Klk5l1 (kallikrein related-peptidase 5 like 1) - Rat Genome Database

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Gene: Klk5l1 (kallikrein related-peptidase 5 like 1) Rattus norvegicus
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Symbol: Klk5l1
Name: kallikrein related-peptidase 5 like 1
RGD ID: 1598667
Description: INTERACTS WITH 17beta-estradiol; bisphenol A; Cuprizon
Type: protein-coding
RefSeq Status: MODEL
Previously known as: KAL; KALA; Kallikrein 1 renal/pancreas/salivary; kallikrein 5; kallikrein 5-like; kallikrein related-peptidase 5 like; kallikrein-2; Klk1; Klk5; Klk5l; prostate-specific antigen; RATKALA
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,694,483 - 103,705,483 (+)NCBIGRCr8
mRatBN7.2194,566,688 - 94,571,882 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.01100,055,956 - 100,058,334 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01101,112,112 - 101,123,187 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,537,507 - 94,548,507 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera188,833,565 - 88,835,943 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klk5l1Rat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in increased expression of KLK5L1 mRNACTDPMID:26496021
Klk5l1Ratbisphenol A multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in increased expression of KLK5L1 mRNA and [bisphenol A co-treated with Testosterone] results in increased expression of KLK5L1 mRNACTDPMID:26496021
Klk5l1RatCuprizon affects expressionEXP 6480464Cuprizone affects the expression of KLK5L1 mRNACTDPMID:27523638
Klk5l1Rattestosterone multiple interactionsEXP 6480464[bisphenol A co-treated with Testosterone] results in increased expression of KLK5L1 mRNACTDPMID:26496021
Klk5l1Ratvinclozolin decreases expressionEXP 6480464vinclozolin results in decreased expression of KLK5L1 mRNACTDPMID:23869203


#
Reference Title
Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:2183721   PMID:2194829   PMID:2708383   PMID:2849988   PMID:3482210   PMID:15060002   PMID:15060019   PMID:15809361   PMID:17366701   PMID:21873635  



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Variants in Klk5l1
64 total Variants

1 to 10 of 44 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat

1 to 10 of 44 rows






RefSeq Acc Id: XM_063280699   ⟹   XP_063136769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81103,694,483 - 103,705,483 (+)NCBI
Protein RefSeqs XP_063136769 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE51906 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_063136769   ⟸   XM_063280699
- UniProtKB: Q6IE13 (UniProtKB/TrEMBL)
Peptidase S1



1 to 14 of 14 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-59803 BioCyc
Gene3D-CATH Trypsin-like serine proteases UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
NCBI Gene 408211 ENTREZGENE
PANTHER KALLIKREIN-2 UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Klk5l1 PhenoGen
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Trypsin-like serine proteases UniProtKB/TrEMBL
UniProt Q6IE13 ENTREZGENE, UniProtKB/TrEMBL
1 to 14 of 14 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-25 Klk5l1  kallikrein related-peptidase 5 like 1  Klk5l  kallikrein related-peptidase 5 like  Name and Symbol changed 629549 APPROVED
2022-04-22 Klk5l  kallikrein related-peptidase 5 like  Klk5l  kallikrein 5-like  Name changed 629549 APPROVED
2008-03-17 Klk5l  kallikrein 5-like  Klk5  kallikrein 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-12-10 Klk5  kallikrein 5      Symbol and Name status set to provisional 70820 PROVISIONAL