ABCC2 (ATP binding cassette subfamily C member 2) - Rat Genome Database
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Gene: ABCC2 (ATP binding cassette subfamily C member 2) Homo sapiens
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Symbol: ABCC2
Name: ATP binding cassette subfamily C member 2
RGD ID: 619569
HGNC Page HGNC
Description: Exhibits ABC-type xenobiotic transporter activity. Involved in bile acid and bile salt transport; drug export; and drug transmembrane transport. Localizes to apical plasma membrane and cell surface. Implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); drug-induced hepatitis; leukemia (multiple); and non-alcoholic fatty liver disease. Biomarker of cholestasis and pancreatic cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABC30; ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; canalicular multidrug resistance protein; canalicular multispecific organic anion transporter 1; CMOAT; cMRP; DJS; KIAA1010; MRP2; multidrug resistance-associated protein 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1099,782,640 - 99,852,594 (+)EnsemblGRCh38hg38GRCh38
GRCh381099,782,602 - 99,853,741 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710101,542,397 - 101,612,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610101,532,493 - 101,601,571 (+)NCBINCBI36hg18NCBI36
Build 3410101,532,562 - 101,601,571NCBI
Celera1095,279,806 - 95,349,643 (+)NCBI
Cytogenetic Map10q24.2NCBI
HuRef1095,169,835 - 95,239,503 (+)NCBIHuRef
CHM1_110101,824,803 - 101,894,655 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (EXP,ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
(S)-colchicine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2',3'-dideoxyadenosine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-acetamidofluorene  (EXP,ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3',4',7-trihydroxyisoflavone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
4'-epidoxorubicin  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
5(6)-carboxy-2',7'-dichlorofluorescein  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP)
5-chloromethylfluorescein diacetate  (EXP)
5-fluorouracil  (EXP)
5-formyltetrahydrofolic acid  (ISO)
5-methoxypsoralen  (EXP)
6-bromoindirubin-3'-oxime  (EXP)
6-carboxyfluorescein  (EXP)
6-propyl-2-thiouracil  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (ISO)
abietic acid  (ISO)
acadesine  (ISO)
acetamide  (ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (EXP)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
allyl alcohol  (ISO)
alpha-amanitin  (ISO)
aluminium hydroxide  (ISO)
amiodarone  (ISO)
angelicin  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP)
atazanavir sulfate  (EXP)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP,ISO)
azathioprine  (EXP,ISO)
aztreonam  (ISO)
benzbromarone  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzoylaconine  (EXP)
benzoylhypaconine  (EXP)
benzoylmesaconine  (EXP)
benzylpenicillin  (EXP,ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP,ISO)
bilirubin IXalpha  (ISO)
biochanin A  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (EXP)
bisphenol A  (EXP,ISO)
Boldine  (ISO)
bortezomib  (EXP)
bosentan  (EXP,ISO)
bromfenac  (EXP)
bromosulfophthalein  (EXP)
bucladesine  (EXP,ISO)
buspirone  (ISO)
buta-1,3-diene  (ISO)
butanal  (EXP)
butylated hydroxyanisole  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcein  (EXP)
calcein am  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbon monoxide  (ISO)
carboplatin  (EXP)
carmustine  (EXP)
cefaloridine  (ISO)
cefalotin  (ISO)
celecoxib  (EXP)
cerivastatin  (EXP)
chenodeoxycholic acid  (EXP,ISO)
chlorambucil  (EXP)
chlordecone  (EXP)
chlorogenic acid  (ISO)
chloroquine  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholic acid  (EXP,ISO)
choline  (ISO)
chrysin  (EXP)
chrysophanol  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
citalopram  (EXP)
clobazam  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
clotrimazole  (EXP)
colforsin daropate hydrochloride  (EXP)
coniferyl aldehyde  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
curcumin  (EXP)
cyazofamid  (EXP)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
dapsone  (ISO)
daunorubicin  (EXP)
DDE  (ISO)
DDT  (EXP)
demethoxycurcumin  (EXP)
deoxycholic acid  (ISO)
desloratadine  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP)
diclofenac  (EXP,ISO)
dicrotophos  (EXP)
dieldrin  (EXP)
diethyl maleate  (ISO)
dimethylarsinic acid  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
doramapimod  (ISO)
dorsomorphin  (ISO)
dothiepin  (EXP)
doxorubicin  (ISO)
DPDPE  (ISO)
E3040  (EXP)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
estrone 3-sulfate  (EXP,ISO)
etacrynic acid  (EXP)
ethoxyquin  (ISO)
etoposide  (EXP)
fenofibrate  (ISO)
Fexofenadine hydrochloride  (EXP,ISO)
fipronil  (ISO)
Fluo-3  (ISO)
flutamide  (ISO)
fluvastatin  (EXP,ISO)
formononetin  (EXP,ISO)
fosinopril  (EXP,ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
furan  (ISO)
furosemide  (EXP,ISO)
fusidic acid  (ISO)
geneticin  (EXP)
genistein  (EXP)
gentamycin  (ISO)
geraniol  (ISO)
Ginkgolide A  (EXP)
ginkgolide B  (EXP)
ginsenoside Rb2  (ISO)
ginsenoside Re  (EXP,ISO)
ginsenoside Rg1  (EXP,ISO)
ginsenoside Rg2  (ISO)
glafenine  (ISO)
glucose  (ISO)
glutathione  (EXP,ISO)
glutathione disulfide  (ISO)
glyburide  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
Goe 6976  (EXP,ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
hepoxilin A3  (ISO)
heptachlor  (EXP)
Heptachlor epoxide  (ISO)
hydrogen peroxide  (EXP,ISO)
Hypaconitine  (EXP)
imipenem hydrate  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
irinotecan  (EXP,ISO)
iron(III) nitrilotriacetate  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP,ISO)
kojic acid  (ISO)
KT 5720  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP,ISO)
L-methionine  (ISO)
leukotriene C4  (EXP,ISO)
levetiracetam  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP,ISO)
lopinavir  (EXP)
Loratadine  (EXP)
lovastatin  (EXP,ISO)
luteolin  (ISO)
LY294002  (EXP)
macitentan  (EXP)
manganese(II) chloride  (ISO)
Maprotiline  (ISO)
Meclizine  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
Mesaconitine  (EXP)
metformin  (EXP)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (EXP)
methylarsonic acid  (EXP,ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (ISO)
metronidazole  (ISO)
microcystin LF  (EXP)
microcystin RR  (EXP)
microcystin-LR  (EXP,ISO)
Midecamycin  (EXP,ISO)
mifepristone  (ISO)
MK 571  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mono(glucosyluronic acid)bilirubin  (ISO)
monosodium L-glutamate  (ISO)
montelukast  (EXP)
myricetin  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (ISO)
N-Vinyl-2-pyrrolidone  (ISO)
nelfinavir  (EXP)
neomycin  (ISO)
nifedipine  (ISO)
nimesulide  (ISO)
nitric oxide  (EXP,ISO)
nitrogen dioxide  (EXP)
nocodazole  (EXP)
norgestimate  (EXP)
notoginsenoside R1  (EXP,ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
olmesartan  (EXP)
oltipraz  (EXP,ISO)
organoselenium compound  (EXP)
orphenadrine  (ISO)
ortho-Aminoazotoluene  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (EXP,ISO)
pantoprazole  (EXP)
paracetamol  (EXP,ISO)
paroxetine  (EXP)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (ISO)
phalloidin  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP,ISO)
phenol red  (ISO)
phenytoin  (EXP,ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
physcion  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (EXP,ISO)
pitavastatin(1-)  (EXP,ISO)
platinum  (EXP)
platinum(0)  (EXP)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (EXP,ISO)
prochloraz  (ISO)
progesterone  (EXP)
propane-1,2-diol  (ISO)
protein kinase inhibitor  (ISO)
Prulifloxacin  (ISO)
psoralen  (ISO)
pyrazinecarboxamide  (ISO)
pyrrolidines  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
robinetin  (EXP)
rosuvastatin calcium  (EXP,ISO)
rubitecan  (EXP)
S-(2,4-dinitrophenyl)glutathione  (EXP,ISO)
S-nitrosoglutathione  (ISO)
saquinavir  (EXP)
selenium atom  (ISO)
senecionine  (EXP,ISO)
sevoflurane  (ISO)
simvastatin  (EXP,ISO)
sincalide  (EXP)
sirolimus  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
sodium hydrogencarbonate  (ISO)
sorafenib  (EXP)
soybean oil  (ISO)
spironolactone  (ISO)
stilbene oxide  (ISO)
streptozocin  (ISO)
succimer  (EXP,ISO)
sulfasalazine  (ISO)
sulfinpyrazone  (EXP)
sulforaphane  (EXP,ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
taurine  (ISO)
tauro-beta-muricholic acid  (ISO)
taurochenodeoxycholic acid  (ISO)
taurocholic acid  (ISO)
taurolithocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
Temocaprilat  (ISO)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
texas red  (ISO)
thiacloprid  (ISO)
thioacetamide  (ISO)
thiophanate-methyl  (ISO)
thyroxine  (ISO)
tiagabine  (ISO)
ticlopidine  (EXP,ISO)
Tolvaptan  (EXP)
topiramate  (ISO)
topotecan  (EXP)
trans-piceid  (EXP)
trichostatin A  (EXP)
triclosan  (EXP)
trimethylarsine oxide  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
tyrphostin AG 1478  (ISO)
uranium atom  (ISO)
urethane  (EXP)
ursodeoxycholic acid  (EXP,ISO)
vadimezan  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
verapamil  (EXP)
vincaleukoblastine  (EXP,ISO)
vincristine  (EXP)
vitamin E  (ISO)
wortmannin  (ISO)
Y-27632  (EXP)
Yangonin  (ISO)
yohimbine  (ISO)
zearalenone  (EXP)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anion transmembrane transport  (IEA)
antibiotic metabolic process  (ISO)
benzylpenicillin metabolic process  (IEA,ISO)
bile acid and bile salt transport  (IMP,ISO)
bile acid signaling pathway  (IEA,ISO)
bilirubin transport  (IMP)
canalicular bile acid transport  (IEA,ISO)
cellular chloride ion homeostasis  (IEA,ISO)
cellular response to dexamethasone stimulus  (IEA,ISO)
cellular response to drug  (IEA,ISO)
cellular response to interleukin-1  (IEA,ISO)
cellular response to interleukin-6  (IEA,ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
detoxification of mercury ion  (ISO)
drug export  (IMP)
drug transmembrane transport  (IMP)
female pregnancy  (IEA,ISO)
heme catabolic process  (TAS)
inflammatory response  (IEA,ISO)
leukotriene transport  (IMP,ISO)
mercury ion transport  (IEA,ISO)
negative regulation of gene expression  (ISO,ISS)
organic anion transport  (IEA,ISO)
prostaglandin transport  (IEA,ISO)
regulation of bile acid secretion  (IEA,ISO)
regulation of gene expression  (ISO)
response to 17alpha-ethynylestradiol  (IEA,ISO)
response to antineoplastic agent  (IEA,ISO)
response to arsenic-containing substance  (IEA,ISO)
response to drug  (ISO)
response to estradiol  (IEA,ISO)
response to estrogen  (IEA,ISO)
response to glucagon  (IEA,ISO)
response to heat  (IEA,ISO)
response to lipopolysaccharide  (ISO)
response to methotrexate  (IEA,ISO)
response to oxidative stress  (IEA,ISO)
response to steroid hormone  (ISO)
thyroid hormone transport  (IEA,ISO)
transepithelial transport  (ISO,ISS)
transmembrane transport  (IBA,IEA,TAS)
transport across blood-brain barrier  (NAS)
xenobiotic catabolic process  (IEA,ISO)
xenobiotic detoxification by transmembrane export across the plasma membrane  (IEA,ISO)
xenobiotic transport across blood-brain barrier  (ISO,ISS)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
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49. Zollner G, etal., Digestion. 2014;90(2):81-8. doi: 10.1159/000365003. Epub 2014 Sep 4.
Additional References at PubMed
PMID:7559771   PMID:8797578   PMID:8894702   PMID:9185779   PMID:9284939   PMID:9425227   PMID:9525973   PMID:9878557   PMID:10361853   PMID:10464142   PMID:10496535   PMID:10573531  
PMID:11004020   PMID:11076395   PMID:11093739   PMID:11266082   PMID:11477083   PMID:11500505   PMID:11677213   PMID:11745434   PMID:11937269   PMID:11952788   PMID:12068294   PMID:12130697  
PMID:12222674   PMID:12388192   PMID:12395335   PMID:12477932   PMID:12576456   PMID:12615054   PMID:12628490   PMID:12702717   PMID:12704183   PMID:12890151   PMID:12942343   PMID:12960109  
PMID:14568249   PMID:15211708   PMID:15226675   PMID:15519273   PMID:15801936   PMID:15848949   PMID:15870973   PMID:15922475   PMID:16041239   PMID:16330681   PMID:16332456   PMID:16341674  
PMID:16385451   PMID:16426233   PMID:16505951   PMID:16542205   PMID:16628674   PMID:16672223   PMID:16712791   PMID:16771603   PMID:16788565   PMID:16791115   PMID:16821592   PMID:16946557  
PMID:17047488   PMID:17060857   PMID:17083032   PMID:17112803   PMID:17145840   PMID:17156953   PMID:17185998   PMID:17287630   PMID:17403188   PMID:17478601   PMID:17485564   PMID:17494643  
PMID:17578901   PMID:17606722   PMID:17622941   PMID:17725603   PMID:17825285   PMID:17890284   PMID:17906856   PMID:17924828   PMID:17925548   PMID:17997497   PMID:18038766   PMID:18176959  
PMID:18180270   PMID:18192894   PMID:18221820   PMID:18245269   PMID:18334920   PMID:18381564   PMID:18381794   PMID:18416940   PMID:18439156   PMID:18445995   PMID:18498916   PMID:18509327  
PMID:18518855   PMID:18597651   PMID:18676680   PMID:18690847   PMID:18695635   PMID:18697280   PMID:18799096   PMID:18838068   PMID:18946804   PMID:18974617   PMID:18981587   PMID:19010343  
PMID:19017997   PMID:19038257   PMID:19074644   PMID:19098406   PMID:19167193   PMID:19170196   PMID:19214140   PMID:19343046   PMID:19349540   PMID:19400747   PMID:19415824   PMID:19421150  
PMID:19442037   PMID:19480556   PMID:19494809   PMID:19513507   PMID:19541926   PMID:19568750   PMID:19581412   PMID:19625176   PMID:19636001   PMID:19692168   PMID:19696793   PMID:19730281  
PMID:19771428   PMID:19776292   PMID:19842932   PMID:19857663   PMID:19865079   PMID:19885582   PMID:19885591   PMID:19890061   PMID:19937833   PMID:19944137   PMID:19956635   PMID:19956884  
PMID:20061166   PMID:20082599   PMID:20102361   PMID:20124171   PMID:20147615   PMID:20173083   PMID:20193114   PMID:20200426   PMID:20204280   PMID:20216337   PMID:20351751   PMID:20368715  
PMID:20404332   PMID:20439344   PMID:20453000   PMID:20530282   PMID:20565459   PMID:20658178   PMID:20679960   PMID:20702406   PMID:20720558   PMID:20738239   PMID:20839930   PMID:20922799  
PMID:20973683   PMID:21039333   PMID:21044052   PMID:21059598   PMID:21072184   PMID:21134393   PMID:21160029   PMID:21170509   PMID:21206495   PMID:21449672   PMID:21451505   PMID:21541183  
PMID:21691255   PMID:21799461   PMID:21864659   PMID:21873635   PMID:21899702   PMID:21918980   PMID:21945491   PMID:21986666   PMID:21988832   PMID:22027652   PMID:22062654   PMID:22095822  
PMID:22112610   PMID:22186618   PMID:22201120   PMID:22256867   PMID:22275271   PMID:22307138   PMID:22318656   PMID:22407408   PMID:22428913   PMID:22454528   PMID:22469515   PMID:22473764  
PMID:22534871   PMID:22630058   PMID:22664480   PMID:22673116   PMID:22676135   PMID:22695893   PMID:22744337   PMID:22899102   PMID:22922069   PMID:22939629   PMID:22955427   PMID:23052037  
PMID:23069858   PMID:23131697   PMID:23135210   PMID:23190519   PMID:23222202   PMID:23232902   PMID:23237922   PMID:23278697   PMID:23381786   PMID:23506516   PMID:23562342   PMID:23633119  
PMID:23697249   PMID:23700788   PMID:23717663   PMID:23841074   PMID:23896815   PMID:24325761   PMID:24552501   PMID:24567120   PMID:24624913   PMID:24641901   PMID:24711118   PMID:24732756  
PMID:24737748   PMID:24743544   PMID:24788661   PMID:25155934   PMID:25162314   PMID:25163515   PMID:25388687   PMID:25425682   PMID:25744397   PMID:25788542   PMID:25793771   PMID:25801567  
PMID:25823783   PMID:25847339   PMID:25890497   PMID:26067485   PMID:26109419   PMID:26212029   PMID:26292095   PMID:26295158   PMID:26350512   PMID:26403473   PMID:26500117   PMID:26502886  
PMID:26590417   PMID:26681017   PMID:27109321   PMID:27180762   PMID:27394416   PMID:27527855   PMID:27590272   PMID:27816260   PMID:27886333   PMID:27943270   PMID:28196047   PMID:28405913  
PMID:28442702   PMID:28532626   PMID:28532671   PMID:28753789   PMID:29052767   PMID:29178257   PMID:29453415   PMID:29464551   PMID:29660381   PMID:29724294   PMID:29873816   PMID:30021884  
PMID:30024814   PMID:30280653   PMID:30345879   PMID:30360603   PMID:30458661   PMID:30629142   PMID:30639242   PMID:30652415   PMID:30767719   PMID:30783141   PMID:30896644   PMID:30959153  
PMID:31132291   PMID:31195293   PMID:31244920   PMID:31316180   PMID:31615114   PMID:31677118   PMID:31691080   PMID:31870219   PMID:31874997   PMID:32727778   PMID:33208122  


Genomics

Comparative Map Data
ABCC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1099,782,640 - 99,852,594 (+)EnsemblGRCh38hg38GRCh38
GRCh381099,782,602 - 99,853,741 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710101,542,397 - 101,612,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610101,532,493 - 101,601,571 (+)NCBINCBI36hg18NCBI36
Build 3410101,532,562 - 101,601,571NCBI
Celera1095,279,806 - 95,349,643 (+)NCBI
Cytogenetic Map10q24.2NCBI
HuRef1095,169,835 - 95,239,503 (+)NCBIHuRef
CHM1_110101,824,803 - 101,894,655 (+)NCBICHM1_1
Abcc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391943,770,747 - 43,826,771 (+)NCBIGRCm39mm39
GRCm39 Ensembl1943,770,631 - 43,829,179 (+)Ensembl
GRCm381943,782,308 - 43,838,332 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1943,782,192 - 43,840,740 (+)EnsemblGRCm38mm10GRCm38
MGSCv371943,856,798 - 43,912,708 (+)NCBIGRCm37mm9NCBIm37
MGSCv361943,835,715 - 43,891,248 (+)NCBImm8
Celera1944,567,463 - 44,621,438 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.67NCBI
Abcc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21242,664,657 - 242,723,239 (+)NCBI
Rnor_6.0 Ensembl1263,554,453 - 263,613,252 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01263,554,426 - 263,612,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01270,999,832 - 271,057,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1238,483,399 - 238,539,595 (+)NCBICelera
Cytogenetic Map1q54NCBI
Abcc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555075,724,762 - 5,790,812 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555075,724,788 - 5,791,281 (+)NCBIChiLan1.0ChiLan1.0
ABCC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11099,889,021 - 99,947,452 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1099,889,160 - 99,947,270 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01096,385,534 - 96,458,571 (+)NCBIMhudiblu_PPA_v0panPan3
ABCC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2812,670,885 - 12,740,740 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12812,670,885 - 12,740,124 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Abcc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936636292,631 - 341,999 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14110,955,656 - 111,078,873 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114110,955,698 - 111,038,898 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,400,787 - 120,484,137 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1992,826,423 - 92,902,389 (+)NCBI
ChlSab1.1 Ensembl992,841,818 - 92,902,265 (+)Ensembl
Abcc2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473711,593,701 - 11,686,790 (+)NCBI

Position Markers
G49565  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710101,587,239 - 101,587,441UniSTSGRCh37
Build 3610101,577,229 - 101,577,431RGDNCBI36
Celera1095,324,594 - 95,324,796RGD
Cytogenetic Map10q24UniSTS
HuRef1095,214,592 - 95,214,794UniSTS
TNG Radiation Hybrid Map1047371.0UniSTS
RH119574  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710101,543,217 - 101,543,495UniSTSGRCh37
Build 3610101,533,207 - 101,533,485RGDNCBI36
Celera1095,280,560 - 95,280,838RGD
Cytogenetic Map10q24UniSTS
HuRef1095,170,589 - 95,170,867UniSTS
TNG Radiation Hybrid Map1047330.0UniSTS
SHGC-154232  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710101,606,213 - 101,606,527UniSTSGRCh37
Build 3610101,596,203 - 101,596,517RGDNCBI36
Celera1095,344,194 - 95,344,508RGD
Cytogenetic Map10q24UniSTS
HuRef1095,234,054 - 95,234,368UniSTS
TNG Radiation Hybrid Map1047375.0UniSTS
ABCC2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710101,590,132 - 101,590,540UniSTSGRCh37
Build 3610101,580,122 - 101,580,530RGDNCBI36
Celera1095,327,484 - 95,327,892RGD
HuRef1095,217,481 - 95,217,889UniSTS
D10S2172  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710101,553,310 - 101,553,745UniSTSGRCh37
Build 3610101,543,300 - 101,543,735RGDNCBI36
Celera1095,290,654 - 95,291,089RGD
Cytogenetic Map10q24UniSTS
HuRef1095,180,685 - 95,181,120UniSTS
GeneMap99-GB4 RH Map10467.38UniSTS
Whitehead-RH Map10558.4UniSTS
Whitehead-YAC Contig Map10 UniSTS
NCBI RH Map101089.7UniSTS
D10S2421  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710101,556,986 - 101,557,154UniSTSGRCh37
Build 3610101,546,976 - 101,547,144RGDNCBI36
Celera1095,294,333 - 95,294,501RGD
Cytogenetic Map10q24UniSTS
HuRef1095,184,364 - 95,184,532UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR297hsa-miR-297OncomiRDBexternal_infoNANA22676135

Predicted Target Of
Summary Value
Count of predictions:759
Count of miRNA genes:574
Interacting mature miRNAs:638
Transcripts:ENST00000370434, ENST00000370449, ENST00000496621
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 110 5 425 425 59 429 93 5 27 130 17 59 15 22 1
Low 1957 1760 872 164 1398 32 3906 1326 1149 207 1215 1368 140 1184 2459 3
Below cutoff 369 1218 424 32 479 3 356 862 2528 73 213 178 30 5 307 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006717630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006717631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011539291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017015675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_945604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_945605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF144630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF163577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ005200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ245625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ245626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ245627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL133353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL392107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC136419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM765259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB120555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS172499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GM000488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U49248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U63970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U66683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X96395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000370434
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1099,782,763 - 99,798,096 (+)Ensembl
RefSeq Acc Id: ENST00000496621
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1099,792,289 - 99,794,623 (+)Ensembl
RefSeq Acc Id: ENST00000647814   ⟹   ENSP00000497274
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1099,782,640 - 99,852,594 (+)Ensembl
RefSeq Acc Id: ENST00000647836
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1099,782,640 - 99,796,692 (+)Ensembl
RefSeq Acc Id: ENST00000648324   ⟹   ENSP00000497248
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1099,782,705 - 99,799,215 (+)Ensembl
RefSeq Acc Id: ENST00000648523   ⟹   ENSP00000497778
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1099,845,749 - 99,852,044 (+)Ensembl
RefSeq Acc Id: ENST00000648689   ⟹   ENSP00000496972
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1099,782,640 - 99,794,348 (+)Ensembl
RefSeq Acc Id: ENST00000649459
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1099,843,710 - 99,850,713 (+)Ensembl
RefSeq Acc Id: ENST00000649493   ⟹   ENSP00000496847
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1099,782,803 - 99,799,220 (+)Ensembl
RefSeq Acc Id: ENST00000649932   ⟹   ENSP00000498120
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1099,782,705 - 99,799,220 (+)Ensembl
RefSeq Acc Id: NM_000392   ⟹   NP_000383
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381099,782,640 - 99,852,594 (+)NCBI
GRCh3710101,542,457 - 101,611,662 (+)NCBI
Build 3610101,532,493 - 101,601,571 (+)NCBI Archive
HuRef1095,169,835 - 95,239,503 (+)ENTREZGENE
CHM1_110101,824,803 - 101,894,655 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006717630   ⟹   XP_006717693
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381099,796,667 - 99,853,741 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006717631   ⟹   XP_006717694
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381099,782,602 - 99,830,396 (+)NCBI
Sequence: