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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734434
Species: Mus musculus
RGD Object: Gene
Symbol: Abcc6
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 6
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ABCC6 mRNA

PMID:28433925
affects expressionISORGD:7344336480464CTDbisphenol A affects the expression of ABCC6 mRNA

PMID:30903817
decreases expressionISORGD:6202686480464CTDbisphenol A results in decreased expression of ABCC6 mRNA

PMID:25181051
multiple interactionsISORGD:6202686480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ABCC6 promoter

PMID:23359474
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.