Ldha (lactate dehydrogenase A) - Rat Genome Database

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Gene: Ldha (lactate dehydrogenase A) Rattus norvegicus
Analyze
Symbol: Ldha
Name: lactate dehydrogenase A
RGD ID: 2996
Description: Enables several functions, including L-lactate dehydrogenase activity; NAD binding activity; and identical protein binding activity. Involved in several processes, including NAD metabolic process; response to cAMP; and response to estrogen. Predicted to be located in cytosol and sperm fibrous sheath. Predicted to be part of oxidoreductase complex. Biomarker of hyperglycemia. Orthologous to human LDHA (lactate dehydrogenase A); PARTICIPATES IN hypoxia inducible factor pathway; cysteine and methionine metabolic pathway; gluconeogenesis pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CDK1; L-lactate dehydrogenase A chain; lactate dehydrogenase A-like; LDH muscle subunit; LDH-A; LDH-M; Ldh1; LOC100364670
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2197,371,823 - 97,381,247 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,366,021 - 97,433,472 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1102,764,365 - 102,773,796 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01111,236,347 - 111,245,778 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01104,520,156 - 104,529,575 (+)NCBIRnor_WKY
Rnor_6.01102,900,288 - 102,909,713 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,900,286 - 102,909,707 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,975,209 - 103,984,638 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,403,077 - 97,412,547 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1197,481,187 - 97,490,658 (+)NCBI
Celera191,618,363 - 91,627,752 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R)-tramadol  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(Z)-3-butylidenephthalide  (ISO)
1,10-phenanthroline  (ISO)
1,4-benzoquinone  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-bromopyruvic acid  (ISO)
3-methyladenine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
aconitine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
AM-251  (EXP)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bezafibrate  (EXP)
bicalutamide  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
bucladesine  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CCCP  (ISO)
celecoxib  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corilagin  (EXP)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
D-glucose  (EXP,ISO)
DDT  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
diethylstilbestrol  (EXP)
dihydroartemisinin  (ISO)
dihydrogen  (ISO)
dioxygen  (EXP,ISO)
diprotium  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
furan  (EXP)
Fusaric acid  (ISO)
gallic acid  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
graphite  (ISO)
GW 4064  (ISO)
hexamethylene diisocyanate  (ISO)
indometacin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
lead diacetate  (EXP,ISO)
LY294002  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
methidathion  (ISO)
methimazole  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
naringin  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
niclosamide  (ISO)
Nonidet P-40  (ISO)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
oxamic acid  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
procarbazine  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
Propiverine  (EXP)
propofol  (ISO)
prostaglandin A1  (ISO)
prostaglandin E2  (ISO)
puerarin  (EXP)
pyrimidifen  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
roxadustat  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sildenafil citrate  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tadalafil  (EXP)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
tapentadol  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
thimerosal  (ISO)
thioacetamide  (ISO)
toxaphene  (EXP)
tramadol  (ISO)
trans-caffeic acid  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
Yessotoxin  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Purification and radioimmunoassay of rat lactate dehydrogenase A and B subunits. Beebee TJ and Carty DS, Biochem J. 1982 Aug 1;205(2):313-20.
2. A study of lactate dehydrogenase levels and turnover rates during postnatal development in the rat. Beebee TJ and Carty DS, Biochim Biophys Acta. 1983 May 25;757(2):209-18.
3. Effect of intermittent high altitude hypoxia on gene expression in rat heart and lung. Deindl E, etal., Physiol Res. 2003;52(2):147-57.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Identification of estrogen-regulated genes by microarray analysis of the uterus of immature rats exposed to endocrine disrupting chemicals. Hong EJ, etal., Reprod Biol Endocrinol. 2006 Sep 29;4:49.
7. Transcriptional regulation of the lactate dehydrogenase A subunit gene by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Huang D and Jungmann RA, Mol Cell Endocrinol. 1995 Feb 27;108(1-2):87-94.
8. High glucose stimulates early response gene c-Myc expression in rat pancreatic beta cells. Jonas JC, etal., J Biol Chem. 2001 Sep 21;276(38):35375-81. Epub 2001 Jul 16.
9. M-LDH serves as a regulatory subunit of the cytosolic substrate-channelling complex in vivo. Jovanovic S, etal., J Mol Biol. 2007 Aug 10;371(2):349-61. Epub 2007 Jun 2.
10. Cyclic AMP regulation of lactate dehydrogenase. Isoproterenol and N6,O2-dibutyryl cyclic amp increase the rate of transcription and change the stability of lactate dehydrogenase a subunit messenger RNA in rat C6 glioma cells. Jungmann RA, etal., J Biol Chem. 1983 Apr 25;258(8):5312-8.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes. Laybutt DR, etal., J Biol Chem. 2003 Jan 31;278(5):2997-3005. Epub 2002 Nov 15.
13. Tumor induction by the c-Myc target genes rcl and lactate dehydrogenase A. Lewis BC, etal., Cancer Res. 2000 Nov 1;60(21):6178-83.
