APOC1 (apolipoprotein C1) - Rat Genome Database

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Gene: APOC1 (apolipoprotein C1) Homo sapiens
Analyze
Symbol: APOC1
Name: apolipoprotein C1
RGD ID: 735472
HGNC Page HGNC:607
Description: Enables fatty acid binding activity and phospholipase inhibitor activity. Involved in several processes, including lipid transport; negative regulation of lipid metabolic process; and negative regulation of transport. Located in endoplasmic reticulum. Part of high-density lipoprotein particle and very-low-density lipoprotein particle. Implicated in Alzheimer's disease and obesity. Biomarker of pancreatic ductal carcinoma and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Apo-CI; apo-CIB; ApoC-I; apoC-IB; apolipoprotein C-I; apolipoprotein C-I variant I; apolipoprotein C-I variant II
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: APOC1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,914,325 - 44,919,346 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1944,914,247 - 44,919,349 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,417,582 - 45,422,603 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,109,761 - 50,114,446 (+)NCBINCBI36hg18NCBI36
Build 341950,109,760 - 50,114,446NCBI
Celera1942,222,238 - 42,226,929 (+)NCBI
Cytogenetic Map19q13.32NCBI
HuRef1941,848,690 - 41,853,227 (+)NCBIHuRef
CHM1_11945,420,643 - 45,425,333 (+)NCBICHM1_1
T2T-CHM13v2.01947,739,017 - 47,744,046 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-ephedrine  (EXP)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-hexachlorocyclohexane  (ISO)
ammonium chloride  (ISO)
arachidonic acid  (ISO)
belinostat  (EXP)
Benoxacor  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (EXP)
caffeine  (EXP,ISO)
capsaicin  (EXP)
chlordecone  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
Cuprizon  (ISO)
cyclosporin A  (EXP)
dexamethasone  (EXP)
dioxygen  (ISO)
doxorubicin  (EXP)
flutamide  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
hydrazine  (ISO)
indometacin  (EXP,ISO)
isotretinoin  (EXP)
lithocholic acid  (ISO)
methapyrilene  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
mifepristone  (EXP,ISO)
nickel atom  (EXP)
nitrofen  (ISO)
ochratoxin A  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pioglitazone  (EXP)
pirinixic acid  (ISO)
quercetin  (EXP)
resveratrol  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
Tanshinone I  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
tributylstannane  (ISO)
urethane  (EXP)
valproic acid  (EXP)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. APOE and APOC1 genetic polymorphisms in age-associated memory impairment. Bartres-Faz D, etal., Neurogenetics. 2001 Oct;3(4):215-9.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Very low-density lipoprotein-apoprotein CI is increased in diabetic nephropathy: comparison with apoprotein CIII. Hirano T, etal., Kidney Int. 2003 Jun;63(6):2171-7.
4. Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3. Jong MC, etal., Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):472-84.
5. Protection from obesity and insulin resistance in mice overexpressing human apolipoprotein C1. Jong MC, etal., Diabetes. 2001 Dec;50(12):2779-85.
6. Correlation of a T45S variant of apolipoprotein C1 with elevated BMI in persons of American Indian and Mexican ancestries. Kasthuri RS, etal., Int J Obes (Lond). 2007 Aug;31(8):1334-6. Epub 2007 Feb 20.
7. Genetic association of an apolipoprotein C-I (APOC1) gene polymorphism with late-onset Alzheimer's disease. Ki CS, etal., Neurosci Lett. 2002 Feb 15;319(2):75-8.
8. Abnormal composition of apoproteins C-I, C-II, and C-III in plasma and very-low-density lipoproteins of non-insulin-dependent diabetic Chinese. Pan XR, etal., Clin Chem. 1986 Oct;32(10):1914-20.
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Stromal responses to carcinomas of the pancreas: juxtatumoral gene expression conforms to the infiltrating pattern and not the biologic subtype. Ricci F, etal., Cancer Biol Ther. 2005 Mar;4(3):302-7. Epub 2005 Mar 23.
