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Gene: Ldha (lactate dehydrogenase A) Ictidomys tridecemlineatus

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Symbol:

Ldha

Name:

lactate dehydrogenase A

RGD ID:

12590711

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); kinase binding (ortholog); L-lactate dehydrogenase activity (ortholog); INVOLVED IN cellular response to phorbol 13-acetate 12-myristate (ortholog); glucose catabolic process to lactate via pyruvate (ortholog); lactate metabolic process (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Animal Disease Models (ortholog); cardiomyopathy (ortholog); FOUND IN cytosol (ortholog); oxidoreductase complex (ortholog); sperm fibrous sheath (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

L-lactate dehydrogenase A chain

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LDHA (lactate dehydrogenase A)	NCBI	Ortholog
Mus musculus (house mouse):	Ldha (lactate dehydrogenase A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ldha (lactate dehydrogenase A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ldha (lactate dehydrogenase A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LDHA (lactate dehydrogenase A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LDHA (lactate dehydrogenase A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LDHA (lactate dehydrogenase A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LDHA (lactate dehydrogenase A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	44,832,627 - 44,845,986 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936528	866,607 - 879,977 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Liver Failure (ISO)

Animal Disease Models (ISO)

cardiomyopathy (ISO)

COVID-19 (ISO)

Experimental Neoplasms (ISO)

Fanconi syndrome (ISO)

Fanconi-Bickel syndrome (ISO)

genetic disease (ISO)

Glycogen Storage Disease XI (ISO)

hyperglycemia (ISO)

hypertension (ISO)

hypertrophic cardiomyopathy 12 (ISO)

intellectual disability (ISO)

lung adenocarcinoma (ISO)

myocardial infarction (ISO)

myoglobinuria (ISO)

pancreatic cancer (ISO)

progressive myoclonus epilepsy 7 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carboxylic acid metabolic process (IEA)

cellular response to phorbol 13-acetate 12-myristate (ISO)

glucose catabolic process to lactate via pyruvate (ISO)

lactate metabolic process (IEA,ISO)

liver development (ISO)

NAD metabolic process (ISO)

positive regulation of apoptotic process (ISO)

pyruvate catabolic process (ISO)

pyruvate metabolic process (IEA)

response to cAMP (ISO)

response to estrogen (ISO)

response to glucose (ISO)

response to hydrogen peroxide (ISO)

response to hypoxia (ISO)

response to nutrient (ISO)

response to xenobiotic stimulus (ISO)

skeletal muscle tissue development (ISO)

substantia nigra development (ISO)

Cellular Component

cytoplasm (IEA)

cytosol (ISO)

oxidoreductase complex (ISO)

sperm fibrous sheath (ISO)

Molecular Function

identical protein binding (ISO)

kinase binding (ISO)

L-lactate dehydrogenase activity (IEA,ISO)

lactate dehydrogenase activity (ISO)

NAD binding (ISO)

oxidoreductase activity (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

hypoxia inducible factor pathway (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Ldha
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	44,832,627 - 44,845,986 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936528	866,607 - 879,977 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LDHA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	18,394,563 - 18,408,425 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	18,394,560 - 18,408,425 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	18,416,110 - 18,429,972 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	18,372,687 - 18,385,969 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	18,372,686 - 18,385,969	NCBI
Celera	11	18,550,876 - 18,564,695 (+)	NCBI		Celera
Cytogenetic Map	11	p15.1	NCBI
HuRef	11	18,101,143 - 18,114,981 (+)	NCBI		HuRef
CHM1_1	11	18,415,425 - 18,429,229 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	18,492,694 - 18,506,551 (+)	NCBI		T2T-CHM13v2.0

Ldha
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	46,491,698 - 46,505,051 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	46,490,899 - 46,505,051 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	46,842,274 - 46,855,627 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	46,841,475 - 46,855,627 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	54,101,174 - 54,110,997 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	46,715,255 - 46,723,668 (+)	NCBI		MGSCv36	mm8
Celera	7	42,325,754 - 42,335,573 (+)	NCBI		Celera
Cytogenetic Map	7	B3	NCBI
cM Map	7	30.6	NCBI

