HYPOXIA INDUCIBLE FACTOR PATHWAY (PW:0000360)

View Ontology Report

Description

Maintaining adequate levels of oxygen is crucial for the proper functioning of cells and tissues as either excess or deficiency of oxygen can have profound pathological consequences. Oxygen is the terminal electron acceptor of the respiratory chain - the electron transport pathway (ETC) whose resulting electrochemical proton gradient drives the synthesis of ATP. ETC also produces reactive oxygen species (ROS) and it is thought that the switch to glycolysis for ATP production when oxygen levels b

Pathway Diagram:

Ariadne Genomics Inc. Crebbp N-OH P-OH EP300 Hif1a-O2 Egln1 Egln2 Egln3 Hif1a+O2 Hif target genes Tceb1 recruited complex Hif-alpha ubiquitination, proteasomal degradation Arnt Hif1a+O2 ---- Os9 Egln1 ---- Os9 Os9 Hif1a+O2 ---- Vhl Hif1an ---> Hif1a+O2 Gnb2l1 ---- Hif1a+O2 Hif1an Hif1a+O2 ---| Crebbp Hif1a+O2 ---| EP300 Hif1a+O2 ---- Sat2 Sat2 Vhl Sat2 ---- Vhl Hif1a+O2 ---- Sat1 Tceb1 Tceb1 ---- Vhl Sat2 ---- Tceb1 Sat1 Gnb2l1 Gnb2l1 ---- Sat1 Gnb2l1 ---- Tceb1 Tceb1 ---- Tceb1 recruited complex Epas1 Hif3a Arnt2 Hif1a-O2 ---> Hif target genes Egln1 ---> Hif1a+O2
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Genes in Pathway:

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hypoxia inducible factor pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6484113
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6484113
G Adm adrenomedullin JBrowse link 1 175,443,189 175,447,260 RGD:6484113
G Adora2a adenosine A2a receptor JBrowse link 20 14,265,251 14,282,873 RGD:6484113
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
G Aldoa aldolase, fructose-bisphosphate A JBrowse link 1 198,228,387 198,233,988 RGD:6484113
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 15 27,849,943 27,852,083 RGD:6484113
G Arnt aryl hydrocarbon receptor nuclear translocator JBrowse link 2 196,594,178 196,651,486 RGD:6483352
RGD:6484113
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 JBrowse link 1 146,399,217 146,556,437 RGD:6483352
G Bhlhe40 basic helix-loop-helix family, member e40 JBrowse link 4 140,703,619 140,709,319 RGD:6484113
G Bhlhe41 basic helix-loop-helix family, member e41 JBrowse link 4 180,230,742 180,235,138 RGD:6484113
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:6484113
G Car9 carbonic anhydrase 9 JBrowse link 5 59,008,277 59,015,535 RGD:6484113
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 JBrowse link 1 12,823,363 12,825,806 RGD:6484113
G Cops5 COP9 signalosome subunit 5 JBrowse link 5 8,876,090 8,894,345 RGD:6484113
G Cp ceruloplasmin JBrowse link 2 104,744,249 104,803,034 RGD:6484113
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6484113
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6483358
RGD:6484113
RGD:6483503
G Cul2 cullin 2 JBrowse link 17 56,952,480 56,992,716 RGD:6483358
G Cxcl12 C-X-C motif chemokine ligand 12 JBrowse link 4 149,261,044 149,273,891 RGD:6484113
G Cxcr4 C-X-C motif chemokine receptor 4 JBrowse link 13 45,314,952 45,318,856 RGD:6484113
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6484113
G Efna1 ephrin A1 JBrowse link 2 188,588,808 188,596,156 RGD:6484113
G Egln1 egl-9 family hypoxia-inducible factor 1 JBrowse link 19 57,660,194 57,701,158 RGD:727754
RGD:6484113
RGD:6483503
RGD:6483358
RGD:1334466
G Egln2 egl-9 family hypoxia-inducible factor 2 JBrowse link 1 83,969,456 83,977,665 RGD:6483503
RGD:6484113
G Egln3 egl-9 family hypoxia-inducible factor 3 JBrowse link 6 75,050,329 75,075,795 RGD:6483503
RGD:6484113
G Eif3el1 eukaryotic translation initiation factor 3, subunit E-like 1 JBrowse link 13 100,129,757 100,162,596 RGD:6484113
G Elk1 ELK1, ETS transcription factor JBrowse link X 1,287,875 1,304,822 RGD:6484113
G Elob elongin B JBrowse link 10 13,163,032 13,168,217 RGD:6483358
RGD:6484113
G Eloc elongin C JBrowse link 5 2,042,991 2,059,357 RGD:6483358
RGD:6484113
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:6484113
G Eno1 enolase 1 JBrowse link 5 167,288,223 167,299,610 RGD:6484113
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6483358
RGD:6484113
RGD:6483503
G Epas1 endothelial PAS domain protein 1 JBrowse link 6 10,306,508 10,385,239 RGD:6483352
RGD:6484113
RGD:6483503
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:6484113
G Ets1 ETS proto-oncogene 1, transcription factor JBrowse link 8 33,756,634 33,879,625 RGD:6484113
G Fech ferrochelatase JBrowse link 18 59,941,992 59,975,192 RGD:6484113
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:6484113
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6484113
G Furin furin (paired basic amino acid cleaving enzyme) JBrowse link 1 142,185,092 142,198,167 RGD:6484113
G Fxn frataxin JBrowse link 1 242,123,975 242,152,834 RGD:6484113
G Gata2 GATA binding protein 2 JBrowse link 4 120,129,028 120,142,490 RGD:6484113
G Gck glucokinase JBrowse link 14 86,149,146 86,191,589 RGD:6484113
G Hdac7 histone deacetylase 7 JBrowse link 7 139,280,396 139,319,108 RGD:6484113
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:628389
RGD:6484113
RGD:6483503
RGD:6483352
RGD:2301848
RGD:1580561
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor JBrowse link 1 264,309,214 264,319,269 RGD:1334466
RGD:6484113
RGD:6483358
RGD:6483352
G Hif3a hypoxia inducible factor 3 subunit alpha JBrowse link 1 78,976,318 78,997,869 RGD:68201
RGD:6483352
G Hk1 hexokinase 1 JBrowse link 20 31,911,460 31,979,780 RGD:6484113
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:6484113
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6484113
G Hnf4a hepatocyte nuclear factor 4, alpha JBrowse link 3 159,902,441 159,965,003 RGD:6484113
G Id2 inhibitor of DNA binding 2 JBrowse link 6 44,360,077 44,361,908 RGD:6484113
G Igfbp1 insulin-like growth factor binding protein 1 JBrowse link 14 87,448,716 87,453,783 RGD:6484113
G Itgb2 integrin subunit beta 2 JBrowse link 20 11,777,773 11,815,647 RGD:6484113
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6484113
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:6484113
G Ldha lactate dehydrogenase A JBrowse link 1 102,900,288 102,909,713 RGD:6484113
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6484113
G Mcl1 MCL1, BCL2 family apoptosis regulator JBrowse link 2 197,786,212 197,788,992 RGD:6484113
G Mmp14 matrix metallopeptidase 14 JBrowse link 15 33,074,441 33,083,666 RGD:6484113
G Ncoa1 nuclear receptor coactivator 1 JBrowse link 6 28,677,563 28,931,844 RGD:6484113
G Ncoa2 nuclear receptor coactivator 2 JBrowse link 5 5,466,544 5,696,540 RGD:6484113
G Ndrg1 N-myc downstream regulated 1 JBrowse link 7 107,734,326 107,775,701 RGD:6484113
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6484113
G Npm1 nucleophosmin 1 JBrowse link 10 18,080,949 18,091,062 RGD:6484113
G Nt5e 5' nucleotidase, ecto JBrowse link 8 95,969,002 96,012,733 RGD:6484113
G Os9 OS9, endoplasmic reticulum lectin JBrowse link 7 70,378,625 70,407,135 RGD:6483358
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 JBrowse link 17 70,632,778 70,713,736 RGD:6484113
G Pfkl phosphofructokinase, liver type JBrowse link 20 11,393,860 11,415,889 RGD:6484113
G Pgk1 phosphoglycerate kinase 1 JBrowse link X 77,263,399 77,279,373 RGD:6484113
G Pgm1 phosphoglucomutase 1 JBrowse link 5 118,743,632 118,803,055 RGD:6484113
G Pkm pyruvate kinase M1/2 JBrowse link 8 64,480,963 64,502,957 RGD:6484113
G Plin2 perilipin 2 JBrowse link 5 104,984,413 105,010,863 RGD:6484113
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:6484113
G Rack1 receptor for activated C kinase 1 JBrowse link 10 34,149,717 34,155,198 RGD:6483358
