRCR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29135 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91742 IMAGE-MGC_LOAD
NCBI Gene 29135 ENTREZGENE
PANTHER PTHR24253:SF38 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hepsin-SRCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hpn PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC232122
UniProt A0A0G2K7B4_RAT UniProtKB/TrEMBL
  A0A0G2KB31_RAT UniProtKB/TrEMBL
  F1LS97_RAT UniProtKB/TrEMBL
  HEPS_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6GQQ3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-26 Hpn  hepsin  Hpn  hepsin (transmembrane protease, serine 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Hpn  hepsin (transmembrane protease, serine 1)  Hpn  hepsin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hpn  hepsin      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology 88.7% amino acid sequence identity to human homolog 61628
gene_protein 416 amino acids 61628