Abcc6 (ATP-binding cassette, sub-family C member 6) - Rat Genome Database

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Gene: Abcc6 (ATP-binding cassette, sub-family C member 6) Mus musculus
Analyze
Symbol: Abcc6
Name: ATP-binding cassette, sub-family C member 6 (Ensembl:ATP-binding cassette, sub-family C (CFTR/MRP), member 6)
RGD ID: 734434
MGI Page MGI
Description: Predicted to enable several functions, including ABC-type transporter activity; ATP binding activity; and ATP hydrolysis activity. Involved in several processes, including inhibition of non-skeletal tissue mineralization; inorganic diphosphate transport; and intracellular phosphate ion homeostasis. Located in basolateral plasma membrane. Is expressed in several structures, including bladder; blood vessel; epidermis; epithelium; and liver. Used to study pseudoxanthoma elasticum. Human ortholog(s) of this gene implicated in arterial calcification of infancy; coronary artery disease; and pseudoxanthoma elasticum. Orthologous to human ABCC6 (ATP binding cassette subfamily C member 6).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Abcc1b; ATP-binding cassette sub-family C member 6; ATP-binding cassette, sub-family C (CFTR/MRP), member 6; ATP-binding cassette, sub-family C, member 6; DCC; Dysca; dyscalc; Dyscalc1; Mr; Mrp6; multidrug resistance-associated protein 6; multidrug resistance-associated protein-6
RGD Orthologs
Human
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,625,804 - 45,679,915 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,616,979 - 45,679,726 (-)EnsemblGRCm39 Ensembl
GRCm38745,974,110 - 46,030,491 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,967,555 - 46,030,302 (-)EnsemblGRCm38mm10GRCm38
MGSCv37753,231,750 - 53,285,656 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,844,422 - 45,898,327 (-)NCBIMGSCv36mm8
MGSCv36735,552,479 - 35,606,515 (-)NCBIMGSCv36mm8
Celera741,445,055 - 41,502,729 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.64NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allyl alcohol  (EXP)
amiodarone  (ISO)
ammonium chloride  (ISO)
ATP  (ISO)
belinostat  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beryllium difluoride  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
butylated hydroxyanisole  (EXP)
calcein  (ISO)
calcein am  (ISO)
carbon nanotube  (EXP)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt atom  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (EXP,ISO)
diiodine  (EXP)
doxorubicin  (ISO)
emodin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethoxyquin  (EXP)
flutamide  (ISO)
furan  (ISO)
genistein  (EXP)
glutathione  (ISO)
glyphosate  (ISO)
GW 4064  (EXP)
Heliotrine  (ISO)
heptachlor  (ISO)
indometacin  (ISO)
inulin  (EXP)
isoniazide  (ISO)
kojic acid  (EXP,ISO)
L-ethionine  (ISO)
leukotriene C4  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (EXP)
magnesium atom  (EXP)
magnesium dichloride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
mirex  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-Ethylmaleimide-S-glutathione  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
oltipraz  (EXP)
omeprazole  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
probenecid  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
SCH 23390  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
soybean oil  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
vincristine  (ISO)
warfarin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Mutations in ABCC6 cause pseudoxanthoma elasticum. Bergen AA, etal., Nat Genet 2000 Jun;25(2):228-31.
3. A novel Q378X mutation exists in the transmembrane transporter protein ABCC6 and its pseudogene: implications for mutation analysis in pseudoxanthoma elasticum. Cai L, etal., J Mol Med (Berl). 2001 Sep;79(9):536-46.
4. ABCC6 mutations in Italian families affected by pseudoxanthoma elasticum (PXE). Gheduzzi D, etal., Hum Mutat. 2004 Nov;24(5):438-9.
5. Effect of inflammation on molecular targets and drug transporters. Hanafy S, etal., J Pharm Pharm Sci. 2012;15(3):361-75.
6. Analysis of the frequent R1141X mutation in the ABCC6 gene in pseudoxanthoma elasticum. Hu X, etal., Invest Ophthalmol Vis Sci. 2003 May;44(5):1824-9.
7. Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues. Klement JF, etal., Mol Cell Biol. 2005 Sep;25(18):8299-310.
8. Abcc6 Knockout Rat Model Highlights the Role of Liver in PPi Homeostasis in Pseudoxanthoma Elasticum. Li Q, etal., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19.
