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![]() Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTPRH mRNA] | CTD | PMID:31150632 | 17beta-estradiol | increases expression | ISO | RGD:1345629 | 6480464 | Estradiol results in increased expression of PTPRH mRNA | CTD | PMID:20106945 | 17beta-estradiol | multiple interactions | ISO | RGD:1345629 | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of PTPRH mRNA | CTD | PMID:30165855 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PTPRH mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1610968 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PTPRH mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1345629 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PTPRH mRNA | CTD | PMID:21632981 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | ISO | RGD:1610968 | 6480464 | 2 more ... | CTD | PMID:25768209 | 4,4'-sulfonyldiphenol | decreases expression | ISO | RGD:1345629 | 6480464 | bis(4-hydroxyphenyl)sulfone results in decreased expression of PTPRH mRNA | CTD | PMID:27685785 | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2, 6-dinitrotoluene affects the expression of PTPRH mRNA | CTD | PMID:21346803 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of PTPRH mRNA | CTD | PMID:24780913 | acrylamide | affects expression | EXP | | 6480464 | Acrylamide affects the expression of PTPRH mRNA | CTD | PMID:28959563 | aflatoxin B1 | decreases methylation | ISO | RGD:1345629 | 6480464 | Aflatoxin B1 results in decreased methylation of PTPRH intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | RGD:1345629 | 6480464 | Tretinoin results in increased expression of PTPRH mRNA | CTD | PMID:23724009, PMID:23830798 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PTPRH mRNA | CTD | PMID:16483693 | benzo[a]pyrene | affects methylation | ISO | RGD:1345629 | 6480464 | Benzo(a)pyrene affects the methylation of PTPRH exon | CTD | PMID:30157460 | benzo[e]pyrene | decreases methylation | ISO | RGD:1345629 | 6480464 | benzo(e)pyrene results in decreased methylation of PTPRH exon | CTD | PMID:30157460 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PTPRH mRNA | CTD | PMID:25181051 | bisphenol A | affects expression | ISO | RGD:1345629 | 6480464 | bisphenol A affects the expression of PTPRH mRNA | CTD | PMID:30903817 | butanal | increases expression | ISO | RGD:1345629 | 6480464 | butyraldehyde results in increased expression of PTPRH mRNA | CTD | PMID:26079696 | copper atom | multiple interactions | ISO | RGD:1345629 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of PTPRH mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | RGD:1345629 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of PTPRH mRNA | CTD | PMID:20971185 | copper(II) sulfate | increases expression | ISO | RGD:1345629 | 6480464 | Copper Sulfate results in increased expression of PTPRH mRNA | CTD | PMID:19549813 | cyclosporin A | increases expression | ISO | RGD:1345629 | 6480464 | Cyclosporine results in increased expression of PTPRH mRNA | CTD | PMID:20106945 more ... | doxorubicin | affects response to substance | ISO | RGD:1345629 | 6480464 | PTPRH mRNA affects the susceptibility to Doxorubicin | CTD | PMID:16044152 | ketamine | decreases expression | EXP | | 6480464 | Ketamine results in decreased expression of PTPRH mRNA | CTD | PMID:20080153 | leflunomide | increases expression | ISO | RGD:1345629 | 6480464 | leflunomide results in increased expression of PTPRH mRNA | CTD | PMID:28988120 | methapyrilene | decreases methylation | ISO | RGD:1345629 | 6480464 | Methapyrilene results in decreased methylation of PTPRH exon | CTD | PMID:30157460 | mono(2-ethylhexyl) phthalate | increases expression | ISO | RGD:1610968 | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of PTPRH mRNA | CTD | PMID:22401849 | N-methyl-4-phenylpyridinium | increases expression | ISO | RGD:1345629 | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of PTPRH mRNA | CTD | PMID:24810058 | phenobarbital | affects expression | ISO | RGD:1345629 | 6480464 | Phenobarbital affects the expression of PTPRH mRNA | CTD | PMID:19159669 | quercetin | increases expression | ISO | RGD:1345629 | 6480464 | Quercetin results in increased expression of PTPRH mRNA | CTD | PMID:21632981 | raloxifene | affects expression | ISO | RGD:1345629 | 6480464 | Raloxifene Hydrochloride affects the expression of PTPRH mRNA | CTD | PMID:14699072 | silicon dioxide | increases expression | ISO | RGD:1345629 | 6480464 | Silicon Dioxide analog results in increased expression of PTPRH mRNA | CTD | PMID:25895662 | sodium arsenite | decreases expression | ISO | RGD:1345629 | 6480464 | sodium arsenite results in decreased expression of PTPRH mRNA | CTD | PMID:28595984 | tamoxifen | multiple interactions | ISO | RGD:1345629 | 6480464 | ESR2 protein affects the reaction [Tamoxifen results in decreased expression of PTPRH mRNA] | CTD | PMID:14699072 | tamoxifen | affects expression | ISO | RGD:1345629 | 6480464 | Tamoxifen affects the expression of PTPRH mRNA | CTD | PMID:14699072 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of PTPRH mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTPRH mRNA] | CTD | PMID:31150632 | thapsigargin | increases expression | ISO | RGD:1345629 | 6480464 | Thapsigargin results in increased expression of PTPRH mRNA | CTD | PMID:22378314 | triclosan | increases expression | ISO | RGD:1345629 | 6480464 | Triclosan results in increased expression of PTPRH mRNA | CTD | PMID:30510588 | tunicamycin | increases expression | ISO | RGD:1345629 | 6480464 | Tunicamycin results in increased expression of PTPRH mRNA | CTD | PMID:22378314 | urethane | increases expression | ISO | RGD:1345629 | 6480464 | Urethane results in increased expression of PTPRH mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | ISO | RGD:1345629 | 6480464 | Valproic Acid results in increased methylation of PTPRH gene | CTD | PMID:29154799 | zinc atom | multiple interactions | ISO | RGD:1345629 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of PTPRH mRNA | CTD | PMID:18593933 | zinc(0) | multiple interactions | ISO | RGD:1345629 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of PTPRH mRNA | CTD | PMID:18593933 | |
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1. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
2. | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
3. | RGD automated data pipeline |
4. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
5. | RGD automated import pipeline for gene-chemical interactions |
Ptprh (Rattus norvegicus - Norway rat) |
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PTPRH (Homo sapiens - human) |
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Ptprh (Mus musculus - house mouse) |
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Ptprh (Chinchilla lanigera - long-tailed chinchilla) |
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PTPRH (Pan paniscus - bonobo/pygmy chimpanzee) |
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PTPRH (Canis lupus familiaris - dog) |
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Ptprh (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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PTPRH (Sus scrofa - pig) |
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AU047868 |
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The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
testis | heart | brain | ovary | uterus | colon | gastrocnemius | forebrain | hindbrain | lung | spleen | liver | kidney | adrenal gland | thymus | |
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High | |||||||||||||||
Medium | 3 | ||||||||||||||
Low | 11 | 4 | 7 | 4 | 4 | 16 | 15 | 7 | 4 | 35 | 1 | ||||
Below cutoff | 9 | 23 | 8 | 9 | 3 | 10 | 6 | 4 | 7 | 6 | 18 | 8 | 6 |
RefSeq Transcripts | NM_001191945 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_008758887 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AAHX01003924 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AAHX01003925 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AC097997 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH474075 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
D45413 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | NM_001191945 ⟹ NP_001178874 | |||||||||||||||||||
RefSeq Status: | PROVISIONAL | |||||||||||||||||||
Type: | CODING | |||||||||||||||||||
Position: |
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Sequence: |
ATGGCCAGAGCTGGTGGGAACTGTGGGGTTTGGGGGAGCTTGGTGCTATTGGGTTTGTGTGGTThide sequence |
RefSeq Acc Id: | XM_008758887 ⟹ XP_008757109 | |||||||||
RefSeq Status: | ||||||||||
Type: | CODING | |||||||||
Position: |
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Sequence: |
GTGTGTGTGTGTGTGTAAATGTGTACATGTTCTTGTATGTGTGTTTAAGATAGGAGCTGATTCThide sequence |
Protein RefSeqs | NP_001178874 | (Get FASTA) | NCBI Sequence Viewer |
XP_008757109 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | BAA08253 | (Get FASTA) | NCBI Sequence Viewer |
EDL75843 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_001178874 ⟸ NM_001191945 |
