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PYRUVATE METABOLIC PATHWAY (PW:0000043)

View Ontology Report

Description

The pyruvate metabolic pathway, the sum of biochemical reactions involving pyruvate, is at the intersection of pathways important for glucose and energy homeostasis. Reaction 10 at the end of glycolysis, carried out by pyruvate kinases, converts phosphoenolpyruvate (PEP) to ATP and pyruvate which can be converted to acetyl-CoA or anaerobically to lactate (considered the end of anaerobic glycolysis). Pyruvate, and to a much lesser extent acetyl-CoA, can also be derived from the breakdown of sever

Pathway Diagram:

Ariadne Genomics Inc. Pdp members Pdk members Dld Dlat Pdha1 pyruvate ---> acetyl-CoA Pdhx Pdhb thiamine-diphosphate Pkm2 Pklr Pc oxaloacetate ---> acetyl-CoA oxaloacetate ---> gluconeogenesis pathway pyruvate ---> oxaloacetate pyruvate fatty acid beta degradation pathway ---> acetyl-CoA acetyl-CoA ---> fatty acid biosynthetic pathway glycolysis pathway ---> pyruvate oxaloacetate acetyl-CoA ---> citrate cycle pathway acetyl-CoA acetyl-CoA <--> ketone bodies metabolic pathway Pdk members ---| Pdha1 Pdp members --+> Pdha1 glycolysis pathway gluconeogenesis pathway citrate cycle pathway ketone bodies metabolic pathway fatty acid beta degradation pathway fatty acid biosynthetic pathway
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Genes in Pathway:


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pyruvate metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha IEA
ISO
KEGG
SMPDB
SMP:00060 rno:00620 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acacb acetyl-CoA carboxylase beta IEA KEGG rno:00620 NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 IEA
ISO
KEGG
SMPDB
SMP:00060 rno:00620 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 IEA KEGG rno:00620 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
JBrowse link
G Acot12 acyl-CoA thioesterase 12 IEA
ISO
KEGG
SMPDB
SMP:00060 rno:00620 NCBI chr 2:22,986,867...23,027,538
Ensembl chr 2:22,986,626...23,027,536
JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 IEA KEGG rno:00620 NCBI chr 3:139,450,383...139,500,325
Ensembl chr 3:139,450,383...139,500,325
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 IEA
ISO
KEGG
SMPDB
SMP:00060 rno:00620 NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
JBrowse link
G Acyp1 acylphosphatase 1 IEA
ISO
KEGG
SMPDB
SMP:00060 rno:00620 NCBI chr 6:104,919,162...104,932,348
Ensembl chr 6:104,919,162...104,932,387
JBrowse link
G Acyp2 acylphosphatase 2 IEA KEGG rno:00620 NCBI chr14:104,201,894...104,371,415
Ensembl chr14:104,201,895...104,371,386
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 IEA
ISO
KEGG
SMPDB
SMP:00060 rno:00620 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 IEA KEGG rno:00620 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 IEA KEGG rno:00620 NCBI chr 1:218,201,443...218,241,410 JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 IEA KEGG rno:00620 NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member IEA
ISO
KEGG
SMPDB
SMP:00060 rno:00620 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 IEA KEGG rno:00620 NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 IEA KEGG rno:00620 NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193
JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 IEA KEGG rno:00620 NCBI chr13:79,505,738...79,522,539