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:6483358
G Sat1 spermidine/spermine N1-acetyl transferase 1 JBrowse link X 43,626,480 43,629,767 RGD:6483358
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 JBrowse link 10 56,227,703 56,229,796 RGD:6483358
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6484113
G Slc11a2 solute carrier family 11 member 2 JBrowse link 7 142,025,812 142,062,892 RGD:6484113
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:6484113
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:6484113
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:6484113
G Sp1 Sp1 transcription factor JBrowse link 7 144,014,173 144,044,635 RGD:6484113
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:6484113
G Tf transferrin JBrowse link 8 111,694,570 111,721,275 RGD:6484113
G Tff3 trefoil factor 3 JBrowse link 20 9,850,800 9,855,481 RGD:6484113
G Tfrc transferrin receptor JBrowse link 11 71,397,423 71,419,263 RGD:6484113
G Twist1 twist family bHLH transcription factor 1 JBrowse link 6 53,401,241 53,403,235 RGD:6484113
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6484113
G Vhl von Hippel-Lindau tumor suppressor JBrowse link 4 145,580,869 145,587,835 RGD:1358257
RGD:6484113
RGD:6483358
RGD:1580561
altered hypoxia inducible factor pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vhl von Hippel-Lindau tumor suppressor JBrowse link 4 145,580,869 145,587,835 RGD:6907133

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculeN-OHhydroxylated asparagine
Small MoleculeP-OHhydroxylated prolines
ComplexTceb1 recruited complexProtein complec recruited by the VHL bound Tceb1/Elongin C
Gene GroupHif target genesselected Hif target genes

Pathway Gene Annotations

Disease Annotations Associated with Genes in the hypoxia inducible factor pathway
Disease TermsGene Symbols
abdominal aortic aneurysmAdm , Hmox1 , Mmp14 , Nos2 , Serpine1
abdominal obesity-metabolic syndromeLep
Aberrant Crypt FociFos
Abortion, SpontaneousArnt , Igfbp1 , Tfrc
aceruloplasminemiaCp
AcidosesAdm
acoustic neuromaVegfa
acquired immunodeficiency syndromeCxcl12
Acquired Protein C DeficiencySerpine1
Acro-OsteolysisSmad4
acrocephalosyndactyliaTwist1
acute chest syndromeHmox1 , Vegfa
Acute Coronary SyndromeEno1
Acute HepatitisNos2
acute kidney failureCp , Edn1 , Egln1 , Egln3 , Epas1 , Epo , Hif1a , Hmox1 , Igfbp1 , Nos2 , Tf , Tff3 , Vegfa
Acute Liver FailureNos2
Acute Lung InjuryEdn1 , Flt1 , Hmox1 , Itgb2 , Kdr , Nos2 , Serpine1 , Vegfa
acute myeloid leukemiaAbcg2 , Crebbp , Cxcr4 , Gata2 , Hmox1 , Id2 , Ncoa2 , Npm1 , Tert , Vegfa
acute promyelocytic leukemiaAkt1 , Itgb2 , Npm1
Acute-Phase ReactionEpo , Hif1a , Tf , Tfrc
adenocarcinomaEno1 , Hmox1 , Kdr , Mmp14 , Vegfa
adenoid cystic carcinomaCrebbp , Ep300
adenomaAbcg2 , Vhl
adrenocortical carcinomaAbcb1a , Tert
adrenoleukodystrophyHmox1
adult respiratory distress syndromeEdn1 , Hmox1 , Lep , Serpine1
adult-onset Still's diseaseVegfa
advanced sleep phase syndromeBhlhe40
AIDS Dementia ComplexEpo
AlbuminuriaAdm , Cp , Edn1 , Epo , Serpine1
alcohol use disorderTf
Alcoholic Fatty LiverSerpine1
alcoholic liver cirrhosisSmad3
Alcoholic Liver DiseasesHif1a
allergic contact dermatitisFlt1 , Kdr , Sat1 , Vegfa
allergic hypersensitivity diseaseItgb2
allergic rhinitisAbcb1a , Serpine1
alopecia areataHdac7
Altitude SicknessHmox1
Alzheimer's diseaseAkt1 , Crebbp , Elk1 , Eno1 , Ep300 , Epo , Hif1a , Hmox1 , Lep , Nos2 , Slc2a1 , Tf , Vegfa
amphetamine abuseAdora2a , Akt1 , Fos , Pou5f1
amyloidosisSerpine1
amyotrophic lateral sclerosisAkt1 , Epo , Kdr , Nos2 , Slc11a2 , Vegfa
amyotrophic lateral sclerosis type 1Crebbp , Fos , Vegfa
AnaplasiaCar9 , Hif1a
anaplastic large cell lymphomaNpm1 , Twist1
Anastomotic LeakEpo
anemiaEpo , Gata2 , Hk1 , Slc11a2 , Tf
Anemia, Hypochromic Microcytic, with Iron OverloadSlc11a2
Anemia, RefractoryTert
Anemia, Refractory, with Excess of BlastsTert
AneurysmSmad3
angiosarcomaFlt1 , Jun , Kdr , Vegfa
angle-closure glaucomaEdn1
Animal Disease ModelsAkt1 , Apex1 , Eno1 , Fos , Hk1 , Hk2 , Ldha , Npm1 , Serpine1
anterior uveitisNos2
anterolateral myocardial infarctionEdn1 , Serpine1
Anthracycline-induced CardiotoxicityAbcb1a
anti-basement membrane glomerulonephritisCxcl12 , Mmp14 , Nos2
anxiety disorderAdora2a , Fos
aortic aneurysmSerpine1 , Smad3
aortic diseaseSmad4
Aortic RemodelingSerpine1
Aortic Valve, Calcification ofAkt1
aplastic anemiaGata2 , Tert
Arenaviridae InfectionsTfrc
Arsenic PoisoningId2 , Pfkfb3
ARTERIAL DISSECTIONSmad3
Arterial ThrombosisHif1a , Serpine1
arteriosclerosisFurin , Hmox1 , Kdr , Mmp14
Arteriovenous FistulaVegfa
arteriovenous malformationEng
arteriovenous malformations of the brainEng , Flt1 , Kdr , Vegfa
asbestosisNos2
AsphyxiaHif1a , Jun
aspiration pneumoniaEdn1 , Nos2
asthmaAbcb1a , Adora2a , Edn1 , Hif1a , Hmox1 , Kdr , Lep , Nos2 , Serpine1 , Vegfa
astrocytomaAkt1 , Hif1a , Ndrg1
AtaxiaCp , Slc2a1
atherosclerosisAkt1 , Edn1 , Egln1 , Kdr , Nos2 , Serpine1 , Vegfa
atransferrinemiaTf
atrial fibrillationEdn1 , Flt1 , Hif1a , Vegfa
atrial heart septal defect 8Cited2
attention deficit hyperactivity disorderCrebbp , Vegfa
Auriculo-Condylar SyndromeEdn1
Auriculocondylar Syndrome 3Edn1
autism spectrum disorderAldoa
autistic disorderAdm , Cp , Crebbp , Lep , Nos2 , Serpine1 , Tf
autoimmune hepatitisLep
autoimmune polyendocrine syndrome type 1Itgb2 , Pfkl
Autosomal Dominant Dyskeratosis CongenitaTert
autosomal dominant dyskeratosis congenita 1Tert
autosomal dominant polycystic kidney diseaseEdn1 , Fos
Autosomal Recessive Dyskeratosis CongenitaTert
autosomal recessive dyskeratosis congenita 1Tert
autosomal recessive dyskeratosis congenita 4Tert
autosomal recessive limb-girdle muscular dystrophy type 2BAbcb1a
autosomal recessive limb-girdle muscular dystrophy type 2JAbcb1a
autosomal recessive polycystic kidney diseaseAkt1
azoospermiaEpas1
B-cell lymphomaAbcg2
background diabetic retinopathyFlt1
bacterial pneumoniaLep , Serpine1
Barrett's esophagusMcl1
basal cell carcinomaTert
Behcet's diseaseAbcb1a , Edn1 , Hmox1 , Itgb2 , Serpine1 , Vegfa
benign epilepsy with centrotemporal spikesSlc2a1
berylliosisHmox1
beta thalassemiaEpo , Tert , Tfrc
bile duct diseaseFech
bipolar disorderAkt1 , Bhlhe40
bladder neck obstructionHif1a
bladder urothelial carcinomaAkt1 , Crebbp , Ep300
Blast CrisisHmox1
blindnessVegfa
blood coagulation diseaseHmox1
Body Weight ChangesLep
brachydactylySmad4
BradycardiaEdn1
Brain DeathHmox1
brain diseaseCp
brain edemaCp , Hmox1 , Nos2 , Vegfa
Brain HypoxiaEp300 , Epo
brain infarctionAdm
Brain InjuriesAkt1 , Apex1 , Elk1 , Epas1 , Epo , Fos , Hmox1 , Jun , Kdr , Lep , Nos2 , Nt5e , Tf , Vegfa
brain ischemiaAkt1 , Apex1 , Cited2 , Cp , Creb1 , Cxcl12 , Edn1 , Hif1a , Hmox1 , Jun , Kdr , Mmp14 , Nos2 , Serpine1 , Slc11a2
Brain NeoplasmsItgb2 , Vegfa
breast adenocarcinomaAkt1
breast cancerAkt1 , Smad4
Breast NeoplasmsAbcb1a , Abcg2 , Adm , Akt1 , Aldoa , Apex1 , Car9 , Cxcl12 , Cxcr4 , Efna1 , Eng , Eno1 , Ep300 , Epo , Flt1 , Fos , Hif1a , Hmox1 , Igfbp1 , Jun , Kdr , Lep , Mmp14 , Ncoa1 , Ncoa2 , Ndrg1 , Nos2 , Serpine1 , Slc2a1 , Smad4 , Tert , Tfrc , Vegfa
bronchial diseaseNos2
Bronchial HyperreactivityNos2
bronchiolitis obliteransAdora2a , Edn1 , Hmox1 , Nos2
Bronchitis, ChronicEdn1 , Nos2 , Vegfa
Bronchopulmonary DysplasiaEdn1 , Epas1 , Flt1 , Hif1a , Serpine1
bullous pemphigoidVegfa
BurnsHif1a , Igfbp1 , Nos2
Calcification of Joints and ArteriesNt5e
calcinosisEpo , Itgb2
Cancer PainCxcr4
cannabis abuseAbcb1a , Akt1
Carbon Monoxide PoisoningHmox1
Carbon Tetrachloride PoisoningHmox1
carcinomaAbcb1a , Eno1 , Furin , Hif1a , Pkm , Tf , Vhl
