Kmt2b (lysine methyltransferase 2B) - Rat Genome Database

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Gene: Kmt2b (lysine methyltransferase 2B) Rattus norvegicus
Analyze
Symbol: Kmt2b
Name: lysine methyltransferase 2B
RGD ID: 7678027
Description: Predicted to enable histone H3K4 methyltransferase activity; unmethylated CpG binding activity; and zinc ion binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within female gamete generation; ovarian follicle development; and regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of MLL1/2 complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; colorectal adenocarcinoma; dystonia; and hepatocellular carcinoma. Orthologous to human KMT2B (lysine methyltransferase 2B); PARTICIPATES IN histone modification pathway; INTERACTS WITH bisphenol A; glyphosate; (1->4)-beta-D-glucan (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: histone-lysine N-methyltransferase 2B; histone-lysine N-methyltransferase 2B-like; LOC102550344; LOC361543; lysine (K)-specific methyltransferase 2B; Mll4; myeloid/lymphoid or mixed-lineage leukemia 4; RGD1308331; similar to Trithorax homolog 2 (Mixed lineage leukemia gene homolog 2 protein); Wbp7; WW domain binding protein 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,949,144 - 94,969,239 (-)NCBIGRCr8
mRatBN7.2185,821,700 - 85,840,987 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,821,753 - 85,841,326 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0189,022,889 - 89,042,176 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,023,200 - 89,042,176 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,177,704 - 90,197,879 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,613,847 - 85,633,136 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
histone modification pathway  (ISO)

External Pathway Database Links

KEGG Pathway Lysine degradation

References

References - curated
# Reference Title Reference Citation
1. Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis. Ananthanarayanan M, etal., Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G771-81. doi: 10.1152/ajpgi.00499.2010. Epub 2011 Feb 17.
2. Mixed lineage leukaemia-4 regulates cell-cycle progression and cell viability and its depletion suppresses growth of xenografted tumour in vivo. Ansari KI, etal., Br J Cancer. 2012 Jul 10;107(2):315-24. doi: 10.1038/bjc.2012.263. Epub 2012 Jun 19.
3. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells. Kim JH, etal., Cancer Res. 2014 Mar 15;74(6):1705-17. doi: 10.1158/0008-5472.CAN-13-1896. Epub 2014 Feb 3.
6. Epigenetic Role of Histone Lysine Methyltransferase and Demethylase on the Expression of Transcription Factors Associated with the Epithelial-to-Mesenchymal Transition of Lung Adenocarcinoma Metastasis to the Brain. Lee YM, etal., Cancers (Basel). 2020 Dec 4;12(12). pii: cancers12123632. doi: 10.3390/cancers12123632.
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Integration of hepatitis B virus DNA into the myeloid/lymphoid or mixed-lineage leukemia (MLL4) gene and rearrangements of MLL4 in human hepatocellular carcinoma. Saigo K, etal., Hum Mutat. 2008 May;29(5):703-8. doi: 10.1002/humu.20701.
11. DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier. Santos MA, etal., Nature. 2014 Oct 2;514(7520):107-11. doi: 10.1038/nature13483. Epub 2014 Jul 27.
12. Deregulated expression of selected histone methylases and demethylases in prostate carcinoma. Vieira FQ, etal., Endocr Relat Cancer. 2013 Dec 16;21(1):51-61. doi: 10.1530/ERC-13-0375. Print 2014 Feb.
Additional References at PubMed
PMID:17166833   PMID:17500065   PMID:20808952   PMID:25561738   PMID:25834037   PMID:29276034   PMID:36162497  


