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Gene: Abcc6 (ATP binding cassette subfamily C member 6) Rattus norvegicus
Symbol: Abcc6
Name: ATP binding cassette subfamily C member 6
Description: Exhibits ATP binding activity and ATPase activity. Predicted to be involved in transmembrane transport. Localizes to the apical plasma membrane; basolateral plasma membrane; and lateral plasma membrane. Used to study pseudoxanthoma elasticum. Human ortholog(s) of this gene implicated in arterial calcification of infancy; coronary artery disease; and pseudoxanthoma elasticum. Orthologous to human ABCC6 (ATP binding cassette subfamily C member 6); PARTICIPATES IN multidrug resistance-associated protein mediated transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: ATP-binding cassette sub-family C member 6; ATP-binding cassette, sub-family C (CFTR/MRP), member 6; ATP-binding cassette, subfamily C (CFTR/MRP), member 6; liver multidrug resistance-associated protein 6; MLP-1; MRP-like protein 1; Mrp6; multidrug resistance-associated protein 6
Homo sapiens (human) : ABCC6 (ATP binding cassette subfamily C member 6)  HGNC  Alliance
Mus musculus (house mouse) : Abcc6 (ATP-binding cassette, sub-family C (CFTR/MRP), member 6)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Abcc6 (ATP binding cassette subfamily C member 6)
Canis lupus familiaris (dog) : ABCC6 (ATP binding cassette subfamily C member 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Abcc6 (ATP binding cassette subfamily C member 6)
Sus scrofa (pig) : ABCC6 (ATP binding cassette subfamily C member 6)
more info ...
Allele / Splice: Abcc6em1Qlju   Abcc6em2Qlju   Abcc6em3Qlju   Abcc6em4Qlju   Abcc6em5Qlju  
Genetic Models: SD-Abcc6em4Qlju-/- SD-Abcc6em2Qlju-/- SD-Abcc6em2Qlju+/- SD-Abcc6em1Qlju-/- SD-Abcc6em3Qlju-/- SD-Abcc6em5Qlju-/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01101,954,786 - 102,013,252 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01103,042,723 - 103,096,453 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,448,588 - 96,524,655 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1196,526,698 - 96,602,766 (-)NCBI
Celera190,699,816 - 90,752,348 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Abcc6
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620268
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.