cardiac arrestAkt1 , Ep300
Cardiac ArrhythmiasAdm , Edn1
Cardiac FibrosisEdn1 , Serpine1
Cardiogenic ShockEpo
CardiomegalyAkt1 , Edn1 , Ep300 , Epas1 , Hif1a , Hmox1
cardiomyopathyAdora2a , Akt1 , Edn1 , Ep300 , Epo , Ldha , Vegfa
Cardiovascular AbnormalitiesEdn1 , Gata2 , Nos2
cardiovascular system diseaseEdn1
carotid artery diseaseHmox1
Carotid Artery InjuriesSerpine1 , Sp1
carotid artery thrombosisHmox1
carotid stenosisMmp14
cartilage diseaseEdn1 , Gata2
cataractSlc2a1
celiac diseaseEts1 , Tfrc
Cell Transformation, NeoplasticCxcr4 , Edn1 , Epas1 , Fos , Jun , Mmp14 , Nos2 , Slc2a1 , Sp1 , Tfrc
central nervous system diseaseCrebbp , Epo
Central Serous ChorioretinopathySerpine1
cerebellar angioblastomaVhl
cerebellar ataxiaSlc2a1
cerebral cavernous malformationFlt1 , Kdr
Cerebral HemorrhageApex1 , Cxcr4 , Flt1 , Hmox1 , Itgb2 , Kdr , Vegfa
cerebral infarctionHmox1 , Serpine1
cerebrovascular diseaseEdn1
cervix uteri carcinoma in situTert , Vegfa
Charcot-Marie-Tooth diseaseNdrg1
Charcot-Marie-Tooth disease type 4DNdrg1
Charcot-Marie-Tooth disease type 4GHk1
Chemical and Drug Induced Liver InjuryAbcb1a , Arnt , Cp , Eng , Eno1 , Flt1 , Hmox1 , Pgm1 , Tf , Vegfa
childhood absence epilepsySlc2a1
childhood onset GLUT1 deficiency syndrome 2Slc2a1
Chlamydophila InfectionsMmp14
ChloracneItgb2
cholangiocarcinomaEpo , Nos2 , Smad4
cholestasisEng , Nos2 , Serpine1
cholesteatomaVegfa
cholesteatoma of middle earHif1a , Vegfa
Choroidal NeovascularizationFlt1 , Kdr , Lep , Vegfa
Choroidal Neovascularization, ExperimentalSerpine1
Chromosome AberrationsEpas1
Chronic Allograft NephropathySerpine1
Chronic Cerebral HypoperfusionHif1a , Tfrc
Chronic Intermittent HypoxiaBnip3 , Hk1 , Hk2
chronic kidney diseaseTert
Chronic Lung Allograft DysfunctionEpas1
Chronic Lymphocytic Leukemia, B-CellAbcg2 , Tert , Tfrc
chronic myeloid leukemiaAbcb1a , Abcg2 , Akt1 , Car9 , Hmox1 , Npm1 , Tert , Vegfa
chronic obstructive pulmonary diseaseAdora2a , Bnip3 , Edn1 , Flt1 , Hmox1 , Kdr , Lep , Mmp14 , Nos2 , Serpine1 , Smad4 , Vegfa
Chronic PeriodontitisCxcl12 , Cxcr4 , Itgb2
chronic recurrent multifocal osteomyelitisTert
Chronic Relapsing Experimental Autoimmune EncephalomyelitisSerpine1
chronic rhinitisEdn1
chronic ulcer of skinItgb2
Chuvash polycythemiaVhl
CicatrixSmad4
clear cell renal cell carcinomaEgln3 , Eng , Ep300 , Vegfa
Cocaine-Related DisordersCreb1 , Fos , Smad3
Cognition DisordersEpo , Smad4
colitisHmox1 , Itgb2 , Kdr , Nos2
colon adenocarcinomaTert
colon cancerAkt1
colon carcinomaAkt1 , Ep300 , Flt1 , Kdr
Colonic NeoplasmsCp , Fos , Hdac7 , Hif1a , Igfbp1 , Jun , Kdr , Lep , Nos2 , Slc2a1 , Tff3 , Vegfa
colorectal adenocarcinomaFos , Jun
colorectal adenomaFos , Jun
colorectal cancerAkt1 , Ep300 , Smad4
Colorectal NeoplasmsAbcb1a , Abcg2 , Akt1 , Arnt , Crebbp , Ep300 , Fos , Hk1 , Kdr , Pgm1 , Smad4 , Tfrc
congenital diaphragmatic herniaEdn1
congenital disorder of glycosylationPgm1
congenital disorder of glycosylation type IPgm1
congenital heart diseaseAbcb1a , Cited2 , Edn1 , Hif1a , Pou5f1 , Vegfa
Congenital HyperinsulinismGck , Hnf4a
congenital nonspherocytic hemolytic anemiaHk1
congestive heart failureAdm , Bnip3 , Edn1 , Eng , Ep300 , Epo , Fos , Hif1a , Hmox1 , Lep , Mmp14 , Nos2 , Serpine1 , Vegfa
Constriction, PathologicHmox1
contact dermatitisHmox1 , Kdr , Vegfa
corneal neovascularizationFlt1 , Kdr , Vegfa
coronary artery diseaseAkt1 , Cxcl12 , Edn1 , Eng , Epo , Gck , Hmox1 , Nos2 , Serpine1 , Tert , Vegfa
Coronary DiseaseFlt1 , Hmox1 , Kdr , Tert , Vegfa
coronary restenosisHmox1 , Itgb2
coronary stenosisEdn1
coronin-1A deficiencyAldoa
Cowden diseaseAkt1
Cowden Syndrome 6Akt1
Cowden-Like SyndromeAkt1
Craniofacial AbnormalitiesEdn1 , Ep300 , Gata2 , Smad3 , Smad4
craniosynostosisTwist1
Cri-du-Chat syndromeTert
Crohn's diseaseAbcb1a , Kdr , Lep , Smad3 , Vegfa
Cronkhite-Canada syndromeAbcb1a , Eng , Smad4
Cryohydrocytosis, Stomatin-Deficient, with Mental Retardation, Seizures, Cataracts, and Massive HepatosplenomegalySlc2a1
Cutaneous Malignant Melanoma, Susceptibility To, 1Akt1
cutaneous porphyriaFech
cutaneous T cell lymphomaMcl1
cystadenomaAldoa
cystic fibrosisEdn1 , Hmox1 , Lep , Nos2
cystic kidney diseaseVhl
cystitisKdr
DeafnessSmad4
decubitus ulcerHif1a , Kdr , Vegfa
dementiaCp , Nos2
Dermal FibrosisSerpine1
dermatitisCxcl12 , Itgb2
dermatitis herpetiformisVegfa
Developmental DisabilitiesEp300 , Slc2a1
Diabetes ComplicationsHif1a , Vegfa
diabetes mellitusAbcg2 , Cp , Fxn , Gck , Hnf4a , Lep , Serpine1 , Slc2a1
diabetic angiopathyCxcl12 , Hmox1 , Igfbp1 , Mmp14 , Nos2 , Serpine1 , Vegfa
Diabetic CardiomyopathiesHmox1 , Tert
Diabetic NephropathiesCreb1 , Edn1 , Eng , Ep300 , Epas1 , Epo , Flt1 , Hif1a , Hmox1 , Hnf4a , Igfbp1 , Kdr , Lep , Serpine1 , Slc2a1 , Tf , Vegfa
diabetic neuropathyEpo , Nos2 , Vegfa
diabetic retinopathyAdm , Cxcl12 , Edn1 , Eng , Ep300 , Epo , Flt1 , Hif1a , Serpine1 , Vegfa
DIAMOND-BLACKFAN ANEMIA-LIKEEpo
diffuse large B-cell lymphomaAbcb1a , Abcg2
diffuse sclerodermaKdr
DiGeorge syndromeVegfa
Dilatation, PathologicHmox1
dilated cardiomyopathyCreb1 , Edn1 , Egln1 , Mmp14
disease of cellular proliferationAbcb1a , Cited2 , Tert , Vegfa , Vhl
disease of mental healthAbcb1a
Disease ProgressionAbcb1a , Apex1 , Flt1 , Tert
Dissecting AneurysmSmad3
disseminated intravascular coagulationSerpine1
drug allergyAdora2a
Drug-induced NeutropeniaAbcb1a
Drug-Related Side Effects and Adverse ReactionsAbcb1a , Abcg2 , Adora2a , Cp , Hmox1 , Igfbp1 , Tf
Ductal CarcinomaCar9 , Hif1a , Slc2a1
ductal carcinoma in situBnip3 , Car9 , Flt1 , Hif1a , Slc2a1 , Tert , Vegfa
duodenal ulcerNos2 , Slc11a2 , Tfrc , Vegfa
dysgerminomaPou5f1
dyskeratosis congenitaTert
DyskinesiasCp
DyspneaEdn1
dystoniaSlc2a1
dystonia 9Slc2a1
echinococcosisTf
EdemaNos2
EmbolismMmp14
Embryo LossCxcl12
embryonal carcinomaPou5f1
EmphysemaNos2
encephalitisAbcb1a
end stage renal failureAbcb1a , Bnip3 , Edn1 , Epo , Hmox1 , Lep , Serpine1
Endometrial HyperplasiaCar9
Endometrial NeoplasmsApex1 , Ep300 , Flt1 , Jun , Kdr , Ncoa1 , Pgm1 , Smad3 , Smad4 , Tert , Vegfa
Endometrioid CarcinomasAkt1 , Car9 , Kdr
endometriosisArnt , Fos , Igfbp1 , Kdr , Ncoa1 , Vegfa
EndotoxemiaAbcb1a , Aldoa , Edn1 , Ep300 , Epo , Hmox1 , Igfbp1 , Nos2 , Serpine1
EnterocolitisItgb2
EosinophiliaAbcb1a
epilepsyAbcb1a , Akt1 , Cp , Fos , Slc2a1
EpistaxisEng
erythema multiformeVegfa
erythropoietic protoporphyriaAbcg2 , Fech
Escherichia Coli InfectionsAbcb1a
esophageal carcinomaEp300 , Smad4
Esophageal NeoplasmsAbcb1a , Eno1 , Ep300 , Hmox1 , Kdr , Mmp14 , Nos2 , Smad4
esophagus adenocarcinomaSmad4
esophagus squamous cell carcinomaCrebbp , Ep300 , Hif1a
essential hypertensionNos2
exfoliation syndromeEdn1
Experimental ArthritisAbcb1a , Abcg2 , Akt1 , Cp , Edn1 , Flt1 , Hif1a , Itgb2 , Lep , Nos2 , Vegfa
Experimental Autoimmune EncephalomyelitisEpo , Flt1 , Kdr , Nos2 , Serpine1 , Vegfa
Experimental Autoimmune NeuritisEpas1 , Epo , Hif1a , Nos2
Experimental ColitisKdr , Smad4 , Vegfa
Experimental Diabetes MellitusAbcb1a , Abcg2 , Adm , Adora2a , Akt1 , Cp , Cxcl12 , Edn1 , Ep300 , Epo , Ets1 , Flt1 , Furin , Gck , Hif1a , Hk1 , Hmox1 , Hnf4a , Kdr , Lep , Nos2 , Nt5e , Serpine1 , Slc2a1 , Tert , Tf , Vegfa
Experimental Liver CirrhosisAbcb1a , Adm , Adora2a , Cxcl12 , Edn1 , Fos , Gck , Hmox1 , Id2 , Igfbp1 , Itgb2 , Lep , Ndrg1 , Nos2 , Nt5e , Plin2 , Smad4 , Tert , Tf , Vegfa
Experimental NeoplasmsArnt , Ldha , Vegfa
Experimental SarcomaEpo
extrahepatic cholestasisFos , Jun
extrinsic allergic alveolitisNos2 , Vegfa
extrinsic cardiomyopathyPfkfb3
factor VIII deficiencyHmox1
familial adenomatous polyposisAkt1
