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Gene: Slc7a10 (solute carrier family 7 member 10) Rattus norvegicus

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Symbol:

Slc7a10

Name:

solute carrier family 7 member 10

RGD ID:

621672

Description:

Predicted to enable L-amino acid transmembrane transporter activity and neutral L-amino acid transmembrane transporter activity. Predicted to be involved in negative regulation of brown fat cell differentiation; neutral amino acid transport; and positive regulation of glycinergic synaptic transmission. Located in apical dendrite and neuronal cell body. Orthologous to human SLC7A10 (solute carrier family 7 member 10); INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Asc-1; asc-type amino acid transporter 1; D- and L-serine transporter Asc-1; D-serine transporter; solute carrier family 7 (cationic amino acid transporter, y+ system), member 10; solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10; solute carrier family 7, (cationic amino acid transporter, y+ system) member 10; solute carrier family 7, (neutral amino acid transporter, y+ system) member 10

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC7A10 (solute carrier family 7 member 10)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Slc7a10 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc7a10 (solute carrier family 7 member 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC7A10 (solute carrier family 7 member 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC7A10 (solute carrier family 7 member 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc7a10 (solute carrier family 7 member 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC7A10 (solute carrier family 7 member 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC7A10 (solute carrier family 7 member 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc7a10 (solute carrier family 7 member 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SLC7A8 (solute carrier family 7 member 8)	HGNC	OrthoDB
Homo sapiens (human):	KIF19 (kinesin family member 19)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SLC7A10 (solute carrier family 7 member 10)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc7a10 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 10)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc7a10a (solute carrier family 7 member 10a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc7a10b (solute carrier family 7 member 10b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MUP1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MUP1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	aat-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	JhI-21	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	MUP3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc7a10	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	96,966,030 - 96,982,020 (+)	NCBI		GRCr8
GRCr8 Ensembl	1	96,966,076 - 96,982,018 (+)	Ensembl		GRCr8 Ensembl
mRatBN7.2	1	87,829,084 - 87,845,073 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	87,829,175 - 87,845,071 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	93,235,422 - 93,251,543 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	101,701,408 - 101,717,518 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	94,993,724 - 95,009,846 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	91,432,952 - 91,448,566 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	91,433,030 - 91,448,564 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	92,563,339 - 92,579,264 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	87,695,658 - 87,711,595 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	82,180,310 - 82,195,867 (+)	NCBI		Celera
RGSC_v3.1	1	87,773,768 - 87,789,704 (+)	NCBI
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

hereditary spastic paraplegia 75 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (EXP)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

atrazine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

butanal (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

chloroprene (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

D-glucose (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (ISO)

fructose (ISO)

gentamycin (EXP)

glucose (ISO)

ketamine (EXP)

lead diacetate (ISO)

Licarin A (ISO)

mono(2-ethylhexyl) phthalate (ISO)

ozone (ISO)

panobinostat (ISO)

paraquat (EXP)

pentanal (ISO)

perfluorooctanoic acid (EXP)

phosgene (ISO)

propanal (ISO)

pyrazinecarboxamide (EXP)

SB 431542 (ISO)

sevoflurane (EXP)

sodium arsenite (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

trimellitic anhydride (ISO)

troglitazone (ISO)

valproic acid (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amino acid transport (IEA)

D-alanine transmembrane transport (IBA,IEA,ISO)

D-serine transmembrane transport (IBA,IEA,ISO)

glycine transport (IEA,ISO)

L-alpha-amino acid transmembrane transport (IEA)

negative regulation of brown fat cell differentiation (IEA,ISO)

neutral amino acid transport (IEA,ISO,ISS)

positive regulation of synaptic transmission, glycinergic (IEA,ISO)

transmembrane transport (IEA)

Cellular Component

apical dendrite (IDA)

membrane (IEA)

neuronal cell body (IDA)

plasma membrane (IEA,ISO)

Molecular Function

L-amino acid transmembrane transporter activity (IBA)

neutral L-amino acid transmembrane transporter activity (IBA,IEA,ISO,ISS)

protein binding (ISO)

transmembrane transporter activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	High affinity D- and L-serine transporter Asc-1: cloning and dendritic localization in the rat cerebral and cerebellar cortices.	Matsuo H, etal., Neurosci Lett 2004 Mar 25;358(2):123-6.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10734121	PMID:10863037	PMID:12477932	PMID:17432963	PMID:23581544	PMID:30187927

Genomics

Comparative Map Data

Slc7a10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	96,966,030 - 96,982,020 (+)	NCBI		GRCr8
GRCr8 Ensembl	1	96,966,076 - 96,982,018 (+)	Ensembl		GRCr8 Ensembl
mRatBN7.2	1	87,829,084 - 87,845,073 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	87,829,175 - 87,845,071 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	93,235,422 - 93,251,543 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	101,701,408 - 101,717,518 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	94,993,724 - 95,009,846 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	91,432,952 - 91,448,566 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	91,433,030 - 91,448,564 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	92,563,339 - 92,579,264 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	87,695,658 - 87,711,595 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	82,180,310 - 82,195,867 (+)	NCBI		Celera
RGSC_v3.1	1	87,773,768 - 87,789,704 (+)	NCBI
Cytogenetic Map	1	q21	NCBI

SLC7A10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	33,208,664 - 33,225,850 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	33,208,664 - 33,225,850 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	33,699,570 - 33,716,756 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	38,391,411 - 38,408,548 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	38,391,410 - 38,408,548	NCBI
Celera	19	30,393,162 - 30,410,341 (-)	NCBI		Celera
Cytogenetic Map	19	q13.11	NCBI
HuRef	19	30,201,437 - 30,218,673 (-)	NCBI		HuRef
CHM1_1	19	33,700,507 - 33,717,756 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	35,727,305 - 35,744,598 (-)	NCBI		T2T-CHM13v2.0

Slc7a10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	34,885,520 - 34,900,539 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	34,885,810 - 34,900,539 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	35,186,095 - 35,201,116 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	35,186,385 - 35,201,114 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	35,971,404 - 35,986,130 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	34,895,178 - 34,909,870 (+)	NCBI		MGSCv36	mm8
Celera	7	30,326,223 - 30,340,996 (+)	NCBI		Celera
Cytogenetic Map	7	B2	NCBI
cM Map	7	21.13	NCBI

Slc7a10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	2,968,720 - 2,984,125 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955468	2,968,720 - 2,984,101 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC7A10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	39,181,203 - 39,198,257 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	41,180,514 - 41,197,587 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	30,130,974 - 30,148,055 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	38,876,098 - 38,893,018 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	38,876,098 - 38,893,018 (-)	Ensembl	panpan1.1		panPan2

SLC7A10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	118,908,087 - 118,923,034 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	118,907,184 - 118,923,215 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	118,308,994 - 118,323,875 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	119,506,650 - 119,521,536 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	119,506,605 - 119,521,705 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	119,067,024 - 119,081,913 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	118,693,471 - 118,708,387 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	119,752,439 - 119,767,380 (+)	NCBI		UU_Cfam_GSD_1.0

Slc7a10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	9,056,066 - 9,070,105 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936570	2,575,386 - 2,593,299 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936570	2,575,784 - 2,589,808 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC7A10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	43,002,431 - 43,017,554 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	43,002,427 - 43,017,605 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	38,579,833 - 38,595,001 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC7A10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	28,249,906 - 28,267,262 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	28,249,278 - 28,267,221 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	5,886,131 - 5,903,492 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc7a10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	9,876,606 - 9,891,366 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624794	9,876,197 - 9,891,398 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc7a10
52 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	178
Count of miRNA genes:	132
Interacting mature miRNAs:	147
Transcripts:	ENSRNOT00000015205
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	51940904	101229020	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	87889942	132889942	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
2300324	Fetw1	Fetal weight QTL 1	12.1	0.005	fetal growth trait (VT:0004201)	fetal body weight (CMO:0002080)	1	92963855	109494029	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	87785026	142582336	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	83019780	128019780	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	81269860	99645535	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	93903998	191260518	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	84107164	115183752	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	91302413	136302413	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	86622262	131622262	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	58769992	103769992	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	0.00039	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)	1	92683681	137683681	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	52891222	109116986	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	86993904	131993904	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	87558587	132558587	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	92683681	137683681	Rat
724529	Cm16	Cardiac mass QTL 16	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	1	96717367	160111531	Rat

