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Gene: Lnpep (leucyl and cystinyl aminopeptidase) Rattus norvegicus
Symbol: Lnpep
Name: leucyl and cystinyl aminopeptidase
Description: Exhibits aminopeptidase activity. Involved in several processes, including neuropeptide catabolic process; positive regulation of blood pressure; and regulation of long-term neuronal synaptic plasticity. Localizes to several cellular components, including the insulin-responsive compartment; neuronal cell body; and perinuclear region of cytoplasm. Used to study type 2 diabetes mellitus. Orthologous to human LNPEP (leucyl and cystinyl aminopeptidase); PARTICIPATES IN angiotensin IV signaling pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; long term potentiation; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-naphthylamine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: aminopeptidase Vp165; angiotensin IV receptor; cystinyl aminopeptidase; GP160; insulin-regulated membrane aminopeptidase IRAP; insulin-responsive aminopeptidase; IRAP; leucyl-cystinyl aminopeptidase; leucyl/cystinyl aminopeptidase; OTase; oxytocinase; P-LAP; placental leucine aminopeptidase; vesicle protein of 165 kDa; Vp165
Homo sapiens (human) : LNPEP (leucyl and cystinyl aminopeptidase)  HGNC  Alliance
Mus musculus (house mouse) : Lnpep (leucyl/cystinyl aminopeptidase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lnpep (leucyl and cystinyl aminopeptidase)
Pan paniscus (bonobo/pygmy chimpanzee) : LNPEP (leucyl and cystinyl aminopeptidase)
Canis lupus familiaris (dog) : LNPEP (leucyl and cystinyl aminopeptidase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lnpep (leucyl and cystinyl aminopeptidase)
Sus scrofa (pig) : LNPEP (leucyl and cystinyl aminopeptidase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0159,289,392 - 59,384,540 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl159,297,294 - 59,347,472 (-)Ensembl
Rnor_6.0 Ensembl168,436,593 - 68,488,427 (+)Ensembl
Rnor_5.0169,224,555 - 69,275,898 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4156,063,361 - 56,151,257 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1156,074,764 - 56,154,202 (-)NCBI
Celera154,460,876 - 54,549,335 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Lnpep
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621752
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.