Lgals7 (galectin 7) - Rat Genome Database

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Gene: Lgals7 (galectin 7) Rattus norvegicus
Analyze
Symbol: Lgals7
Name: galectin 7
RGD ID: 61951
Description: Predicted to enable carbohydrate binding activity. Predicted to be involved in apoptotic process. Predicted to be located in cytoplasm; extracellular region; and nucleus. Predicted to be active in cornified envelope. Orthologous to several human genes including LGALS7 (galectin 7); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: gal-7; Galectin-7; lectin, galactose binding, soluble 7; lectin, galactoside-binding, soluble, 7
RGD Orthologs
Human
Mouse
Squirrel
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,275,092 - 93,279,529 (+)NCBIGRCr8
mRatBN7.2184,148,612 - 84,152,016 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,150,252 - 84,152,015 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,560,269 - 89,562,025 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0198,019,035 - 98,020,821 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,316,129 - 91,317,885 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0187,044,823 - 87,047,223 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,045,335 - 87,047,223 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,224,505 - 88,227,841 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,968,263 - 83,970,018 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1184,046,373 - 84,048,126 (+)NCBI
Celera178,540,566 - 78,542,321 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Changes in galectin-7 and cytokeratin-19 expression during the progression of malignancy in thyroid tumors: diagnostic and biological implications. Rorive S, etal., Mod Pathol 2002 Dec;15(12):1294-301.
7. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8889548   PMID:9697310   PMID:19199708   PMID:21677144   PMID:23376485   PMID:33416139  


Genomics

Comparative Map Data
Lgals7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,275,092 - 93,279,529 (+)NCBIGRCr8
mRatBN7.2184,148,612 - 84,152,016 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,150,252 - 84,152,015 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,560,269 - 89,562,025 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0198,019,035 - 98,020,821 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,316,129 - 91,317,885 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0187,044,823 - 87,047,223 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,045,335 - 87,047,223 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,224,505 - 88,227,841 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,968,263 - 83,970,018 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1184,046,373 - 84,048,126 (+)NCBI
Celera178,540,566 - 78,542,321 (+)NCBICelera
Cytogenetic Map1q21NCBI
LGALS7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,770,968 - 38,773,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,770,968 - 38,773,517 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,789,200 - 38,791,754 (+)EnsemblGRCh38hg38GRCh38
GRCh371939,261,608 - 39,264,157 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361943,953,445 - 43,955,983 (-)NCBINCBI36Build 36hg18NCBI36
Build 341943,971,693 - 43,974,232NCBI
Celera1936,063,616 - 36,066,165 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,727,171 - 35,729,720 (+)NCBIHuRef
CHM1_11939,262,048 - 39,264,610 (-)NCBICHM1_1
T2T-CHM13v2.01941,575,026 - 41,577,575 (-)NCBIT2T-CHM13v2.0
Lgals7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,563,258 - 28,565,711 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,563,278 - 28,565,709 (+)EnsemblGRCm39 Ensembl
GRCm38728,863,796 - 28,866,285 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,863,853 - 28,866,284 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,649,405 - 29,651,303 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,573,146 - 28,575,044 (+)NCBIMGSCv36mm8
Celera723,425,320 - 23,427,218 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.94NCBI
Lgals7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,261,564 - 13,263,639 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049368011,426,920 - 1,428,976 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGALS7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1647,588,983 - 47,604,520 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,151,691 - 43,230,013 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Lgals7
49 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:118
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000027620
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat

Markers in Region
RH137014  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2184,151,437 - 84,151,975 (+)MAPPERmRatBN7.2
Rnor_6.0187,046,644 - 87,047,181NCBIRnor6.0
Rnor_5.0188,227,262 - 88,227,799UniSTSRnor5.0
RGSC_v3.4183,969,440 - 83,969,977UniSTSRGSC3.4
Celera178,541,743 - 78,542,280UniSTS
RH 3.4 Map1829.8UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 6
Low 2 11 10 2 14 2 1 1 12 25 5 1
Below cutoff 1 21 9 8 5 8 4 7 39 23 10 4

Sequence


RefSeq Acc Id: ENSRNOT00000027620   ⟹   ENSRNOP00000027620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,150,252 - 84,152,013 (+)Ensembl
Rnor_6.0 Ensembl187,045,796 - 87,047,221 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084393   ⟹   ENSRNOP00000068607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,150,312 - 84,152,015 (+)Ensembl
Rnor_6.0 Ensembl187,045,335 - 87,047,223 (+)Ensembl
RefSeq Acc Id: NM_022582   ⟹   NP_072104
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,277,774 - 93,279,529 (+)NCBI
mRatBN7.2184,150,261 - 84,152,016 (+)NCBI
Rnor_6.0187,045,467 - 87,047,222 (+)NCBI
Rnor_5.0188,224,505 - 88,227,841 (+)NCBI
RGSC_v3.4183,968,263 - 83,970,018 (+)RGD
Celera178,540,566 - 78,542,321 (+)RGD
Sequence:
RefSeq Acc Id: XM_039109505   ⟹   XP_038965433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,275,092 - 93,279,526 (+)NCBI
mRatBN7.2184,148,612 - 84,152,016 (+)NCBI
RefSeq Acc Id: XM_039109509   ⟹   XP_038965437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,275,092 - 93,279,526 (+)NCBI
mRatBN7.2184,148,612 - 84,152,016 (+)NCBI
RefSeq Acc Id: NP_072104   ⟸   NM_022582
- UniProtKB: O54958 (UniProtKB/Swiss-Prot),   P97590 (UniProtKB/Swiss-Prot),   A6J9L7 (UniProtKB/TrEMBL),   F8WG95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068607   ⟸   ENSRNOT00000084393
RefSeq Acc Id: ENSRNOP00000027620   ⟸   ENSRNOT00000027620
RefSeq Acc Id: XP_038965433   ⟸   XM_039109505
- Peptide Label: isoform X1
- UniProtKB: P97590 (UniProtKB/Swiss-Prot),   O54958 (UniProtKB/Swiss-Prot),   A6J9L7 (UniProtKB/TrEMBL),   F8WG95 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965437   ⟸   XM_039109509
- Peptide Label: isoform X1
- UniProtKB: P97590 (UniProtKB/Swiss-Prot),   O54958 (UniProtKB/Swiss-Prot),   A6J9L7 (UniProtKB/TrEMBL),   F8WG95 (UniProtKB/TrEMBL)
Protein Domains
Galectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97590-F1-model_v2 AlphaFold P97590 1-136 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689890
Promoter ID:EPDNEW_R413
Type:single initiation site
Name:Lgals7_1
Description:galectin 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0187,045,444 - 87,045,504EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61951 AgrOrtholog
BioCyc Gene G2FUF-60211 BioCyc
Ensembl Genes ENSRNOG00000020380 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055033298 UniProtKB/Swiss-Prot
  ENSRNOG00060032195 UniProtKB/Swiss-Prot
  ENSRNOG00065034055 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027620 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000027620.6 UniProtKB/Swiss-Prot
  ENSRNOT00000084393.2 UniProtKB/TrEMBL
  ENSRNOT00055057553 UniProtKB/Swiss-Prot
  ENSRNOT00060055797 UniProtKB/Swiss-Prot
  ENSRNOT00065058494 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galectin_CRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29518 ENTREZGENE
PANTHER PTHR11346 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11346:SF107 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Gal-bind_lectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lgals7 PhenoGen
PROSITE GALECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020380 RatGTEx
  ENSRNOG00055033298 RatGTEx
  ENSRNOG00060032195 RatGTEx
  ENSRNOG00065034055 RatGTEx
SMART Gal-bind_lectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218382
UniProt A0A8L2QZL5_RAT UniProtKB/TrEMBL
  A6J9L7 ENTREZGENE, UniProtKB/TrEMBL
  F8WG95 ENTREZGENE, UniProtKB/TrEMBL
  LEG7_RAT UniProtKB/Swiss-Prot
  O54958 ENTREZGENE
  P97590 ENTREZGENE
UniProt Secondary O54958 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-18 Lgals7  galectin 7  Lgals7  lectin, galactoside-binding, soluble, 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-30 Lgals7  lectin, galactoside-binding, soluble, 7  Lgals7  lectin, galactose binding, soluble 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Lgals7  lectin, galactose binding, soluble 7      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference