Apoc1 (apolipoprotein C1) - Rat Genome Database

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Gene: Apoc1 (apolipoprotein C1) Rattus norvegicus
Analyze
Symbol: Apoc1 (Ensembl: NEWGENE_2134)
Name: apolipoprotein C1
RGD ID: 2134
Description: Predicted to enable fatty acid binding activity and phospholipase inhibitor activity. Involved in regulation of lipid transport. Part of high-density lipoprotein particle and very-low-density lipoprotein particle. Human ortholog(s) of this gene implicated in Alzheimer's disease and obesity. Orthologous to human APOC1 (apolipoprotein C1); PARTICIPATES IN altered lipoprotein metabolic pathway; lipoprotein metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-methylcholanthrene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ALPCI; apo-CI; Apo-CIB; apoC-I; ApoC-IB; apolipoprotein C-I; liver regeneration-related protein LRRG04; LRRG04; NEWGENE_2134
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2179,347,057 - 79,350,340 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,346,136 - 79,350,375 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,741,974 - 84,745,241 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0193,293,309 - 93,296,592 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0186,497,080 - 86,500,347 (-)NCBIRnor_WKY
Rnor_6.0180,606,638 - 80,609,921 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,606,638 - 80,609,921 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,872,116 - 81,875,399 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,996,677 - 78,999,960 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1179,074,789 - 79,077,986 (-)NCBI
Celera173,806,255 - 73,809,538 (-)NCBICelera
Cytogenetic Map1 NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-ephedrine  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
alpha-hexachlorocyclohexane  (EXP)
ammonium chloride  (EXP)
arachidonic acid  (ISO)
belinostat  (ISO)
Benoxacor  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
butanal  (ISO)
caffeine  (EXP,ISO)
capsaicin  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
flutamide  (EXP)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
hydrazine  (EXP)
indometacin  (EXP,ISO)
isotretinoin  (ISO)
lithocholic acid  (ISO)
methapyrilene  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP,ISO)
nickel atom  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
tributylstannane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. APOE and APOC1 genetic polymorphisms in age-associated memory impairment. Bartres-Faz D, etal., Neurogenetics. 2001 Oct;3(4):215-9.
2. Serum apolipoproteins C-I and C-III are reduced in stomach cancer patients: results from MALDI-based peptidome and immuno-based clinical assays. Cohen M, etal., PLoS One. 2011 Jan 18;6(1):e14540. doi: 10.1371/journal.pone.0014540.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Very low-density lipoprotein-apoprotein CI is increased in diabetic nephropathy: comparison with apoprotein CIII. Hirano T, etal., Kidney Int. 2003 Jun;63(6):2171-7.
6. Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3. Jong MC, etal., Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):472-84.
7. Protection from obesity and insulin resistance in mice overexpressing human apolipoprotein C1. Jong MC, etal., Diabetes. 2001 Dec;50(12):2779-85.
8. Genetic association of an apolipoprotein C-I (APOC1) gene polymorphism with late-onset Alzheimer's disease. Ki CS, etal., Neurosci Lett. 2002 Feb 15;319(2):75-8.
9. Human apoA-I expression in CETP transgenic rats leads to lower levels of apoC-I in HDL and to magnification of CETP-mediated lipoprotein changes. Masson D, etal., J Lipid Res. 2006 Feb;47(2):356-65. Epub 2005 Nov 10.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Abnormal composition of apoproteins C-I, C-II, and C-III in plasma and very-low-density lipoproteins of non-insulin-dependent diabetic Chinese. Pan XR, etal., Clin Chem. 1986 Oct;32(10):1914-20.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Stromal responses to carcinomas of the pancreas: juxtatumoral gene expression conforms to the infiltrating pattern and not the biologic subtype. Ricci F, etal., Cancer Biol Ther. 2005 Mar;4(3):302-7. Epub 2005 Mar 23.
17. Two coding regions closely linked to the rat apolipoprotein E gene: nucleotide sequences of rat apolipoprotein C-I and ECL cDNA. Shen P and Howlett GJ, Arch Biochem Biophys 1992 Sep;297(2):345-53.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Diagnostic and prognostic significance of mRNA expressions of apolipoprotein A and C family genes in hepatitis B virus-related hepatocellular carcinoma. Wang X, etal., J Cell Biochem. 2019 Oct;120(10):18246-18265. doi: 10.1002/jcb.29131. Epub 2019 Jun 18.
Additional References at PubMed
PMID:182536   PMID:1917954   PMID:2302419   PMID:2771655   PMID:4020294   PMID:7848292   PMID:10978346   PMID:11162594   PMID:12477932   PMID:15576844   PMID:17339654   PMID:23376485  


