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Gene: Actn4 (actinin alpha 4) Rattus norvegicus
Symbol: Actn4
Name: actinin alpha 4
Description: Exhibits protein N-terminus binding activity. Involved in regulation of apoptotic process and response to hypoxia. Localizes to several cellular components, including cytoplasm; neuron projection; and nucleus. Colocalizes with stress fiber. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 1. Orthologous to human ACTN4 (actinin alpha 4); PARTICIPATES IN platelet-derived growth factor signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; Entamoebiasis pathway; INTERACTS WITH 2,2,2-tetramine; 2,6-dinitrotoluene; 2-nitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha actinin 4; alpha actinin 4 between D1Rat178 and D1Rat97; alpha-actinin-4; F-actin cross-linking protein; non-muscle alpha-actinin 4
Homo sapiens (human) : ACTN4 (actinin alpha 4)  HGNC  Alliance
Mus musculus (house mouse) : Actn4 (actinin alpha 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Actn4 (actinin alpha 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ACTN4 (actinin alpha 4)
Canis lupus familiaris (dog) : ACTN4 (actinin alpha 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Actn4 (actinin alpha 4)
Sus scrofa (pig) : ACTN4 (actinin alpha 4)
Chlorocebus sabaeus (African green monkey) : ACTN4 (actinin alpha 4)
Heterocephalus glaber (naked mole-rat) : Actn4 (actinin alpha 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0187,078,012 - 87,147,347 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,078,020 - 87,147,333 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,258,630 - 88,327,965 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,000,723 - 84,073,767 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1184,079,711 - 84,151,876 (-)NCBI
Celera178,572,890 - 78,641,919 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Actn4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61816
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.