Gene: Siglec8 (sialic acid binding Ig-like lectin 8) Rattus norvegicus
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Symbol: Siglec8
Name: sialic acid binding Ig-like lectin 8
Description: ENCODES a protein that exhibits monosaccharide binding (ortholog); sialic acid binding (ortholog); INVOLVED IN cell adhesion (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of phagocytosis, engulfment (ortholog); FOUND IN external side of plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine (ortholog); benzalkonium chloride (ortholog); pirinixic acid (ortholog)
AGR Description: Predicted to have monosaccharide binding activity and sialic acid binding activity; predicted to be involved in cell adhesion, negative regulation of inflammatory response, and negative regulation of phagocytosis, engulfment; predicted to localize to the external side of plasma membrane; orthologous to human SIGLEC8 (sialic acid binding Ig like lectin 8).
Merged Description: Predicted to have monosaccharide binding activity and sialic acid binding activity; predicted to be involved in cell adhesion, negative regulation of inflammatory response, and negative regulation of phagocytosis, engulfment; predicted to localize to the external side of plasma membrane; orthologous to human SIGLEC8 (sialic acid binding Ig like lectin 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine (ortholog); benzalkonium chloride (ortholog); pirinixic acid (ortholog).
Type: gene
RefSeq Status: MODEL
Also known as: LOC292846; RGD1563073; similar to SIGLEC-like 1
Orthologs:
Homo sapiens (human) : SIGLEC8 (sialic acid binding Ig like lectin 8)  HGNC  Alliance
Mus musculus (house mouse) : Siglece (sialic acid binding Ig-like lectin E)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : LOC103785254 (sialic acid-binding Ig-like lectin 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0199,576,946 - 99,587,441 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01100,645,666 - 100,656,065 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,062,030 - 94,071,181 (-)NCBIRGSC3.4rn4RGSC3.4
Celera188,361,882 - 88,372,377 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
  
More on Siglec8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1563073
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.