Gene: Ryr1 (ryanodine receptor 1) Rattus norvegicus
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Symbol: Ryr1
Name: ryanodine receptor 1
Description: ENCODES a protein that exhibits ryanodine-sensitive calcium-release channel activity; ATP binding (ortholog); calcium channel activity (ortholog); INVOLVED IN calcium ion transport; cellular response to ATP; regulation of cytosolic calcium ion concentration; PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH ankyloglossia (ortholog); Arthrogryposis (ortholog); arthrogryposis due to muscular dystrophy (ortholog); FOUND IN extrinsic component of cytoplasmic side of plasma membrane; sarcolemma; sarcoplasmic reticulum; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,4,6-trinitrobenzenesulfonic acid; acrylamide
AGR Description: Exhibits ryanodine-sensitive calcium-release channel activity; involved in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, response to estradiol, and response to purine-containing compound; localizes to the cytoplasm, extrinsic component of cytoplasmic side of plasma membrane, and sarcolemma; orthologous to human RYR1 (ryanodine receptor 1).
Merged Description: Exhibits ryanodine-sensitive calcium-release channel activity; involved in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, response to estradiol, and response to purine-containing compound; localizes to the cytoplasm, extrinsic component of cytoplasmic side of plasma membrane, and sarcolemma; orthologous to human RYR1 (ryanodine receptor 1); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,4,6-trinitrobenzenesulfonic acid; acrylamide.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC686059; LOW QUALITY PROTEIN: ryanodine receptor 1; ryanodine receptor 1 (skeletal); ryanodine receptor 1, skeletal muscle; ryanodine receptor 1-like; ryanodine receptor 1-like, skeletal muscle; RYR-1; Ryr1l; similar to ryanodine receptor 1 (skeletal); skeletal muscle calcium release channel; skeletal muscle ryanodine receptor; skeletal muscle-type ryanodine receptor; type 1 ryanodine receptor
Orthologs:
Homo sapiens (human) : RYR1 (ryanodine receptor 1)  HGNC  Alliance
Mus musculus (house mouse) : Ryr1 (ryanodine receptor 1, skeletal muscle)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ryr1 (ryanodine receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RYR1 (ryanodine receptor 1)
Canis lupus familiaris (dog) : RYR1 (ryanodine receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ryr1 (ryanodine receptor 1)
Sus scrofa (pig) : RYR1 (ryanodine receptor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0187,959,596 - 88,066,252 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0189,135,622 - 89,241,311 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,116,098 - 84,254,503 (-)NCBIRGSC3.4rn4RGSC3.4
Celera178,682,691 - 78,812,242 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ryr1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1586637
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.