Ensembl chr13:79,505,695...79,540,568
JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase ISO
IEA
KEGG
SMPDB
RGD
PMID:11795479 SMP:00060 rno:00620, RGD:2307427 NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
JBrowse link
G Dld dihydrolipoamide dehydrogenase ISO
IEA
KEGG
SMPDB
RGD
PMID:11795479 SMP:00060 rno:00620, RGD:2307427 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795
JBrowse link
G Glo1 glyoxalase 1 IEA
ISO
KEGG
SMPDB
SMP:00060 rno:00620 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Grhpr glyoxylate and hydroxypyruvate reductase ISO SMPDB SMP:00060 NCBI chr 5:59,234,179...59,243,614
Ensembl chr 5:59,234,192...59,243,603
JBrowse link
G Hagh hydroxyacyl glutathione hydrolase IEA
ISO
KEGG
SMPDB
SMP:00060 rno:00620 NCBI chr10:13,874,883...13,889,527
Ensembl chr10:13,875,241...13,889,504
JBrowse link
G Ldha lactate dehydrogenase A IEA KEGG rno:00620 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Ldhal1 lactate dehydrogenase A like 1 IEA KEGG rno:00620 NCBI chr 8:30,363,220...30,364,836 JBrowse link
G Ldhal6b lactate dehydrogenase A-like 6B IEA KEGG rno:00620 NCBI chr 1:45,997,845...45,999,268
Ensembl chr 1:45,991,991...45,999,272
JBrowse link
G Ldhb lactate dehydrogenase B IEA KEGG rno:00620 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
JBrowse link
G Ldhc lactate dehydrogenase C IEA KEGG rno:00620 NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378
JBrowse link
G Ldhd lactate dehydrogenase D IEA
ISO
KEGG
SMPDB
SMP:00060 rno:00620 NCBI chr19:39,583,529...39,588,397
Ensembl chr19:39,573,621...39,595,575
JBrowse link
G Mdh1 malate dehydrogenase 1 IEA
ISO
KEGG
SMPDB
SMP:00060 rno:00620 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
JBrowse link
G Mdh2 malate dehydrogenase 2 IEA KEGG rno:00620 NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271
JBrowse link
G Me1 malic enzyme 1 IEA
ISO
KEGG
SMPDB
SMP:00060 rno:00620 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Me2 malic enzyme 2 IEA
ISO
KEGG
SMPDB
SMP:00060 rno:00620 NCBI chr18:67,350,833...67,400,987
Ensembl chr18:67,355,795...67,400,987
JBrowse link
G Me3 malic enzyme 3 IEA KEGG rno:00620 NCBI chr 1:143,534,024...143,735,551
Ensembl chr 1:143,534,139...143,733,132
JBrowse link
G Pc pyruvate carboxylase IEA
IDA
ISO
KEGG
SMPDB
RGD
PMID:15507531 SMP:00060 rno:00620, RGD:1601554 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 IEA
ISO
KEGG lists it, no info KEGG
SMPDB
SMP:00060 rno:00620 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) IEA KEGG rno:00620 NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 IEA
ISO
KEGG lists it but there is info KEGG
SMPDB
RGD
PMID:11795479 SMP:00060 rno:00620, RGD:2307427 NCBI chr  X:34,700,481...34,714,309
Ensembl chr  X:34,700,409...34,714,311
JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 IEA
ISO
KEGG
RGD
PMID:11795479 rno:00620, RGD:2307427 NCBI chr 2:229,872,300...229,873,848 JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta ISO
IEA
KEGG
SMPDB
RGD
PMID:11795479 SMP:00060 rno:00620, RGD:2307427 NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500
JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X ISO RGD PMID:11795479 RGD:2307427 NCBI chr 3:89,372,248...89,431,779
Ensembl chr 3:89,371,497...89,431,773
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 ISO RGD PMID:11795479 PMID:17310282 RGD:2307427, RGD:2307428 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 ISO RGD PMID:11795479 PMID:17310282 RGD:2307427, RGD:2307428 NCBI chr10:79,972,550...79,987,074