Markers in Region

D7Bwg0847e

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	87,841,635 - 87,841,887 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	91,445,129 - 91,445,380	NCBI	Rnor6.0
Rnor_5.0	1	92,575,827 - 92,576,078	UniSTS	Rnor5.0
RGSC_v3.4	1	87,708,158 - 87,708,409	UniSTS	RGSC3.4
Celera	1	82,192,430 - 82,192,681	UniSTS
Cytogenetic Map	1	q21	UniSTS

RH131383

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	87,845,004 - 87,845,223 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	91,448,498 - 91,448,716	NCBI	Rnor6.0
Rnor_5.0	1	92,579,196 - 92,579,414	UniSTS	Rnor5.0
RGSC_v3.4	1	87,711,527 - 87,711,745	UniSTS	RGSC3.4
Celera	1	82,195,799 - 82,196,017	UniSTS
RH 3.4 Map	1	864.7	UniSTS
Cytogenetic Map	1	q21	UniSTS

RH132091

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	87,843,885 - 87,844,087 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	91,447,379 - 91,447,580	NCBI	Rnor6.0
Rnor_5.0	1	92,578,077 - 92,578,278	UniSTS	Rnor5.0
RGSC_v3.4	1	87,710,408 - 87,710,609	UniSTS	RGSC3.4
Celera	1	82,194,680 - 82,194,881	UniSTS
RH 3.4 Map	2	13.3	UniSTS
Cytogenetic Map	1	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
9	11	46	113	81	80	49	25	49	6	204	94	9	93	44	60	31	9	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053726	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588653	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588654	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107883	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107930	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB126813	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC109741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC127467	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000015205 ⟹ ENSRNOP00000015205

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	96,966,076 - 96,982,015 (+)	Ensembl
mRatBN7.2 Ensembl	1	87,829,175 - 87,845,071 (+)	Ensembl
Rnor_6.0 Ensembl	1	91,433,030 - 91,448,564 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000132681 ⟹ ENSRNOP00000107645

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	96,966,115 - 96,982,018 (+)	Ensembl

RefSeq Acc Id:

NM_053726 ⟹ NP_446178

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	96,966,122 - 96,982,020 (+)	NCBI
mRatBN7.2	1	87,829,175 - 87,845,073 (+)	NCBI
Rnor_6.0	1	91,433,030 - 91,448,566 (+)	NCBI
Rnor_5.0	1	92,563,339 - 92,579,264 (+)	NCBI
RGSC_v3.4	1	87,695,658 - 87,711,595 (+)	RGD
Celera	1	82,180,310 - 82,195,867 (+)	RGD

Sequence:

show sequence

CCGACGGAGGACTGGCGGCGGGCCGGATAGACGGGGTAGCGCAGAGAGCTGGGATGAGGCGGGA
CAGCGACATGACAGGCCATATACAGCAGCCAGGCGGGCGCGGGAACCCCAGCCCTGCGCCCTCG
CCCTCCCCGGGCCCTGGTCCTGGCCCGGGCGCCTCGGAGCGGGTGGCACTCAAGAAAGAGATCG
GGCTGGTGAGCGCCTGCACCATCATCATCGGGAACATCATTGGCTCGGGTATCTTCATCTCACC
GAAGGGCGTCCTGGAACACTCGGGCTCCGTGGGTTTGGCCCTCTTCGTCTGGGTCCTGGGTGGG
GGCGTGACAGCTCTAGGCTCTCTCTGCTATGCAGAGCTGGGCGTCACCATCCCCAAGTCTGGTG
GGGACTACGCCTATGTCACTGAGATCTTCGGGGGCCTGGCTGGATTCCTGCTGCTCTGGAGTGC
TGTCCTCATCATGTACCCCACCAGCCTGGCTGTCATCTCCATGACATTCTCCAACTATGTGCTT
CAGCCTGTCTTTCCCAACTGTATCCCCCCAGCCACAGCCTCTCGAGTACTCTCCATGGCCTGCC
TGATGCTCCTGACATGGGTGAACAGCTCCAGCGTACGCTGGGCCACGCGCATCCAGGTTATCTT
CACTGGCGGGAAGCTGTTGGCGTTGTCTCTCATCATCACCGTGGGCTTTGTCCAGATCTTCCAA
GGACACTTTGAAGAGCTGAGACCCACCAATGCCTTCACCTTCTGGATGACACCGTCTGTGGGTC
ACCTAGCCCTGGCTTTCCTCCAAGGTTCTTTTGCCTTCAGTGGTTGGAACTTCCTCAACTATGT
CACCGAGGAGCTGGTTGACCCTCGAAAGAACCTACCTCGTGCCATCTTCATTTCCATCCCACTG
GTCACCTTTGTGTACACATTCACCAATGTTGCCTACTTCACTGCCATGTCCCCCCAGGAGCTGC
TGTCCTCCAACGCAGTGGCTGTGACCTTCGGCGAGAAGCTGCTGGGCTACTTTTCGTGGGTCAT
GCCTGTGTCTGTGGCGCTGTCTACTTTTGGAGGGATCAATGGCTACCTGTTCACCTCATCCAGG
CTATGTTTCTCTGGAGCCCGAGAGGGACACTTACCCAGCTTTCTGGCCATGATTCATGTCAGAC
GCTGTACCCCAATCCCTGCCCTCCTTGTCTGTTGCGGGGCCACAGCGGTCATCATGCTCGTGGG
TGACACATACACACTCATCAACTATGTGTCCTTCATCAACTACCTCTGCTACGGAGTCACTATC
CTGGGCCTGCTTGTGCTGCGCTGGAGACGGCCGGCACTTCACAGGCCCATTAAGGTGAACCTCC
TCATTCCTGTTGTGTACTTGGTGTTCTGGGCATTCCTCCTGGTCTTCAGCTTCATCTCGGAGCC
CATGGTCTGTGGGGTCGGCATCATCATTATCCTCACTGGGGTCCCCATCTTCTTCCTGGGAGTG
TTCTGGAGAAGCAAACCAAAGTGTGTACACAGATTCACAGAGTCCATGACACGCTGGGGCCAGG
AGCTGTGTTTCGTGGTTTACCCCCAGGGCTCCCTGGAGGAGGAGGAAAATGGCCCCATGGGCCA
GCCCTCCCCATTGCCCATCACGGACAAGCCCTTGAAGACACAATGAGACCTAGTAGAGACTGGA
ACAGCTGATTCTGTTTACATGTTGTTTATTGAGAAGGGGTTTGTGTTCTGTTTTGTTTTCAAAA
ATTTTTTTTTCTGCACAAAAAAAGAGACCCGACCCTTAGAGGCCTATTGTAAGGGACTGGCCAC
TGGGGTCGGGCTTCCTGCCTTAGCAATGCCCTGCTAGCTTCTCCAGAAAAGTCTGTAAATAAAC
AGGGCTGGTTGTTCTGTGTGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039107883 ⟹ XP_038963811

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	96,966,030 - 96,982,015 (+)	NCBI
mRatBN7.2	1	87,829,087 - 87,845,068 (+)	NCBI

RefSeq Acc Id:

XM_039107930 ⟹ XP_038963858

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	96,966,030 - 96,982,015 (+)	NCBI
mRatBN7.2	1	87,829,087 - 87,845,068 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_446178	(Get FASTA)	NCBI Sequence Viewer
	XP_038963811	(Get FASTA)	NCBI Sequence Viewer
	XP_038963858	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI27468	(Get FASTA)	NCBI Sequence Viewer
	BAD17967	(Get FASTA)	NCBI Sequence Viewer
	EDM07629	(Get FASTA)	NCBI Sequence Viewer
	EDM07630	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015205
	ENSRNOP00000107645
GenBank Protein	P63116	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446178 ⟸ NM_053726

- UniProtKB:

Q75T81 (UniProtKB/TrEMBL), A6JAA5 (UniProtKB/TrEMBL), A6JAA4 (UniProtKB/TrEMBL), A1L115 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRRDSDMTGHIQQPGGRGNPSPAPSPSPGPGPGPGASERVALKKEIGLVSACTIIIGNIIGSGI
FISPKGVLEHSGSVGLALFVWVLGGGVTALGSLCYAELGVTIPKSGGDYAYVTEIFGGLAGFLL
LWSAVLIMYPTSLAVISMTFSNYVLQPVFPNCIPPATASRVLSMACLMLLTWVNSSSVRWATRI
QVIFTGGKLLALSLIITVGFVQIFQGHFEELRPTNAFTFWMTPSVGHLALAFLQGSFAFSGWNF
LNYVTEELVDPRKNLPRAIFISIPLVTFVYTFTNVAYFTAMSPQELLSSNAVAVTFGEKLLGYF
SWVMPVSVALSTFGGINGYLFTSSRLCFSGAREGHLPSFLAMIHVRRCTPIPALLVCCGATAVI
MLVGDTYTLINYVSFINYLCYGVTILGLLVLRWRRPALHRPIKVNLLIPVVYLVFWAFLLVFSF
ISEPMVCGVGIIIILTGVPIFFLGVFWRSKPKCVHRFTESMTRWGQELCFVVYPQGSLEEEENG
PMGQPSPLPITDKPLKTQ

hide sequence

Ensembl Acc Id:

ENSRNOP00000015205 ⟸ ENSRNOT00000015205

RefSeq Acc Id:	XP_038963811 ⟸ XM_039107883
- Peptide Label:	isoform X1
- UniProtKB:	A6JAA4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963858 ⟸ XM_039107930
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000107645 ⟸ ENSRNOT00000132681

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P63116-F1-model_v2	AlphaFold	P63116	1-530	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689965

Promoter ID:

EPDNEW_R489

Type:

single initiation site

Name:

Slc7a10_1

Description:

solute carrier family 7 member 10

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	91,433,019 - 91,433,079	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621672	AgrOrtholog
BioCyc Gene	G2FUF-59982	BioCyc
Ensembl Genes	ENSRNOG00000010938	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000015205	ENTREZGENE
	ENSRNOT00000132681	ENTREZGENE
Gene3D-CATH	Amino acid/polyamine transporter I	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7313174	IMAGE-MGC_LOAD
InterPro	AA/rel_permease1	UniProtKB/Swiss-Prot
	AminoAcid_Transporter	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:156544	IMAGE-MGC_LOAD
NCBI Gene	114518	ENTREZGENE
PANTHER	AMINO ACID TRANSPORTER	UniProtKB/Swiss-Prot
	ASC-TYPE AMINO ACID TRANSPORTER 1	UniProtKB/Swiss-Prot
Pfam	AA_permease_2	UniProtKB/Swiss-Prot
PhenoGen	Slc7a10	PhenoGen
PIRSF	AA_transporter	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000010938	RatGTEx
UniProt	A1L115	ENTREZGENE, UniProtKB/TrEMBL
	A6JAA4	ENTREZGENE, UniProtKB/TrEMBL
	A6JAA5	ENTREZGENE
	AAA1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q75T81	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	Q9CW25	UniProtKB/Swiss-Prot
	Q9JMH8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-24	Slc7a10	solute carrier family 7 member 10	Slc7a10	solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-01	Slc7a10	solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10	Slc7a10	solute carrier family 7, (neutral amino acid transporter, y+ system) member 10	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-23	Slc7a10	solute carrier family 7, (neutral amino acid transporter, y+ system) member 10	Slc7a10	solute carrier family 7 (cationic amino acid transporter, y+ system), member 10	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Slc7a10	solute carrier family 7 (cationic amino acid transporter, y+ system), member 10		solute carrier family 7, (cationic amino acid transporter, y+ system) member 10	Name updated	1299863	APPROVED
2002-08-07	Slc7a10	solute carrier family 7, (cationic amino acid transporter, y+ system) member 10			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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