LDHA (lactate dehydrogenase A) - Rat Genome Database

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Gene: LDHA (lactate dehydrogenase A) Sus scrofa
Analyze
Symbol: LDHA
Name: lactate dehydrogenase A
RGD ID: 13904100
Description: ENCODES a protein that exhibits identical protein binding (ortholog); kinase binding (ortholog); L-lactate dehydrogenase activity (ortholog); INVOLVED IN cellular response to extracellular stimulus (ortholog); glucose catabolic process to lactate via pyruvate (ortholog); lactate metabolic process (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH Animal Disease Models (ortholog); cardiomyopathy (ortholog); COVID-19 (ortholog); FOUND IN cytosol (ortholog); sperm fibrous sheath (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide; bisphenol A; cadmium atom
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: L-lactate dehydrogenase A chain; LDH muscle subunit; LDH-A; LDH-M
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl240,812,453 - 40,826,715 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1240,814,163 - 40,827,284 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2243,896,319 - 43,909,457 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:838465   PMID:1678537   PMID:2950811   PMID:7937776   PMID:14681463   PMID:17145712   PMID:17334683   PMID:19830590   PMID:27751602  


Genomics

Comparative Map Data
LDHA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl240,812,453 - 40,826,715 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1240,814,163 - 40,827,284 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2243,896,319 - 43,909,457 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LDHA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1118,394,560 - 18,408,425 (+)EnsemblGRCh38hg38GRCh38
GRCh381118,394,563 - 18,408,425 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371118,416,110 - 18,429,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,372,687 - 18,385,969 (+)NCBINCBI36hg18NCBI36
Build 341118,372,686 - 18,385,969NCBI
Celera1118,550,876 - 18,564,695 (+)NCBI
Cytogenetic Map11p15.1NCBI
HuRef1118,101,143 - 18,114,981 (+)NCBIHuRef
CHM1_11118,415,425 - 18,429,229 (+)NCBICHM1_1
Ldha
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,491,698 - 46,505,051 (+)NCBIGRCm39mm39
GRCm39 Ensembl746,490,899 - 46,505,051 (+)Ensembl
GRCm38746,842,274 - 46,855,627 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,841,475 - 46,855,627 (+)EnsemblGRCm38mm10GRCm38
MGSCv37754,101,174 - 54,110,997 (+)NCBIGRCm37mm9NCBIm37
MGSCv36746,715,255 - 46,723,668 (+)NCBImm8
Celera742,325,754 - 42,335,573 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.6NCBI
Ldha
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2197,371,823 - 97,381,247 (+)NCBI
Rnor_6.0 Ensembl1102,900,286 - 102,909,707 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01102,900,288 - 102,909,713 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01103,975,209 - 103,984,638 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,403,077 - 97,412,547 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1197,481,187 - 97,490,658 (+)NCBI
Celera191,618,363 - 91,627,752 (+)NCBICelera
Cytogenetic Map1q22NCBI
Ldha
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541433,087,745 - 33,100,846 (+)NCBIChiLan1.0ChiLan1.0
LDHA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11118,115,250 - 18,128,400 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,115,250 - 18,128,400 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01118,432,347 - 18,445,694 (+)NCBIMhudiblu_PPA_v0panPan3
LDHA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12140,829,844 - 40,840,947 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2140,309,124 - 40,320,220 (+)NCBI
ROS_Cfam_1.02141,953,737 - 41,963,155 (+)NCBI
UMICH_Zoey_3.12140,945,678 - 40,956,764 (+)NCBI
UNSW_CanFamBas_1.02141,134,448 - 41,145,537 (+)NCBI
UU_Cfam_GSD_1.02141,511,954 - 41,523,047 (+)NCBI
Ldha
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494744,832,627 - 44,845,986 (-)NCBI
SpeTri2.0NW_004936528866,607 - 879,977 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LDHA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,525,090 - 46,542,587 (-)NCBI
Vero_WHO_p1.0NW_023666038143,887,277 - 143,900,854 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High 2
Medium 10 3 1 5 11 2 3 3
Low 1 2 12
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001172363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013994501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021081651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021081655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021081659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ557231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ557232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ557233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ557234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK236433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK343612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK343811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK391205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK391208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK391657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK395255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU468483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ865398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01014971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU126386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000014597   ⟹   ENSSSCP00000014202
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl240,814,164 - 40,826,005 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000040830   ⟹   ENSSSCP00000042682
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl240,812,453 - 40,823,622 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000046190   ⟹   ENSSSCP00000036508
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl240,814,164 - 40,825,882 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000053481   ⟹   ENSSSCP00000033168
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl240,814,164 - 40,826,715 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000062740   ⟹   ENSSSCP00000050647
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl240,814,170 - 40,823,499 (-)Ensembl
RefSeq Acc Id: NM_001172363   ⟹   NP_001165834
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1240,814,164 - 40,825,329 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013994501   ⟹   XP_013849955
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1240,814,163 - 40,827,284 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021081651   ⟹   XP_020937310
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1240,814,163 - 40,825,247 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021081655   ⟹   XP_020937314
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1240,814,164 - 40,825,254 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021081659   ⟹   XP_020937318
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1240,814,164 - 40,825,253 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_013849955   ⟸   XM_013994501
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020937310   ⟸   XM_021081651
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001165834   ⟸   NM_001172363
- UniProtKB: D2SW96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020937314   ⟸   XM_021081655
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020937318   ⟸   XM_021081659
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSSSCP00000042682   ⟸   ENSSSCT00000040830
RefSeq Acc Id: ENSSSCP00000036508   ⟸   ENSSSCT00000046190
RefSeq Acc Id: ENSSSCP00000033168   ⟸   ENSSSCT00000053481
RefSeq Acc Id: ENSSSCP00000014202   ⟸   ENSSSCT00000014597
RefSeq Acc Id: ENSSSCP00000050647   ⟸   ENSSSCT00000062740
Protein Domains
Ldh_1_C   Ldh_1_N


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013366 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005016454 UniProtKB/Swiss-Prot
  ENSSSCG00070007248 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000014202 UniProtKB/TrEMBL
  ENSSSCP00000033168 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000036508 UniProtKB/TrEMBL
  ENSSSCP00000042682 UniProtKB/TrEMBL
  ENSSSCP00000050647 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00005015775 UniProtKB/Swiss-Prot
  ENSSSCP00070011516 UniProtKB/Swiss-Prot
  ENSSSCP00070011528 UniProtKB/TrEMBL
  ENSSSCP00070011540 UniProtKB/TrEMBL
  ENSSSCP00070011544 UniProtKB/TrEMBL
  ENSSSCP00070011546 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014597 UniProtKB/TrEMBL
  ENSSSCT00000040830 UniProtKB/TrEMBL
  ENSSSCT00000046190 UniProtKB/TrEMBL
  ENSSSCT00000053481 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000062740 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00005026037 UniProtKB/Swiss-Prot
  ENSSSCT00070013974 UniProtKB/Swiss-Prot
  ENSSSCT00070013987 UniProtKB/TrEMBL
  ENSSSCT00070013999 UniProtKB/TrEMBL
  ENSSSCT00070014003 UniProtKB/TrEMBL
  ENSSSCT00070014005 UniProtKB/TrEMBL
Gene3D-CATH 3.90.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro L-lactate/malate_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L-lactate_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L-lactate_DH_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lactate/malate_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lactate/malate_DH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lactate_DH/Glyco_Ohase_4_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:407245 UniProtKB/TrEMBL
NCBI Gene LDHA ENTREZGENE
Pfam Ldh_1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldh_1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Lac_mal_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LLDHDRGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE L_LDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56327 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs L-LDH-NAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286ZNX3_PIG UniProtKB/TrEMBL
  A0A286ZXT7_PIG UniProtKB/TrEMBL
  A0A287AFC1_PIG UniProtKB/TrEMBL
  A0A287B2H7_PIG UniProtKB/TrEMBL
  A0A385JGP0_PIG UniProtKB/TrEMBL
  A0A4X1T6G7_PIG UniProtKB/TrEMBL
  A0A4X1T6H3_PIG UniProtKB/TrEMBL
  A0A4X1T837_PIG UniProtKB/TrEMBL
  A0A4X1T9Q1_PIG UniProtKB/TrEMBL
  A0A5S6GD60_PIG UniProtKB/TrEMBL
  D2SW96 ENTREZGENE, UniProtKB/TrEMBL
  LDHA_PIG UniProtKB/Swiss-Prot, ENTREZGENE
  Q70PG4_PIG UniProtKB/TrEMBL
VGNC ID VGNC:99784 ENTREZGENE