Genomics

Comparative Map Data
Apoc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2179,347,057 - 79,350,340 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,346,136 - 79,350,375 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,741,974 - 84,745,241 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0193,293,309 - 93,296,592 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0186,497,080 - 86,500,347 (-)NCBIRnor_WKY
Rnor_6.0180,606,638 - 80,609,921 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,606,638 - 80,609,921 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,872,116 - 81,875,399 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,996,677 - 78,999,960 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1179,074,789 - 79,077,986 (-)NCBI
Celera173,806,255 - 73,809,538 (-)NCBICelera
Cytogenetic Map1 NCBI
APOC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,914,325 - 44,919,346 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1944,914,247 - 44,919,349 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,417,582 - 45,422,603 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,109,761 - 50,114,446 (+)NCBINCBI36Build 36hg18NCBI36
Build 341950,109,760 - 50,114,446NCBI
Celera1942,222,238 - 42,226,929 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1941,848,690 - 41,853,227 (+)NCBIHuRef
CHM1_11945,420,643 - 45,425,333 (+)NCBICHM1_1
T2T-CHM13v2.01947,739,017 - 47,744,046 (+)NCBIT2T-CHM13v2.0
Apoc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,423,405 - 19,426,584 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,423,406 - 19,426,585 (-)EnsemblGRCm39 Ensembl
GRCm38719,689,480 - 19,692,659 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,689,481 - 19,692,660 (-)EnsemblGRCm38mm10GRCm38
MGSCv37720,274,830 - 20,278,007 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,848,007 - 18,851,095 (-)NCBIMGSCv36mm8
Celera717,095,563 - 17,098,741 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.94NCBI
Apoc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555552,005,962 - 2,007,239 (+)NCBIChiLan1.0ChiLan1.0
APOC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11950,468,337 - 50,480,967 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01941,862,168 - 41,878,231 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
APOC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,520,177 - 110,522,563 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,520,198 - 110,631,412 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1110,001,120 - 110,003,506 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01111,049,949 - 111,052,329 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,049,970 - 111,194,226 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,724,595 - 110,726,986 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,360,068 - 110,362,462 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,228,866 - 111,231,250 (-)NCBIUU_Cfam_GSD_1.0
Apoc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,171,122 - 17,173,636 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367061,519,248 - 1,520,102 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Apoc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,758,696 - 1,760,611 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249071,758,671 - 1,760,611 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Apoc1
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:59
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000046169
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 23 23 23
Medium 20 18 18 9 1 11 2
Low 2 30 16 2 19 2 8 8 51 18 29 9 8
Below cutoff 1 12 7 7 7 1 16 13 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000046169   ⟹   ENSRNOP00000040585
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,347,053 - 79,350,340 (-)Ensembl
Rnor_6.0 Ensembl180,606,638 - 80,609,921 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091647   ⟹   ENSRNOP00000068542
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl180,606,640 - 80,609,836 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115465   ⟹   ENSRNOP00000081499
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,346,136 - 79,350,375 (-)Ensembl
RefSeq Acc Id: NM_001109996   ⟹   NP_001103466
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2179,347,057 - 79,350,340 (-)NCBI
Rnor_6.0180,606,638 - 80,609,921 (-)NCBI
Rnor_5.0181,872,116 - 81,875,399 (-)NCBI
RGSC_v3.4178,996,677 - 78,999,960 (-)RGD
Celera173,806,255 - 73,809,538 (-)RGD
Sequence:
RefSeq Acc Id: NM_012824   ⟹   NP_036956
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2179,347,057 - 79,350,255 (-)NCBI
Rnor_6.0180,606,638 - 80,609,921 (-)NCBI
Rnor_5.0181,872,116 - 81,875,399 (-)NCBI
RGSC_v3.4178,996,677 - 78,999,960 (-)RGD
Celera173,806,255 - 73,809,538 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036956   ⟸   NM_012824
- Peptide Label: precursor
- UniProtKB: Q53ZD8 (UniProtKB/Swiss-Prot),   P19939 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001103466   ⟸   NM_001109996
- Peptide Label: precursor
- UniProtKB: Q53ZD8 (UniProtKB/Swiss-Prot),   P19939 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068542   ⟸   ENSRNOT00000091647
RefSeq Acc Id: ENSRNOP00000040585   ⟸   ENSRNOT00000046169
RefSeq Acc Id: ENSRNOP00000081499   ⟸   ENSRNOT00000115465

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19939-F1-model_v2 AlphaFold P19939 1-88 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689779
Promoter ID:EPDNEW_R303
Type:multiple initiation site
Name:Apoc1_1
Description:apolipoprotein C1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0180,609,921 - 80,609,981EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2134 AgrOrtholog
BioCyc Gene G2FUF-60489 BioCyc
Ensembl Genes ENSRNOG00000018426 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000040585.3 UniProtKB/TrEMBL
  ENSRNOP00000081499.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000046169.4 UniProtKB/TrEMBL
  ENSRNOT00000115465.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.260.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7372566 IMAGE-MGC_LOAD
InterPro ApoC-1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ApoC-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25292 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112622 IMAGE-MGC_LOAD
NCBI Gene 25292 ENTREZGENE
PANTHER PTHR16565 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ApoC-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Apoc1 PhenoGen
TIGR TC209704
UniProt A0A8I5ZRS9_RAT UniProtKB/TrEMBL
  A0A8L2ULG0_RAT UniProtKB/TrEMBL
  APOC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q53ZD8 ENTREZGENE
UniProt Secondary Q53ZD8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Apoc1  apolipoprotein C1  NEWGENE_2134  apolipoprotein C1  Data Merged 737654 PROVISIONAL
2016-08-02 NEWGENE_2134  apolipoprotein C1      Symbol and Name status set to provisional 70820 PROVISIONAL
2016-05-04 Apoc1  apolipoprotein C1  Apoc1  apolipoprotein C-I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Apoc1  apolipoprotein C-I    Apolipoprotein C1  Name updated 629478 APPROVED
2002-06-10 Apoc1  Apolipoprotein C1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 70608
gene_mapping maps 4.5 kb downstream of the Apoe gene 70608
gene_protein mature protein contains histidine and lacks valine 70608