Ldha
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	106,508,092 - 106,517,512 (+)	NCBI		GRCr8
mRatBN7.2	1	97,371,823 - 97,381,247 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	97,366,021 - 97,433,472 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	102,764,365 - 102,773,796 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	111,236,347 - 111,245,778 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	104,520,156 - 104,529,575 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	102,900,288 - 102,909,713 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	102,900,286 - 102,909,707 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	103,975,209 - 103,984,638 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	97,403,077 - 97,412,547 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	97,481,187 - 97,490,658 (+)	NCBI
Celera	1	91,618,363 - 91,627,752 (+)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

Ldha
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955414	33,087,745 - 33,100,846 (+)	NCBI	ChiLan1.0	ChiLan1.0

LDHA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	20,711,342 - 20,724,695 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	20,671,712 - 20,685,058 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	18,432,347 - 18,445,694 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	18,115,250 - 18,128,400 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	18,115,250 - 18,128,400 (+)	Ensembl	panpan1.1		panPan2

LDHA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	40,829,844 - 40,840,947 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	40,309,124 - 40,320,220 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	41,953,737 - 41,963,155 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	21	40,945,678 - 40,956,764 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	41,134,448 - 41,145,537 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	41,511,954 - 41,523,047 (+)	NCBI		UU_Cfam_GSD_1.0

LDHA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	40,814,169 - 40,826,715 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	40,814,163 - 40,827,284 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	43,896,319 - 43,909,457 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LDHA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	46,525,090 - 46,542,587 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	143,887,277 - 143,900,854 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005326744	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040284635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005326744 ⟹ XP_005326801

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	44,832,627 - 44,845,986 (-)	NCBI
SpeTri2.0	NW_004936528	866,607 - 879,977 (-)	NCBI

Sequence:

show sequence

CAACCCACACGTGGGTTCCCGCACGTCCGCCTGGCTCCACTCCTGACGTCAGCTTCGAGGTTCC
ATTTAAGGCCCCTCCCGCGCCCAGCCTTGAGTGCCGGAGACTCTGCTGCAGAGTGCGGATTCTA
TTGCTGCGCGCCCCCGACGCCTTCTCAACGTGCACTCCCGATTCCTTTTGGTTCCAAGTCCAAG
ATGGCAAGTCTCAAGGATCAGCTGATTGTGAATCTTCTTAAGGAAGAACAGGTCCCCCAGAATA
AGATTACAGTTGTTGGGGTTGGTGCTGTTGGCATGGCCTGTGCCATCAGTATCTTAATGAAGGA
CTTGGCAGATGAACTTGCTCTTGTTGATGTCATGGAAGATAAATTGAAGGGAGAGATGATGGAT
CTCCAGCATGGCAGCCTTTTCCTTAGAACACCAAAAATTGTCTCTGGCAAAGACTATAATGTGA
CTGCAAACTCCAAGCTCGTCATTATCACAGCTGGGGCACGTCAGCAAGAGGGAGAAAGCCGTCT
TAATTTGGTCCAGCGTAATGTGAACATCTTCAAGTTCATCATTCCCAATGTTGTAAAATACAGC
CCACATTGCAAGTTGCTTATTGTTTCCAATCCAGTGGATATCTTGACCTATGTGGCTTGGAAGA
TAAGTGGCTTTCCCAAAAACCGTGTTATTGGAAGTGGTTGCAATCTGGATTCAGCACGATTCCG
TTACCTGATGGGGGAAAGGCTGGGAGTTCACCCATTAAGCTGTCATGGGTGGGTCCTTGGGGAG
CATGGAGACTCTAGTGTGCCTGTATGGAGTGGAGTGAATGTTGCTGGTGTCTCCTTGAAGAATC
TGCACCCAGATTTAGGCACTGATGCAGATAAGGAACATTGGAAAGAGGTTCATAAGCAGGTGGT
TGACAGCGCTTATGAGGTGATCAAACTAAAAGGCTATACATCCTGGGCCATTGGACTGTCTGTG
GCAGATTTGGCAGAAAGTATAATGAAGAATCTTAGACGGGTGCATCCAATTTCCACCATGATTA
AGGGTCTCTATGGAATAAAGGATGATGTTTTTCTAAGTGTGCCTTGCATCTTGGGACAAAATGG
AATCTCAGATGTTGTGAAGGTGAATTTGACTCCTGAGGAAGAGGCACGTTTGAAGAAGAGTGCA
GACACACTTTGGGGAATCCAAAAAGAGCTGCAGTTTTAGAGGCTTCTAATGTCATACCACTTCA
CTGTCTAGGATACAACAGGATTTTAGTTGGAGGTGTACATGTTATCCTTTATATCTGTTCTGAG
ATTAAAGCAGATGGCCTGGGAAAAACATCAATTTTCTAAAGTTAGAAATAGGAATGGCGTATAA
AACCCTACAGATATCCTGATGCTGGATAGTACTTAACTTGTGTAGTCCTAAAATAGTGTAAAAT
AGTTCCACCATCTCTGAGATACCACTGCCAATGTTGCACAACATTGTGCATGTTGTGTGATATA
CCTTCATCAAACATGCCTAGTCCAACTTTGTTTTTGTTTTTTTTTTTTTTTTCATTCAGTCACA
TCCTGGGATCCAATGTTAAATCCAATATCACATGTCTTATGTATAACTGTTCTAAAGGATTTTA
TTTTGTGTATTATATGTATCTGTAGTGTACATTTCCATATAATGTAAAAGAAAGATCTACATAT
GAACATTGCAACCAGCTATCCAAGTGTCATACCAACTGAAATATCAAATAAACCTTGAACAGTG
ACTATTCTA