9. A mouse model of beta-thalassemia shows a liver-specific down-regulation of Abcc6 expression. Martin L, etal., Am J Pathol. 2011 Feb;178(2):774-83. doi: 10.1016/j.ajpath.2010.10.004.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Mutation detection in the ABCC6 gene and genotype-phenotype analysis in a large international case series affected by pseudoxanthoma elasticum. Pfendner EG, etal., J Med Genet. 2007 Oct;44(10):621-8. Epub 2007 Jul 6.
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Novel mutations in the ABCC6 gene of German patients with pseudoxanthoma elasticum. Schulz V, etal., Hum Biol. 2005 Jun;77(3):367-84.
20. Mutational analysis of the ABCC6 gene and the proximal ABCC6 gene promoter in German patients with pseudoxanthoma elasticum (PXE). Schulz V, etal., Hum Mutat. 2006 Aug;27(8):831.
21. Frequent mutation in the ABCC6 gene (R1141X) is associated with a strong increase in the prevalence of coronary artery disease. Trip MD, etal., Circulation. 2002 Aug 13;106(7):773-5.
Additional References at PubMed
PMID:8643601   PMID:9878516   PMID:10395807   PMID:10708515   PMID:11526197   PMID:12115029   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15039225   PMID:15489334   PMID:15802388  
PMID:15888484   PMID:15900406   PMID:16297187   PMID:16602821   PMID:16705021   PMID:16926270   PMID:16997394   PMID:17214963   PMID:17273159   PMID:17360558   PMID:17845218   PMID:17942075  
PMID:17979973   PMID:18049453   PMID:18201967   PMID:18685618   PMID:19122649   PMID:20031637   PMID:20090764   PMID:20185580   PMID:21267068   PMID:21435020   PMID:21677750   PMID:21873635  
PMID:21979437   PMID:22056557   PMID:22421595   PMID:22469843   PMID:22716256   PMID:22811557   PMID:22846719   PMID:23014343   PMID:23041262   PMID:23415960   PMID:23625951   PMID:23644099  
PMID:23746654   PMID:23774530   PMID:23935882   PMID:24277820   PMID:24330694   PMID:24352041   PMID:24479134   PMID:24586646   PMID:24670382   PMID:24675664   PMID:24732453   PMID:24969777  
PMID:24994603   PMID:25607347   PMID:26375467   PMID:27758107   PMID:27826008   PMID:28416300   PMID:28592560   PMID:28652107   PMID:28701330   PMID:29501384   PMID:29643466   PMID:29991491  
PMID:30112102   PMID:30611276   PMID:31207231   PMID:31449775   PMID:31704980   PMID:33483533   PMID:33490088   PMID:33594095   PMID:34597610   PMID:35143822   PMID:35216422   PMID:36400944  
PMID:37189419   PMID:37894722   PMID:38057332  


Genomics

Comparative Map Data
Abcc6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,625,804 - 45,679,915 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,616,979 - 45,679,726 (-)EnsemblGRCm39 Ensembl
GRCm38745,974,110 - 46,030,491 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,967,555 - 46,030,302 (-)EnsemblGRCm38mm10GRCm38
MGSCv37753,231,750 - 53,285,656 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,844,422 - 45,898,327 (-)NCBIMGSCv36mm8
MGSCv36735,552,479 - 35,606,515 (-)NCBIMGSCv36mm8
Celera741,445,055 - 41,502,729 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.64NCBI
ABCC6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381616,149,565 - 16,223,494 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1616,149,565 - 16,223,522 (-)EnsemblGRCh38hg38GRCh38
GRCh371616,243,422 - 16,317,351 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361616,150,923 - 16,224,838 (-)NCBINCBI36Build 36hg18NCBI36
Build 341616,151,490 - 16,224,815NCBI
Celera1615,923,582 - 15,972,084 (-)NCBICelera
Cytogenetic Map16p13.11NCBI
HuRef1615,637,406 - 15,701,476 (-)NCBIHuRef
HuRef1617,226,645 - 17,228,924 (+)NCBIHuRef
CHM1_11616,327,717 - 16,401,692 (-)NCBICHM1_1
T2T-CHM13v2.01616,154,422 - 16,229,003 (-)NCBIT2T-CHM13v2.0
Abcc6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,583,681 - 105,637,895 (-)NCBIGRCr8
mRatBN7.2196,447,224 - 96,501,464 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,447,251 - 96,501,464 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,833,395 - 101,887,602 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,305,383 - 110,359,590 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,595,749 - 103,649,961 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,954,786 - 102,013,252 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,959,540 - 102,013,243 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,042,723 - 103,096,453 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,448,588 - 96,524,655 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,526,698 - 96,602,766 (-)NCBI
Celera190,699,816 - 90,752,348 (-)NCBICelera
Cytogenetic Map1q22NCBI
Abcc6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955442865,238 - 922,221 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955442865,292 - 921,739 (-)NCBIChiLan1.0ChiLan1.0
ABCC6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1627,800,060 - 27,849,170 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl627,798,835 - 27,848,689 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,163,710 - 29,212,774 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0627,963,339 - 28,012,220 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl627,963,425 - 28,011,739 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1627,766,376 - 27,815,441 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0627,656,383 - 27,705,374 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0628,061,767 - 28,110,633 (+)NCBIUU_Cfam_GSD_1.0
Abcc6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344115,372,021 - 115,412,095 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365013,469,928 - 3,508,577 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl328,261,282 - 28,356,646 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1328,260,935 - 28,356,706 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2328,960,801 - 29,063,405 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1515,169,725 - 15,243,731 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl515,168,156 - 15,242,811 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606814,739,120 - 14,812,929 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624782594,511 - 640,180 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624782590,174 - 640,576 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Abcc6
1704 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:663
Count of miRNA genes:425
Interacting mature miRNAs:490
Transcripts:ENSMUST00000002850, ENSMUST00000134200, ENSMUST00000146866
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73171484565715077Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73239453266394681Mouse
4142003W3q10_mweight 3 weeks QTL 10 (mouse)Not determined3349772758148965Mouse
4142102Tailq5_mtail length QTL 5 (mouse)Not determined3349772758148965Mouse
4142218W6q17_mweight 6 weeks QTL 17 (mouse)Not determined3349772758148965Mouse
4141909W10q18_mweight 10 weeks QTL 18 (mouse)Not determined3349772758148965Mouse
1357883Epfq5_mepididymal fat pad weight QTL 5 (mouse)Not determined73349772758148965Mouse
1357634Splq7_mspleen weight QTL 7 (mouse)Not determined73349772758148965Mouse
39128210Lwq19_mliver weight QTL 19 (mouse)73349772758148965Mouse
1357469Kidq5_mkidney weight QTL 5 (mouse)Not determined73349772758148965Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73405302568053223Mouse
38501071Stsl6_mSalmonella typhimurium susceptibility locus 6 (mouse)73419942551149748Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73431688768317043Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73729942572049748Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73789138671891582Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73842154872421684Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74114882075148965Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74524974879249748Mouse
12738416Lfibq14_mliver fibrosis QTL 14 (mouse)74564899345816434Mouse
12738430Lfibq21_mliver fibrosis QTL 21 (mouse)74564899345816434Mouse

Markers in Region
D7Mit229  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38745,686,980 - 45,687,102UniSTSGRCm38
MGSCv37752,942,350 - 52,942,472UniSTSGRCm37
Celera741,149,543 - 41,149,681UniSTS
Cytogenetic Map7B3UniSTS
Cytogenetic Map7B4UniSTS
cM Map723.0UniSTS
Whitehead Genetic718.6UniSTS
G67881  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38745,979,748 - 45,979,950UniSTSGRCm38
MGSCv37753,235,118 - 53,235,320UniSTSGRCm37
Celera741,448,430 - 41,448,632UniSTS
Cytogenetic Map7B3UniSTS
cM Map729.64UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000002850   ⟹   ENSMUSP00000002850
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl745,625,804 - 45,679,726 (-)Ensembl
GRCm38.p6 Ensembl745,976,380 - 46,030,302 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209985
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl745,626,320 - 45,627,110 (-)Ensembl
GRCm38.p6 Ensembl745,976,896 - 45,977,686 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210962
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl745,616,983 - 45,622,743 (-)Ensembl
GRCm38.p6 Ensembl745,967,559 - 45,973,319 (-)Ensembl
RefSeq Acc Id: ENSMUST00000211220   ⟹   ENSMUSP00000147676
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl745,616,979 - 45,629,430 (-)Ensembl
GRCm38.p6 Ensembl745,967,555 - 45,980,006 (-)Ensembl
RefSeq Acc Id: ENSMUST00000211780
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl745,646,101 - 45,650,493 (-)Ensembl
GRCm38.p6 Ensembl745,996,677 - 46,001,069 (-)Ensembl
RefSeq Acc Id: NM_018795   ⟹   NP_061265
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,625,804 - 45,679,710 (-)NCBI
GRCm38745,976,380 - 46,030,286 (-)NCBI
MGSCv37753,231,750 - 53,285,656 (-)RGD
Celera741,445,055 - 41,502,729 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540946   ⟹   XP_006541009
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,626,869 - 45,679,915 (-)NCBI
GRCm38745,977,445 - 46,030,491 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006540947   ⟹   XP_006541010
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,632,745 - 45,679,915 (-)NCBI
GRCm38745,983,329 - 46,030,491 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006540948   ⟹   XP_006541011
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,639,718 - 45,679,915 (-)NCBI
GRCm38745,990,295 - 46,030,491 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006540949   ⟹   XP_006541012
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,646,324 - 45,679,915 (-)NCBI
GRCm38745,996,900 - 46,030,491 (-)NCBI
Sequence:
RefSeq Acc Id: XR_391346
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,632,775 - 45,679,915 (-)NCBI
GRCm38745,983,351 - 46,030,491 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_061265   ⟸   NM_018795
- UniProtKB: F8VPT2 (UniProtKB/Swiss-Prot),   A2TAJ1 (UniProtKB/Swiss-Prot),   A2TAJ0 (UniProtKB/Swiss-Prot),   Q80YB6 (UniProtKB/Swiss-Prot),   Q9R1S7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006541009   ⟸   XM_006540946
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006541010   ⟸   XM_006540947
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006541011   ⟸   XM_006540948
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006541012   ⟸   XM_006540949
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSMUSP00000147676   ⟸   ENSMUST00000211220
RefSeq Acc Id: ENSMUSP00000002850   ⟸   ENSMUST00000002850
Protein Domains
ABC transmembrane type-1   ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1S7-F1-model_v2 AlphaFold Q9R1S7 1-1498 view protein structure

Promoters
RGD ID:8664111
Promoter ID:EPDNEW_M10086
Type:initiation region
Name:Abcc6_1
Description:Mus musculus ATP-binding cassette, sub-family C (CFTR/MRP), member6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38746,030,287 - 46,030,347EPDNEW
RGD ID:6840350
Promoter ID:MM_KWN:50479
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000077531
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36753,232,891 - 53,233,391 (-)MPROMDB
RGD ID:6848061
Promoter ID:MM_ACW:44537
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ABCC6.BSEP07,   ABCC6.CSEP07,   ABCC6.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36753,234,941 - 53,235,441 (-)MPROMDB
RGD ID:6840351
Promoter ID:MM_KWN:50480
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000077530
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36753,255,916 - 53,256,416 (-)MPROMDB
RGD ID:6840346
Promoter ID:MM_KWN:50481
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000077529
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36753,285,359 - 53,285,859 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1351634 AgrOrtholog
Ensembl Genes ENSMUSG00000030834 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000002850 ENTREZGENE
  ENSMUST00000002850.8 UniProtKB/Swiss-Prot
  ENSMUST00000211220.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ABC1_TM_dom UniProtKB/Swiss-Prot
  ABC1_TM_sf UniProtKB/Swiss-Prot
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:27421 UniProtKB/Swiss-Prot
MGD MGI:1351634 ENTREZGENE
NCBI Gene 27421 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24223:SF339 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/Swiss-Prot
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ABCC6 RGD
PhenoGen Abcc6 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot
UniProt A0A1B0GRV2_MOUSE UniProtKB/TrEMBL
  A2TAJ0 ENTREZGENE
  A2TAJ1 ENTREZGENE
  F8VPT2 ENTREZGENE
  MRP6_MOUSE UniProtKB/Swiss-Prot
  Q80YB6 ENTREZGENE
  Q9R1S7 ENTREZGENE
UniProt Secondary A2TAJ0 UniProtKB/Swiss-Prot
  A2TAJ1 UniProtKB/Swiss-Prot
  F8VPT2 UniProtKB/Swiss-Prot
  Q80YB6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Abcc6  ATP-binding cassette, sub-family C member 6  Abcc6  ATP-binding cassette, sub-family C (CFTR/MRP), member 6  Symbol and/or name change 5135510 APPROVED