14. Effects of propofol on invasion and migration of colon cancer cells and JAK2/STAT3 signaling pathway. Liang B and Dong T, Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Mar 28;45(3):290-296. doi: 10.11817/j.issn.1672-7347.2020.180704.
15. Gene expression changes in rat white adipose tissue after a high-fat diet determined by differential display. Lopez IP, etal., Biochem Biophys Res Commun. 2004 May 21;318(1):234-9.
16. Epidermal growth factor or serum stimulation of rat fibroblasts induces an elevation in mRNA levels for lactate dehydrogenase and other glycolytic enzymes. Matrisian LM, etal., Nucleic Acids Res 1985 Feb 11;13(3):711-26.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Identification of mono-ubiquitinated LDH-A in skeletal muscle cells exposed to oxidative stress. Onishi Y, etal., Biochem Biophys Res Commun. 2005 Oct 28;336(3):799-806.
20. Anesthetic concentrations of propofol protect against oxidative stress in primary astrocyte cultures: comparison with hypothermia. Peters CE, etal., Anesthesiology. 2001 Feb;94(2):313-21.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. A unique glucose-dependent apoptotic pathway induced by c-Myc. Shim H, etal., Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1511-6.
27. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
28. Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer. Tan WL, etal., Cancer Biol Ther. 2011 Mar 15;11(6):599-608. Epub 2011 Mar 15.
29. Effect of Anabolic Steroid Nandrolone Decanoate on the Properties of Certain Enzymes in the Heart, Liver, and Muscle of Rats, and their Effect on Rats' Cardiac Electrophysiology. Tylicki A, etal., Horm Metab Res. 2007 Apr;39(4):268-72.
Additional References at PubMed
PMID:1996957   PMID:2991914   PMID:3796661   PMID:7323947   PMID:8224816   PMID:9125149   PMID:10322635   PMID:11276087   PMID:11487543   PMID:11980919   PMID:14760703   PMID:15489334  
PMID:15878851   PMID:16687649   PMID:18534967   PMID:18614015   PMID:19056867   PMID:19946888   PMID:20458337   PMID:21630459   PMID:21988832   PMID:22082260   PMID:22871113   PMID:22926577  
PMID:23376485   PMID:23533145   PMID:24086675   PMID:24625528   PMID:24835193   PMID:25468996   PMID:25502805   PMID:26316108   PMID:27654895   PMID:27988334   PMID:28495754   PMID:28818664  
PMID:28894025   PMID:29476059   PMID:29867124   PMID:30171160   PMID:31515488   PMID:32321555  


Genomics

Comparative Map Data
Ldha
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2197,371,823 - 97,381,247 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,366,021 - 97,433,472 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1102,764,365 - 102,773,796 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01111,236,347 - 111,245,778 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01104,520,156 - 104,529,575 (+)NCBIRnor_WKY
Rnor_6.01102,900,288 - 102,909,713 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,900,286 - 102,909,707 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,975,209 - 103,984,638 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,403,077 - 97,412,547 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1197,481,187 - 97,490,658 (+)NCBI
Celera191,618,363 - 91,627,752 (+)NCBICelera
Cytogenetic Map1q22NCBI
LDHA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381118,394,563 - 18,408,425 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1118,394,560 - 18,408,425 (+)EnsemblGRCh38hg38GRCh38
GRCh371118,416,110 - 18,429,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,372,687 - 18,385,969 (+)NCBINCBI36Build 36hg18NCBI36
Build 341118,372,686 - 18,385,969NCBI
Celera1118,550,876 - 18,564,695 (+)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1118,101,143 - 18,114,981 (+)NCBIHuRef
CHM1_11118,415,425 - 18,429,229 (+)NCBICHM1_1
T2T-CHM13v2.01118,492,694 - 18,506,551 (+)NCBIT2T-CHM13v2.0
Ldha
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,491,698 - 46,505,051 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,490,899 - 46,505,051 (+)EnsemblGRCm39 Ensembl
GRCm38746,842,274 - 46,855,627 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,841,475 - 46,855,627 (+)EnsemblGRCm38mm10GRCm38
MGSCv37754,101,174 - 54,110,997 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36746,715,255 - 46,723,668 (+)NCBIMGSCv36mm8
Celera742,325,754 - 42,335,573 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.6NCBI
Ldha
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541433,087,745 - 33,100,846 (+)NCBIChiLan1.0ChiLan1.0
LDHA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11118,115,250 - 18,128,400 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,115,250 - 18,128,400 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01118,432,347 - 18,445,694 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LDHA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12140,829,844 - 40,840,947 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2140,309,124 - 40,320,220 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02141,953,737 - 41,963,155 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12140,945,678 - 40,956,764 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02141,134,448 - 41,145,537 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02141,511,954 - 41,523,047 (+)NCBIUU_Cfam_GSD_1.0
Ldha
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494744,832,627 - 44,845,986 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936528866,607 - 879,977 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LDHA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl240,814,169 - 40,826,715 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1240,814,163 - 40,827,284 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2243,896,319 - 43,909,457 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LDHA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,525,090 - 46,542,587 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038143,887,277 - 143,900,854 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ldha