Additional References at PubMed
PMID:166984   PMID:182536   PMID:1917954   PMID:2302419   PMID:2835369   PMID:2897845   PMID:2985493   PMID:3013172   PMID:3017837   PMID:4020294   PMID:4369340   PMID:6328444  
PMID:6789904   PMID:7471419   PMID:7779782   PMID:8125298   PMID:8432525   PMID:8804993   PMID:9300485   PMID:10391210   PMID:10520737   PMID:10978346   PMID:11054415   PMID:11076863  
PMID:11162594   PMID:11256614   PMID:11702052   PMID:11991719   PMID:12032151   PMID:12044170   PMID:12113906   PMID:12220441   PMID:12429068   PMID:12477932   PMID:12678662   PMID:12705839  
PMID:12736801   PMID:12805445   PMID:12860251   PMID:12962909   PMID:14523051   PMID:14705977   PMID:14746139   PMID:15077570   PMID:15174051   PMID:15339254   PMID:15364690   PMID:15489334  
PMID:15489336   PMID:15576844   PMID:15767578   PMID:15769335   PMID:15777558   PMID:15793777   PMID:15840864   PMID:15900219   PMID:16159884   PMID:16344560   PMID:16381901   PMID:16459141  
PMID:16478678   PMID:16544732   PMID:16608402   PMID:16631424   PMID:16763159   PMID:16935938   PMID:16981907   PMID:17053273   PMID:17254710   PMID:17339654   PMID:17341095   PMID:17463246  
PMID:17474819   PMID:17667986   PMID:17761674   PMID:17936795   PMID:17975299   PMID:17998437   PMID:18037960   PMID:18049452   PMID:18160739   PMID:18193043   PMID:18193044   PMID:18262040  
PMID:18667498   PMID:18802019   PMID:18835943   PMID:18976728   PMID:18984910   PMID:18992221   PMID:19014618   PMID:19060906   PMID:19062221   PMID:19197348   PMID:19252179   PMID:19336475  
PMID:19336575   PMID:19368908   PMID:19417222   PMID:19494537   PMID:19567438   PMID:19761869   PMID:19785722   PMID:19808960   PMID:19812053   PMID:19913121   PMID:19936222   PMID:20145290  
PMID:20209111   PMID:20308432   PMID:20331378   PMID:20339536   PMID:20430392   PMID:20442857   PMID:20498921   PMID:20571754   PMID:20580041   PMID:20628086   PMID:20686565   PMID:20691829  
PMID:20714348   PMID:20838585   PMID:20864672   PMID:20880607   PMID:20972250   PMID:21103663   PMID:21187063   PMID:21196492   PMID:21267442   PMID:21300955   PMID:21533863   PMID:21740922  
PMID:21873635   PMID:21900206   PMID:21909108   PMID:21943158   PMID:22003152   PMID:22005931   PMID:22022282   PMID:22054870   PMID:22264166   PMID:22286219   PMID:22404376   PMID:22474067  
PMID:22710912   PMID:22832961   PMID:22916037   PMID:22995522   PMID:23031429   PMID:23118302   PMID:23376485   PMID:23383108   PMID:23419831   PMID:23455636   PMID:23555584   PMID:23620136  
PMID:23670531   PMID:23726366   PMID:24023261   PMID:24097068   PMID:24121499   PMID:24498013   PMID:24574346   PMID:24582705   PMID:24688116   PMID:24755620   PMID:24816252   PMID:25350695  
PMID:25785516   PMID:26576771   PMID:26639962   PMID:26657933   PMID:27040450   PMID:27052600   PMID:27179730   PMID:27707806   PMID:27805002   PMID:27806189   PMID:27976371   PMID:28065845  
PMID:28486432   PMID:29636060   PMID:30130702   PMID:30559175   PMID:30684189   PMID:31006040   PMID:31211449   PMID:31615875   PMID:31779116   PMID:32296183   PMID:32619263   PMID:32826950  
PMID:32961112   PMID:33305507   PMID:33591959   PMID:33935285   PMID:33961781   PMID:34596727   PMID:34625307   PMID:34711951   PMID:35695660  


Genomics

Candidate Gene Status
APOC1 is a candidate Gene for QTL BW139_H
Comparative Map Data
APOC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,914,325 - 44,919,346 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1944,914,247 - 44,919,349 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,417,582 - 45,422,603 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,109,761 - 50,114,446 (+)NCBINCBI36hg18NCBI36
Build 341950,109,760 - 50,114,446NCBI
Celera1942,222,238 - 42,226,929 (+)NCBI
Cytogenetic Map19q13.32NCBI
HuRef1941,848,690 - 41,853,227 (+)NCBIHuRef
CHM1_11945,420,643 - 45,425,333 (+)NCBICHM1_1
T2T-CHM13v2.01947,739,017 - 47,744,046 (+)NCBI
Apoc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,423,405 - 19,426,584 (-)NCBIGRCm39mm39
GRCm39 Ensembl719,423,406 - 19,426,585 (-)Ensembl
GRCm38719,689,480 - 19,692,659 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,689,481 - 19,692,660 (-)EnsemblGRCm38mm10GRCm38