hide sequence

RefSeq Acc Id:

XM_040284635 ⟹ XP_040140569

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	44,832,627 - 44,843,980 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005326801	(Get FASTA)	NCBI Sequence Viewer
	XP_040140569	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000000014.2
	ENSSTOP00000031082.1
GenBank Protein	KAG3285628	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005326801 ⟸ XM_005326744
- Peptide Label:	isoform X1
- UniProtKB:	A0A287DBY6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASLKDQLIVNLLKEEQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMD LQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYS PHCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGE HGDSSVPVWSGVNVAGVSLKNLHPDLGTDADKEHWKEVHKQVVDSAYEVIKLKGYTSWAIGLSV ADLAESIMKNLRRVHPISTMIKGLYGIKDDVFLSVPCILGQNGISDVVKVNLTPEEEARLKKSA DTLWGIQKELQF hide sequence

RefSeq Acc Id:	XP_040140569 ⟸ XM_040284635
- Peptide Label:	isoform X2
- UniProtKB:	I3LVU2 (UniProtKB/TrEMBL)

Protein Domains

Lactate/malate dehydrogenase C-terminal Lactate/malate dehydrogenase N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000000014	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000000014.3	UniProtKB/TrEMBL
	ENSSTOT00000042164.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.110.10	UniProtKB/TrEMBL
	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	L-lactate/malate_DH	UniProtKB/TrEMBL
	L-lactate_DH	UniProtKB/TrEMBL
	L-lactate_DH_AS	UniProtKB/TrEMBL
	Lactate/malate_DH_C	UniProtKB/TrEMBL
	Lactate/malate_DH_N	UniProtKB/TrEMBL
	Lactate_DH/Glyco_Ohase_4_C	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Ldha	ENTREZGENE
PANTHER	L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))	UniProtKB/TrEMBL
	L-LACTATE DEHYDROGENASE A CHAIN	UniProtKB/TrEMBL
Pfam	Ldh_1_C	UniProtKB/TrEMBL
	Ldh_1_N	UniProtKB/TrEMBL
PIRSF	Lac_mal_DH	UniProtKB/TrEMBL
PRINTS	LLDHDRGNASE	UniProtKB/TrEMBL
PROSITE	L_LDH	UniProtKB/TrEMBL
	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
	SSF56327	UniProtKB/TrEMBL
UniProt	A0A287DBY6	ENTREZGENE, UniProtKB/TrEMBL
	I3LVU2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)