familial combined hyperlipidemiaHnf4a , Serpine1
Familial Erythrocytosis 3Egln1
Familial Erythrocytosis 4Epas1
familial erythrocytosis 5Epo
familial hypercholesterolemiaSerpine1
familial hyperlipidemiaAbcb1a , Lep
familial Mediterranean feverSerpine1
familial temporal lobe epilepsy 3Abcb1a
Fanconi anemiaVhl
Fanconi Renotubular Syndrome 4 with Maturity-Onset Diabetes of the YoungHnf4a
Fanconi syndromeLdha
FatigueEpo
fatty liver diseaseCreb1 , Epas1 , Gck , Lep , Plin2 , Serpine1 , Tf
Female InfertilityLep
Femoral FracturesCxcl12 , Cxcr4 , Lep
Fetal DiseasesNos2
Fetal DistressEpo
Fetal Growth RetardationAbcb1a , Elk1 , Hnf4a , Lep , Nos2 , Serpine1 , Slc2a1 , Tff3
Fetal MacrosomiaHnf4a
FeverHmox1 , Serpine1
Fibromatosis, AggressiveSerpine1
fibrosarcomaSerpine1 , Tert
FibrosisAkt1 , Car9 , Fech , Hmox1
Fibrous Dysplasia of BoneFos
focal segmental glomerulosclerosisEdn1 , Nos2 , Serpine1
follicular lymphomaCrebbp
Fractures, StressEng
Friedreich ataxiaFxn
Friedreich Ataxia 1Fxn
Fungal Lung DiseasesGata2 , Nos2
Gallbladder NeoplasmsNos2
gastric adenocarcinomaAkt1 , Crebbp , Smad4
gastric ulcerAdm , Epo , Lep , Nos2 , Vegfa
Gastrointestinal DiseasesEdn1 , Tf
Gastrointestinal NeoplasmsSmad4
gastroparesisHmox1
gastroschisisNos2
Generalized EpilepsyPgk1
genetic diseaseCp , Crebbp , Egln1 , Ep300 , Gck , Hnf4a , Pgk1 , Slc2a1 , Smad4 , Twist1
Genetic Predisposition to DiseaseAbcb1a , Adora2a , Apex1
Germ Cell and Embryonal NeoplasmsAbcb1a , Pou5f1
gestational diabetesGck , Lep
Gestational Trophoblastic DiseasePou5f1
gingivitisVegfa
glaucomaCrebbp , Epo , Serpine1 , Vegfa
glioblastoma multiformeAkt1 , Bhlhe40 , Crebbp , Hif1a , Ndrg1 , Vegfa
gliosarcomaVegfa
glomerulonephritisAdm , Ep300 , Fos , Itgb2 , Serpine1 , Tf , Vegfa
glomerulosclerosisSerpine1 , Slc2a1
Glomus Tympanicum TumorVegfa
glucose intoleranceLep
GLUT1 Deficiency SyndromeSlc2a1
glycogen storage disease VHif1a
glycogen storage disease VIIHif1a
Glycogen Storage Disease XIIAldoa
Glycogen Storage Disease XIVPgm1
goutAbcg2
Graft Occlusion, VascularHmox1
Graft vs Host DiseaseSerpine1 , Vegfa
granulosa cell tumorVegfa
Graves OphthalmopathySerpine1
Graves' diseaseSerpine1 , Vegfa
Growth DisordersHmox1
Growth Mental Deficiency Syndrome of MyhreSmad4
Hand-Foot SyndromeKdr
Head and Neck NeoplasmsVegfa
head and neck squamous cell carcinomaAbcb1a , Abcg2 , Akt1 , Crebbp , Ep300 , Ndrg1 , Serpine1 , Smad4
Hearing Loss, Noise-InducedHif1a
Hearing Loss, SuddenSerpine1
heart diseaseAbcb1a , Apex1 , Cp , Edn1 , Ep300 , Epo , Vegfa
heart septal defectCited2
heart valve diseaseItgb2
Heat StrokeFos , Jun
Helicobacter InfectionsHmox1 , Tfrc
hemangioblastomaHif1a , Ndrg1
hemangiomaSlc2a1
Hemangioma, Capillary InfantileKdr , Slc2a1
Hematologic NeoplasmsAbcb1a
Hematoma, Subdural, AcuteEpo
hematopoietic system diseaseSerpine1
HematuriaFos
Heme Oxygenase 1 DeficiencyHmox1
hemochromatosisCp , Hmox1 , Slc11a2
HemolysisHmox1
hemolytic anemiaEpo , Hmox1 , Pgk1
Hemolytic Anemia, Nonspherocytic, due to Hexokinase DeficiencyHk1
hemolytic-uremic syndromeEpo , Fos
HemorrhageBnip3 , Fos , Gata2 , Serpine1
hemosiderosisCp
Hemosiderosis, Systemic, due to AceruloplasminemiaCp
Henoch-Schoenlein purpuraHmox1
hepatic encephalopathyHif1a , Hmox1 , Nos2
Hepatic PorphyriasFech
hepatic veno-occlusive diseaseHmox1
HepatitisHmox1 , Nos2 , Tf
Hepatitis, AnimalCp , Tff3
Hepatitis, ChronicCp , Nos2
hepatocellular carcinomaAbcb1a , Akt1 , Apex1 , Cops5 , Cp , Crebbp , Cxcl12 , Eng , Eno1 , Ep300 , Fos , Hif1a , Hnf4a , Jun , Pgk1 , Pkm , Slc2a1 , Smad4 , Tert , Tfrc
hepatopulmonary syndromeEdn1 , Hmox1
hepatorenal syndromeEdn1 , Hmox1
hereditary fructose intolerance syndromeAldoa
hereditary hemorrhagic telangiectasiaEng , Smad4
Hereditary Hemorrhagic Telangiectasia, Type 1Eng , Smad4
Hereditary Hemorrhagic Telangiectasia, Type 2Eng
Hereditary Motor and Sensory Neuropathy, LOM TypeNdrg1
Hereditary Neoplastic SyndromesSmad4 , Vhl
Hermansky-Pudlak syndromeCp , Cxcr4
Hermansky-Pudlak syndrome 3Cp
Hernias, Diaphragmatic, CongenitalEp300 , Epo , Vegfa
heroin dependenceLep
herpes simplex virus keratitisKdr
Hirschsprung Disease 1Crebbp , Kdr
Hirschsprung's diseaseSlc2a1
HirsutismEp300
Histiocytoma, Angiomatoid FibrousCreb1
Hodgkin's lymphomaJun
holoprosencephalyCreb1
Hot FlashesHif1a
Hoyeraal Hreidarsson SyndromeTert
human immunodeficiency virus infectious diseaseAbcb1a , Cxcl12
Human InfluenzaNos2
Huntington's diseaseCreb1 , Crebbp , Elk1 , Ep300 , Hdac7 , Lep
Hyaline Membrane DiseaseSerpine1
hydrophthalmosFlt1 , Kdr
HyperalgesiaAdm , Edn1 , Ep300 , Fos , Hif1a , Nos2
Hyperbilirubinemia, NeonatalHmox1
HypercapniaEdn1 , Lep
HypercholesterolemiaEdn1 , Eng , Lep , Vegfa
HyperemiaEgln1 , Nos2
hyperglycemiaEpas1 , Gck , Ldha , Sp1 , Tf
hyperinsulinemic hypoglycemiaGck
Hyperinsulinemic Hypoglycemia, Familial, 3Gck
hyperinsulinismAdm , Gck , Hmox1 , Hnf4a , Lep
HyperkinesisAdora2a , Fos
HyperoxiaBnip3 , Edn1
Hyperoxic Lung InjuryHmox1
HyperphagiaLep
Hyperphosphatasia with Mental Retardation Syndrome 2Car9
HyperplasiaAkt1 , Hif1a , Hmox1 , Lep , Vegfa
hypertensionAdm , Adora2a , Akt1 , Edn1 , Egln1 , Eng , Eno1 , Ep300 , Epo , Fos , Gck , Hif1a , Hmox1 , Jun , Kdr , Lep , Nos2 , Serpine1 , Slc2a1 , Tf , Vegfa , Vhl
Hypertension, Pregnancy-InducedEdn1 , Hmox1
hyperthyroidismCp , Hmox1 , Serpine1
HypertriglyceridemiaHnf4a , Lep , Plin2
hypertrophic cardiomyopathyAdm , Edn1 , Npm1
HypertrophyEdn1
Hypertrophy, Left VentricularEdn1
Hypertrophy, Right VentricularAkt1 , Car9 , Eng , Hmox1
hyperuricemiaAbcg2
hypochromic anemiaSlc11a2
hypochromic microcytic anemiaSlc11a2 , Tf , Tfrc
Hypoglossal Nerve InjuriesSmad3 , Smad4
hypoglycemiaCreb1 , Epo , Gck , Hnf4a
hypogonadismEdn1 , Lep
HypotensionAdora2a , Edn1
Hypotension, OrthostaticAbcb1a
HypothermiaNos2
hypothyroidismNcoa1 , Nos2 , Slc2a1
HypoventilationLep
HypoxiaCar9
Hypoxia-Ischemia, BrainEpo , Hif1a , Hmox1 , Kdr , Nos2 , Serpine1 , Tert , Tf , Vegfa
idiopathic generalized epilepsySlc2a1
idiopathic pulmonary fibrosisHif1a , Tert
IgA glomerulonephritisMmp14
ileusHmox1
Immunodeficiency 21Gata2
Immunodeficiency 46Tfrc
impotenceAkt1 , Edn1 , Kdr , Nos2 , Vegfa
in situ carcinomaAkt1 , Pou5f1
InfarctionEpas1 , Hif1a
InflammationAbcb1a , Akt1 , Edn1 , Epo , Hmox1 , Lep , Nos2 , Tf , Tfrc , Vegfa
inflammatory bowel diseaseCul2 , Nos2 , Vegfa
inflammatory bowel disease 13Abcb1a
inherited metabolic disorderSlc2a1
Insulin ResistanceFxn , Gck , Hmox1 , Lep , Nos2 , Plin2 , Serpine1 , Tf
insulinomaAdm , Cxcl12
intellectual disabilityEp300 , Slc2a1
intermediate coronary syndromeAkt1 , Edn1
intermittent claudicationEpas1
interstitial cystitisNos2
interstitial lung diseaseHmox1 , Nos2 , Serpine1
Intervertebral Disc DiseaseHif1a
Intervertebral Disc DisplacementAkt1
intestinal diseaseNos2
Intestinal IschemiaAdm
Intestinal PolypsJun , Serpine1
Intestinal Reperfusion InjuryHmox1 , Serpine1
intracranial aneurysmMmp14
Intracranial HemorrhagesTf
intracranial vasospasmHmox1
invasive ductal carcinomaAbcb1a , Akt1 , Hif1a , Smad4
Invasive Pulmonary AspergillosisVegfa
inverted papillomaKdr , Vegfa
iron deficiency anemiaSlc11a2 , Tf , Tfrc
iron metabolism diseaseCp , Hmox1 , Tfrc
Iron OverloadCp , Epas1 , Slc11a2 , Tf
ischemiaCp , Cxcl12 , Flt1 , Hmox1 , Mmp14
ischemic colitisSerpine1 , Vegfa
JaundiceFech
juvenile myelomonocytic leukemiaGata2
juvenile polyposis syndromeEng , Smad4
Juvenile Polyposis with Hereditary Hemorrhagic TelangiectasiaSmad4
juvenile rheumatoid arthritisCxcr4 , Fos , Jun , Smad3
Kawasaki diseaseFlt1 , Hmox1 , Vegfa
Keratosis Follicularis Spinulosa Decalvans, X-LinkedSat1
