Zfp568 (zinc finger protein 568) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Zfp568 (zinc finger protein 568) Rattus norvegicus
Analyze
Symbol: Zfp568 (Ensembl: LOC108348102)
Name: zinc finger protein 568 (Ensembl:zinc finger protein 30 homolog)
RGD ID: 11363847
Description: Predicted to enable transcription cis-regulatory region binding activity and transcription corepressor binding activity. Predicted to be involved in in utero embryonic development and negative regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including convergent extension; embryonic placenta morphogenesis; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus; INTERACTS WITH bisphenol A; (1->4)-beta-D-glucan (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC102547059; LOC108348102; RGD1560682; zinc finger protein 30 homolog; zinc finger protein 420-like
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2185,206,643 - 85,257,759 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,207,579 - 85,257,505 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0188,281,402 - 88,336,445 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0189,443,124 - 89,497,831 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0189,044,324 - 89,092,701 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera179,580,762 - 79,631,808 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
Additional References at PubMed
PMID:15632090  


Genomics

Comparative Map Data
Zfp568
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2185,206,643 - 85,257,759 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,207,579 - 85,257,505 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0188,281,402 - 88,336,445 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0189,443,124 - 89,497,831 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0189,044,324 - 89,092,701 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera179,580,762 - 79,631,808 (+)NCBICelera
Cytogenetic Map1q21NCBI
Zfp568
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39729,683,380 - 29,727,707 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl729,683,380 - 29,727,707 (+)EnsemblGRCm39 Ensembl
GRCm38729,983,955 - 30,028,282 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl729,983,955 - 30,028,282 (+)EnsemblGRCm38mm10GRCm38
MGSCv37730,768,974 - 30,813,301 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36729,692,717 - 29,733,871 (+)NCBIMGSCv36mm8
Celera724,565,239 - 24,609,959 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map717.26NCBI

Variants

.
Variants in Zfp568
349 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat


Expression


Sequence


RefSeq Acc Id: NM_001419981   ⟹   NP_001406910
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2185,207,570 - 85,257,759 (+)NCBI
RefSeq Acc Id: XM_039093718   ⟹   XP_038949646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2185,206,643 - 85,257,759 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001406910 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949646 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM07807 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066106
  ENSRNOP00000066106.3
RefSeq Acc Id: XP_038949646   ⟸   XM_039093718
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001406910   ⟸   NM_001419981
Protein Domains
C2H2-type   KRAB

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-60157 BioCyc
Ensembl Genes ENSRNOG00000046652 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072762 ENTREZGENE
  ENSRNOT00000072762.4 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene LOC108348102 ENTREZGENE
PANTHER ZINC FINGER PROTEIN 200 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 436 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_4 UniProtKB/TrEMBL
PhenoGen Zfp568 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046652 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt M0R9D8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-01-06 Zfp568  zinc finger protein 568  LOC108348102  zinc finger protein 30 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 LOC108348102  zinc finger protein 30 homolog  LOC102547059  zinc finger protein 420-like  Data merged from RGD:7510295 737654 PROVISIONAL
2016-08-02 LOC108348102  zinc finger protein 30 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-12-17 LOC102547059  zinc finger protein 420-like      Symbol and Name status set to provisional 70820 PROVISIONAL