Ensembl chr10:79,972,556...79,987,085
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 ISO RGD PMID:11795479 PMID:17310282 RGD:2307427, RGD:2307428 NCBI chr  X:58,486,699...58,553,533
Ensembl chr  X:58,486,554...58,553,557
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 ISO RGD PMID:11795479 PMID:17310282 RGD:2307427, RGD:2307428 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Pdp1 pyruvate dehydrogenase phosphatase catalytic subunit 1 ISO RGD PMID:17310282 RGD:2307428 NCBI chr 5:25,446,843...25,455,107
Ensembl chr 5:25,446,272...25,455,217
JBrowse link
G Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 ISO RGD PMID:17310282 RGD:2307428 NCBI chr19:386,408...394,068
Ensembl chr19:386,406...394,074
JBrowse link
G Pklr pyruvate kinase L/R IEA
IDA
ISO
KEGG
SMPDB
RGD
PMID:4273555 SMP:00060 rno:00620, RGD:2302790 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Pkm pyruvate kinase M1/2 IDA RGD PMID:4273555 RGD:2302790 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassPdk memberspyruvate dehydrogenase kinase members
Functional ClassPdp memberspyruvate dehydrogenase phosphatase members

Pathway Gene Annotations

Disease Annotations Associated with Genes in the pyruvate metabolic pathway
Disease TermsGene Symbols
3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndromeAcat2
Acetyl-Coa Carboxylase DeficiencyAcaca
acromesomelic dysplasia, Maroteaux typeGrhpr
Acute Alcohol SensitivityAldh2
Acute Coronary SyndromeLdhb
Acute Liver FailureLdha , Mdh1
acute promyelocytic leukemiaMe1
adult respiratory distress syndromeAkr1b1 , Mdh1
adult-onset autosomal dominant demyelinating leukodystrophyAldh7a1
Aicardi-Goutieres Syndrome 3Pc
AlbuminuriaAkr1b1
alcohol dependenceAldh2
alcohol use disorderAldh2
alcohol-induced mental disorderAldh2
Alcoholic Fatty LiverAldh2
alcoholic liver cirrhosisAldh2
Alcoholic Liver DiseasesAldh2
allergic diseaseAkr1b1
Alzheimer's diseaseAldh2 , Pck1
AMED syndromeAldh2
Animal Disease ModelsLdha
Animal Mammary NeoplasmsMdh2 , Pkm
anxiety disorderGlo1
arteriosclerosisAcat1 , Acat2 , Akr1b1
asthmaAldh2
ataxia telangiectasiaAcat1 , Dlat
atherosclerosisAcaca
autism spectrum disorderAcaca , Acacb , Aldh1a1 , Aldh2 , Aldh3a2
autistic disorderAcaca , Aldh3a2 , Glo1 , Pdha1 , Pdk3
autosomal dominant dyskeratosis congenita 6Pdp2
azoospermiaPdha2
Bardet-Biedl syndromeMdh1
benign neonatal seizuresAldh7a1
beta-ketothiolase deficiencyAcat1 , Acat2
BH4-deficient hyperphenylalaninemia ADlat
bipolar disorderPc
Bloom syndromeLdhal6b , Pkm
bone diseaseAldh7a1
brain diseaseMdh2
brain infarctionAldh2
brain ischemiaMdh2
Brain-Lung-Thyroid SyndromePck2
Breast NeoplasmsAcacb , Ldhal6b , Ldhb
Burkitt lymphomaPc
BurnsPklr
carbohydrate metabolic disorderAcat1
carcinomaMdh2 , Pkm
Cardiac FibrosisAcacb
cardiomyopathyLdha , Pdk2
CardiotoxicityAcacb
Carney-Stratakis syndromeDlat
cataractAkr1b1
cataract 5 multiple typesPdp2
celiac diseasePck1
Charcot-Marie-Tooth diseasePdk3
Charcot-Marie-Tooth disease type 2Pklr
Charcot-Marie-Tooth disease X-linked dominant 6Pdk3
Chemical and Drug Induced Liver InjuryAldh2 , Aldh9a1 , Dlat , Mdh1 , Me1 , Pc , Pdk4
cholestasisAldh1b1
Chromosome 11, Partial Trisomy 11qAcat1 , Dlat
chromosome 17q12 deletion syndromeAcaca
Chromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MBMdh2
Chronic Intermittent HypoxiaPck1