52 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:224
Count of miRNA genes:168
Interacting mature miRNAs:185
Transcripts:ENSRNOT00000017468, ENSRNOT00000074013
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 8 19 13 13 3 4
Medium 3 35 44 28 19 28 8 8 70 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC084698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC168737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M54926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X01964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X89821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000017468   ⟹   ENSRNOP00000017468
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl197,371,823 - 97,381,243 (+)Ensembl
Rnor_6.0 Ensembl1102,900,286 - 102,909,707 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097479   ⟹   ENSRNOP00000096315
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl197,373,069 - 97,433,472 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102543   ⟹   ENSRNOP00000083496
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl197,372,732 - 97,381,243 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107981   ⟹   ENSRNOP00000095297
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl197,372,021 - 97,381,243 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115850   ⟹   ENSRNOP00000088214
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl197,366,021 - 97,381,243 (+)Ensembl
RefSeq Acc Id: NM_017025   ⟹   NP_058721
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2197,371,823 - 97,381,242 (+)NCBI
Rnor_6.01102,900,288 - 102,909,707 (+)NCBI
Rnor_5.01103,975,209 - 103,984,638 (+)NCBI
RGSC_v3.4197,403,077 - 97,412,547 (+)RGD
Celera191,618,363 - 91,627,752 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229232   ⟹   XP_006229294
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2197,373,143 - 97,381,247 (+)NCBI
Rnor_6.01102,901,586 - 102,909,713 (+)NCBI
Rnor_5.01103,975,209 - 103,984,638 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097411   ⟹   XP_038953339
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2197,371,824 - 97,381,247 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058721   ⟸   NM_017025
- UniProtKB: P04642 (UniProtKB/Swiss-Prot),   B5DEN4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229294   ⟸   XM_006229232
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZX39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017468   ⟸   ENSRNOT00000017468
RefSeq Acc Id: XP_038953339   ⟸   XM_039097411
- Peptide Label: isoform X2
- UniProtKB: P04642 (UniProtKB/Swiss-Prot),   B5DEN4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083496   ⟸   ENSRNOT00000102543
RefSeq Acc Id: ENSRNOP00000088214   ⟸   ENSRNOT00000115850
RefSeq Acc Id: ENSRNOP00000095297   ⟸   ENSRNOT00000107981
RefSeq Acc Id: ENSRNOP00000096315   ⟸   ENSRNOT00000097479
Protein Domains
Ldh_1_C   Ldh_1_N

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04642-F1-model_v2 AlphaFold P04642 1-332 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690068
Promoter ID:EPDNEW_R592
Type:multiple initiation site
Name:Ldha_1
Description:lactate dehydrogenase A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01102,900,288 - 102,900,348EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2996 AgrOrtholog
BioCyc Gene G2FUF-59608 BioCyc
BioCyc Pathway PWY-5031 [L-histidine degradation V] BioCyc
Ensembl Genes ENSRNOG00000013009 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000017468 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000083496 ENTREZGENE
  ENSRNOP00000083496.1 UniProtKB/TrEMBL
  ENSRNOP00000088214.1 UniProtKB/TrEMBL
  ENSRNOP00000095297.1 UniProtKB/TrEMBL
  ENSRNOP00000096315.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017468 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000097479.1 UniProtKB/TrEMBL
  ENSRNOT00000102543 ENTREZGENE
  ENSRNOT00000102543.1 UniProtKB/TrEMBL
  ENSRNOT00000107981.1 UniProtKB/TrEMBL
  ENSRNOT00000115850.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6919582 IMAGE-MGC_LOAD
  IMAGE:7122339 IMAGE-MGC_LOAD
InterPro L-lactate/malate_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L-lactate_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L-lactate_DH_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lactate/malate_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lactate/malate_DH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lactate_DH/Glyco_Ohase_4_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24533 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105462 IMAGE-MGC_LOAD
  MGC:72944 IMAGE-MGC_LOAD
NCBI Gene 24533 ENTREZGENE
Pfam Ldh_1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldh_1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ldha PhenoGen
PIRSF Lac_mal_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LLDHDRGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE L_LDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56327 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs L-LDH-NAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZX39 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AAB9_RAT UniProtKB/TrEMBL
  A0A8I6AMT0_RAT UniProtKB/TrEMBL
  A0A8I6AT42_RAT UniProtKB/TrEMBL
  B5DEN4 ENTREZGENE, UniProtKB/TrEMBL
  LDHA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-29 Ldha  lactate dehydrogenase A  LOC100364670  lactate dehydrogenase A-like  Data Merged 737654 PROVISIONAL
2010-05-05 LOC100364670  lactate dehydrogenase A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-11-06 Ldha  lactate dehydrogenase A    Lactate dehydrogenase A  Name updated 625702 APPROVED
2002-06-10 Ldha  Lactate dehydrogenase A      Symbol and Name status set to approved 70586 APPROVED