Predicted to enable histone H3K4 methyltransferase activity; unmethylated CpG binding activity; and zinc ion binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within female gamete generation; ovarian follicle development; and regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of MLL1/2 complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; colorectal adenocarcinoma; dystonia; and hepatocellular carcinoma. Orthologous to human KMT2B (lysine methyltransferase 2B); PARTICIPATES IN histone modification pathway; INTERACTS WITH bisphenol A; glyphosate; (1->4)-beta-D-glucan (ortholog).
[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of KMT2B mRNA and [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of KMT2B mRNA
Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis.
Epigenetic Role of Histone Lysine Methyltransferase and Demethylase on the Expression of Transcription Factors Associated with the Epithelial-to-Mesenchymal Transition of Lung Adenocarcinoma Metastasis to the Brain.
Integration of hepatitis B virus DNA into the myeloid/lymphoid or mixed-lineage leukemia (MLL4) gene and rearrangements of MLL4 in human hepatocellular carcinoma.