chronic recurrent multifocal osteomyelitisAcyp2
Coffin-Lowry syndromePdha1
colobomaAldh7a1
Colonic NeoplasmsAldh1b1
colorectal cancerLdhal6b , Pkm
Colorectal NeoplasmsAldh2
common variable immunodeficiency 2Aldh3a2
congenital disorder of glycosylation IlDlat
Congenital Infantile Lactic AcidosisPc
Congenital Infantile Lactic Acidosis due to LAD DeficiencyDld
congenital nonspherocytic hemolytic anemiaPklr
congestive heart failureAcaca , Mdh2 , Pck1
coronary artery diseaseAcat2
COVID-19Aldh9a1 , Grhpr , Ldha , Me1 , Pck2 , Pkm
Creutzfeldt-Jakob diseaseAldh1a1
Cytosolic Acetoacetyl-CoA Thiolase DeficiencyAcat2
depressive disorderGlo1
developmental and epileptic encephalopathy 1Aldh7a1 , Hagh , Pdk3
developmental and epileptic encephalopathy 13Aldh7a1
developmental and epileptic encephalopathy 2Pdha1
developmental and epileptic encephalopathy 51Mdh2
developmental and epileptic encephalopathy 88Mdh1
Developmental DisabilitiesAcyp1 , Pc
Diabetes ComplicationsAkr1b1 , Aldh2 , Glo1
Diabetic NephropathiesAkr1b1 , Glo1
diabetic neuropathyAkr1b1 , Aldh2
diabetic retinopathyAkr1b1 , Glo1
Diastolic DysfunctionAcacb
dilated cardiomyopathy 1IIDlat
dilated cardiomyopathy 1OLdhb
Disease ProgressionAldh7a1 , Pdha1
distal arthrogryposis type 1AGrhpr
ductal carcinoma in situLdhb
early-onset vitamin B6-dependent epilepsy 4Aldh7a1
Elevated Adenosine Triphosphate of ErythrocytesPklr
end stage renal diseaseAcat1 , Glo1
Endometrial NeoplasmsAkr1b1
endometriosisAkr1b1
EndotoxemiaPck1 , Pck2
Endotoxin-Induced UveitisAkr1b1
epilepsyAldh7a1 , Hagh , Pdha1 , Pdhb
esophageal cancerAldh2
Esophageal NeoplasmsAldh2
esophagus squamous cell carcinomaAldh2 , Glo1
Experimental Diabetes MellitusAkr1b1 , Pc , Pck1 , Pdk4 , Pdp2 , Pklr
Experimental Liver CirrhosisAcat1 , Akr1b1 , Aldh1a1 , Aldh1b1 , Aldh2 , Hagh , Ldhb , Mdh1 , Pc , Pck1 , Pck2 , Pklr
Experimental Mammary NeoplasmsMdh2 , Pkm
Experimental MelanomaAcss1 , Acss2
Experimental NeoplasmsLdha
exudative vitreoretinopathy 1Me3
familial adenomatous polyposis 1Aldh7a1
familial hypocalciuric hypercalcemiaGrhpr
Fanconi syndromeLdha
Fetal Growth RetardationPck1
FlushingAldh2
focal segmental glomerulosclerosis 6Ldhal6b
frontotemporal dementia and/or amyotrophic lateral sclerosis 6Grhpr
galactose epimerase deficiencyAldh7a1
galactosemiaAkr1b1 , Grhpr
gastrointestinal stromal tumorAldh9a1 , Pklr
Gaucher's diseasePklr
genetic diseaseAcat1 , Aldh1b1 , Aldh3a2 , Aldh7a1 , Dlat , Dld , Ldha , Mdh2 , Me3 , Pc , Pck1 , Pdha1 , Pdhb , Pdhx , Pdp1 , Pklr
Genetic Predisposition to DiseaseAldh2
glutathione synthetase deficiencyAcss2
glycogen storage disease IXAPdha1
Glycogen Storage Disease XILdha
Glyoxalase II DeficiencyHagh
heart diseaseAldh2
Heart InjuriesAldh2
hemolytic anemiaPklr
Hemorrhagic ShockAldh1a7
hepatocellular carcinomaAcaca , Akr1b1 , Aldh2 , Aldh7a1 , Me1 , Pck1 , Pdk4 , Pkm
HepatomegalyAldh1b1
hereditary breast ovarian cancer syndromeAcaca , Aldh7a1
Hereditary Neoplastic SyndromesAldh7a1
heroin dependenceAldh2
hydrocephalusAldh7a1
HyperalgesiaAkr1b1
HypercholesterolemiaAcat2
hyperglycemiaAkr1b1 , Ldha , Pck1 , Pklr
hyperinsulinismPklr
hyperphosphatasia with impaired intellectual development syndrome 5Acaca
hypertensionAldh2 , Ldha , Mdh1 , Pkm
HypertriglyceridemiaAcaca , Acacb , Pklr
hypertrophic cardiomyopathyAcacb
hypertrophic cardiomyopathy 12Ldha , Ldhc
hypokalemiaAkr1b1
HypothermiaAcss1
HypoxiaPck2
idiopathic generalized epilepsyHagh
immunodeficiency 23Me1
immunodeficiency 42Pklr
immunodeficiency with hyper IgM type 5Acacb
InflammationAcss2 , Akr1b1
inherited metabolic disorderLdhb
Insulin ResistanceAcaca , Acacb , Aldh2 , Pklr
intellectual disabilityAcat1 , Acyp1 , Aldh7a1 , Dlat , Ldha , Ldhc , Me2 , Me3 , Pc , Pdhx
Joubert syndrome 1Aldh3a2 , Pdp1
Kidney Reperfusion InjuryAldh2 , Glo1
Lactate Dehydrogenase B DeficiencyLdhb
lactic acidosisPdha1
Lactic Aciduria due to D-Lactic AcidLdhd
Leigh diseaseDld
Leigh Necrotizing Encephalopathy due to Pyruvate Carboxylase DeficiencyPc
Leigh Syndrome, X-LinkedPdha1 , Pdhx
LeukoencephalopathiesAldh7a1
lissencephaly 5Dld
liver cancerAcot12 , Aldh2
liver diseaseAldh1a1 , Aldh2
Liver InjuryMdh1
Liver Reperfusion InjuryAldh2
long QT syndromeAcss2
lung adenocarcinomaLdha
lung diseaseLdhc
lymphangioleiomyomatosisAcss2 , Pkm
lysinuric protein intolerancePck2
macular corneal dystrophyLdhd
malariaPklr
male infertilityAldh2 , Ldhc
maple syrup urine diseaseDld
Meckel Syndrome 9Aldh3a2
melanomaAldh1a1 , Glo1
MelanosisAldh2
metabolic dysfunction-associated steatohepatitisAcaca , Pck1
metabolic dysfunction-associated steatotic liver diseaseAcaca , Acacb , Aldh1a1 , Aldh1b1 , Aldh2 , Pdk4 , Pklr
Metabolic SyndromeAcaca , Acacb , Acat2 , Pck1
MHC class II deficiencyPklr
mitochondrial metabolism diseasePdha1
morbid obesityAcss2
myocardial infarctionAldh2 , Ldha , Mdh2
Myocardial IschemiaAkr1b1 , Aldh2 , Dlat , Pdha1 , Pdk4
Myocardial Reperfusion InjuryAldh2
myoglobinuriaLdha
Nance-Horan syndromePdha1
Neoplasm InvasivenessLdhb , Pkm
Neoplastic Cell TransformationAldh1a1
nephrocalcinosisGrhpr
nephrogenic diabetes insipidusAkr1b1
nephrotic syndromeAcat1
Nervous System MalformationsAldh7a1
Neurodevelopmental DisordersAcaca , Acot12 , Aldh7a1 , Pdha1 , Pdk3
Niemann-Pick disease type C1Acyp1
Niemann-Pick disease type C2Acyp1
obesityAcacb , Me1 , Pck1 , Pdp1 , Pklr
occupational dermatitisAldh2
orofacial cleftAcss2
osteoarthritisPdha1
osteogenesis imperfecta type 1Pdk2
osteoporosisPkm
ovarian carcinomaMdh2
pancreatic cancerAldh1a1 , Aldh2 , Ldha
paraplegiaGrhpr , Ldhd
parathyroid carcinomaAldh9a1 , Pklr
Parkinson's diseaseAldh2
ParkinsonismAldh1a1
perinatal necrotizing enterocolitisAldh2
Phosphoenolpyruvate Carboxykinase DeficiencyPck1
Phosphoenolpyruvate Carboxykinase Deficiency, CytosolicPck1
Phosphoenolpyruvate Carboxykinase Deficiency, MitochondrialPck2
pleomorphic xanthoastrocytomaAkr1b1 , Dld , Mdh2 , Pdk4
Potocki-Lupski syndromeAldh3a2
pre-malignant neoplasmAldh2
primary ciliary dyskinesiaGrhpr
primary hyperoxaluriaGrhpr
primary hyperoxaluria type 2Grhpr
progressive myoclonus epilepsy 7Ldha , Ldhc
prostate cancerAldh9a1 , Dlat , Pdk4 , Pdp2
Prostatic NeoplasmsGrhpr , Ldhb , Pdha1 , Pdp1
pyridoxine-dependent epilepsyAldh7a1
pyruvate carboxylase deficiency diseasePc
pyruvate decarboxylase deficiencyDld , Pdha1 , Pdhb , Pdhx , Pdp1
Pyruvate Dehydrogenase E1 Alpha DeficiencyPdha1 , Pdhx
Pyruvate Dehydrogenase E1-Beta DeficiencyPdhb
Pyruvate Dehydrogenase E2 DeficiencyDlat
Pyruvate Dehydrogenase E3-Binding Protein DeficiencyPdhx
Pyruvate Dehydrogenase Phosphatase DeficiencyPdhb , Pdp1
pyruvate kinase deficiency of red cellsPklr
Pyruvate Metabolism, Inborn ErrorsPdha1
Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular MalformationsPc
renal cell carcinomaAldh1a1 , Ldhb , Pdhb
Reperfusion InjuryPklr
retinitis pigmentosa 27Pck2
Right Ventricular HypertrophyMe1 , Me2
sarcomaPdhx
schizophreniaAcaca
SepsisAldh2
severe congenital neutropenia 3Pklr
severe congenital neutropenia 5Pklr
short-rib thoracic dysplasia 9 with or without polydactylyHagh
Sjogren-Larsson syndromeAldh3a2
Sleep DeprivationDlat
Specific Granule DeficiencyPck2
spermatogenic failure 1Pdha2
Spermatogenic Failure 70Pdha2
split hand-foot malformation 5Pdk1
steatotic liver diseaseAcaca , Acacb , Acat1
stomach cancerAkr1b1
Stomach NeoplasmsAldh7a1 , Pdha1
Subacute Necrotizing Encephalopathy of Leigh, InfantileDld
sudden infant death syndromePdha1
syndromic X-linked intellectual disability Lubs typePdha1 , Pdk3
Tay-Sachs diseasePkm
trichodontoosseous syndromePdk2
tuberous sclerosis 2Hagh
type 1 diabetes mellitusAldh2
type 2 diabetes mellitusAkr1b1 , Aldh2 , Glo1 , Pc , Pck1 , Pklr
vascular diseaseAldh2 , Glo1
Ventricular DysfunctionAldh2
VentriculomegalyAldh7a1
visual epilepsyAldh7a1
Weight GainMe1
Pathway Annotations Associated with Genes in the pyruvate metabolic pathway
Pathway TermsGene Symbols
2-aminoadipic 2-oxoadipic aciduria pathwayAcat1 , Aldh7a1 , Dld
3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathwayAcat1 , Aldh2 , Dld
3-hydroxyacyl-CoA dehydrogenase deficiency pathwayAcat1
3-hydroxyisobutyric aciduria pathwayAcat1 , Aldh2 , Dld
3-methylcrotonyl CoA carboxylase 1 deficiency pathwayAcat1 , Aldh2 , Dld
3-methylglutaconic aciduria type 1 pathwayAcat1 , Aldh2 , Dld
3-methylglutaconic aciduria type 3 pathwayAcat1 , Aldh2 , Dld
alanine metabolic pathwayPc
alendronate pharmacodynamics pathwayAcat2
altered galactose metabolic pathwayAkr1b1
arginine and proline metabolic pathwayAldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1
ascorbate and aldarate metabolic pathwayAldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1
beta-alanine metabolic pathwayAldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1
butanoate metabolic pathwayAcat1 , Acat2 , Pdha1 , Pdha2 , Pdhb
carnitine biosynthetic pathwayAldh9a1
carnitine palmitoyltransferase I deficiency pathwayAcat1
carnosinemia pathwayAldh2
cholesterol biosynthetic pathwayAcat2
cholesterol ester storage disease pathwayAcat2
choline metabolic pathwayAldh7a1
citric acid cycle pathwayDlat , Dld , Mdh1 , Mdh2 , Pc , Pck1 , Pck2 , Pdha1 , Pdha2 , Pdhb
congenital hemidysplasia with ichthyosiform erythroderma and limb defects pathwayAcat2
cyclophosphamide pharmacodynamics pathwayAldh1a1
cyclophosphamide pharmacokinetics pathwayAldh1a1
cysteine and methionine metabolic pathwayLdha , Ldhal1 , Ldhal6b , Ldhb , Ldhc
D-glycericacidemia pathwayAkr1b1
desmosterolosis pathwayAcat2
diabetic nephropathy pathwayAkr1b1
dihydropyrimidine dehydrogenase deficiency pathwayAldh2 , Dld
dimethylglycine dehydrogenase deficiency pathwayAldh2 , Dld
disulfiram pharmacodynamics pathwayAcss1 , Acss2 , Aldh1b1 , Aldh2
dopa responsive dystonia pathwayAkr1b1
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaMe1 , Pck1 , Pck2
epidermal growth factor/neuregulin signaling pathwayPdk1
ethylmalonic encephalopathy pathwayAcat1
familial lipoprotein lipase deficiency pathwayAkr1b1
Fanconi syndrome pathwayPklr
fatty acid beta degradation pathwayAcat1 , Acss1 , Acss2
fatty acid biosynthetic pathwayAcaca , Acacb
fatty acid metabolic pathwayAcat1 , Acat2 , Aldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1
Fc epsilon receptor mediated signaling pathwayPdk1
folate cycle metabolic pathwayDld
forkhead class A signaling pathwayPck1 , Pklr
fructose and mannose metabolic pathwayAkr1b1
fructose-1,6-bisphosphatase deficiency pathwayMdh2 , Pc , Pck1
fructosuria pathwayAkr1b1
fumaric aciduria pathwayDlat , Dld , Mdh2 , Pc , Pdha1 , Pdhb
GABA aminotransferase deficiency pathwayAldh2
galactose metabolic pathwayAkr1b1
galactosemia pathwayAkr1b1
gluconeogenesis pathwayAcss1 , Acss2 , Aldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1 , Dlat , Dld , Ldha , Ldhal1 , Ldhal6b , Ldhb , Ldhc , Mdh2 , Pc , Pck1 , Pck2 , Pdha1 , Pdha2 , Pdhb , Pklr
glutaric aciduria type I pathwayAcat1 , Aldh7a1 , Dld
glycerol kinase deficiency pathwayAkr1b1
glycerolipid metabolic pathwayAkr1b1 , Aldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1
glycine, serine and threonine metabolic pathwayAldh7a1 , Dld
glycogen storage disease type Ia pathwayMdh2 , Pc , Pck1
glycogen storage disease type Ib pathwayMdh2 , Pc , Pck1
glycogen storage disease type VII pathwayPklr
glycolysis pathwayAcss1 , Acss2 , Aldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1 , Dlat , Dld , Ldha , Ldhal1 , Ldhal6b , Ldhb , Ldhc , Pck1 , Pck2 , Pdha1 , Pdha2 , Pdhb , Pklr , Pkm
glycolysis/gluconeogenesis pathwayAcss1 , Acss2 , Aldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1 , Dlat , Dld , Ldha , Ldhal1 , Ldhal6b , Ldhb , Ldhc , Pck1 , Pck2 , Pdha1 , Pdha2 , Pdhb , Pklr
glyoxalase metabolic pathwayGlo1 , Hagh , Ldhd
glyoxylate and dicarboxylate metabolic pathwayAcat1 , Acat2 , Mdh1 , Mdh2
hepatitis C pathwayPdk1
hereditary fructose intolerance syndrome pathwayAkr1b1
histidine metabolic pathwayAldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1
histidinemia pathwayAldh2
hypercholesterolemia pathwayAcat2
hyperlysinemia pathwayAcat1 , Aldh7a1 , Dld
hypoxia inducible factor pathwayLdha , Pkm
ibandronate pharmacodynamics pathwayAcat2
ifosfamide pharmacodynamics pathwayAldh1a1
ifosfamide pharmacokinetics pathwayAldh1a1
insulin signaling pathwayAcaca , Acacb , Pck1 , Pck2 , Pklr
isobutyryl-CoA dehydrogenase deficiency pathwayAcat1 , Aldh2 , Dld
isovaleric acidemia pathwayAcat1 , Aldh2 , Dld
ketone bodies metabolic pathwayAcat1 , Acat2
lactic acidosis pathwayPc
Leigh disease pathwayAcaca , Acat1 , Acot12 , Acss2 , Acyp1 , Akr1b1 , Aldh2 , Dlat , Dld , Glo1 , Grhpr , Hagh , Ldhd , Mdh1 , Me1 , Me2 , Pc , Pck1 , Pdha1 , Pdhb , Pklr
lysine biosynthetic pathwayAldh7a1
lysine degradation pathwayAcat1 , Acat2 , Aldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1 , Dld
malonic aciduria pathwayAcaca , Acat1 , Acss1 , Dld , Ldhal6b
maple syrup urine disease pathwayAcat1 , Aldh2 , Dld
maturity-onset diabetes of the young pathwayPklr
medium chain acyl-CoA dehydrogenase deficiency pathwayAcat1
methylmalonate semialdehyde dehydrogenase deficiency pathwayAcat1 , Aldh2 , Dld
methylmalonic acidemia pathwayAcat1 , Aldh2 , Dld
methylmalonic aciduria, cobalamin-related pathwayAcaca , Acat1 , Acss1 , Dld , Ldhal6b
mevalonic aciduria pathwayAcat2
mitochondrial complex II deficiency pathwayDlat , Dld , Mdh2 , Pc , Pdha1 , Pdhb
neurotrophic factor signaling pathwayPdk1
neviparine pharmacokinetics pathwayAldh1a1
nicotinamide adenine dinucleotide metabolic pathwayMdh1 , Mdh2
nitrogenous bisphosphonate pharmacodynamics pathwayAcat2
nonketotic hyperglycinemia pathwayAldh2 , Dld
pamidronate pharmacodynamics pathwayAcat2
pentose and glucuronate interconversion pathwayAkr1b1 , Aldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2
phosphoenolpyruvate carboxykinase deficiency pathwayMdh2 , Pc , Pck1
phytanic acid degradation pathwayAldh3a2
polyol pathwayAkr1b1
primary hyperoxaluria type 1 pathwayPc
primary hyperoxaluria type 2 pathwayAcaca , Acat1 , Acot12 , Acss2 , Acyp1 , Akr1b1 , Aldh2 , Dlat , Dld , Glo1 , Grhpr , Hagh , Ldhd , Mdh1 , Me1 , Me2 , Pc , Pck1 , Pdha1 , Pdhb , Pklr
propanoate metabolic pathwayAcaca , Acacb , Acat1 , Acat2 , Acss1 , Acss2 , Aldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1 , Dld , Ldha , Ldhal1 , Ldhal6b , Ldhb , Ldhc
propionic acidemia pathwayAcat1 , Aldh2 , Dld
prostaglandin biosynthetic pathwayAkr1b1
purine metabolic pathwayPklr
pyruvate carboxylase deficiency pathwayPc
pyruvate decarboxylase deficiency pathwayAcaca , Acat1 , Acot12 , Acss2 , Acyp1 , Akr1b1 , Aldh2 , Dlat , Dld , Glo1 , Grhpr , Hagh , Ldhd , Mdh1 , Me1 , Me2 , Pc , Pck1 , Pdha1 , Pdhb , Pklr
pyruvate dehydrogenase E1 deficiency pathwayAcaca , Acat1 , Acot12 , Acss2 , Acyp1 , Akr1b1 , Aldh2 , Dlat , Dld , Glo1 , Grhpr , Hagh , Ldhd , Mdh1 , Me1 , Me2 , Pc , Pck1 , Pdha1 , Pdhb , Pklr
pyruvate dehydrogenase E2 deficiency pathwayDlat , Dld , Mdh2 , Pc , Pdha1 , Pdhb
pyruvate dehydrogenase E3 deficiency pathwayDlat , Dld , Mdh2 , Pc , Pdha1 , Pdhb
pyruvate kinase deficiency of red cells pathwayAcaca , Acat1 , Acot12 , Acss2 , Acyp1 , Akr1b1 , Aldh2 , Dlat , Dld , Glo1 , Grhpr , Hagh , Ldhd , Mdh1 , Me1 , Me2 , Pc , Pck1 , Pdha1 , Pdhb , Pklr
pyruvate metabolic pathwayAcaca , Acacb , Acat1 , Acat2 , Acot12 , Acss1 , Acss2 , Acyp1 , Acyp2 , Akr1b1 , Aldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1 , Dlat , Dld , Glo1 , Grhpr , Hagh , Ldha , Ldhal1 , Ldhal6b , Ldhb , Ldhc , Ldhd , Mdh1 , Mdh2 , Me1 , Me2 , Me3 , Pc , Pck1 , Pck2 , Pdha1 , Pdha2 , Pdhb , Pdhx , Pdk1 , Pdk2 , Pdk3 , Pdk4 , Pdp1 , Pdp2 , Pklr , Pkm
Refsum disease pathwayAldh3a2
remethylation pathway of homocysteine metabolism - cobalamin independent, betaine dependentAldh7a1
retinoic acid metabolic pathwayAldh1a1
retinol metabolic pathwayAldh1a1
risedronate pharmacodynamics pathwayAcat2
saccharopinuria pathwayAcat1 , Aldh7a1 , Dld
sarcosinemia pathwayAldh2 , Dld
Segawa syndrome pathwayAkr1b1
short-chain acyl-CoA dehydrogenase deficiency pathwayAcat1
Smith-Lemli-Opitz Syndrome pathwayAcat2
statin pharmacodynamics pathwayAcat2
succinyl-CoA:3-oxoacid transferase deficiency pathwayAcat1
T cell receptor signaling pathwayPdk1
terpenoid biosynthetic pathwayAcat1 , Acat2
toxoplasmosis pathwayPdk1
trifunctional protein deficiency pathwayAcat1
triosephosphate isomerase deficiency pathwayMdh2 , Pc , Pck1
tryptophan metabolic pathwayAcat1 , Acat2 , Aldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1
type 2 diabetes mellitus pathwayPklr
valine, leucine and isoleucine biosynthetic pathwayPdha1 , Pdha2 , Pdhb
valine, leucine and isoleucine degradation pathwayAcat1 , Acat2 , Aldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1 , Dld
very long-chain acyl-CoA dehydrogenase deficiency pathwayAcat1
vitamin A deficiency pathwayAldh1a1
Wolman disease pathwayAcat2
X-linked dominant chondrodysplasia punctata 2 pathwayAcat2
zoledronate pharmacodynamics pathwayAcat2
Phenotype Annotations Associated with Genes in the pyruvate metabolic pathway

References Associated with the pyruvate metabolic pathway:

Ontology Path Diagram:

paths to the root
paths to the root

Import into Pathway Studio: