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Gene: Siglec8 (sialic acid binding Ig-like lectin 8) Rattus norvegicus
Symbol: Siglec8
Name: sialic acid binding Ig-like lectin 8
Description: Predicted to have monosaccharide binding activity and sialic acid binding activity. Predicted to be involved in cell adhesion; negative regulation of inflammatory response; and negative regulation of phagocytosis, engulfment. Predicted to localize to external side of plasma membrane. Orthologous to human SIGLEC8 (sialic acid binding Ig like lectin 8); INTERACTS WITH bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); benzalkonium chloride (ortholog).
Type: gene
RefSeq Status: MODEL
Also known as: LOC292846; RGD1563073; similar to SIGLEC-like 1
Homo sapiens (human) : SIGLEC8 (sialic acid binding Ig like lectin 8)  HGNC  Alliance
Mus musculus (house mouse) : Siglece (sialic acid binding Ig-like lectin E)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : LOC103785254 (sialic acid-binding Ig-like lectin 8)
Canis lupus familiaris (dog) : LOC484344 (sialic acid-binding Ig-like lectin 13)
Heterocephalus glaber (naked mole-rat) : Siglec8 (sialic acid binding Ig like lectin 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0199,576,946 - 99,587,441 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,578,372 - 99,587,205 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01100,645,666 - 100,656,065 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,062,030 - 94,071,181 (-)NCBIRGSC3.4rn4RGSC3.4
Celera188,361,882 - 88,372,377 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Siglec8
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1563073
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.