- Peptide Label: | precursor |
- UniProtKB: | A0A0G2K754 (UniProtKB/TrEMBL) |
- Sequence: |
MARAGGNCGVWGSLVLLGLCGCSVVRTAGTRVTVDRLAPASSYEFSVWAEKDGVSGSPQTLIAThide sequence |
RefSeq Acc Id: | XP_008757109 ⟸ XM_008758887 |
- Peptide Label: | isoform X1 |
- Sequence: |
MARAGGNCGVWGSLVLLGLCGCSVVRTAAPNPVINLRTETQTNTSITLRWEVPDGTDPQNLTYWhide sequence |
RGD ID: | 13689704 | |||||||||
Promoter ID: | EPDNEW_R228 | |||||||||
Type: | initiation region | |||||||||
Name: | Ptprh_1 | |||||||||
Description: | protein tyrosine phosphatase, receptor type, H | |||||||||
SO ACC ID: | SO:0000170 | |||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | |||||||||
Experiment Methods: | Single-end sequencing. | |||||||||
Position: |
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Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
1 | 72810569 | 72810570 | G | A | snv | SR/JrHsd (RGD), SR/JrHsd (MCW), SS/JrHsdMcwi (RGD), SS/Jr (RGD), SS/JrHsdMcwi (MCW) |
1 | 72811907 | 72811908 | T | A | snv | FHL/EurMcwi (RGD), SBH/Ygl (RGD), FHL/EurMcwi (MCW), LH/MavRrrc (RGD), FHH/EurMcwi (MCW), SBH/Ygl (MCW), FHH/EurMcwi (RGD) |
1 | 72811988 | 72811989 | G | C | snv | FHL/EurMcwi (MCW), SBH/Ygl (MCW), FHH/EurMcwi (RGD), FHL/EurMcwi (RGD), LH/MavRrrc (RGD), SBH/Ygl (RGD), FHH/EurMcwi (MCW) |
1 | 72812009 | 72812010 | C | T | snv | SBH/Ygl (RGD), SBH/Ygl (MCW) |
1 | 72815109 | 72815110 | A | T | snv | SR/JrHsd (MCW), SS/JrHsdMcwi (MCW) |
1 | 72818148 | 72818149 | A | C | snv | FHL/EurMcwi (MCW), SBH/Ygl (MCW), FHH/EurMcwi (MCW) |
1 | 72818168 | 72818169 | G | C | snv | SR/JrHsd (MCW), SS/JrHsdMcwi (MCW) |
1 | 72818232 | 72818233 | G | A | snv | SBH/Ygl (MCW), FHL/EurMcwi (MCW), FHH/EurMcwi (MCW) |
1 | 72818233 | 72818234 | G | C | snv | SR/JrHsd (MCW), SS/JrHsdMcwi (MCW) |
1 | 72822750 | 72822751 | A | C | snv | FHH/EurMcwi (MCW) |
1 | 72822834 | 72822835 | G | A | snv | FHH/EurMcwi (MCW), FHL/EurMcwi (MCW) |
1 | 72822849 | 72822850 | C | T | snv | SS/JrHsdMcwi (MCW), SR/JrHsd (MCW) |
1 | 72829537 | 72829538 | G | T | snv | SR/JrHsd (MCW) |
1 | 72829540 | 72829541 | G | A | snv | WN/N (MCW) |
1 | 72832805 | 72832806 | A | C | snv | FHH/EurMcwi (MCW), FHL/EurMcwi (MCW) |
1 | 72832886 | 72832887 | G | T | snv | SR/JrHsd (MCW) |
1 | 72837889 | 72837890 | A | C | snv | FHL/EurMcwi (MCW), FHH/EurMcwi (MCW) |
1 | 72841625 | 72841626 | A | G | snv | SS/JrHsdMcwi (MCW) |
Database | Acc Id | Source(s) |
AGR Gene | RGD:620553 | AgrOrtholog |
Ensembl Genes | ENSRNOG00000058906 | ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Protein | ENSRNOP00000074068 | ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000092117 | ENTREZGENE, UniProtKB/TrEMBL |
Gene3D-CATH | 2.60.40.10 | UniProtKB/TrEMBL |
3.90.190.10 | UniProtKB/TrEMBL | |
InterPro | Dual-sp/Tyr_phosphatase | UniProtKB/TrEMBL |
Fibronectin_type3 | UniProtKB/TrEMBL | |
FN3_sf | UniProtKB/TrEMBL | |
Ig-like_fold | UniProtKB/TrEMBL | |
Prot-tyrosine_phosphatase-like | UniProtKB/TrEMBL | |
R-PTP-H | UniProtKB/TrEMBL | |
Tyr_Pase_AS | UniProtKB/TrEMBL | |
Tyr_Pase_cat | UniProtKB/TrEMBL | |
Tyr_Pase_rcpt/non-rcpt | UniProtKB/TrEMBL | |
KEGG Report | rno:171125 | UniProtKB/TrEMBL |
NCBI Gene | 171125 | ENTREZGENE |
PANTHER | PTHR19134:SF297 | UniProtKB/TrEMBL |
Pfam | fn3 | UniProtKB/TrEMBL |
Y_phosphatase | UniProtKB/TrEMBL | |
PhenoGen | Ptprh | PhenoGen |
PRINTS | PRTYPHPHTASE | UniProtKB/TrEMBL |
PROSITE | FN3 | UniProtKB/TrEMBL |
TYR_PHOSPHATASE_1 | UniProtKB/TrEMBL | |
TYR_PHOSPHATASE_2 | UniProtKB/TrEMBL | |
TYR_PHOSPHATASE_PTP | UniProtKB/TrEMBL | |
SMART | FN3 | UniProtKB/TrEMBL |
PTPc | UniProtKB/TrEMBL | |
PTPc_motif | UniProtKB/TrEMBL | |
Superfamily-SCOP | FN_III-like | UniProtKB/TrEMBL |
SSF52799 | UniProtKB/TrEMBL | |
UniGene | Rn.10285 | ENTREZGENE |
UniProt | A0A0G2K754 | ENTREZGENE, UniProtKB/TrEMBL |
Q64642_RAT | UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
---|---|---|---|---|---|---|---|
2004-09-10 | Ptprh | protein tyrosine phosphatase, receptor type, H | Bem2 | brain-enriched membrane-associated protein tyrosine BEM-2 | Symbol and Name updated | 1299863 | APPROVED |
2002-08-07 | Bem2 | brain-enriched membrane-associated protein tyrosine BEM-2 | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
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More on Ptprh | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
RGD Object Information | |
RGD ID: | 620553 |
Created: | 2002-08-06 |
Species: | Rattus norvegicus |
Last Modified: | 2019-11-27 |
Status: | ACTIVE |
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.