MGSCv37720,274,830 - 20,278,007 (-)NCBIGRCm37mm9NCBIm37
MGSCv36718,848,007 - 18,851,095 (-)NCBImm8
Celera717,095,563 - 17,098,741 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.94NCBI
Apoc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2179,347,057 - 79,350,340 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl179,346,136 - 79,350,375 (-)Ensembl
Rnor_6.0180,606,638 - 80,609,921 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,606,638 - 80,609,921 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,872,116 - 81,875,399 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,996,677 - 78,999,960 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1179,074,789 - 79,077,986 (-)NCBI
Celera173,806,255 - 73,809,538 (-)NCBICelera
Cytogenetic Map1 NCBI
Apoc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555552,005,962 - 2,007,239 (+)NCBIChiLan1.0ChiLan1.0
APOC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11950,468,337 - 50,480,967 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01941,862,168 - 41,878,231 (+)NCBIMhudiblu_PPA_v0panPan3
APOC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,520,177 - 110,522,563 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,520,198 - 110,631,412 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1110,001,120 - 110,003,506 (-)NCBI
ROS_Cfam_1.01111,049,949 - 111,052,329 (-)NCBI
ROS_Cfam_1.0 Ensembl1111,049,970 - 111,194,226 (-)Ensembl
UMICH_Zoey_3.11110,724,595 - 110,726,986 (-)NCBI
UNSW_CanFamBas_1.01110,360,068 - 110,362,462 (-)NCBI
UU_Cfam_GSD_1.01111,228,866 - 111,231,250 (-)NCBI
Apoc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,171,122 - 17,173,636 (+)NCBI
SpeTri2.0NW_0049367061,519,248 - 1,520,102 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Apoc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,758,696 - 1,760,611 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046249071,758,671 - 1,760,611 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
PMC164795P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371945,429,809 - 45,430,280UniSTSGRCh37
GRCh371945,417,713 - 45,418,196UniSTSGRCh37
Build 361950,109,553 - 50,110,036RGDNCBI36
Celera1942,234,132 - 42,234,603UniSTS
Celera1942,222,030 - 42,222,513RGD
Cytogenetic Map19q13.2UniSTS
HuRef1941,848,482 - 41,848,965UniSTS
HuRef1941,860,362 - 41,860,833UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3192
Count of miRNA genes:567
Interacting mature miRNAs:641
Transcripts:ENST00000252491, ENST00000586638, ENST00000588750, ENST00000588802, ENST00000589078, ENST00000589781, ENST00000590334, ENST00000592176, ENST00000592535, ENST00000592885
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 1 2 477 411 9 411 5 4 8 10 7
Medium 464 425 814 98 652 42 1700 84 2175 183 602 1208 57 819 578 4
Low 1788 1967 429 113 801 11 2484 1843 1510 215 824 359 113 385 2050
Below cutoff 171 550 1 403 162 265 16 10 10 27 156

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001379687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC011481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF050154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF308154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF308155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI310334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI885116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY422954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA445083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA482306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ525874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M20843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M20902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000586638   ⟹   ENSP00000466146
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1944,914,869 - 44,919,346 (+)Ensembl
RefSeq Acc Id: ENST00000588750   ⟹   ENSP00000465356
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1944,914,247 - 44,919,342 (+)Ensembl
RefSeq Acc Id: ENST00000588802   ⟹   ENSP00000468029
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1944,914,325 - 44,919,346 (+)Ensembl
RefSeq Acc Id: ENST00000589078   ⟹   ENSP00000465710
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1944,914,840 - 44,916,292 (+)Ensembl
RefSeq Acc Id: ENST00000589781   ⟹   ENSP00000467504
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1944,914,710 - 44,919,343 (+)Ensembl
RefSeq Acc Id: ENST00000590334   ⟹   ENSP00000465190
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1944,914,869 - 44,919,342 (+)Ensembl
RefSeq Acc Id: ENST00000592176   ⟹   ENSP00000466227
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1944,914,869 - 44,919,349 (+)Ensembl
RefSeq Acc Id: ENST00000592535   ⟹   ENSP00000468276
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1944,914,608 - 44,919,346 (+)Ensembl
RefSeq Acc Id: ENST00000592885   ⟹   ENSP00000467368
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1944,914,703 - 44,919,344 (+)Ensembl
RefSeq Acc Id: NM_001321065   ⟹   NP_001307994
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381944,914,325 - 44,919,346 (+)NCBI
CHM1_11945,420,226 - 45,425,333 (+)NCBI
T2T-CHM13v2.01947,739,017 - 47,744,046 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001321066   ⟹   NP_001307995
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381944,914,325 - 44,919,346 (+)NCBI
CHM1_11945,420,226 - 45,425,333 (+)NCBI
T2T-CHM13v2.01947,739,017 - 47,744,046 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001379687   ⟹   NP_001366616
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381944,914,672 - 44,919,346 (+)NCBI
T2T-CHM13v2.01947,739,364 - 47,744,046 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001645   ⟹   NP_001636
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381944,914,608 - 44,919,346 (+)NCBI
GRCh371945,417,577 - 45,422,606 (+)NCBI
Build 361950,109,761 - 50,114,446 (+)NCBI Archive
HuRef1941,848,690 - 41,853,227 (+)ENTREZGENE
CHM1_11945,420,534 - 45,425,333 (+)NCBI
T2T-CHM13v2.01947,739,300 - 47,744,046 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001636   ⟸   NM_001645
- Peptide Label: isoform a precursor
- UniProtKB: P02654 (UniProtKB/Swiss-Prot),   A0A024R0T8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001307995   ⟸   NM_001321066
- Peptide Label: isoform a precursor
- UniProtKB: P02654 (UniProtKB/Swiss-Prot),   A0A024R0T8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001307994   ⟸   NM_001321065
- Peptide Label: isoform a precursor
- UniProtKB: P02654 (UniProtKB/Swiss-Prot),   A0A024R0T8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001366616   ⟸   NM_001379687
- Peptide Label: isoform b precursor
RefSeq Acc Id: ENSP00000466146   ⟸   ENST00000586638
RefSeq Acc Id: ENSP00000465356   ⟸   ENST00000588750
RefSeq Acc Id: ENSP00000468029   ⟸   ENST00000588802
RefSeq Acc Id: ENSP00000465710   ⟸   ENST00000589078
RefSeq Acc Id: ENSP00000467504   ⟸   ENST00000589781
RefSeq Acc Id: ENSP00000465190   ⟸   ENST00000590334
RefSeq Acc Id: ENSP00000467368   ⟸   ENST00000592885
RefSeq Acc Id: ENSP00000466227   ⟸   ENST00000592176
RefSeq Acc Id: ENSP00000468276   ⟸   ENST00000592535

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02654-F1-model_v2 AlphaFold P02654 1-83 view protein structure

Promoters
RGD ID:7240359
Promoter ID:EPDNEW_H25926
Type:initiation region
Name:APOC1_2
Description:apolipoprotein C1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25927  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381944,914,325 - 44,914,385EPDNEW
RGD ID:7240365
Promoter ID:EPDNEW_H25927
Type:multiple initiation site
Name:APOC1_1
Description:apolipoprotein C1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25926  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381944,914,708 - 44,914,768EPDNEW
RGD ID:6795141
Promoter ID:HG_KWN:30241
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:NM_001645,   UC002PAC.1,   UC002PAD.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361950,109,596 - 50,110,096 (+)MPROMDB
RGD ID:6852788
Promoter ID:EP74196
Type:single initiation site
Name:HS_APOC1
Description:Apolipoprotein C-I.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:No map positions available.

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh37/hg19 19q13.2-13.32(chr19:43013365-47241534)x1 copy number loss See cases [RCV000240182] Chr19:43013365..47241534 [GRCh37]
Chr19:19q13.2-13.32
pathogenic
GRCh37/hg19 19q13.32(chr19:45284576-45978239)x3 copy number gain See cases [RCV000239782] Chr19:45284576..45978239 [GRCh37]
Chr19:19q13.32
uncertain significance
GRCh37/hg19 19q13.31-13.32(chr19:44300416-45639540)x1 copy number loss See cases [RCV000512107] Chr19:44300416..45639540 [GRCh37]
Chr19:19q13.31-13.32
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19q13.32(chr19:45338895-45618902)x3 copy number gain not provided [RCV000752710] Chr19:45338895..45618902 [GRCh37]
Chr19:19q13.32
benign
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33
pathogenic
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42
pathogenic
GRCh37/hg19 19q13.31-13.32(chr19:45074342-46133841) copy number gain not specified [RCV002052686] Chr19:45074342..46133841 [GRCh37]
Chr19:19q13.31-13.32
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:607 AgrOrtholog
COSMIC APOC1 COSMIC
Ensembl Genes ENSG00000130208 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000465190.1 UniProtKB/TrEMBL
  ENSP00000465356 ENTREZGENE
  ENSP00000465356.1 UniProtKB/Swiss-Prot
  ENSP00000465710.1 UniProtKB/TrEMBL
  ENSP00000466146.1 UniProtKB/TrEMBL
  ENSP00000466227.1 UniProtKB/TrEMBL
  ENSP00000467368 ENTREZGENE
  ENSP00000467368.1 UniProtKB/TrEMBL
  ENSP00000467504.1 UniProtKB/TrEMBL
  ENSP00000468029 ENTREZGENE
  ENSP00000468029.1 UniProtKB/Swiss-Prot
  ENSP00000468276 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000468276.2 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000586638.5 UniProtKB/TrEMBL
  ENST00000588750 ENTREZGENE
  ENST00000588750.5 UniProtKB/Swiss-Prot
  ENST00000588802 ENTREZGENE
  ENST00000588802.5 UniProtKB/Swiss-Prot
  ENST00000589078.1 UniProtKB/TrEMBL
  ENST00000589781.1 UniProtKB/TrEMBL
  ENST00000590334.5 UniProtKB/TrEMBL
  ENST00000592176.1 UniProtKB/TrEMBL
  ENST00000592535 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000592535.6 UniProtKB/Swiss-Prot
  ENST00000592885 ENTREZGENE
  ENST00000592885.5 UniProtKB/TrEMBL
Gene3D-CATH 4.10.260.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000130208 GTEx
HGNC ID HGNC:607 ENTREZGENE
Human Proteome Map APOC1 Human Proteome Map
InterPro ApoC-1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ApoC-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:341 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 341 ENTREZGENE
OMIM 107710 OMIM
PANTHER PTHR16565 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ApoC-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA51 PharmGKB
UniProt A0A024R0T8 ENTREZGENE, UniProtKB/TrEMBL
  APOC1_HUMAN UniProtKB/Swiss-Prot
  K7EJI9_HUMAN UniProtKB/TrEMBL
  K7EKP1_HUMAN UniProtKB/TrEMBL
  K7ELM9_HUMAN UniProtKB/TrEMBL
  K7ELU7_HUMAN UniProtKB/TrEMBL
  K7EPF9_HUMAN UniProtKB/TrEMBL
  K7EPR9_HUMAN UniProtKB/TrEMBL
  K7ERI9_HUMAN UniProtKB/TrEMBL
  P02654 ENTREZGENE
UniProt Secondary B2R526 UniProtKB/Swiss-Prot
  Q6IB97 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-03 APOC1  apolipoprotein C1    apolipoprotein C-I  Symbol and/or name change 5135510 APPROVED
2011-08-16 APOC1  apolipoprotein C-I  APOC1  apolipoprotein C-I  Symbol and/or name change 5135510 APPROVED