Lnpep (leucyl and cystinyl aminopeptidase) - Rat Genome Database

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Gene: Lnpep (leucyl and cystinyl aminopeptidase) Rattus norvegicus
Symbol: Lnpep
Name: leucyl and cystinyl aminopeptidase
RGD ID: 621752
Description: Enables aminopeptidase activity. Involved in several processes, including neuropeptide catabolic process; positive regulation of blood pressure; and regulation of long-term neuronal synaptic plasticity. Located in several cellular components, including insulin-responsive compartment; neuronal cell body; and perinuclear region of cytoplasm. Used to study type 2 diabetes mellitus. Orthologous to human LNPEP (leucyl and cystinyl aminopeptidase); PARTICIPATES IN angiotensin IV signaling pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; long term potentiation; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-naphthylamine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aminopeptidase Vp165; angiotensin IV receptor; cystinyl aminopeptidase; GP160; insulin-regulated membrane aminopeptidase IRAP; insulin-responsive aminopeptidase; IRAP; leucyl-cystinyl aminopeptidase; leucyl-cystinyl aminopeptidase-like; leucyl/cystinyl aminopeptidase; LOC100912445; LOC108348118; OTase; oxytocinase; P-LAP; placental leucine aminopeptidase; vesicle protein of 165 kDa; Vp165
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8166,931,712 - 67,027,610 (-)NCBIGRCr8
mRatBN7.2158,258,642 - 58,355,532 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl158,258,642 - 58,354,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx163,102,623 - 63,198,136 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0171,789,691 - 71,885,226 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0165,012,661 - 65,108,180 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0159,289,392 - 59,384,540 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl159,297,294 - 59,347,472 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,436,593 - 68,488,427 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0169,224,555 - 69,275,898 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4156,063,361 - 56,151,257 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1156,074,764 - 56,154,202 (-)NCBI
Celera154,460,876 - 54,549,335 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-naphthylamine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
crotonaldehyde  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
scopolamine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thimerosal  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement. Albiston AL, etal., Trends Endocrinol Metab. 2003 Mar;14(2):72-7.
2. Identification and characterization of two distinct intracellular GLUT4 pools in rat skeletal muscle: evidence for an endosomal and an insulin-sensitive GLUT4 compartment. Aledo JC, etal., Biochem J. 1997 Aug 1;325 ( Pt 3):727-32.
3. Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system. Fernando RN, etal., J Comp Neurol. 2005 Jul 11;487(4):372-90.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. A role for the angiotensin IV/AT4 system in mediating natriuresis in the rat. Hamilton TA, etal., Peptides. 2001 Jun;22(6):935-44.
7. Early primary diagnosis of ovarian cancer and detection of recurrence by serum cystine aminopeptidase assay. Kalinkov D and Buchholz R, Am J Obstet Gynecol. 1980 Dec 15;138(8):1148-50.
8. Acyl-coenzyme A dehydrogenases are localized on GLUT4-containing vesicles via association with insulin-regulated aminopeptidase in a manner dependent on its dileucine motif. Katagiri H, etal., Mol Endocrinol 2002 May;16(5):1049-59.
9. Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesicles. Keller SR, etal., J Biol Chem 1995 Oct 6;270(40):23612-8.
10. The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro. Kramar EA, etal., Brain Res. 2001 Apr 6;897(1-2):114-21.
11. The GLUT4 code. Larance M, etal., Mol Endocrinol. 2008 Feb;22(2):226-33. Epub 2007 Aug 23.
12. Cystinyl aminopeptidase activity is decreased in renal cell carcinomas. Larrinaga G, etal., Regul Pept. 2007 Dec 4;144(1-3):56-61. Epub 2007 Jun 21.
13. Insulin-regulated aminopeptidase marks an antigen-stimulated recycling compartment in mast cells. Liao H, etal., Traffic. 2006 Feb;7(2):155-67.
14. Role of insulin-dependent cortical fodrin/spectrin remodeling in glucose transporter 4 translocation in rat adipocytes. Liu L, etal., Mol Biol Cell. 2006 Oct;17(10):4249-56. Epub 2006 Jul 26.
15. Adipocytes exhibit abnormal subcellular distribution and translocation of vesicles containing glucose transporter 4 and insulin-regulated aminopeptidase in type 2 diabetes mellitus: implications regarding defects in vesicle trafficking. Maianu L, etal., J Clin Endocrinol Metab. 2001 Nov;86(11):5450-6.
16. Vp165 and GLUT4 share similar vesicle pools along their trafficking pathways in rat adipose cells. Malide D, etal., FEBS Lett. 1997 Jun 16;409(3):461-8.
17. Aminopeptidase activities in breast cancer tissue. Martinez JM, etal., Clin Chem. 1999 Oct;45(10):1797-802.
18. Involvement of the V2 receptor in vasopressin-stimulated translocation of placental leucine aminopeptidase/oxytocinase in renal cells. Masuda S, etal., Eur J Biochem 2003 May;270(9):1988-94.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. IRAP deficiency attenuates diet-induced obesity in mice through increased energy expenditure. Niwa M, etal., Biochem Biophys Res Commun. 2015 Jan 30;457(1):12-8. doi: 10.1016/j.bbrc.2014.12.071. Epub 2014 Dec 19.
22. Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory. Pearson-Leary J and McNay EC, J Neurosci. 2016 Nov 23;36(47):11851-11864. doi: 10.1523/JNEUROSCI.1700-16.2016.
23. Insulin-regulated aminopeptidase/placental leucil Aminopeptidase (IRAP/P-lAP) and angiotensin IV-forming activities are modified in serum of rats with breast cancer induced by N-methyl-nitrosourea. Pilar Carrera M, etal., Anticancer Res. 2006 Mar-Apr;26(2A):1011-4.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. The renin-angiotensin system: peptides and enzymes beyond angiotensin II. Reudelhuber TL Curr Opin Nephrol Hypertens. 2005 Mar;14(2):155-9.
27. GOA pipeline RGD automated data pipeline
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Protein kinase C-zeta phosphorylates insulin-responsive aminopeptidase in vitro at Ser-80 and Ser-91. Ryu J, etal., Arch Biochem Biophys 2002 Jul 1;403(1):71-82.
30. [Feto-placental system in diabetes mellitus and hydramnios] Savchenko ON, etal., Akush Ginekol (Mosk). 1991 Dec;(12):12-5.
31. Placental leucine aminopeptidase (P-LAP) expression is associated with chemosensitivity in human endometrial carcinoma. Shibata K, etal., Gynecol Oncol. 2004 Nov;95(2):307-13.
32. Placental leucine aminopeptidase (P-LAP) and glucose transporter 4 (GLUT4) expression in benign, borderline, and malignant ovarian epithelia. Shibata K, etal., Gynecol Oncol. 2005 Jul;98(1):11-8.
33. Expression of placental leucine aminopeptidase is associated with a poor outcome in endometrial endometrioid adenocarcinoma. Shibata K, etal., Oncology. 2004;66(4):288-95.
34. Involvement of the somatostatin-2 receptor in the anti-convulsant effect of angiotensin IV against pilocarpine-induced limbic seizures in rats. Stragier B, etal., J Neurochem. 2006 Aug;98(4):1100-13. Epub 2006 Jun 12.
35. Impaired insulin-regulated membrane aminopeptidase translocation to the plasma membrane in adipocytes of Otsuka Long Evans Tokushima Fatty rats. Takeuchi M, etal., Nagoya J Med Sci. 2006 Jun;68(3-4):155-63.
36. A Glut4-vesicle marker protein, insulin-responsive aminopeptidase, is localized in a novel vesicular compartment in PC12 cells. Thoidis G and Kandror KV, Traffic. 2001 Aug;2(8):577-87.
37. Increased decidual mRNA expression levels of candidate maternal pre-eclampsia susceptibility genes are associated with clinical severity. Yong HE, etal., Placenta. 2014 Feb;35(2):117-24. doi: 10.1016/j.placenta.2013.11.008. Epub 2013 Nov 25.
Additional References at PubMed
PMID:8119954   PMID:9668046   PMID:11062501   PMID:11108258   PMID:11884418   PMID:12490950   PMID:15691326   PMID:15800058   PMID:16343778   PMID:17169335   PMID:17897319   PMID:19468242  
PMID:19498108   PMID:19918052   PMID:19946888   PMID:20096929   PMID:21207221   PMID:23390484   PMID:26006037   PMID:26311777   PMID:27038740   PMID:28356324  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8166,931,712 - 67,027,610 (-)NCBIGRCr8
mRatBN7.2158,258,642 - 58,355,532 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl158,258,642 - 58,354,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx163,102,623 - 63,198,136 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0171,789,691 - 71,885,226 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0165,012,661 - 65,108,180 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0159,289,392 - 59,384,540 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl159,297,294 - 59,347,472 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,436,593 - 68,488,427 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0169,224,555 - 69,275,898 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4156,063,361 - 56,151,257 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1156,074,764 - 56,154,202 (-)NCBI
Celera154,460,876 - 54,549,335 (-)NCBICelera
Cytogenetic Map1q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38596,936,080 - 97,037,513 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl596,935,394 - 97,037,513 (+)EnsemblGRCh38hg38GRCh38
GRCh37596,271,784 - 96,373,217 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36596,297,102 - 96,390,871 (+)NCBINCBI36Build 36hg18NCBI36
Build 34596,297,554 - 96,390,496NCBI
Celera592,155,866 - 92,249,526 (+)NCBICelera
Cytogenetic Map5q15NCBI
HuRef591,461,444 - 91,554,831 (+)NCBIHuRef
CHM1_1595,704,043 - 95,797,761 (+)NCBICHM1_1
T2T-CHM13v2.0597,435,206 - 97,538,276 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391717,747,985 - 17,846,303 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1717,741,672 - 17,845,312 (-)EnsemblGRCm39 Ensembl
GRCm381717,527,723 - 17,624,489 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1717,521,410 - 17,625,050 (-)EnsemblGRCm38mm10GRCm38
MGSCv371717,664,687 - 17,761,453 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361717,232,341 - 17,329,107 (-)NCBIMGSCv36mm8
Celera1718,469,713 - 18,559,683 (-)NCBICelera
Cytogenetic Map17A3.2NCBI
cM Map179.77NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541815,640,143 - 15,718,711 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541815,631,703 - 15,718,711 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2492,184,252 - 92,287,343 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1590,338,199 - 90,476,858 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0592,247,060 - 92,348,900 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1597,800,922 - 97,902,830 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl597,842,110 - 97,893,876 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1312,668,994 - 12,766,712 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl312,681,577 - 12,767,183 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha314,009,029 - 14,107,850 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0312,551,891 - 12,650,977 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl312,564,239 - 12,650,899 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1312,513,108 - 12,612,033 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0312,508,231 - 12,607,129 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0312,708,005 - 12,806,860 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213168,257,072 - 168,346,916 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365236,445,939 - 6,532,566 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365236,443,571 - 6,533,122 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl2103,567,602 - 103,661,070 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12103,568,366 - 103,659,589 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22107,369,918 - 107,462,862 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2p17-p14NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1490,769,988 - 90,872,205 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl490,770,272 - 90,863,268 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604939,417,543 - 39,519,028 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474315,606,836 - 15,705,832 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474315,606,873 - 15,696,593 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Lnpep
423 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:113
Interacting mature miRNAs:125
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2158,322,365 - 58,322,590 (+)MAPPERmRatBN7.2
Rnor_6.0159,352,191 - 59,352,415NCBIRnor6.0
Rnor_5.0160,278,510 - 60,278,734UniSTSRnor5.0
RGSC_v3.4156,119,023 - 56,119,247UniSTSRGSC3.4
Celera154,516,537 - 54,516,761UniSTS
RH 3.4 Map1657.0UniSTS
Cytogenetic Map1q12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 2 2
Low 3 39 27 12 17 12 8 9 68 34 35 11 8
Below cutoff 1 3 33 24 11 24 2 4 9 4 9 5 2


RefSeq Acc Id: ENSRNOT00000017718   ⟹   ENSRNOP00000017718
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl158,258,642 - 58,354,544 (-)Ensembl
Rnor_6.0 Ensembl159,297,294 - 59,347,472 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080325   ⟹   ENSRNOP00000069259
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl158,258,642 - 58,318,387 (-)Ensembl
Rnor_6.0 Ensembl168,436,593 - 68,488,229 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088586   ⟹   ENSRNOP00000070725
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl158,258,642 - 58,318,486 (-)Ensembl
Rnor_6.0 Ensembl168,436,917 - 68,488,427 (+)Ensembl
RefSeq Acc Id: NM_001113403   ⟹   NP_001106874
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8166,931,712 - 67,027,610 (-)NCBI
mRatBN7.2158,258,642 - 58,354,544 (-)NCBI
Rnor_6.0159,297,451 - 59,384,344 (-)NCBI
Rnor_5.0169,224,555 - 69,275,898 (+)NCBI
RGSC_v3.4156,063,361 - 56,151,257 (-)RGD
Celera154,460,876 - 54,549,335 (-)RGD
RefSeq Acc Id: NP_001106874   ⟸   NM_001113403
- UniProtKB: Q11009 (UniProtKB/Swiss-Prot),   P97629 (UniProtKB/Swiss-Prot),   A6KB65 (UniProtKB/TrEMBL),   A0A0G2JUW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069259   ⟸   ENSRNOT00000080325
RefSeq Acc Id: ENSRNOP00000017718   ⟸   ENSRNOT00000017718
RefSeq Acc Id: ENSRNOP00000070725   ⟸   ENSRNOT00000088586
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97629-F1-model_v2 AlphaFold P97629 1-1025 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621752 AgrOrtholog
BioCyc Gene G2FUF-61277 BioCyc
Ensembl Genes ENSRNOG00000047387 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000055229 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017718 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000017718.7 UniProtKB/Swiss-Prot
  ENSRNOT00000080325.2 UniProtKB/TrEMBL
  ENSRNOT00000088586.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  Aminopeptidase_N-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aminopeptidase_N-like_N UniProtKB/TrEMBL
  ERAP1-like_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M1_APN-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M4/M1_CTD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171105 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11533:SF42 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ERAP1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lnpep PhenoGen
RatGTEx ENSRNOG00000047387 RatGTEx
  ENSRNOG00000055229 RatGTEx
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63737 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary Q11009 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Lnpep  leucyl and cystinyl aminopeptidase  LOC108348118  leucyl-cystinyl aminopeptidase  Data merged from RGD:11480606 737654 PROVISIONAL
2020-08-21 Lnpep  leucyl and cystinyl aminopeptidase  LOC100912445  leucyl-cystinyl aminopeptidase-like  Data merged from RGD:6487002 737654 PROVISIONAL
2016-10-26 Lnpep  leucyl and cystinyl aminopeptidase  Lnpep  leucyl/cystinyl aminopeptidase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-08-02 LOC108348118  leucyl-cystinyl aminopeptidase      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100912445  leucyl-cystinyl aminopeptidase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Lnpep  leucyl/cystinyl aminopeptidase    aminopeptidase Vp165  Name updated 1299863 APPROVED
2004-09-10 Lnpep  aminopeptidase Vp165  Vp165    Symbol and Name updated 1299863 APPROVED
2002-08-07 Vp165  aminopeptidase Vp165      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to vesicles and upon insulin stimulation is recruited to the plasma membrane  
gene_domains contains two dileucine motifs, a large extracellular catalytic domain and a single transmembrane domain