kidney diseaseAbcb1a , Edn1 , Epo , Nos2 , Tert , Tff3
kidney failureEdn1 , Epo , Hif1a
Kidney NeoplasmsAbcb1a , Akt1 , Flt1 , Itgb2 , Jun , Kdr , Ndrg1 , Vhl
Kidney Reperfusion InjuryAdm , Bnip3 , Egln1 , Egln3 , Eng , Ep300 , Epo , Fos , Hif1a , Hmox1 , Itgb2 , Lep
Kuhnt-Junius degenerationFlt1 , Kdr , Vegfa
Lactate Dehydrogenase Deficiency Type ALdha
Laryngotracheal Stenosis, Progressive, with Short Stature and ArthropathySmad4
LathyrismKdr
Lead Poisoning, Nervous SystemEp300
learning disabilityHmox1 , Vegfa
leiomyomaSmad3
leiomyosarcomaFlt1 , Tert
leishmaniasisMcl1
LEPTIN DEFICIENCY OR DYSFUNCTIONLep
leukocyte adhesion deficiencyItgb2
leukocyte adhesion deficiency 1Itgb2
leukocyte diseaseItgb2
leukopeniaCxcr4
Lewy body dementiaEdn1 , Elk1 , Nos2
Leydig cell tumorFlt1
Limb IschemiaEpo , Hif1a , Hmox1 , Vegfa
limited sclerodermaKdr , Serpine1
liver cancerAkt1 , Crebbp
liver cirrhosisArnt , Cp , Edn1 , Flt1 , Hnf4a , Igfbp1 , Smad3 , Vegfa
liver diseaseHmox1 , Nos2
Liver FailureVegfa
Liver InjuryAbcg2 , Gck , Npm1
liver neoplasmEgln3 , Hmox1 , Jun , Ndrg1 , Serpine1 , Slc11a2 , Slc2a1 , Tert
Liver Neoplasms, ExperimentalCp , Kdr , Nos2
Liver Reperfusion InjuryAdm , Hmox1 , Serpine1 , Tert
Loeys-Dietz syndromeSmad3
Loeys-Dietz Syndrome 3Smad3
low tension glaucomaEdn1
lung adenocarcinomaAkt1 , Aldoa , Apex1 , Crebbp , Eno1 , Ep300 , Hk1 , Hk2 , Ldha , Npm1 , Smad4 , Tf
lung diseaseAdora2a , Apex1 , Hif1a , Hmox1 , Lep , Nos2 , Serpine1 , Vegfa
Lung InjuryHmox1 , Slc11a2
Lung NeoplasmsAkt1 , Bhlhe41 , Fos , Hmox1 , Jun , Mcl1 , Nos2 , Tert , Tfrc , Vhl
Lung Reperfusion InjuryHmox1 , Serpine1
lung small cell carcinomaAkt1 , Crebbp , Ep300 , Id2 , Ndrg1
lung squamous cell carcinomaAkt1 , Crebbp , Ep300
lymphangiomaKdr
Lymphatic MetastasisCar9 , Kdr , Pou5f1 , Smad4 , Vegfa
lymphedemaGata2
Lymphedema, Primary, with MyelodysplasiaGata2
lymphoid leukemiaEng , Tert
Lymphoma, AIDS-RelatedTfrc
Lymphoma, Extranodal NK-T-CellAbcb1a
Lynch syndromeSmad3 , Smad4
macular degenerationFlt1 , Kdr , Serpine1 , Vegfa
macular retinal edemaEpo , Flt1 , Kdr , Vegfa
malariaHmox1 , Nos2
male infertilityEno1
malignant gliomaEpo , Kdr , Serpine1 , Tert , Tfrc
malignant hypertensionAdm
malignant mesotheliomaCxcl12 , Slc2a1 , Tf
Mammary Neoplasms, AnimalEno1 , Furin , Kdr , Pkm , Tf
Mammary Neoplasms, ExperimentalAbcb1a , Abcg2 , Akt1 , Car9 , Eno1 , Epo , Furin , Hif1a , Hmox1 , Kdr , Lep , Ncoa1 , Pkm , Tf , Vegfa
Mandibular FracturesCited2
Manganese PoisoningBnip3 , Nos2
Marfan syndromeMmp14 , Nos2
maturity-onset diabetes of the youngGck , Hnf4a
maturity-onset diabetes of the young type 1Hnf4a
maturity-onset diabetes of the young type 2Gck
medulloblastomaCrebbp , Ep300
megakaryocytic leukemiaAbcg2
melanomaAkt1 , Apex1 , Arnt , Cp , Crebbp , Eng , Ep300 , Epo , Flt1 , Kdr , Ndrg1 , Tert , Vegfa
Melanoma, Cutaneous Malignant, Susceptibility To, 9Tert
Melanoma, ExperimentalTert
membranoproliferative glomerulonephritisEdn1 , Ep300
membranous glomerulonephritisTf
Memory DisordersCreb1 , Hif1a , Vegfa
Meningeal NeoplasmsAkt1
meningiomaAkt1
Menkes diseaseCp
mental depressionAdora2a , Gata2 , Jun
Mercury Poisoning, Nervous SystemJun
metabolic acidosisEdn1
Metabolic SyndromeAldoa , Hmox1 , Hnf4a , Lep , Serpine1 , Tf , Vegfa
metabolic syndrome XLep
MetaplasiaCar9 , Tff3
microcephalyEp300 , Slc2a1
MicrognathismEp300
Micronuclei, Chromosome-DefectiveApex1 , Hif1a
Microphthalmia, Cataracts, and Iris AbnormalitiesSmad4
Microvascular Complications of Diabetes, Susceptibility to, 1Vegfa
Microvascular Complications of Diabetes, Susceptibility to, 2Epo , Vegfa
Microvascular Complications of Diabetes, Susceptibility to, 3Epo
Microvascular Complications of Diabetes, Susceptibility to, 7Epo , Vegfa
middle cerebral artery infarctionBnip3 , Edn1 , Eng , Epo , Fos , Hif1a , Hmox1 , Nos2 , Serpine1 , Slc2a1
migraineSlc2a1
mitochondrial metabolism diseaseNos2
morbid obesityHif1a , Lep
morphine dependenceCreb1
Mouth NeoplasmsEno1 , Ets1 , Ndrg1 , Rack1
movement diseaseAdora2a
mucositisNos2 , Tff3
Multiple AbnormalitiesCrebbp , Ep300
multiple myelomaAbcg2 , Bnip3 , Eng , Hk1 , Mcl1 , Tert , Tfrc , Vegfa
Multiple Organ FailureSerpine1
multiple sclerosisEdn1 , Vegfa
Multiple TraumaSerpine1
Muscle HypotoniaEp300
Muscle SpasticityCrebbp
Muscle WeaknessSlc2a1
muscular atrophyAkt1 , Cited2 , Serpine1 , Tfrc
muscular diseaseSmad4
Musculoskeletal AbnormalitiesEpas1
Mycoplasma InfectionsNos2
mycosis fungoidesHif1a
myelodysplastic syndromeCrebbp , Epo , Gata2 , Npm1 , Tert
myeloid leukemiaGata2 , Vegfa
myeloid neoplasmNpm1
myelomeningoceleSlc2a1
myocardial infarctionAkt1 , Bnip3 , Creb1 , Cxcl12 , Edn1 , Egln1 , Egln3 , Epas1 , Epo , Flt1 , Hif1a , Hmox1 , Kdr , Ldha , Mmp14 , Nos2 , Npm1 , Serpine1 , Smad4 , Vegfa
Myocardial IschemiaAdm , Aldoa , Bhlhe40 , Edn1 , Hif1a , Hk1 , Hk2 , Hmox1 , Kdr , Pfkfb3 , Pgm1 , Tfrc , Vegfa
Myocardial Reperfusion InjuryAkt1 , Apex1 , Bnip3 , Edn1 , Egln1 , Hif1a , Hmox1 , Lep , Nos2 , Serpine1 , Slc2a1 , Smad3 , Smad4 , Tfrc , Vegfa
myocardial stunningNos2
myoglobinuriaLdha
myopiaAdora2a , Ep300
Nasal PolypsAbcb1a , Jun , Kdr , Nos2 , Vegfa
NauseaAbcb1a
NecrosisEpo , Nos2
NeointimaFlt1 , Hmox1 , Serpine1
neonatal diabetes mellitusGck
Neoplasm InvasivenessAldoa , Cxcl12 , Cxcr4 , Eno1 , Epo , Hif1a , Hmox1 , Mmp14 , Pkm , Sp1 , Tf , Twist1
Neoplasm MetastasisAbcb1a , Aldoa , Cxcl12 , Cxcr4 , Edn1 , Epo , Flt1 , Kdr , Ncoa1 , Ndrg1 , Nos2 , Sp1 , Twist1 , Vegfa
Neoplasm Recurrence, LocalVegfa
neovascular glaucomaEdn1 , Vegfa
Neovascularization, PathologicKdr , Serpine1 , Vegfa
nephritisEdn1 , Itgb2
nephroblastomaAbcb1a , Flt1 , Hif1a , Slc2a1 , Tert , Vhl
nephronophthisis-like nephropathy 1Ep300 , Rbx1
Nephropathy, Chronic TubulointerstitialEdn1 , Hmox1
nephrosisEdn1 , Itgb2
nephrotic syndromeEpo , Serpine1 , Tf
Nerve DegenerationCp , Epo , Lep , Tf , Vegfa
nervous system diseaseAbcb1a , Abcg2 , Fos , Serpine1 , Slc2a1
neural tube defectCited2 , Npm1
NeuralgiaCxcr4 , Kdr
neurilemmomaKdr , Serpine1
neuroblastomaAbcb1a , Tert
neurodegenerative diseaseEpo , Hmox1
Neurofibromatosis 1Vegfa
Neurofibromatosis 2Vegfa
neurofibrosarcomaKdr , Vegfa
Neuropathy, PainfulEp300
neutropeniaAbcb1a
Neutropenia, Nonimmune Chronic Idiopathic, AdultTert
newborn respiratory distress syndromeEpas1 , Hmox1 , Vegfa
non-Hodgkin lymphomaTfrc
non-small cell lung carcinomaAbcb1a , Akt1 , Eno1 , Epas1 , Hif1a , Lep , Ndrg1 , Tert , Vegfa
nonalcoholic fatty liver diseaseAbcb1a , Lep , Nos2 , Serpine1 , Tfrc
nonpapillary renal cell carcinomaVhl
Noonan syndromeSerpine1
nutrition diseaseTfrc
nutritional deficiency diseaseCp
obesityAdm , Akt1 , Bnip3 , Edn1 , Ep300 , Fxn , Gck , Hk1 , Hk2 , Hmox1 , Lep , Ncoa1 , Nos2 , Pfkfb3 , Sat1 , Serpine1 , Slc2a1 , Tf , Tfrc
obstructive jaundiceAdm
obstructive sleep apneaAbcb1a , Edn1 , Hmox1 , Lep , Nos2 , Serpine1
Odontogenic CystsSmad4
olfactory neuroblastomaHif1a
optic nerve diseaseEdn1
Optic Nerve InjuriesEdn1 , Ep300 , Jun
oral squamous cell carcinomaSerpine1
Oral UlcerEdn1 , Lep
Oropharyngeal NeoplasmsNdrg1
Ossification, HeterotopicSmad4
osteoarthritisEno1 , Epas1 , Flt1 , Hif1a , Lep , Slc2a1 , Smad3
Osteoarthritis, ExperimentalFlt1
Osteoarthritis, KneeEpas1 , Epo , Lep
osteochondrodysplasiaFlt1 , Kdr , Vegfa
osteogenesis imperfectaSmad4
osteopetrosisJun
osteoporosisEno1 , Lep , Pkm
Osteoporosis, PostmenopausalHif1a
osteosarcomaAkt1 , Cited2 , Jun , Vegfa
otitis mediaNos2 , Vegfa
Otitis Media with EffusionFlt1 , Kdr , Vegfa
ovarian cancerAkt1
Ovarian NeoplasmsAbcb1a , Abcg2 , Akt1 , Apex1 , Edn1 , Flt1 , Hif1a , Kdr , Slc2a1 , Smad4 , Tert , Tfrc , Vegfa
Overactive Urinary BladderEdn1
Oxygen-Induced RetinopathyHif1a , Kdr , Serpine1 , Vegfa
PainAbcb1a , Adm , Akt1 , Cxcl12 , Edn1
Pain, PostoperativeAbcb1a
pancreas diseaseHmox1
pancreatic adenocarcinomaCxcr4 , Smad4
pancreatic cancerAdm , Akt1 , Hif1a , Kdr , Nos2 , Smad3 , Smad4 , Tert , Vhl
pancreatic carcinomaSmad4
Pancreatic CystVhl
pancreatic ductal carcinomaNdrg1 , Nos2 , Vegfa , Vhl
pancreatic intraductal papillary-mucinous neoplasmAkt1
pancreatitisItgb2
Pancreatitis, Acute NecrotizingNos2 , Serpine1
pancytopeniaEpas1 , Epo
panic disorderAdora2a
Paraneoplastic SyndromesEpo
ParaparesisHmox1
paraplegiaAkt1 , Nos2
Parasitic Liver DiseasesSmad4
ParatuberculosisTf
Parkinson's diseaseAbcb1a , Akt1 , Cp , Edn1 , Epo , Hmox1 , Lep , Nos2 , Slc11a2
Parkinsonian DisordersHmox1 , Slc11a2 , Vhl
paroxysmal nocturnal hemoglobinuriaCxcr4
Pasteurellaceae InfectionsCp
peptic ulcer diseaseEdn1 , Hmox1
Perennial Allergic RhinitisHmox1 , Nos2
perinatal necrotizing enterocolitisAbcb1a , Bnip3 , Eno1 , Nos2
Periodontal AtrophyVegfa
periodontitisCxcl12
peripheral artery diseaseSerpine1
peripheral nervous system diseaseAbcb1a , Jun
peripheral vascular diseaseAdm
Peritoneal AdhesionsSerpine1
Peritoneal FibrosisSerpine1
Peritoneal NeoplasmsSlc2a1
permanent neonatal diabetes mellitusGck
phaeochromocytomaVhl
Phosphoglycerate Kinase 1 DeficiencyPgk1
Phyllodes TumorHif1a , Tfrc
Pick's diseaseCreb1 , Fos
placental insufficiencyEpo , Serpine1
Plaque, AtheroscleroticItgb2 , Sp1
plasmacytic leukemiaTert
Plasminogen Activator Inhibitor-1 DeficiencySerpine1
platelet-type bleeding disorder 10Serpine1
pleomorphic xanthoastrocytomaAbcb1a , Epo , Gck , Igfbp1 , Lep , Serpine1 , Twist1
pleurisyNos2 , Serpine1
Pneumococcal PneumoniaHmox1 , Lep , Nos2
pneumocystosisNos2
pneumoniaAdora2a , Edn1 , Hmox1 , Itgb2 , Serpine1 , Slc11a2
PneumoperitoneumEdn1
pneumothoraxHmox1
PoisoningAbcb1a , Epo
polyarteritis nodosaVegfa
Polycystic Kidney DiseasesEpas1 , Hif1a
polycystic ovary syndromeLep , Serpine1 , Tfrc , Vegfa
polycythemiaEgln1 , Epas1 , Serpine1 , Vhl
PolydipsiaLep
polyneuropathyEpo , Serpine1
Polypoidal Choroidal VasculopathyVegfa
PolyuriaLep
porphyriaEpo
portal hypertensionAdm , Edn1 , Hmox1 , Vegfa
pre-eclampsiaCp , Edn1 , Eng , Epas1 , Flt1 , Hmox1 , Lep , Serpine1 , Vegfa
pre-malignant neoplasmAkt1 , Igfbp1 , Smad3 , Smad4 , Tff3 , Vegfa
precursor lymphoblastic lymphoma/leukemiaAbcb1a , Abcg2 , Arnt , Crebbp , Eng , Hk1 , Tert
precursor T-lymphoblastic lymphoma/leukemiaAbcg2 , Cxcr4
Pregnancy ComplicationsEpo , Ncoa2 , Serpine1
Pregnancy in DiabeticsEng , Vegfa
Premature BirthEdn1
PresbycusisEdn1
primary biliary cirrhosisAbcg2 , Hif1a , Hmox1 , Igfbp1 , Lep , Nos2
primary immunodeficiency diseaseTfrc
primary open angle glaucomaEdn1
primary polycythemiaEgln1 , Epas1
primary pulmonary hypertensionAdora2a , Eng , Smad4
proliferative diabetic retinopathyFlt1 , Serpine1 , Vegfa
proliferative vitreoretinopathyEdn1
prostate adenocarcinomaAkt1 , Smad4 , Tert
prostate cancerHif1a , Kdr , Tf
prostate carcinoma in situApex1 , Flt1 , Smad4
prostatic hypertrophyKdr
Prostatic NeoplasmsAkt1 , Apex1 , Bnip3 , Crebbp , Cxcl12 , Eng , Ep300 , Flt1 , Hif1a , Hmox1 , Jun , Kdr , Lep , Ncoa1 , Ncoa2 , Ndrg1 , Serpine1 , Smad3 , Smad4 , Tert , Tff3 , Tfrc , Vegfa
prostatitisSmad4
proteinuriaLep , Vegfa
Proteus syndromeAkt1
pseudoxanthoma elasticumVegfa
psoriasisCp , Epas1 , Flt1 , Hif1a , Itgb2 , Kdr , Nos2 , Vegfa
psoriatic arthritisNos2
pterygiumKdr , Vegfa
Pulmonary Arterial Hypertension, Hereditary Hemorrhagic Telangiectasia-RelatedEng
pulmonary edemaAdora2a , Nos2 , Vegfa
Pulmonary Edema of MountaineersHmox1
pulmonary embolismEdn1 , Epo
pulmonary emphysemaHmox1 , Jun , Nos2
pulmonary eosinophiliaEpas1 , Nos2
pulmonary fibrosisEdn1 , Hmox1 , Nos2 , Serpine1 , Smad4 , Twist1
Pulmonary Fibrosis and/or Bone Marrow Failure, Telomere-Related, 1Tert
pulmonary hypertensionAdm , Car9 , Edn1 , Eng , Epas1 , Epo , Hif1a , Hif3a , Hk1 , Hmox1 , Nos2 , Serpine1 , Smad4 , Tert
Pulmonary Hypertension, Hypoxia-Induced Egln1 , Egln3
pulmonary sarcoidosisHmox1 , Nos2
pulmonary tuberculosisJun , Nos2
Question Mark Ears, IsolatedEdn1
Radiation InjuriesHif1a
Radiation Injuries, ExperimentalEng , Hif1a , Hmox1
Radiation NephropathySerpine1
rectal neoplasmFos
RecurrenceCxcl12 , Flt1
relapsing-remitting multiple sclerosisSerpine1
renal artery diseaseEdn1
renal cell carcinomaAbcb1a , Abcg2 , Akt1 , Arnt , Car9 , Egln1 , Egln2 , Egln3 , Eloc , Epas1 , Flt1 , Hif1a , Jun , Kdr , Lep , Ndrg1 , Pgk1 , Slc2a1 , Smad4 , Tert , Tfrc , Vegfa , Vhl
renal fibrosisEng , Epas1 , Serpine1
renal hypertensionHmox1 , Nos2
renovascular hypertensionAdm
Reperfusion InjuryAbcb1a , Abcg2 , Adm , Adora2a , Akt1 , Aldoa , Apex1 , Cxcl12 , Edn1 , Ep300 , Ets1 , Fos , Hif1a , Hmox1 , Jun , Kdr , Lep , Nos2 , Slc2a1 , Tert
respiratory allergyNos2 , Serpine1
restless legs syndromeSlc11a2 , Tf
Retina Reperfusion InjuryHmox1 , Vegfa
retinal degenerationCp , Edn1 , Epo
retinal detachmentBnip3 , Edn1 , Epo
retinal diseaseEpas1 , Hmox1 , Nos2 , Vegfa
retinal ischemiaHif1a , Hmox1 , Vegfa
Retinal NeovascularizationHif1a , Vegfa
retinal telangiectasiaKdr , Vegfa
retinal vein occlusionSerpine1 , Vegfa
retinitis pigmentosaEdn1 , Hk1 , Vegfa
RETINITIS PIGMENTOSA 79Hk1
retinopathy of prematurityEpo , Flt1 , Kdr , Nos2 , Serpine1 , Vegfa
RetrognathiaEp300
RhabdomyolysisHmox1
rhabdomyosarcomaVegfa
rheumatoid arthritisAbcb1a , Abcg2 , Adora2a , Cp , Cxcr4 , Edn1 , Eno1 , Epas1 , Hif1a , Mmp14 , Vegfa
rhinitisLep , Nos2 , Serpine1 , Vegfa
RhinosinusitisSerpine1
Robinow Sorauf SyndromeTwist1
Rubinstein-Taybi syndromeCrebbp , Ep300
Saethre-Chotzen syndromeTwist1
sarcomaKdr , Mcl1
Schistosomiasis MansoniNos2
schizophreniaAdora2a , Akt1 , Aldoa , Cp , Creb1 , Elk1 , Kdr , Tfrc
sciatic neuropathyCreb1 , Hmox1 , Serpine1
sclerosing cholangitisHif1a , Nos2
scoliosisCrebbp
Seasonal Allergic RhinitisKdr , Vegfa
secondary hyperparathyroidismAbcg2 , Eng
secondary Parkinson diseaseAbcb1a , Nos2
seminomaPou5f1 , Smad4 , Vegfa
SepsisAdm , Adora2a , Edn1 , Ep300 , Flt1 , Lep , Nos2 , Serpine1
severe combined immunodeficiencyEpo , Tfrc
Sezary's diseaseCrebbp
Shock, HemorrhagicAdm , Epo , Hmox1 , Nos2
short bowel syndromeLep
sickle cell anemiaHk1 , Hmox1
sideroblastic anemiaTfrc
silicosisHmox1 , Nos2
Sjogren's syndromeHmox1
skin diseaseId2 , Pfkfb3
skin melanomaHif1a , Tert
Skin NeoplasmsAkt1 , Flt1 , Hif1a , Sp1 , Vegfa
sleep apneaSerpine1
sleep disorderBhlhe41
Sleep Initiation and Maintenance DisordersAdora2a
sleeping sicknessNos2
Slow Coronary FlowEdn1
Small-For-Size SyndromeVegfa
Smith-Magenis syndromeNos2
smooth muscle tumorNdrg1
spina bifidaApex1 , Crebbp
Spinal Cord CompressionEpo
Spinal Cord InjuriesAdora2a , Akt1 , Apex1 , Bnip3 , Epo , Flt1 , Hif1a , Hmox1 , Id2 , Jun , Kdr , Lep , Nos2 , Tert , Vegfa , Vhl
Spinal Cord Reperfusion InjuryCxcl12 , Cxcr4
spinocerebellar ataxia type 17Hmox1
Spondylocostal Dysostosis 5Aldoa
squamous cell carcinomaAkt1 , Crebbp , Eno1 , Ep300 , Kdr , Rack1 , Vegfa
StarvationAdm
status epilepticusAbcb1a , Abcg2 , Apex1 , Cxcl12 , Epo , Fos , Hmox1 , Jun , Nos2 , Nt5e , Vegfa
Stevens-Johnson syndromeCops5 , Ep300 , Nos2 , Rbx1
Stomach NeoplasmsApex1 , Bnip3 , Eno1 , Hmox1 , Jun , Npm1 , Nt5e , Plin2 , Serpine1 , Smad4 , Twist1
StrokeAdm , Akt1 , Edn1 , Hmox1 , Kdr , Nos2 , Serpine1 , Vegfa
Subarachnoid HemorrhageBnip3 , Edn1 , Epo , Hif1a , Hmox1 , Nos2
substance-induced psychosisAdora2a , Akt1
sudden infant death syndromeVegfa , Vhl
SWEENEY-COX SYNDROMETwist1
Systemic Inflammatory Response SyndromeNos2
systemic lupus erythematosusEng , Ep300 , Ets1 , Nos2 , Tert
Systemic Lupus Erythematosus 16Eng
systemic mastocytosisHmox1
systemic sclerodermaEdn1 , Kdr , Serpine1 , Vegfa
T-Cell LymphomaAkt1 , Ep300
TachycardiaLep
Tachycardia, VentricularEpo
Takayasu's arteritisNos2
temporal lobe epilepsyAbcb1a , Cxcr4 , Kdr , Vegfa
Temporomandibular Joint DisordersHif1a
Tendon InjuriesFos
teratomaPgm1 , Tert
Testis Reperfusion InjuryHif1a , Hmox1
tethered spinal cord syndromeCrebbp
tetralogy of FallotCited2
thoracic aortic aneurysmMmp14 , Serpine1 , Smad3
thrombocytopeniaEpo
thrombosisEpo , Hmox1 , Serpine1
Thrombotic MicroangiopathiesNos2 , Vegfa
Thumb DeformityCrebbp , Ep300
thyroid gland diseaseId2
thyroid hormone resistance syndromeNcoa1
Thyroid NeoplasmsAkt1 , Cp , Epo , Hif1a , Tert
Tobacco Addiction, Susceptibility ToEgln2
Tongue NeoplasmsFos , Vegfa
tongue squamous cell carcinomaKdr
toxic encephalopathyAbcb1a , Abcg2 , Fos
toxic shock syndromeAdm , Hmox1 , Nos2 , Serpine1
transient cerebral ischemiaBnip3 , Creb1 , Cxcl12 , Elk1 , Ep300 , Epo , Flt1 , Hif1a , Rack1 , Serpine1 , Tert
transient neonatal diabetes mellitusGck
transitional cell carcinomaAkt1 , Car9 , Crebbp , Ep300 , Kdr , Mmp14 , Pou5f1 , Smad4 , Tert , Tfrc
Translocation, GeneticAbcb1a
Transplant RejectionKdr
TremorAdora2a
trigeminal neuralgiaFos
Tubulointerstitial FibrosisEpo
Tumor Predisposition SyndromeSmad4 , Vhl
Turner syndromeNos2
Tympanic Membrane PerforationVegfa
type 1 diabetes mellitusCp , Cxcl12 , Edn1 , Ets1 , Nos2 , Tf
type 2 diabetes mellitusAbcb1a , Adm , Akt1 , Arnt , Cp , Cxcl12 , Edn1 , Ep300 , Epas1 , Epo , Ets1 , Flt1 , Fxn , Gck , Hif1a , Hk1 , Hk2 , Hmox1 , Hnf4a , Kdr , Lep , Nos2 , Serpine1 , Slc2a1 , Smad4 , Vegfa
UlcerHif1a , Mmp14
ulcerative colitisCxcr4 , Hnf4a , Kdr , Vegfa
uremiaEdn1 , Epo , Flt1 , Kdr , Nos2
ureteral obstructionAdm , Akt1 , Edn1 , Nos2 , Serpine1
URIC ACID CONCENTRATION, SERUM, QUANTITATIVE TRAIT LOCUS 1Abcg2
urinary bladder cancerAkt1 , Apex1 , Car9 , Crebbp , Ep300 , Hk1 , Kdr , Serpine1 , Smad4 , Tert , Tfrc , Vegfa , Vhl
Urinary RetentionEdn1
Urinary Tract InfectionsNos2
Urologic NeoplasmsHif1a , Vegfa
Uterine Cervical NeoplasmsAkt1 , Apex1 , Car9 , Crebbp , Ep300 , Flt1 , Fos , Kdr , Smad4 , Tert , Tfrc , Vegfa
Uterine NeoplasmsFlt1 , Smad3 , Tert
uveal melanomaKdr , Serpine1 , Vegfa
uveitisNos2
varicoceleHif1a , Hmox1
vascular dementiaEpo , Flt1
Vascular DepressionSerpine1
vascular diseaseEpo
Vascular RemodelingSerpine1
Vascular System InjuriesHmox1 , Id2
Venous ThromboembolismSerpine1
Venous ThrombosisEpo , Kdr , Mmp14 , Serpine1
Ventilator-Induced Lung InjuryAkt1 , Serpine1
Ventricular DysfunctionAdora2a
Ventricular FibrillationEpo , Hmox1
Ventricular RemodelingSmad3
ventricular septal defectCited2 , Epo , Fos
Ventricular Septal Defect 2Cited2
Viral BronchiolitisNos2
viral pneumoniaHmox1
visceral leishmaniasisHmox1
visual epilepsyAbcb1a , Adora2a , Apex1 , Epo , Fos , Lep , Nos2 , Slc2a1
Vogt-Koyanagi-Harada diseaseItgb2
VomitingAbcb1a
von Hippel-Lindau diseaseEpas1 , Vhl
Waldenstroem's macroglobulinemiaCxcr4
Weight GainLep
Weight LossAdora2a , Epo , Lep
Werner syndromeHif1a
WHIM syndromeCxcr4
Wilson diseaseCp
Winchester SyndromeMmp14
withdrawal disorderAdora2a , Creb1 , Fos , Nos2
Wounds and InjuriesCxcl12 , Eng , Hmox1 , Vegfa
Wounds, PenetratingCxcl12 , Epo , Serpine1
Pathway Annotations Associated with Genes in the hypoxia inducible factor pathway
Pathway TermsGene Symbols
activin signaling pathwaySmad3
acute intermittent porphyria pathwayFech , Hmox1
acute myeloid leukemia pathwayAkt1
adenosine signaling pathwayAdora2a , Akt1 , Creb1 , Elk1 , Jun
aldosterone signaling pathwayCrebbp , Ncoa1 , Ncoa2
altered androgen signaling pathwayNcoa2
altered energy homeostasis pathwayLep
altered ephrin - ephrin receptor bidirectional signaling pathwayEfna1
altered galactose metabolic pathwayHk2
altered hypoxia inducible factor pathwayVhl
altered leptin system pathwayLep
altered p53 signaling pathwayEts1
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1
altered transforming growth factor-beta Smad dependent signaling pathwaySmad3 , Smad4
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expressionKdr , Vegfa
altered vascular endothelial growth factor signaling pathway involving the main playersKdr , Vegfa
amino sugar metabolic pathwayGck , Hk1 , Hk2 , Pgm1
androgen signaling pathwayCrebbp , Ep300 , Ncoa1 , Ncoa2
antigen processing and presentation pathwayCreb1
apoptotic cell death pathwayAkt1
arginine and proline metabolic pathwayNos2 , Sat1 , Sat2
aryl hydrocarbon receptor signaling pathwayArnt , Arnt2
axitinib pharmacodynamics pathwayFlt1 , Kdr
B cell receptor signaling pathwayAkt1 , Fos , Jun
base excision repair pathwayApex1
bevacizumab pharmacodynamics pathwayFlt1 , Kdr , Vegfa
bile acid transport pathwayAbcb1a , Abcg2 , Slc2a1
Bone morphogenetic proteins signaling pathwaySmad4
butirosin and neomycin biosynthetic pathwayGck , Hk1 , Hk2
calcium/calcium-mediated signaling pathwayAdora2a , Nos2
cell cycle pathway, mitoticCrebbp , Ep300 , Rbx1 , Smad3 , Smad4
ceramide signaling pathwayAkt1 , Smad3 , Smad4 , Vegfa
Chagas disease pathwayAkt1 , Fos , Jun , Nos2 , Serpine1 , Smad3
chemokine mediated signaling pathwayAkt1 , Cxcl12 , Cxcr4
chronic myeloid leukemia pathwayAkt1 , Smad3 , Smad4
clopidogrel pharmacodynamics pathwayAbcb1a
clopidogrel pharmacokinetics pathwayAbcb1a
coagulation cascade pathwaySerpine1
colorectal cancer pathwayAkt1 , Fos , Jun , Smad3 , Smad4
complement system pathwaySerpine1
congenital sucrase-isomaltase deficiency pathwayGck , Hk2 , Pgm1
cortisol signaling pathwayCrebbp , Ep300 , Ncoa1 , Ncoa2
cysteine and methionine metabolic pathwayLdha
cytokine mediated signaling pathwayCxcl12 , Cxcr4 , Epo , Flt1 , Kdr , Lep
docetaxel pharmacodynamics pathwayAbcb1a , Abcg2
doxorubicin pharmacokinetics pathwayAbcb1a , Abcg2
E-cadherin signaling pathwayAkt1 , Efna1
eicosanoid signaling pathwayAkt1
endocytosis pathwayCxcr4 , Flt1 , Kdr , Smad3 , Tfrc
endometrial cancer pathwayAkt1 , Elk1
Endoplasmic Reticulum-associated degradation pathwayOs9 , Rbx1
endothelin signaling pathwayAkt1 , Edn1 , Fos , Jun , Nos2
energy homeostasis pathwayLep
Entamoebiasis pathwayItgb2 , Nos2
ephrin - ephrin receptor bidirectional signaling axisCxcr4 , Efna1 , Tf
epidermal growth factor/neuregulin signaling pathwayAkt1 , Elk1 , Jun
erlotinib pharmacodynamics pathwayAbcb1a , Abcg2
erythropoietic porphyria pathwayFech , Hmox1
erythropoietin signaling pathwayEpo
estrogen signaling pathwayCrebbp , Ep300 , Ncoa1 , Ncoa2
etoposide pharmacodynamics pathwayAbcb1a
etoposide pharmacokinetics pathwayAbcb1a
facilitative sugar transporter mediated glucose transport pathwaySlc2a1
Fanconi syndrome pathwayAldoa , Eno1 , Hk2
FasL mediated signaling pathwayAkt1
Fc epsilon receptor mediated signaling pathwayAkt1
Fc gamma receptor mediated signaling pathwayAkt1
fibrinolysis pathwaySerpine1
fibroblast growth factor signaling pathwayAkt1 , Fos , Jun
follicle-stimulating hormone signaling pathwayCreb1
forkhead class A signaling pathwayAkt1 , Creb1 , Crebbp , Ep300 , Fos , Gck , Hnf4a , Igfbp1 , Jun , Sp1 , Tfrc
french type sialuria pathwayHk1
fructose and mannose metabolic pathwayAldoa , Hk1 , Hk2 , Pfkfb3 , Pfkl
fructose-1,6-bisphosphatase deficiency pathwayAldoa , Eno1 , Hk2 , Pgm1
fructosuria pathwayAldoa , Hk1 , Pfkl
galactokinase deficiency pathwayGck , Pgm1
galactose metabolic pathwayGck , Hk1 , Hk2 , Pfkl , Pgm1
galactosemia pathwayGck , Hk1 , Pgm1
GALE deficiency pathwayGck , Pgm1
glioma pathwayAkt1
gluconeogenesis pathwayAldoa , Eno1 , Gck , Hk1 , Hk2 , Ldha , Pfkl , Pgk1 , Pgm1
Glut1 deficiency syndrome pathwaySlc2a1
glycogen biosynthetic pathwayGck , Pgm1
glycogen degradation pathwayPgm1
glycogen metabolic pathwayGck
glycogen storage disease type Ia pathwayAldoa , Eno1 , Hk2 , Pgm1
glycogen storage disease type Ib pathwayAldoa , Eno1 , Hk2 , Pgm1
glycogen storage disease type III pathwayGck , Hk2 , Pgm1
glycogen storage disease type IV pathwayGck , Hk2 , Pgm1
glycogen storage disease type VI pathwayGck , Hk2 , Pgm1
glycogen storage disease type VII pathwayAldoa , Eno1 , Hk2
glycolysis pathwayAldoa , Eno1 , Gck , Hk1 , Hk2 , Ldha , Pfkfb3 , Pfkl , Pgk1 , Pgm1 , Pkm
glycolysis/gluconeogenesis pathwayAldoa , Eno1 , Gck , Hk1 , Hk2 , Ldha , Pfkl , Pgk1 , Pgm1
glypican signaling pathwayFlt1 , Furin , Vegfa
gonadotropin-releasing hormone signaling pathwayElk1 , Jun , Mmp14
granulocyte-macrophage colony-stimulating factor signaling pathwayFos
Hedgehog signaling pathwayAkt1 , Crebbp
heme biosynthetic pathwayFech
heme degradation pathwayHmox1
hepatitis C pathwayAkt1 , Eif3el1
hereditary coproporphyria pathwayFech , Hmox1
hereditary fructose intolerance syndrome pathwayAldoa , Hk1 , Pfkl
histamine signaling pathway, immunologicalCreb1
histone modification pathwayCrebbp , Ep300 , Hdac7
Huntington's disease pathwayCreb1 , Crebbp , Ep300 , Sp1
hypertension pathwayHmox1
hypoxia inducible factor pathwayAbcb1a , Abcg2 , Adm , Adora2a , Akt1 , Aldoa , Apex1 , Arnt , Arnt2 , Bhlhe40 , Bhlhe41 , Bnip3 , Car9 , Cited2 , Cops5 , Cp , Creb1 , Crebbp , Cul2 , Cxcl12 , Cxcr4 , Edn1 , Efna1 , Egln1 , Egln2 , Egln3 , Eif3el1 , Elk1 , Elob , Eloc , Eng , Eno1 , Ep300 , Epas1 , Epo , Ets1 , Fech , Flt1 , Fos , Furin , Fxn , Gata2 , Gck , Hdac7 , Hif1a , Hif1an , Hif3a , Hk1 , Hk2 , Hmox1 , Hnf4a , Id2 , Igfbp1 , Itgb2 , Jun , Kdr , Ldha , Lep , Mcl1 , Mmp14 , Ncoa1 , Ncoa2 , Ndrg1 , Nos2 , Npm1 , Nt5e , Os9 , Pfkfb3 , Pfkl , Pgk1 , Pgm1 , Pkm , Plin2 , Pou5f1 , Rack1 , Rbx1 , Sat1 , Sat2 , Serpine1 , Slc11a2 , Slc2a1 , Smad3 , Smad4 , Sp1 , Tert , Tf , Tff3 , Tfrc , Twist1 , Vegfa , Vhl
inflammatory response pathwayEdn1
influenza A pathwayAkt1 , Crebbp , Ep300 , Furin , Jun
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1
insulin secretion pathwayGck
insulin signaling pathwayAkt1 , Elk1 , Gck , Hk1 , Hk2
insulin-like growth factor signaling pathwayAkt1 , Igfbp1 , Rack1
integrin mediated signaling pathwayItgb2
interleukin-1 signaling pathwayJun
interleukin-12 signaling pathwayFos , Nos2
interleukin-2 signaling pathwayFos , Jun
interleukin-23 signaling pathwayNos2
interleukin-4 signaling pathwayAkt1 , Ets1 , Sp1 , Tff3
interleukin-6 signaling pathwayAkt1 , Fos , Jun , Mcl1
intrinsic apoptotic pathwayBnip3 , Mcl1
irinotecan pharmacodynamics pathwayAbcb1a , Abcg2
irinotecan pharmacokinetics pathwayAbcb1a , Abcg2
iron efflux pathwayCp
iron uptake pathwaySlc11a2 , Tf , Tfrc
Jak-Stat signaling pathwayAkt1 , Crebbp , Ep300 , Epo , Lep
lactose biosynthetic pathwaySlc2a1
lamivudine pharmacokinetics pathwayAbcb1a , Abcg2 , Pgk1
Leishmaniasis pathwayElk1 , Fos , Itgb2 , Jun , Nos2
leptin system pathwayLep
long term potentiationCrebbp , Ep300
luteinizing hormone signaling pathwayCreb1
malaria pathwayItgb2
maturity-onset diabetes of the young pathwayGck , Hnf4a
measles pathwayAkt1 , Rack1
melanoma pathwayAkt1
mitochondrial autophagy pathwayBnip3
mitogen activated protein kinase signaling pathwayAkt1 , Elk1 , Fos , Jun
monoterpenoid biosynthetic pathwayNt5e
mTOR signaling pathwayAkt1 , Bnip3 , Hif1a , Vegfa
mycophenolic acid pharmacokinetics pathwayAbcb1a , Abcg2
myocarditis pathwayItgb2
neddylation pathwayCul2 , Rbx1
neurotrophic factor signaling pathwayAkt1 , Jun
niacin metabolic pathwayNt5e
non-small cell lung carcinoma pathwayAkt1
Notch signaling pathwayCrebbp , Eno1 , Ep300 , Furin
nuclear factor kappa B signaling pathwayRbx1
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp , Rbx1
nucleotide excision repair pathwayRbx1
nucleotide sugar metabolic pathwayGck , Hk1 , Hk2 , Pgm1
oxygen homeostasis pathwaySerpine1
p38 MAPK signaling pathwayAdm
p53 signaling pathwayAkt1 , Crebbp , Ep300 , Serpine1
pancreatic cancer pathwayAkt1 , Smad3 , Smad4 , Vegfa
paracetamol pharmacokinetics pathwayAbcb1a , Abcg2
pentose phosphate pathwayAldoa , Pfkl , Pgm1
phagocytosis pathwayItgb2 , Tfrc
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1
phosphoenolpyruvate carboxykinase deficiency pathwayAldoa , Eno1 , Hk2 , Pgm1
platelet-derived growth factor signaling pathwayElk1 , Fos , Jun
polyamine metabolic pathwaySat1
porphyrin and chlorophyll metabolic pathwayCp , Fech , Hmox1
porphyrin metabolic pathwayFech , Hmox1
prion disease pathwayElk1
propanoate metabolic pathwayLdha
prostate cancer pathwayAkt1 , Creb1 , Crebbp , Ep300 , Ncoa2
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesCul2 , Rbx1 , Vhl
protein kinase C (PKC) signaling pathwayRack1
purine metabolic pathwayNt5e , Pgm1
pyrimidine metabolic pathwayNt5e
pyruvate metabolic pathwayLdha , Pkm
Reelin signaling pathwayAkt1
renal cell carcinoma pathwayAkt1 , Arnt , Arnt2 , Crebbp , Cul2 , Egln1 , Egln2 , Egln3 , Elob , Eloc , Ep300 , Epas1 , Ets1 , Hif1a , Jun , Rbx1 , Slc2a1 , Vegfa , Vhl
retinoic acid signaling pathwayNcoa1 , Ncoa2
rheumatoid arthritis pathwayCxcl12 , Flt1 , Fos , Itgb2 , Jun , Vegfa
Rho/Rac/Cdc42 mediated signaling pathwayJun
ribose 5-phosphate isomerase deficiency pathwayAldoa , Pfkl , Pgm1
ribosome biogenesis pathwayRack1
RNA degradation pathwayEno1
RNA polymerase I transcription pathwayCrebbp
RNA transport pathwayEif3el1
serotonin signaling pathway via receptors engaging G alphas protein familyCreb1
sialic acid storage disease pathwayHk1
small cell lung carcinoma pathwayAkt1 , Nos2
spermidine metabolic pathwaySat1
spermine metabolic pathwaySat1
sphingosine 1-phosphate signaling pathwayAkt1 , Cxcr4 , Elk1 , Flt1 , Fos , Jun , Kdr , Vegfa
Staphylococcus aureus infection pathwayItgb2
starch and sucrose metabolic pathwayGck , Hk1 , Hk2 , Pgm1
syndecan signaling pathwayCxcl12 , Cxcr4 , Rack1
T cell receptor signaling pathwayAkt1 , Fos , Jun
Tay-Sachs disease pathwayHk1
Toll-like receptor signaling pathwayAkt1 , Fos , Jun
toxoplasmosis pathwayAkt1 , Nos2
transaldolase deficiency pathwayAldoa , Pfkl , Pgm1
transforming growth factor-beta Smad dependent signaling pathwayCreb1 , Crebbp , Smad3 , Smad4
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Ep300 , Id2 , Rbx1 , Smad3 , Smad4 , Sp1
translation initiation pathwayEif3el1
trehalose degradation pathwayGck
triosephosphate isomerase deficiency pathwayAldoa , Eno1 , Hk2 , Pgm1
tuberculosis pathwayAkt1 , Creb1 , Crebbp , Ep300 , Itgb2 , Nos2
tumor necrosis factor mediated signaling pathwayRack1
type 2 diabetes mellitus pathwayGck , Hk1 , Hk2
type II interferon signaling pathwayAkt1 , Crebbp , Ep300
tyrosinemia type III pathwayAbcb1a , Abcg2
ubiquitin/proteasome degradation pathwayCul2 , Elob , Eloc , Rbx1 , Vhl
urinary bladder cancer pathwayVegfa
variegate porphyria pathwayFech , Hmox1
vascular endothelial growth factor signaling pathwayAkt1 , Egln1 , Egln2 , Egln3 , Flt1 , Hif1a , Kdr , Vegfa
vasopressin signaling pathway via receptor type 2Creb1
venlafaxine pharmacokinetics pathwayAbcb1a
vinblastine pharmacodynamics pathwayAbcb1a
vincristine pharmacodynamics pathwayAbcb1a
vindesine pharmacodynamics pathwayAbcb1a
vinorelbine pharmacodynamics pathwayAbcb1a
Wnt signaling pathwayCrebbp , Ep300 , Jun , Rbx1 , Smad3 , Smad4
Wnt signaling, canonical pathwayCrebbp
Phenotype Annotations Associated with Genes in the hypoxia inducible factor pathway

References Associated with the hypoxia inducible factor pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: