Cyp2g1 (cytochrome P450, family 2, subfamily g, polypeptide 1) - Rat Genome Database

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Gene: Cyp2g1 (cytochrome P450, family 2, subfamily g, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp2g1
Name: cytochrome P450, family 2, subfamily g, polypeptide 1
RGD ID: 2477
Description: Predicted to enable arachidonate epoxygenase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in epoxygenase P450 pathway and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm. Orthologous to human CYP2G1P (cytochrome P450 family 2 subfamily G member 1, pseudogene); INTERACTS WITH 5-(2-chloroethyl)-4-methylthiazole; ammonium chloride; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CYPIIG1; cytochrome P-450; cytochrome P450 2G1; Cytochrome P450 an olfactory-specific steroid hydroxylase; cytochrome P450 olfactive; Cytochrome P450, an olfactory-specific steroid hydroxylase; cytochrome P450, subfamily 2G, polypeptide 1; cytochrome P450-OLF1; olfactive; P-450olf1; P450-OLF1
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,273,309 - 91,284,499 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl191,272,680 - 91,284,498 (+)EnsemblGRCr8
mRatBN7.2182,145,635 - 82,156,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,145,073 - 82,156,828 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx187,562,682 - 87,573,880 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,048,902 - 96,060,111 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,318,549 - 89,329,750 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,626,639 - 83,638,154 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,626,639 - 83,637,780 (+)Ensemblrn6Rnor6.0
Rnor_5.0184,842,671 - 84,853,812 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4181,918,200 - 81,929,261 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera176,564,738 - 76,575,911 (+)NCBICelera
RGSC_v3.1181,996,312 - 82,007,746 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. Olfactory-specific cytochrome P-450. cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception. Nef P, etal., J Biol Chem 1989 Apr 25;264(12):6780-5.
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2406242  


Genomics

Comparative Map Data
Cyp2g1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,273,309 - 91,284,499 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl191,272,680 - 91,284,498 (+)EnsemblGRCr8
mRatBN7.2182,145,635 - 82,156,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,145,073 - 82,156,828 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx187,562,682 - 87,573,880 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,048,902 - 96,060,111 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,318,549 - 89,329,750 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,626,639 - 83,638,154 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,626,639 - 83,637,780 (+)Ensemblrn6Rnor6.0
Rnor_5.0184,842,671 - 84,853,812 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4181,918,200 - 81,929,261 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera176,564,738 - 76,575,911 (+)NCBICelera
RGSC_v3.1181,996,312 - 82,007,746 (+)NCBI
Cytogenetic Map1q21NCBI
CYP2G1P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381940,890,826 - 40,900,508 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1940,891,219 - 40,900,155 (+)Ensemblhg38GRCh38
GRCh38.p14 Ensembl1940,890,826 - 40,912,357 (+)Ensemblhg38GRCh38
GRCh371941,396,731 - 41,406,413 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,088,964 - 46,097,897 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1938,197,246 - 38,206,180 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1937,829,744 - 37,839,435 (+)NCBIHuRef
CHM1_11941,396,451 - 41,406,129 (+)NCBICHM1_1
T2T-CHM13v2.01943,711,502 - 43,721,205 (+)NCBIT2T-CHM13v2.0
Cyp2g1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39726,508,352 - 26,520,622 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl726,508,317 - 26,520,630 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38726,808,927 - 26,821,197 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl726,808,892 - 26,821,205 (+)Ensemblmm10GRCm38
MGSCv37727,593,946 - 27,606,216 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36726,517,687 - 26,529,957 (+)NCBIMGSCv36mm8
Celera721,392,851 - 21,404,941 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map715.5NCBI
LOC484492
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,873,533 - 112,883,620 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,237,166 - 112,286,531 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01113,432,522 - 113,482,149 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11112,992,538 - 113,042,065 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,623,934 - 112,673,458 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,618,432 - 113,667,970 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CYP2G2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1649,069,613 - 49,084,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,852,062 - 44,865,622 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Cyp2g1
74 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:187
Count of miRNA genes:138
Interacting mature miRNAs:154
Transcripts:ENSRNOT00000028261
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat


Expression

RNA-SEQ Expression

appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
3 25 6 14 1 1 1 5 9 5 18 30 13

Sequence


Ensembl Acc Id: ENSRNOT00000028261   ⟹   ENSRNOP00000028261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl191,272,680 - 91,284,498 (+)Ensembl
mRatBN7.2 Ensembl182,145,073 - 82,156,828 (+)Ensembl
Rnor_6.0 Ensembl183,626,639 - 83,637,780 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102573   ⟹   ENSRNOP00000083307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl182,145,428 - 82,156,828 (+)Ensembl
RefSeq Acc Id: NM_012787   ⟹   NP_036919
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,273,309 - 91,284,498 (+)NCBI
mRatBN7.2182,145,635 - 82,156,828 (+)NCBI
Rnor_6.0183,626,639 - 83,638,154 (+)NCBI
Rnor_5.0184,842,671 - 84,853,812 (+)NCBI
RGSC_v3.4181,918,200 - 81,929,261 (+)RGD
Celera176,564,738 - 76,575,911 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101529   ⟹   XP_038957457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,275,865 - 91,284,499 (+)NCBI
mRatBN7.2182,148,191 - 82,156,862 (+)NCBI
Protein Sequences
Protein RefSeqs NP_036919 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957457 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41069 (Get FASTA)   NCBI Sequence Viewer  
  AAA41070 (Get FASTA)   NCBI Sequence Viewer  
  EDM07981 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028261
  ENSRNOP00000083307.1
GenBank Protein P10610 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036919   ⟸   NM_012787
- UniProtKB: Q64589 (UniProtKB/Swiss-Prot),   P10610 (UniProtKB/Swiss-Prot),   A6J9A3 (UniProtKB/TrEMBL),   A0A8L2QF71 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028261   ⟸   ENSRNOT00000028261
RefSeq Acc Id: XP_038957457   ⟸   XM_039101529
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000083307   ⟸   ENSRNOT00000102573

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10610-F1-model_v2 AlphaFold P10610 1-494 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2477 AgrOrtholog
BioCyc Gene G2FUF-60337 BioCyc
Ensembl Genes ENSRNOG00000020827 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028261 ENTREZGENE
  ENSRNOT00000102573.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I_CYP2A-like UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot
KEGG Report rno:25251 UniProtKB/Swiss-Prot
NCBI Gene 25251 ENTREZGENE
PANTHER CYTOCHROME P450 UniProtKB/Swiss-Prot
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp2g1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  EP450ICYP2A UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020827 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A8L2QF71 ENTREZGENE, UniProtKB/TrEMBL
  A6J9A3 ENTREZGENE, UniProtKB/TrEMBL
  CP2G1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64589 ENTREZGENE
UniProt Secondary Q64589 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp2g1  cytochrome P450, family 2, subfamily g, polypeptide 1  Cyp2g1  cytochrome P450, subfamily 2G, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cyp2g1  cytochrome P450, subfamily 2G, polypeptide 1    Cytochrome P450, an olfactory-specific steroid hydroxylase  Name updated 625702 APPROVED
2002-06-10 Cyp2g1  Cytochrome P450, an olfactory-specific steroid hydroxylase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the olfactory neuroepithelium 728178
gene_process may play a role in olfactory sensory reception 728178