PTPRH (protein tyrosine phosphatase receptor type H) - Rat Genome Database

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Gene: PTPRH (protein tyrosine phosphatase receptor type H) Canis lupus familiaris
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Symbol: PTPRH
Name: protein tyrosine phosphatase receptor type H
RGD ID: 12195805
Description: ENCODES a protein that exhibits cadherin binding (inferred); phosphoprotein phosphatase activity (inferred); protein tyrosine phosphatase activity (inferred); INVOLVED IN peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity (ortholog); ASSOCIATED WITH hypertrophic cardiomyopathy (ortholog); nemaline myopathy 5A (ortholog); FOUND IN cell projection (inferred); cytosol (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: receptor-type tyrosine-protein phosphatase H
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,440,961 - 102,456,368 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,440,358 - 102,456,881 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,497,447 - 102,513,421 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,093,960 - 103,109,941 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1103,094,042 - 103,109,986 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11102,730,889 - 102,746,872 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,442,799 - 102,458,433 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,206,509 - 103,222,487 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PTPRH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,440,961 - 102,456,368 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,440,358 - 102,456,881 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,497,447 - 102,513,421 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,093,960 - 103,109,941 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1103,094,042 - 103,109,986 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11102,730,889 - 102,746,872 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,442,799 - 102,458,433 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,206,509 - 103,222,487 (+)NCBIUU_Cfam_GSD_1.0
PTPRH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,181,247 - 55,209,501 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1955,181,247 - 55,209,506 (-)EnsemblGRCh38hg38GRCh38
GRCh371955,692,615 - 55,720,869 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,384,428 - 60,412,654 (-)NCBINCBI36Build 36hg18NCBI36
Build 341960,384,427 - 60,412,654NCBI
Celera1952,733,808 - 52,762,437 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1952,015,608 - 52,044,091 (-)NCBIHuRef
CHM1_11955,686,188 - 55,714,448 (-)NCBICHM1_1
T2T-CHM13v2.01958,275,309 - 58,303,271 (-)NCBIT2T-CHM13v2.0
Ptprh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,551,607 - 4,607,040 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl74,551,611 - 4,607,040 (-)EnsemblGRCm39 Ensembl
GRCm3874,548,608 - 4,604,041 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,548,612 - 4,604,041 (-)EnsemblGRCm38mm10GRCm38
MGSCv3774,500,216 - 4,555,643 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3674,152,435 - 4,207,128 (-)NCBIMGSCv36mm8
MGSCv3673,905,427 - 3,958,325 (-)NCBIMGSCv36mm8
Celera74,293,889 - 4,335,235 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.63NCBI
Ptprh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,272,414 - 78,318,977 (+)NCBIGRCr8
mRatBN7.2169,243,704 - 69,276,294 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,242,321 - 69,285,077 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,588,649 - 74,635,216 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,152,964 - 83,199,525 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,304,943 - 76,349,140 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,809,935 - 72,859,161 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,810,545 - 72,859,161 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,692,060 - 75,720,074 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,960,564 - 68,004,280 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,068,899 - 68,082,221 (+)NCBI
Celera167,851,198 - 67,875,796 (-)NCBICelera
Cytogenetic Map1q12NCBI
Ptprh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955567992,880 - 1,018,343 (+)NCBIChiLan1.0ChiLan1.0
PTPRH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,317,595 - 61,345,486 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11963,046,075 - 63,074,599 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01952,221,813 - 52,249,218 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11960,917,244 - 60,943,528 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1960,917,749 - 60,943,528 (-)Ensemblpanpan1.1panPan2
LOC101977901
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,084,951 - 2,101,360 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936886457,873 - 482,345 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,389,290 - 59,416,233 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1659,389,545 - 59,416,248 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,259,269 - 54,275,403 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,776,907 - 47,809,359 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl647,777,454 - 47,808,507 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045334,286 - 400,807 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptprh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248322,042,358 - 2,071,454 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTPRH
212 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
2 5 3 18 12 9 2 5 2 5 18 11 10 13 7

Sequence


Ensembl Acc Id: ENSCAFT00000004106   ⟹   ENSCAFP00000003796
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1102,441,062 - 102,456,881 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000045948   ⟹   ENSCAFP00000039832
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1102,442,496 - 102,456,881 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000047240   ⟹   ENSCAFP00000037423
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1102,441,239 - 102,456,881 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000093297   ⟹   ENSCAFP00000048084
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1102,440,358 - 102,456,881 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845002608   ⟹   ENSCAFP00845002077
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1103,094,042 - 103,109,986 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845002643   ⟹   ENSCAFP00845002100
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1103,094,537 - 103,109,986 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845002669   ⟹   ENSCAFP00845002116
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1103,094,758 - 103,109,986 (+)Ensembl
RefSeq Acc Id: XM_038467037   ⟹   XP_038322965
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11102,730,889 - 102,746,872 (+)NCBI
RefSeq Acc Id: XM_038527773   ⟹   XP_038383701
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01103,206,509 - 103,222,487 (+)NCBI
RefSeq Acc Id: XM_038592088   ⟹   XP_038448016
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01102,442,799 - 102,458,433 (+)NCBI
RefSeq Acc Id: XM_038638622   ⟹   XP_038494550
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1102,497,447 - 102,513,421 (+)NCBI
RefSeq Acc Id: XM_038655849   ⟹   XP_038511777
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01103,093,960 - 103,109,941 (+)NCBI
Ensembl Acc Id: ENSCAFP00000039832   ⟸   ENSCAFT00000045948
Ensembl Acc Id: ENSCAFP00000003796   ⟸   ENSCAFT00000004106
Ensembl Acc Id: ENSCAFP00000048084   ⟸   ENSCAFT00000093297
Ensembl Acc Id: ENSCAFP00000037423   ⟸   ENSCAFT00000047240
RefSeq Acc Id: XP_038322965   ⟸   XM_038467037
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038448016   ⟸   XM_038592088
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038511777   ⟸   XM_038655849
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RQ01 (UniProtKB/TrEMBL),   A0A8P0N5K0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038494550   ⟸   XM_038638622
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RQ01 (UniProtKB/TrEMBL),   A0A8P0N5K0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038383701   ⟸   XM_038527773
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RQ01 (UniProtKB/TrEMBL),   A0A8P0N5K0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845002077   ⟸   ENSCAFT00845002608
Ensembl Acc Id: ENSCAFP00845002116   ⟸   ENSCAFT00845002669
Ensembl Acc Id: ENSCAFP00845002100   ⟸   ENSCAFT00845002643
Protein Domains
Fibronectin type-III   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002611 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845001446 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000004106.5 UniProtKB/TrEMBL
  ENSCAFT00000045948.3 UniProtKB/TrEMBL
  ENSCAFT00000047240.4 UniProtKB/TrEMBL
  ENSCAFT00845002608 ENTREZGENE
  ENSCAFT00845002608.1 UniProtKB/TrEMBL
  ENSCAFT00845002643.1 UniProtKB/TrEMBL
  ENSCAFT00845002669.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTP_cat UniProtKB/TrEMBL
  RTP_Phos/Ushers UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL
NCBI Gene PTPRH ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/TrEMBL
  PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, H UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
UniProt A0A8I3MIL8_CANLF UniProtKB/TrEMBL
  A0A8I3RQ01 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RRJ8_CANLF UniProtKB/TrEMBL
  A0A8P0N5K0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NPD2_CANLF UniProtKB/TrEMBL
  A0A8P0NR45_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:45189 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 PTPRH  protein tyrosine phosphatase receptor type H    protein tyrosine phosphatase, receptor type H  Symbol and/or name change 5135510 APPROVED