Enables several functions, including DNA binding activity; gamma-tubulin binding activity; and nucleoside diphosphate kinase activity. Involved in several processes, including GTP biosynthetic process; cellular response to glucose stimulus; and response to testosterone. Located in centrosome; mitochondrial outer membrane; and perinuclear region of cytoplasm. Colocalizes with intermediate filament. Human ortholog(s) of this gene implicated in neuroblastoma; ovary epithelial cancer; and teratoma. Orthologous to human NME1 (NME/NM23 nucleoside diphosphate kinase 1); PARTICIPATES IN adefovir pharmacokinetics pathway; de novo pyrimidine biosynthetic pathway; E-cadherin signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,6-dinitrotoluene.
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NME1 mRNA, fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of NME1 mRNA]
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NME1 mRNA, fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NME1 mRNA]
[[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of NME1 mRNA
MT1 affects the reaction [Copper results in increased expression of NME1 mRNA], MT2 affects the reaction [Copper results in increased expression of NME1 mRNA]
MT1 affects the reaction [Copper results in increased expression of NME1 mRNA], MT2 affects the reaction [Copper results in increased expression of NME1 mRNA]
fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of NME1 mRNA], fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NME1 mRNA]
[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of NME1 mRNA, [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of NME1 mRNA
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NME1 mRNA
[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NME1 mRNA
Proteomics of rat prostate lobes treated with 2-N-hydroxylamino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 5alpha-dihydrotestosterone, individually and in combination.
Decreased expression of nucleoside diphosphate kinase alpha isoform, an nm23-H2 gene homolog, is associated with metastatic potential of rat mammary-adenocarcinoma cells.
Overexpression of nucleoside diphosphate kinases induces neurite outgrowth and their substitution to inactive forms leads to suppression of nerve growth factor- and dibutyryl cyclic AMP-induced effects in PC12D cells.
Localization and characterization of the mitochondrial isoform of the nucleoside diphosphate kinase in the pancreatic beta cell: evidence for its complexation with mitochondrial succinyl-CoA synthetase.
Activity of nucleoside diphosphate kinase alpha (NDPK alpha) capable of binding to outer mitochondrial membrane accounts for less than 10% of total NDPK activity present in cytoplasm of liver cells.
Activated microglia modulate astroglial enzymes involved in oxidative and inflammatory stress and increase the resistance of astrocytes to oxidative stress in vitro.
Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma.
A second form (beta isoform) of nucleoside diphosphate kinase from rat. Isolation and characterization of complementary and genomic DNA and expression.
Proteome analysis of human pancreatic ductal adenocarcinoma tissue using two-dimensional gel electrophoresis and tandem mass spectrometry for identification of disease-related proteins.
Down-regulation of expression and function of nucleoside diphosphate kinase in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity.