Genomics

Comparative Map Data
Kmt2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,949,144 - 94,969,239 (-)NCBIGRCr8
mRatBN7.2185,821,700 - 85,840,987 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,821,753 - 85,841,326 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0189,022,889 - 89,042,176 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,023,200 - 89,042,176 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,177,704 - 90,197,879 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,613,847 - 85,633,136 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map1q21NCBI
KMT2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,718,003 - 35,738,878 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,717,973 - 35,738,880 (+)EnsemblGRCh38hg38GRCh38
GRCh371936,208,905 - 36,229,779 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,900,761 - 40,921,619 (+)NCBINCBI36Build 36hg18NCBI36
Celera1932,922,394 - 32,943,254 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,713,511 - 32,734,772 (+)NCBIHuRef
CHM1_11936,210,261 - 36,231,101 (+)NCBICHM1_1
T2T-CHM13v2.01938,263,317 - 38,284,192 (+)NCBIT2T-CHM13v2.0
Kmt2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,268,280 - 30,288,371 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,268,283 - 30,288,151 (-)EnsemblGRCm39 Ensembl
GRCm38730,568,855 - 30,589,056 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,568,858 - 30,588,726 (-)EnsemblGRCm38mm10GRCm38
MGSCv37731,353,874 - 31,373,745 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36730,277,619 - 30,297,477 (-)NCBIMGSCv36mm8
Celera725,160,399 - 25,180,234 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map718.63NCBI
Kmt2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554682,813,496 - 2,834,326 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554682,813,183 - 2,834,326 (-)NCBIChiLan1.0ChiLan1.0
KMT2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,712,293 - 41,733,151 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,697,617 - 43,718,475 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,647,815 - 32,668,656 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,382,457 - 41,403,016 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,382,458 - 41,402,695 (+)Ensemblpanpan1.1panPan2
KMT2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,894,024 - 116,913,464 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,893,074 - 116,913,472 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1116,299,287 - 116,318,778 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,497,002 - 117,516,495 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,497,003 - 117,516,495 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11117,060,375 - 117,079,862 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,684,004 - 116,703,492 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,739,382 - 117,758,866 (-)NCBIUU_Cfam_GSD_1.0
Kmt2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,040,036 - 11,062,266 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936570583,616 - 605,603 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936570583,616 - 605,846 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KMT2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,147,566 - 45,166,852 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1645,146,863 - 45,166,854 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,602,309 - 40,622,307 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KMT2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,626,723 - 30,648,204 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,626,848 - 30,647,883 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660738,418,227 - 8,439,584 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kmt2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479410,023,492 - 10,045,820 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479410,023,229 - 10,046,128 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kmt2b
26 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat

Markers in Region
MARC_2763-2764:991933378:3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2185,822,804 - 85,823,278 (+)MAPPERmRatBN7.2
Rnor_6.0189,023,994 - 89,024,467NCBIRnor6.0
Rnor_5.0190,178,809 - 90,179,282UniSTSRnor5.0
RGSC_v3.4185,614,952 - 85,615,425UniSTSRGSC3.4
Celera180,194,326 - 80,194,799UniSTS
Cytogenetic Map1q21UniSTS
ksks195  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2185,822,860 - 85,823,236 (+)MAPPERmRatBN7.2
Rnor_6.0189,024,050 - 89,024,425NCBIRnor6.0
Rnor_5.0190,178,865 - 90,179,240UniSTSRnor5.0
RGSC_v3.4185,615,008 - 85,615,383UniSTSRGSC3.4
Celera180,194,382 - 80,194,757UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 17 14 7 14 66 24 35 3
Low 15 40 27 12 27 8 11 8 11 6 8 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000080842   ⟹   ENSRNOP00000071806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl185,821,753 - 85,841,326 (-)Ensembl
Rnor_6.0 Ensembl189,023,200 - 89,042,176 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096058   ⟹   ENSRNOP00000081983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl185,821,753 - 85,841,326 (-)Ensembl
RefSeq Acc Id: NM_001427141   ⟹   NP_001414070
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,949,144 - 94,968,441 (-)NCBI
RefSeq Acc Id: XM_008759254   ⟹   XP_008757476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,949,144 - 94,969,239 (-)NCBI
mRatBN7.2185,821,977 - 85,840,987 (-)NCBI
Rnor_6.0189,022,889 - 89,042,176 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093878   ⟹   XP_038949806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,949,144 - 94,963,791 (-)NCBI
mRatBN7.2185,821,977 - 85,836,352 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414070 (Get FASTA)   NCBI Sequence Viewer  
  XP_008757476 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949806 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071806.1
  ENSRNOP00000081983.1
RefSeq Acc Id: XP_008757476   ⟸   XM_008759254
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G8S5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071806   ⟸   ENSRNOT00000080842
RefSeq Acc Id: XP_038949806   ⟸   XM_039093878
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000081983   ⟸   ENSRNOT00000096058
RefSeq Acc Id: NP_001414070   ⟸   NM_001427141
- UniProtKB: A0A0G2K1E3 (UniProtKB/TrEMBL),   A0A8I6G8S5 (UniProtKB/TrEMBL)
Protein Domains
CXXC-type   FYR C-terminal   FYR N-terminal   PHD-type   Post-SET   SET

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689926
Promoter ID:EPDNEW_R448
Type:multiple initiation site
Name:Kmt2b_1
Description:lysine methyltransferase 2B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0189,042,187 - 89,042,247EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7678027 AgrOrtholog
BioCyc Gene G2FUF-60094 BioCyc
Ensembl Genes ENSRNOG00000055525 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080842.2 UniProtKB/TrEMBL
  ENSRNOT00000096058.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.920.10 UniProtKB/TrEMBL
  2.170.270.10 UniProtKB/TrEMBL
  3.30.160.360 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro Bromodomain-like_sf UniProtKB/TrEMBL
  EPHD UniProtKB/TrEMBL
  FYrich_C UniProtKB/TrEMBL
  FYrich_N UniProtKB/TrEMBL
  KMT2A_2B_SET UniProtKB/TrEMBL
  KMT2B_ePHD UniProtKB/TrEMBL
  MeTrfase_trithorax UniProtKB/TrEMBL
  Post-SET_dom UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  Znf_CXXC UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene LOC102550344 ENTREZGENE
PANTHER HISTONE-LYSINE N-METHYLTRANSFERASE 2B UniProtKB/TrEMBL
  HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER UniProtKB/TrEMBL
Pfam FYRC UniProtKB/TrEMBL
  FYRN UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
  zf-CXXC UniProtKB/TrEMBL
  zf-HC5HC2H UniProtKB/TrEMBL
PhenoGen Kmt2b PhenoGen
PIRSF Methyltransferase_trithorax UniProtKB/TrEMBL
PRINTS PRICHEXTENSN UniProtKB/TrEMBL
PROSITE EPHD UniProtKB/TrEMBL
  FYRC UniProtKB/TrEMBL
  FYRN UniProtKB/TrEMBL
  POST_SET UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
  ZF_CXXC UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055525 RatGTEx
SMART FYRC UniProtKB/TrEMBL
  FYRN UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  PostSET UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
Superfamily-SCOP FYVE_PHD_ZnF UniProtKB/TrEMBL
  SSF82199 UniProtKB/TrEMBL
UniProt A0A0G2K1E3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G8S5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Kmt2b  lysine methyltransferase 2B  Kmt2b  lysine (K)-specific methyltransferase 2B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-10-17 LOC102550344  histone-lysine N-methyltransferase 2B-like  Kmt2b  lysine (K)-specific methyltransferase 2B  Data merged from RGD:1308331 737654 APPROVED
2014-10-17 Kmt2b  lysine (K)-specific methyltransferase 2B  LOC102550344  histone-lysine N-methyltransferase 2B-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102550344  histone-lysine N-methyltransferase 2B-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-05-15 Kmt2b  lysine (K)-specific methyltransferase 2B  Mll4  myeloid/lymphoid or mixed-lineage leukemia 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Mll4  myeloid/lymphoid or mixed-lineage leukemia 4  Wbp7  WW domain binding protein 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Wbp7  WW domain binding protein 7  RGD1308331_predicted  similar to Trithorax homolog 2 (Mixed lineage leukemia gene homolog 2 protein) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1308331_predicted  similar to Trithorax homolog 2 (Mixed lineage leukemia gene homolog 2 protein) (predicted)  LOC361543_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361543_predicted  similar to Trithorax homolog 2 (Mixed lineage leukemia gene homolog 2 protein) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL