Tgfb1 (transforming growth factor, beta 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tgfb1 (transforming growth factor, beta 1) Rattus norvegicus
Analyze
Symbol: Tgfb1
Name: transforming growth factor, beta 1
RGD ID: 69051
Description: Enables identical protein binding activity. Involved in several processes, including cellular response to acetaldehyde; negative regulation of transport; and regulation of epithelial cell proliferation. Acts upstream of or within positive regulation of smooth muscle cell differentiation. Located in several cellular components, including cell surface; neuronal cell body; and secretory granule. Used to study chronic obstructive pulmonary disease; familial hyperlipidemia; hypertension; proteinuria; and pulmonary fibrosis. Biomarker of several diseases, including allergic rhinitis; artery disease (multiple); cerebrovascular disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; artery disease (multiple); bone disease (multiple); carcinoma (multiple); and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1); PARTICIPATES IN altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; glypican signaling pathway; INTERACTS WITH (+)-schisandrin B; (+)-taxifolin; (+)-Tetrandrine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: TGF-beta-1; Tgfb; transforming growth factor beta-1; transforming growth factor beta-1 proprotein; transforming growth factor, beta-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Tgfb1em3Mcwi   Tgfb1em1Mcwi  
Genetic Models: SS-Tgfb1em3Mcwi SS-Tgfb1em1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,324,312 - 90,340,627 (+)NCBIGRCr8
mRatBN7.2181,196,532 - 81,212,848 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,196,532 - 81,212,847 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,588,717 - 86,605,032 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0195,140,207 - 95,156,569 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,344,513 - 88,360,828 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,480,875 - 82,497,196 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,480,195 - 82,497,199 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,742,151 - 83,758,472 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,894,705 - 80,911,020 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1180,972,549 - 80,988,992 (+)NCBI
Celera175,636,001 - 75,652,315 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acromicric dysplasia  (ISO)
actinic keratosis  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
alcoholic liver cirrhosis  (ISO)
allergic conjunctivitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (IEP)
Anetoderma  (ISO)
anogenital venereal wart  (ISO)
aortic valve insufficiency  (ISO)
aphthous stomatitis  (ISO)
aplastic anemia  (ISO)
arteriosclerosis  (ISO)
asthma  (IEP,ISO)
atopic dermatitis  (ISO)
atrial fibrillation  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
biliary atresia  (ISO)
brain disease  (ISO)
brain ischemia  (IEP)
breast cancer  (ISO)
Cachexia  (ISO)
calcinosis  (ISO)
Camurati-Engelmann disease  (ISO)
carcinoma  (ISO)
carcinosarcoma  (ISO)
Cardiac Fibrosis  (IEP,ISO)
Cardiomegaly  (IEP)
carotid artery disease  (ISO)
Carotid Artery Injuries  (IEP)
Carpenter syndrome 2  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chlamydia  (ISO)
cholangiocarcinoma  (IEP,ISO)
chorioamnionitis  (ISO)
Chronic Experimental Pancreatitis  (IEP)
Chronic Hepatitis  (ISO)
Chronic Hepatitis B  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (IMP,ISO)
cleft palate  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (IEP)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital hypoplastic anemia  (ISO)
Copper-Overload Cirrhosis  (ISO)
coronary artery disease  (ISO)
craniosynostosis 1  (ISO)
cystic fibrosis  (ISO)
degenerative disc disease  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IEP,ISO)
diabetic neuropathy  (IEP,ISO)
Diamond-Blackfan anemia  (ISO)
Diaphragmatic Hernia  (IEP,ISO)
Dilatation, Pathologic  (ISO)
dry eye syndrome  (ISO)
Duchenne muscular dystrophy  (ISO)
duodenal ulcer  (ISO)
Ehlers-Danlos syndrome  (ISO)
end stage renal disease  (IEP,ISO)
endomyocardial fibrosis  (ISO)
eosinophilic esophagitis  (ISO)
epilepsy  (ISO)
essential thrombocythemia  (ISO)
Experimental Arthritis  (IEP)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
factor VIII deficiency  (ISO)
familial hyperlipidemia  (IDA,IEP)
Fibrosis  (IMP,ISO)
focal segmental glomerulosclerosis  (ISO)
Gallbladder Neoplasms  (ISO)
genetic disease  (ISO)
gout  (ISO)
Graves' disease  (ISO)
heart disease  (ISO)
Heart Injuries  (ISO)
Hemorrhagic Shock  (IEP)
hepatic encephalopathy  (ISO)
Hepatic Insufficiency  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
Hereditary Hemorrhagic Telangiectasia, Type 1  (ISO)
Hyperoxia  (IEP,ISO)
Hyperplasia  (ISO)
hypertension  (IAGP,IEP,ISO)
hypertrophic cardiomyopathy  (ISO)
hyperuricemia  (ISO)
IgA glomerulonephritis  (ISO)
impotence  (IEP)
Infant, Newborn, Diseases  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHY  (ISO)
insulinoma  (ISO)
interstitial lung disease  (ISO)
Joubert syndrome 1  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (ISO)
localized scleroderma  (ISO)
lung disease  (IEP,ISO)
Lung Neoplasms  (ISO)
Lymphomatoid Papulosis  (ISO)
maple syrup urine disease  (ISO)
Meckel Syndrome 10  (ISO)
metabolic dysfunction and alcohol associated liver disease  (IEP)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (IEP)
middle cerebral artery infarction  (IEP,ISO)
multiple myeloma  (ISO)
muscular disease  (ISO)
myelofibrosis  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Reperfusion Injury  (IEP)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrolithiasis  (IEP)
nephrosclerosis  (ISO)
nephrotic syndrome  (ISO)
nephrotoxicity  (IEP)
Neuralgia  (IEP)
obesity  (IEP,ISO)
occupational asthma  (ISO)
Occupational Diseases  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
osteochondrodysplasia  (ISO)
osteoporosis  (IEP,ISO)
pancreatic cancer  (ISO)
pancreatic ductal adenocarcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
papilloma  (ISO)
Paraquat Lung  (ISO)
Peritoneal Fibrosis  (IEP,ISO)
Peyronie's disease  (ISO)
pleural disease  (ISO)
pneumonia  (ISO)
Posterior Leukoencephalopathy Syndrome  (ISO)
Postmenopausal Osteoporosis  (ISO)
primary biliary cholangitis  (ISO)
Progressive Diaphyseal Dysplasia 1  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (IMP,ISO)
psoriasis  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (IEP,IMP,ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
Radiation Pneumonitis  (IEP,IMP,ISO)
renal cell carcinoma  (ISO)
rhinitis  (ISO)
Right Ventricular Hypertrophy  (IEP)
sarcoidosis  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (IEP,ISO)
sickle cell anemia  (ISO)
Sjogren's syndrome  (ISO,ISS)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (IMP)
Spontaneous Abortions  (ISO)
Spontaneous Neoplasm Regression  (ISO)
squamous cell carcinoma  (ISO)
Stroke  (ISO)
thrombocytopenia  (ISO)
tracheal stenosis  (ISO)
traumatic brain injury  (IEP)
Tubulointerstitial Fibrosis  (IEP,IMP,ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
uremia  (ISO)
ureteral obstruction  (ISO)
urethral obstruction  (IEP)
urticaria  (ISO)
uveitis  (ISO)
Ventricular Remodeling  (ISO)
vitiligo  (ISO)
Wallerian Degeneration  (IEP)
Wounds and Injuries  (IEP,IMP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-schisandrin B  (EXP,ISO)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (EXP)
(-)-anisomycin  (ISO)
(-)-ephedrine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-amygdalin  (ISO)
(R)-camphor  (ISO)
(R)-carnitine  (EXP)
(R)-linalyl acetate  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (EXP)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitrobenzene  (ISO)
1,3,7,9-tetramethyluric acid  (EXP)
1,8-cineole  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-Hydroxypyrene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-stearoyl-2-arachidonoyl-sn-glycerol  (ISO)
14,15-EET  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (EXP)
2,5-dihydroxybenzoic acid  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
20-HETE  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
26-hydroxycholesterol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3-(1H-indol-3-yl)propanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aminoimidazole-4-carboxamide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-Hydroxycapric acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-aminonicotinamide  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid  (ISO)
7H-xanthine  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
9H-xanthine  (ISO)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
acetic acid  (EXP)
acetylsalicylic acid  (EXP,ISO)
aconitic acid  (ISO)
acrylamide  (EXP,ISO)
acteoside  (ISO)
actinomycin D  (ISO)
adefovir  (EXP)
adenine  (EXP)
adenosine  (ISO)
Aeol 10150  (EXP)
aflatoxin B1  (EXP)
AICA ribonucleotide  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
alendronic acid  (EXP)
alfacalcidol  (ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allantoin  (ISO)
allethrin  (EXP)
allyl alcohol  (EXP)
alogliptin  (EXP)
alpha-D-galactose  (EXP)
alpha-naphthoflavone  (EXP,ISO)
aluminium atom  (ISO)
aluminium hydroxide  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
AM-251  (ISO)
ambroxol  (EXP)
aminoguanidine  (EXP,ISO)
amiodarone  (EXP)
amitrole  (EXP)
amlodipine  (EXP,ISO)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amodiaquine  (ISO)
amosite asbestos  (EXP)
amphibole asbestos  (EXP)
amphotericin B  (ISO)
anagrelide  (ISO)
andrastin A  (ISO)
androgen antagonist  (EXP)
andrographolide  (EXP,ISO)
aniline  (EXP)
anthocyanin  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracene-1,8,9-triol  (ISO)
antimycin A  (ISO)
ANTU  (EXP)
apocynin  (EXP)
arachidonic acid  (EXP)
aristolochic acid A  (EXP,ISO)
aristolochic acids  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (EXP,ISO)
atorvastatin calcium  (EXP)
ATP  (ISO)
atropine  (EXP)
aucubin  (ISO)
Aurothioglucose  (ISO)
azathioprine  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
baicalein  (EXP,ISO)
baicalin  (EXP)
bellidifolin  (EXP,ISO)
benazepril  (EXP,ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzoyl peroxide  (ISO)
berberine  (EXP,ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP)
Betanin  (EXP)
betulin  (EXP)
betulinic acid  (EXP,ISO)
bezafibrate  (EXP,ISO)
bifenthrin  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
Bisibuthiamine  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boric acid  (ISO)
bosentan  (ISO)
Brevianamide A  (ISO)
bromocriptine  (EXP)
bucladesine  (ISO)
budesonide  (ISO)
busulfan  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
caffeine  (EXP)
Calcimycin  (ISO)
calciol  (ISO)
calcipotriol  (EXP)
calcitriol  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium dichloride  (ISO)
calcium silicate  (ISO)
calcium(0)  (EXP,ISO)
calycosin  (EXP)
camostat  (EXP,ISO)
camphor  (ISO)
candesartan  (EXP)
Candesartan cilexetil  (EXP)
canertinib  (ISO)
cannabidiol  (ISO)
Cannabidivarin  (ISO)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
captopril  (EXP)
carbamazepine  (EXP)
Carbaprostacyclin  (ISO)
carbofuran  (EXP)
carbon atom  (ISO)
carbon disulfide  (ISO)
carbon nanotube  (ISO)
carfilzomib  (ISO)
carmustine  (EXP)
carnosine  (EXP)
carrageenan  (ISO)
carteolol  (ISO)
carvacrol  (EXP)
carvedilol  (EXP,ISO)
cefoxitin  (ISO)
celastrol  (EXP,ISO)
celecoxib  (EXP)
cerium trichloride  (ISO)
ceruletide  (ISO)
cetrorelix  (ISO)
CGS-21680  (ISO)
Chebulagic acid  (EXP)
chenodeoxycholic acid  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
cholate  (EXP)
cholesterol  (EXP,ISO)
choline  (ISO)
chromium atom  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
cilazapril monohydrate  (EXP)
cilnidipine  (EXP)
cinaciguat  (EXP)
Cinobufagin  (ISO)
ciprofloxacin  (EXP,ISO)
cisatracurium  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (EXP,ISO)
Clofop  (EXP)
clopidogrel  (ISO)
clotrimazole  (EXP)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
coenzyme Q10  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
colistin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP,ISO)
corilagin  (EXP)
corticosterone  (EXP)
cortisol  (EXP,ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
Cryptotanshinone  (ISO)
cucurbitacin B  (ISO)
cumene hydroperoxide  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
dapsone  (ISO)
DAPT  (EXP)
daunorubicin  (EXP)
DDE  (EXP,ISO)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
delphinidin  (ISO)
Delta(9)-tetrahydrocannabinolic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
diazoxide  (ISO)
dibenziodolium  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
Didecyldimethylammonium  (ISO)
dieckol  (ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydrolipoic acid  (EXP)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl fumarate  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
Diosbulbin B  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
disodium cromoglycate  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dobutamine  (EXP)
domperidone  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Droloxifene  (EXP)
ebselen  (EXP,ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
edaravone  (EXP)
elemental carbon  (ISO)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP,ISO)
emetine  (ISO)
emodin  (EXP)
enalapril  (EXP)
enalaprilat dihydrate  (EXP)
endosulfan  (EXP)
enzacamene  (EXP)
eplerenone  (EXP)
epoxiconazole  (EXP)
eprosartan  (EXP)
erlotinib hydrochloride  (ISO)
esculetin  (EXP)
estriol  (ISO)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
eticlopride(1+)  (EXP)
Evodiamine  (EXP,ISO)
farrerol  (EXP)
fasudil  (EXP,ISO)
fenofibrate  (EXP,ISO)
fenoldopam  (EXP)
fenoprofen  (EXP)
fenthion  (ISO)
fentin hydroxide  (ISO)
fenvalerate  (EXP)
ferbam  (ISO)
ferulic acid  (EXP)
fingolimod hydrochloride  (ISO)
flavonoids  (EXP)
flubendazole  (ISO)
fluoranthene  (ISO)
fluorene  (ISO)
flutamide  (EXP)
fluvastatin  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fosinopril  (ISO)
fragrance  (ISO)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furosemide  (EXP)
gadodiamide hydrate  (EXP,ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (EXP,ISO)
galactose  (EXP)
galangin  (EXP,ISO)
gallic acid  (EXP)
gamma-hexachlorocyclohexane  (EXP)
Ganoderic acid A  (ISO)
gemcitabine  (ISO)
Geniposide  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
geraniol  (EXP)
ghrelin  (ISO)
Ginkgoic acid  (ISO)
ginsenoside Rb1  (EXP)
glucagon  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glyburide  (EXP)
glycerol  (EXP)
glycyrrhizinic acid  (EXP)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (EXP)
graphene oxide  (ISO)
guggulsterone  (ISO)
GW 501516  (ISO)
gypenoside LXXV  (ISO)
heparin  (EXP)
heptachlor  (EXP,ISO)
hesperetin  (EXP)
hexachlorobenzene  (EXP,ISO)
hexacosan-1-ol  (EXP)
hexadecanoic acid  (ISO)
Honokiol  (EXP,ISO)
HU-308  (EXP,ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hypochlorous acid  (ISO)
hypoxanthine  (ISO)
ibuprofen  (EXP)
icariin  (EXP)
Icaritin  (ISO)
icatibant  (EXP)
idelalisib  (ISO)
imidacloprid  (EXP)
imiquimod  (ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (EXP)
indoxyl sulfate  (EXP,ISO)
iohexol  (EXP)
ionomycin  (ISO)
irbesartan  (EXP,ISO)
iron atom  (EXP)
iron dextran  (EXP)
iron(0)  (EXP)
iron(III) nitrilotriacetate  (EXP)
Isoangustone A  (ISO)
isoliquiritigenin  (ISO)
isoorientin  (EXP)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
isotretinoin  (EXP)
ivermectin  (EXP,ISO)
kaempferol  (ISO)
ketamine  (EXP,ISO)
kojic acid  (EXP)
KT 5720  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP)
L-methionine  (EXP,ISO)
lactacystin  (ISO)
lactucin  (EXP,ISO)
lamivudine  (ISO)
lansoprazole  (ISO)
lapatinib  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
lenalidomide  (ISO)
letrozole  (EXP)
leukotriene B4  (ISO)
leukotriene D4  (ISO)
lidocaine  (EXP)
lignan  (ISO)
lignin  (ISO)
limonene  (EXP)
linagliptin  (EXP)
linalool  (ISO)
linalyl acetate  (ISO)
linoleic acid  (ISO)
linsidomine  (EXP)
linuron  (EXP)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (EXP)
lithium chloride  (ISO)
lithocholic acid  (ISO)
loganin  (ISO)
losartan  (EXP,ISO)
lovastatin  (ISO)
luteolin  (ISO)
Luteolin 7-methyl ether  (ISO)
LY-2157299  (EXP,ISO)
LY294002  (EXP,ISO)
lycorine  (ISO)
malonaldehyde  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
manganese(II) sulfate  (EXP)
mangiferin  (EXP,ISO)
manumycin A  (EXP)
masitinib  (ISO)
masoprocol  (EXP)
mebendazole  (ISO)
mechlorethamine  (EXP)
melamine  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
melphalan  (ISO)
mercury diacetate  (ISO)
mercury dichloride  (EXP,ISO)
mesalamine  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
Methanandamide  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylglyoxal  (EXP,ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
methylxanthine  (ISO)
metoprolol  (EXP)
metronidazole  (ISO)
Mezerein  (ISO)
minocycline  (EXP)
mirtazapine  (EXP,ISO)
mithramycin  (EXP)
mitogen  (EXP)
mitomycin C  (ISO)
Mitotane  (ISO)
MitoTEMPO  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (EXP)
morin  (EXP)
morphine  (ISO)
Morroniside  (EXP,ISO)
mycophenolic acid  (EXP)
myricetin  (EXP)
myricitrin  (ISO)
N(5)-ethyl-L-glutamine  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
N-oleoyldopamine  (ISO)
N-palmitoyl dopamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N-Vinyl-2-pyrrolidone  (EXP)
naproxen  (EXP)
naringin  (EXP,ISO)
nemorubicin  (ISO)
neoechinulin A  (ISO)
nerolidol  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
niclosamide  (EXP,ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP,ISO)
nifedipine  (EXP)
nifuroxazide  (EXP)
nilotinib  (EXP)
nitrates  (EXP,ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
nitrogen dioxide  (EXP)
NMN zwitterion  (ISO)
NS-398  (EXP)
obeticholic acid  (EXP,ISO)
ochratoxin A  (EXP,ISO)
octreotide  (EXP)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
olmesartan  (EXP)
Olmesartan medoxomil  (EXP)
olodaterol  (ISO)
omeprazole  (ISO)
Ophiopogonin D  (ISO)
oridonin  (EXP,ISO)
orlistat  (ISO)
osthole  (ISO)
ouabain  (ISO)
oxalic acid  (ISO)
Oxotremorine  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
Pachymic acid  (EXP)
paeoniflorin  (EXP,ISO)
Paeonol  (EXP)
palbociclib  (ISO)
Palmitic acid(d3)  (ISO)
pantoprazole  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
paricalcitol  (EXP)
patulin  (EXP)
PCB138  (EXP)
PD 168393  (EXP)
Pentoxifylline  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP,ISO)
permethrin  (EXP)
peroxides  (EXP)
phenanthrene  (EXP)
phenobarbital  (EXP)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phloroglucinol  (ISO)
Phomenone  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (EXP)
Phyllanthin  (ISO)
pioglitazone  (EXP,ISO)
pirfenidone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (EXP,ISO)
plumbagin  (EXP)
poly(I:C)  (ISO)
poly(methyl methacrylate) macromolecule  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
potassium chromate  (ISO)
potassium iodide  (EXP)
prazosin  (EXP)
prednisolone  (EXP,ISO)
prednisone  (ISO)
pregabalin  (EXP)
proanthocyanidin  (EXP)
probenecid  (EXP,ISO)
probucol  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
propane-1,2-diol  (ISO)
propiconazole  (EXP)
prostaglandin D2  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (EXP)
protoporphyrinogen  (ISO)
puerarin  (EXP,ISO)
pyrethrins  (EXP)
pyridoxamine  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyrvinium  (EXP)
quartz  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (EXP)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ramipril  (EXP,ISO)
raspberry ketone  (EXP)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
Rhein  (EXP)
rifaximin  (ISO)
rimonabant  (EXP)
rivaroxaban  (EXP)
Ro 31-8220  (ISO)
roflumilast  (ISO)
rolipram  (ISO)
rosmarinic acid  (EXP,ISO)
rosuvastatin calcium  (EXP,ISO)
rotenone  (EXP,ISO)
rutin  (EXP,ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-allylcysteine  (EXP)
sabinene  (ISO)
Salidroside  (EXP)
Salinomycin  (ISO)
salubrinal  (EXP)
Salvianolic acid A  (ISO)
salvianolic acid B  (EXP,ISO)
sanguinarine  (ISO)
saroglitazar  (ISO)
sarpogrelate  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP,ISO)
SCH772984  (ISO)
selenium atom  (EXP,ISO)
senecionine  (ISO)
serotonin  (ISO)
serpentine asbestos  (EXP,ISO)
sevoflurane  (EXP,ISO)
sildenafil citrate  (EXP,ISO)
silibinin  (EXP)
silicon atom  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
Sinomenine  (ISO)
sirolimus  (EXP,ISO)
sodium acetate trihydrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP,ISO)
sodium cholate  (EXP)
sodium fluoride  (EXP,ISO)
sodium hydrogencarbonate  (EXP)
sodium nitrite  (EXP)
sodium propionate  (ISO)
sodium stibogluconate  (ISO)
sodium tungstate  (ISO)
sorafenib  (ISO)
spathulenol  (ISO)
spironolactone  (EXP)
SR 144528  (ISO)
stattic  (ISO)
sterigmatocystin  (EXP)
streptozocin  (EXP,ISO)
styrene  (ISO)
succimer  (ISO)
sulfates  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
sulindac  (ISO)
sumatriptan  (EXP)
sunitinib  (EXP)
superoxide  (EXP,ISO)
tacrolimus hydrate  (EXP,ISO)
tadalafil  (EXP)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
taraxasterol  (ISO)
taurine  (EXP,ISO)
taurochenodeoxycholic acid  (EXP)
tauroursodeoxycholic acid  (EXP)
telmisartan  (EXP,ISO)
teprenone  (ISO)
teriflunomide  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
Tetramethylthiourea  (EXP)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (EXP,ISO)
thapsigargin  (EXP,ISO)
theobromine  (EXP)
theophylline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
Thiotepa  (ISO)
thiram  (ISO)
thymol  (EXP,ISO)
thymol sulfate(1-)  (EXP,ISO)
thymoquinone  (ISO)
thyroxine  (ISO)
tipifarnib  (EXP)
Tiron  (ISO)
titanium atom  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
tofacitinib  (ISO)
tolfenamic acid  (ISO)
toluene  (EXP)
toluene 2,4-diisocyanate  (ISO)
torasemide  (EXP)
tranilast  (EXP)
trans-piceid  (EXP)
triadimefon  (EXP)
triamcinolone acetonide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tropisetron  (EXP)
Tubeimoside II  (ISO)
tungsten  (ISO)
tunicamycin  (EXP)
tyrphostin AG 1478  (EXP,ISO)
udenafil  (EXP)
umbelliferone  (EXP)
uranium atom  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
ursolic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP,ISO)
vancomycin  (ISO)
vemurafenib  (ISO)
verapamil  (EXP,ISO)
vildagliptin  (ISO)
vinclozolin  (EXP)
vinorelbine  (ISO)
Vinpocetine  (EXP)
vitamin D  (EXP,ISO)
vitamin E  (EXP,ISO)
WIN 55212-2  (ISO)
Y-27632  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc pyrithione  (ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)
ziram  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains  (IEA,ISO)
animal organ morphogenesis  (IEA)
animal organ regeneration  (IMP)
aortic valve morphogenesis  (IEA,ISO)
apoptotic process  (ISO)
ATP biosynthetic process  (IEA,ISO,ISS)
branch elongation involved in mammary gland duct branching  (IEA,ISO)
bronchiole development  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell activation  (IEA,ISO)
cell morphogenesis  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cell-cell junction organization  (IEA,ISO,ISS)
cellular response to acetaldehyde  (IEP)
cellular response to dexamethasone stimulus  (IDA)
cellular response to glucose stimulus  (IEP)
cellular response to growth factor stimulus  (IEA,ISO)
cellular response to hypoxia  (IEA,ISO)
cellular response to insulin-like growth factor stimulus  (IEP)
cellular response to ionizing radiation  (IEA,IEP,ISO)
cellular response to low-density lipoprotein particle stimulus  (IEA,ISO)
cellular response to mechanical stimulus  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
cellular response to transforming growth factor beta stimulus  (IEA,ISO,ISS)
cellular response to virus  (IEA,ISO)
chondrocyte differentiation  (IEA,ISO,ISS)
columnar/cuboidal epithelial cell maturation  (IEA,ISO)
connective tissue development  (IEA,ISO)
defense response to fungus  (IDA)
digestive tract development  (IEP)
embryonic liver development  (IEA,ISO)
endoderm development  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
epithelial to mesenchymal transition  (IDA,IEA,ISO)
extracellular matrix assembly  (IEA,ISO,ISS)
extrinsic apoptotic signaling pathway  (IEA,ISO,ISS)
face morphogenesis  (IEA,ISO)
female pregnancy  (IEP)
frontal suture morphogenesis  (IEP)
gene expression  (IEA,ISO)
germ cell migration  (IEA,ISO)
heart development  (IEA,ISO)
heart valve morphogenesis  (IEA,ISO)
hematopoietic progenitor cell differentiation  (IEA,ISO,ISS)
hyaluronan catabolic process  (IEA,ISO,ISS)
inflammatory response  (IEA,ISO)
inner ear development  (IEP)
intracellular calcium ion homeostasis  (IEA,ISO)
Langerhans cell differentiation  (IEA,ISO)
lens fiber cell differentiation  (IEA,ISO)
liver regeneration  (IEP)
lung alveolus development  (IEA,ISO)
lung development  (TAS)
lymph node development  (IEA,ISO)
mammary gland branching involved in thelarche  (IEA,ISO)
mammary gland development  (IEA,ISO)
membrane protein intracellular domain proteolysis  (IEA,ISO,ISS)
mononuclear cell proliferation  (IEA,ISO)
morphogenesis of a branching structure  (IDA)
muscle cell cellular homeostasis  (IEA,ISO)
myelination  (IMP)
negative regulation of biomineral tissue development  (IEA,ISO)
negative regulation of blood vessel endothelial cell migration  (IEA,ISO,ISS)
negative regulation of cell cycle  (IEA,ISO,ISS)
negative regulation of cell differentiation  (IEA,ISO)
negative regulation of cell growth  (IEA,ISO,ISS)
negative regulation of cell population proliferation  (IEA,ISO,ISS)
negative regulation of cell-cell adhesion mediated by cadherin  (IEA,ISO,ISS)
negative regulation of DNA-templated transcription  (IEA,ISO,ISS)
negative regulation of epithelial cell proliferation  (IDA,IEA,ISO)
negative regulation of fat cell differentiation  (IEA,ISO,ISS)
negative regulation of gene expression  (IEA,ISO,ISS)
negative regulation of hyaluronan biosynthetic process  (IEA,ISO,ISS)
negative regulation of interleukin-17 production  (IEA,ISO)
negative regulation of macrophage cytokine production  (IEA,ISO,ISS)
negative regulation of miRNA transcription  (ISO)
negative regulation of myoblast differentiation  (IEA,ISO,ISS)
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  (IEA,ISO)
negative regulation of neuroblast proliferation  (IDA)
negative regulation of ossification  (IEA,ISO)
negative regulation of phagocytosis  (IDA)
negative regulation of protein localization to plasma membrane  (IEA,ISO)
negative regulation of release of sequestered calcium ion into cytosol  (IDA)
negative regulation of skeletal muscle tissue development  (IEA,ISO,ISS)
negative regulation of T cell activation  (IEA,ISO)
negative regulation of T cell proliferation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neural tube closure  (IEA,ISO)
neural tube development  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
Notch signaling pathway  (IEA,ISO)
odontoblast differentiation  (IEA,ISO,ISS)
odontogenesis of dentin-containing tooth  (IEP)
oligodendrocyte development  (IEA,ISO)
osteoclast differentiation  (IEA,ISO)
phosphate-containing compound metabolic process  (IEA,ISO,ISS)
phospholipid homeostasis  (IEA,ISO)
positive regulation of apoptotic process  (IDA,IMP)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO,ISS)
positive regulation of branching involved in ureteric bud morphogenesis  (IMP)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of cardiac muscle cell differentiation  (IEA,ISO)
positive regulation of cell division  (IEA)
positive regulation of cell migration  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (IEA,ISO,ISS)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IEA,ISO)
positive regulation of chemotaxis  (IEA,ISO,ISS)
positive regulation of collagen biosynthetic process  (IEA,IMP,ISO,ISS)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of endothelial cell apoptotic process  (IEA,ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (IEA,ISO,ISS)
positive regulation of epithelial cell proliferation  (IDA)
positive regulation of epithelial to mesenchymal transition  (IEA,ISO,ISS)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO,ISS)
positive regulation of exit from mitosis  (IDA)
positive regulation of extracellular matrix assembly  (IEA,ISO)
positive regulation of fibroblast migration  (IEA,ISO,ISS)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO,ISS)
positive regulation of inflammatory response  (IEA,ISO)
positive regulation of interleukin-17 production  (IEA,ISO,ISS)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of isotype switching to IgA isotypes  (IEA,ISO,ISS)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of mesenchymal stem cell proliferation  (IEA,ISO)
positive regulation of microglia differentiation  (IEA,ISO,ISS)
positive regulation of miRNA transcription  (ISO)
positive regulation of mononuclear cell migration  (IMP)
positive regulation of NF-kappaB transcription factor activity  (IDA)
positive regulation of odontogenesis  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of primary miRNA processing  (IEA,ISO)
positive regulation of protein import into nucleus  (IEA,ISO,ISS)
positive regulation of protein localization to nucleus  (IEA,ISO)
positive regulation of protein metabolic process  (IEA,ISO,ISS)
positive regulation of protein secretion  (IEA,ISO,ISS)
positive regulation of protein-containing complex assembly  (IEA,ISO,ISS)
positive regulation of receptor signaling pathway via STAT  (IEA,ISO)
positive regulation of regulatory T cell differentiation  (IEA,ISO)
positive regulation of SMAD protein signal transduction  (IEA,ISO,ISS)
positive regulation of smooth muscle cell differentiation  (IDA)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of stem cell proliferation  (IEA,ISO)
positive regulation of superoxide anion generation  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of vascular permeability  (IEA,ISO)
positive regulation of vasculature development  (IEA,ISO)
protein export from nucleus  (IEA,ISO)
protein phosphorylation  (IDA,ISO)
receptor catabolic process  (IEA,ISO,ISS)
regulation of actin cytoskeleton organization  (IEA,ISO)
regulation of branching involved in mammary gland duct morphogenesis  (IEA,ISO)
regulation of cartilage development  (IEA,ISO)
regulation of cell cycle  (IEA,ISO)
regulation of cell growth  (TAS)
regulation of cell population proliferation  (IBA,IEA,ISO,TAS)
regulation of enamel mineralization  (IEA,ISO)
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
regulation of gene expression  (IEA,ISO)
regulation of interleukin-23 production  (IEA,ISO)
regulation of miRNA transcription  (ISO)
regulation of protein import into nucleus  (IEA,ISO)
regulation of regulatory T cell differentiation  (IEA,ISO)
regulation of sodium ion transport  (IEA,ISO)
regulation of striated muscle tissue development  (IEA,ISO)
regulatory T cell differentiation  (IEA,ISO)
response to cholesterol  (IEA,ISO,ISS)
response to estradiol  (IEA,IEP,ISO,ISS)
response to ethanol  (IEP)
response to gamma radiation  (IEP)
response to glucose  (IEP)
response to hypoxia  (IEP)
response to immobilization stress  (IEP)
response to laminar fluid shear stress  (IEP)
response to progesterone  (IEA,ISO,ISS)
response to salt  (IEP)
response to vitamin D  (IEP)
response to wounding  (IEA,ISO,ISS)
response to xenobiotic stimulus  (IEP)
retina vasculature development in camera-type eye  (IEA,ISO)
salivary gland morphogenesis  (IEA,ISO,ISS)
sprouting angiogenesis  (IEA,ISO)
stem cell proliferation  (IEA,ISO)
surfactant homeostasis  (IEA,ISO)
T cell activation  (IEA,ISO)
T cell differentiation  (IEA,ISO)
T cell homeostasis  (IEA,ISO)
T cell proliferation  (IEA,ISO)
tolerance induction to self antigen  (IEA,ISO)
transforming growth factor beta receptor signaling pathway  (IBA,IEA,IEP,ISO,ISS)
tube development  (IEA)
ureteric bud development  (IEA,ISO)
vasculogenesis  (IEA,ISO)
ventricular cardiac muscle tissue morphogenesis  (IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transforming growth factor-beta1 is up-regulated by podocytes in response to excess intraglomerular passage of proteins: a central pathway in progressive glomerulosclerosis. Abbate M, etal., Am J Pathol 2002 Dec;161(6):2179-93.
2. The angiotensin type 1 receptor antagonist, eprosartan, attenuates the progression of renal disease in spontaneously hypertensive stroke-prone rats with accelerated hypertension. Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21.
3. Tgf-beta1, Tgf-beta2, Tgf-beta3 and Msx2 expression is elevated during frontonasal suture morphogenesis and during active postnatal facial growth. Adab K, etal., Orthod Craniofac Res. 2002 Nov;5(4):227-37.
4. Astaxanthin modulates osteopontin and transforming growth factor beta1 expression levels in a rat model of nephrolithiasis: a comparison with citrate administration. Alex M, etal., BJU Int. 2014 Sep;114(3):458-66. doi: 10.1111/bju.12537. Epub 2014 Feb 19.
5. Reduced transforming growth factor-beta1 production by mononuclear cells from patients with active chronic idiopathic thrombocytopenic purpura. Andersson PO, etal., Br J Haematol. 2002 Mar;116(4):862-7.
6. Transforming growth factor-beta induces cellular injury in experimental diabetic neuropathy. Anjaneyulu M, etal., Exp Neurol. 2008 Jun;211(2):469-79. Epub 2008 Mar 2.
7. Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury. Anscher MS, etal., Int J Radiat Oncol Biol Phys. 2008 Jul 1;71(3):829-37. Epub 2008 Apr 12.
8. Cyclooxygenase-2 is required for activated pancreatic stellate cells to respond to proinflammatory cytokines. Aoki H, etal., Am J Physiol Cell Physiol. 2007 Jan;292(1):C259-68. Epub 2006 Jul 12.
9. Atopic dermatitis is associated with a low-producer transforming growth factor beta(1) cytokine genotype. Arkwright PD, etal., J Allergy Clin Immunol. 2001 Aug;108(2):281-4.
10. Transforming growth factor beta 1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice. Arteaga CL, etal., Cell Growth Differ. 1993 Mar;4(3):193-201.
11. The effect of antibodies to TGF-beta1 and TGF-beta2 at a site of sciatic nerve repair. Atkins S, etal., J Peripher Nerv Syst. 2006 Dec;11(4):286-93.
12. [TGF-Beta1-915G/C and TNF-alpha-308G/A polymorphisms in children with asthma] Aytekin C, etal., Tuberk Toraks. 2009;57(1):62-7.
13. Mechanical load induced by glass microspheres releases angiogenic factors from neonatal rat ventricular myocytes cultures and causes arrhythmias. Barac DY, etal., J Cell Mol Med. 2008 Oct;12(5B):2037-51. doi: 10.1111/j.1582-4934.2008.00193.x.
14. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
15. Differential expression of transforming growth factors-beta1, -beta2 and -beta3 in human colon carcinoma. Bellone G, etal., Eur J Cancer. 2001 Jan;37(2):224-33.
16. Growth hormone treatment prevents osteoporosis in uremic rats. Berger I, etal., Histol Histopathol. 2007 Nov;22(11):1231-9.
17. Abatacept as a therapeutic option in the treatment of encapsulated peritoneal sclerosis: an experimental rat model. Bircan L, etal., Int Urol Nephrol. 2017 May;49(5):909-916. doi: 10.1007/s11255-017-1535-9. Epub 2017 Feb 11.
18. Expression of Genes Involved in Cellular Adhesion and Extracellular Matrix Remodeling Correlates with Poor Survival of Patients with Renal Cancer. Boguslawska J, etal., J Urol. 2016 Jun;195(6):1892-902. doi: 10.1016/j.juro.2015.11.050. Epub 2015 Nov 26.
19. Interaction between a novel TGFB1 haplotype and CFTR genotype is associated with improved lung function in cystic fibrosis. Bremer LA, etal., Hum Mol Genet. 2008 Jul 15;17(14):2228-37. Epub 2008 Apr 17.
20. TGF-beta signaling promotes survival and repair in rat alveolar epithelial type 2 cells during recovery after hyperoxic injury. Buckley S, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Apr;294(4):L739-48. Epub 2008 Feb 1.
21. Effect of radiation and repeated sub-culturing on the transforming growth factor-beta1 signaling pathway in FRTL-5 cells. Burrell CG, etal., In Vivo. 2015 Jan-Feb;29(1):5-15.
22. Enhanced growth of colorectal aberrant crypt foci in fasted/refed rats involves changes in TGFbeta1 and p21CIP expressions. Caderni G, etal., Carcinogenesis 2002 Feb;23(2):323-7.
23. Effects of calorie restriction on transforming growth factor beta 1 and proinflammatory cytokines in murine Sjogren's syndrome. Chandrasekar B, etal., Clin Immunol Immunopathol. 1995 Sep;76(3 Pt 1):291-6.
24. Pyrrolidine dithiocarbamate attenuates paraquat-induced lung injury in rats. Chang X, etal., J Biomed Biotechnol. 2009;2009:619487. Epub 2009 Jul 21.
25. Acetaldehyde stimulates the activation of latent transforming growth factor-beta1 and induces expression of the type II receptor of the cytokine in rat cultured hepatic stellate cells. Chen A Biochem J 2002 Dec 15;368(Pt 3):683-93.
26. Heterozygous knockout of transforming growth factor-ß1 protects Dahl S rats against high salt-induced renal injury. Chen CC, etal., Physiol Genomics. 2013 Feb 4;45(3):110-8. doi: 10.1152/physiolgenomics.00119.2012. Epub 2012 Dec 18.
27. Flexibilide obtained from cultured soft coral has anti-neuroinflammatory and analgesic effects through the upregulation of spinal transforming growth factor-beta1 in neuropathic rats. Chen NF, etal., Mar Drugs. 2014 Jun 27;12(7):3792-817. doi: 10.3390/md12073792.
28. ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma. Chen PF, etal., Mol Med. 2010 Sep-Oct;16(9-10):400-8. Epub 2010 May 14.
29. [Acupoint application of herbal paste relieves symptoms and naso-mucosal inflammatory response by down-regulating serum TGF-β1 in allergic rhinitis rats]. Chen S, etal., Zhen Ci Yan Jiu. 2019 Jun 25;44(6):430-3. doi: 10.13702/j.1000-0607.180369.
30. Risk of aggressive breast cancer in women of Han nationality carrying TGFB1 rs1982073 C allele and FGFR2 rs1219648 G allele in North China. Chen XH, etal., Breast Cancer Res Treat. 2011 Jan;125(2):575-82. doi: 10.1007/s10549-010-1032-7. Epub 2010 Jul 17.
31. [Hyperlipidemia induced by high fat diet ingestion activates TGF-beta/Smad signaling pathway in the kidney of diabetic rats] Chen ZX, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Oct;33(10):906-12.
32. Induction of c-jun and TGF-beta 1 in Fischer 344 rats during amiodarone-induced pulmonary fibrosis. Chung WH, etal., Am J Physiol Lung Cell Mol Physiol 2001 Nov;281(5):L1180-8.
33. Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice. Clouthier DE, etal., J Clin Invest 1997 Dec 1;100(11):2697-713.
34. TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study. Cox DG, etal., BMC Cancer. 2007 Sep 11;7:175.
35. Influence of nephron mass in development of chronic renal failure after prolonged warm renal ischemia. Cruzado JM, etal., Am J Physiol Renal Physiol. 2000 Aug;279(2):F259-69.
36. Lack of transforming growth factor-beta 1 expression in benign skin tumors of p53null mice is prognostic for a high risk of malignant conversion. Cui W, etal., Cancer Res. 1994 Nov 15;54(22):5831-6.
37. Differential expression of cytokines in the rat heart in response to sustained volume overload. Dai RP, etal., Eur J Heart Fail. 2004 Oct;6(6):693-703.
38. New associations: INFG and TGFB1 genes and the inhibitor development in severe haemophilia A. de Alencar JB, etal., Haemophilia. 2015 Jul;21(4):e312-6. doi: 10.1111/hae.12685. Epub 2015 Apr 30.
39. Ontogenic expression of TGFbeta 1, 2, and 3 and its receptors in the rat gastric mucosa. de Andrade Sa ER, etal., Dev Dyn. 2003 Jul;227(3):450-7.
40. Impact of mitomycin C on the mRNA expression signatures of immunological biomarkers in eosinophilic nasal polyposis. de Castro MC, etal., Am J Rhinol Allergy. 2013 Jan;27(1):e32-41. doi: 10.2500/ajra.2013.27.3868.
41. Effect of Avocado/Soybean Unsaponifiables (ASU) on Osseointegration in Rats with Experimental Arthritis. de Paula LGF, etal., Int J Oral Maxillofac Implants. 2018 May/Jun;33(3):603-612. doi: 10.11607/jomi.6124.
42. Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: involvement of nonclassical genomic signaling pathways. Dhandapani KM, etal., Endocrinology. 2005 Jun;146(6):2749-59. Epub 2005 Mar 3.
43. Role for TGF-beta1, FGF-2 and PDGF-AA in a myelination of CNS aggregate cultures enriched with macrophages. Diemel LT, etal., J Neurosci Res. 2003 Dec 15;74(6):858-67.
44. Attenuating effects of heat shock against TGF-beta1-induced apoptosis in cultured rat hepatocytes. Diez-Fernandez C, etal., Free Radic Biol Med 2002 Sep 15;33(6):835-46.
45. Regulatory T cell activity is partly inhibited in a mouse model of chronic Pseudomonas aeruginosa lung infection. Ding FM, etal., Exp Lung Res. 2015 Feb;41(1):44-55. doi: 10.3109/01902148.2014.964351. Epub 2014 Nov 14.
46. Immunoregulatory cytokines gene polymorphisms in Egyptian patients affected with acquired aplastic anemia. El Mahgoub IR, etal., Ann Hematol. 2014 Jun;93(6):923-9. doi: 10.1007/s00277-013-1992-x. Epub 2013 Dec 21.
47. Evaluation of aromatase inhibitor on radiation induced pulmonary fibrosis via TGF- β/Smad 3 and TGF- β/PDGF pathways in rats. Elkiki SM, etal., Toxicol Mech Methods. 2021 Sep;31(7):538-545. doi: 10.1080/15376516.2021.1934765. Epub 2021 Jun 21.
48. Sodium valproate, a histone deacetylase inhibitor, with praziquantel ameliorates Schistosoma mansoni-induced liver fibrosis in mice. Elsakkar MG, etal., Life Sci. 2016 Oct 1;162:95-101. doi: 10.1016/j.lfs.2016.08.010. Epub 2016 Aug 12.
49. Association between TGFβ1 polymorphisms and chronic hepatitis B infection in an Iranian population. Eskandari E, etal., Rev Soc Bras Med Trop. 2017 May-Jun;50(3):301-308. doi: 10.1590/0037-8682-0266-2016.
50. Transforming growth factor beta1 release by human adipose tissue is enhanced in obesity. Fain JN, etal., Metabolism. 2005 Nov;54(11):1546-51.
51. LPS-conditioned dendritic cells confer endotoxin tolerance contingent on tryptophan catabolism. Fallarino F, etal., Immunobiology. 2015 Feb;220(2):315-21. doi: 10.1016/j.imbio.2014.09.017. Epub 2014 Sep 28.
52. Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro. Fan JM, etal., Kidney Int. 1999 Oct;56(4):1455-67.
53. Metformin mitigates carbon tetrachloride-induced TGF-β1/Smad3 signaling and liver fibrosis in mice. Fan K, etal., Biomed Pharmacother. 2017 Jun;90:421-426. doi: 10.1016/j.biopha.2017.03.079. Epub 2017 Apr 5.
54. Association of MBL2, TGF-beta1 and CD14 gene polymorphisms with lung disease severity in cystic fibrosis. Faria EJ, etal., J Bras Pneumol. 2009 Apr;35(4):334-42.
55. Localization of transforming growth factors, TGFbeta1 and TGFbeta3, in hypothalamic magnocellular neurones and the neurohypophysis. Fevre-Montange M, etal., J Neuroendocrinol. 2004 Jul;16(7):571-6.
56. Microarray analysis of mechanical shear effects on flexor tendon cells. Fong KD, etal., Plast Reconstr Surg. 2005 Oct;116(5):1393-404; discussion 1405-6.
57. Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival. Friess H, etal., Gastroenterology. 1993 Dec;105(6):1846-56. doi: 10.1016/0016-5085(93)91084-u.
58. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine Fu Q, etal., Zhong Xi Yi Jie He Xue Bao. 2006 Jul;4(4):408-12.
59. Interleukin 10 and transforming growth factor beta contribute to the development of experimentally induced allergic conjunctivitis in mice during the effector phase. Fukushima A, etal., Br J Ophthalmol. 2006 Dec;90(12):1535-41. Epub 2006 Aug 16.
60. [Expression and pathological implication of transforming growth factor-beta1 mRNA and endothelin-1 mRNA in intraacinar pulmonary arterioles of congenital heart disease accompanied with pulmonary hypertension] Gao BH, etal., Zhonghua Bing Li Xue Za Zhi. 2005 Mar;34(3):159-62.
61. Early administration of propofol protects against endotoxin-induced acute lung injury in rats by inhibiting the TGF-beta1-Smad2 dependent pathway. Gao J, etal., Inflamm Res. 2010 Jul;59(7):491-500. Epub 2009 Nov 27.
62. [Expression of transforming growth factor beta 1 in keratinocytes of oral submucous fibrosis tissue]. Gao Y, etal., Zhonghua Kou Qiang Yi Xue Za Zhi. 1997 Jul;32(4):239-41.
63. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
64. GLUT-1 overexpression: Link between hemodynamic and metabolic factors in glomerular injury? Gnudi L, etal., Hypertension. 2003 Jul;42(1):19-24. Epub 2003 May 27.
65. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
66. Role of transforming growth factor-beta superfamily signaling pathways in human disease. Gordon KJ and Blobe GC, Biochim Biophys Acta. 2008 Apr;1782(4):197-228. Epub 2008 Feb 11.
67. Circulating transforming growth factor-beta-1 and breast cancer prognosis: results from the Shanghai Breast Cancer Study. Grau AM, etal., Breast Cancer Res Treat. 2008 Nov;112(2):335-41. Epub 2007 Dec 13.
68. TGFB1 T29C polymorphism and breast cancer risk: a meta-analysis based on 10,417 cases and 11,455 controls. Gu D, etal., Breast Cancer Res Treat. 2010 Oct;123(3):857-61. doi: 10.1007/s10549-010-0766-6. Epub 2010 Feb 16.
69. [Expression of vascular endothelial growth factor and transforming growth factor-beta 1 in nasal polyps]. Guo J, etal., Zhonghua Er Bi Yan Hou Ke Za Zhi. 2001 Apr;36(2):83-6.
70. [The expression of transforming growth factor beta1 and its I, II receptors in the development of rat embryo and embryonic lung] Guo Q, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007 Apr;23(4):317-9.
71. [The effect of cigarette smoke on the expression of transforming growth factor-beta1 mRNA and collagen type III in airways of asthmatic rats] Guo ZH, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2008 Jan;31(1):42-5.
72. Does Telmisartan prevent hepatic fibrosis in rats with alloxan-induced diabetes? Halici Z, etal., Eur J Pharmacol. 2009 Apr 27.
73. Transforming growth factor-beta (TGF-beta) and tissue transglutaminase expression in the small intestine in children with coeliac disease. Hansson T, etal., Scand J Immunol. 2002 Nov;56(5):530-7.
74. [A study of pulmonary inflammatory reaction induced by N-protein of SARS-CoV in rat models and effects of glucocorticoids on it]. Hao D, etal., Zhonghua Nei Ke Za Zhi. 2005 Dec;44(12):890-3.
75. Osthole Alleviates Bleomycin-Induced Pulmonary Fibrosis via Modulating Angiotensin-Converting Enzyme 2/Angiotensin-(1-7) Axis and Decreasing Inflammation Responses in Rats. Hao Y and Liu Y, Biol Pharm Bull. 2016;39(4):457-65. doi: 10.1248/bpb.b15-00358. Epub 2016 Jan 28.
76. Transforming growth factor-beta(1) in bronchoalveolar lavage fluid from children with cystic fibrosis. Harris WT, etal., Pediatr Pulmonol. 2009 Nov;44(11):1057-64.
77. Dynamic expression patterns of transforming growth factor-beta(2) and transforming growth factor-beta receptors in experimental glomerulonephritis. Hartner A, etal., J Mol Med. 2003 Jan;81(1):32-42. Epub 2002 Dec 14.
78. Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis. Herbach N, etal., Am J Physiol Renal Physiol. 2009 Apr;296(4):F819-29. Epub 2009 Feb 11.
79. Immunocytochemical localization and serologic detection of transforming growth factor beta 1. Association with type I procollagen and inflammatory cell markers in diffuse and limited systemic sclerosis, morphea, and Raynaud's phenomenon. Higley H, etal., Arthritis Rheum. 1994 Feb;37(2):278-88.
80. Alcohol alters insulin-like growth factor-1-induced transforming growth factor beta1 synthesis in the medial basal hypothalamus of the prepubertal female rat. Hiney JK, etal., Alcohol Clin Exp Res. 2014 Oct;38(10):2572-8. doi: 10.1111/acer.12534. Epub 2014 Oct 21.
81. Urinary transforming growth factor-beta(1), collagen IV and the effect of insulin in children at diagnosis of diabetes mellitus. Holmquist P and Torffvit O, Scand J Urol Nephrol. 2009;43(2):142-7.
82. Upregulation of interleukin-1beta/transforming growth factor-beta1 and hypoxia relate to molecular mechanisms underlying immobilization-induced muscle contracture. Honda Y, etal., Muscle Nerve. 2015 Sep;52(3):419-27. doi: 10.1002/mus.24558. Epub 2015 Jun 30.
83. Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression. Hu B, etal., Am J Respir Cell Mol Biol 2003 Sep;29(3 Pt 1):397-404. Epub 2003 Apr 17.
84. [Effect of coicis semen oil on renal interstitial fibrosis in rats with unilateral urethral obstruction]. Hu Y, etal., Zhongguo Zhong Yao Za Zhi. 2013 Jun;38(12):1982-6.
85. Transforming growth factor beta 1 (TGF beta 1) is an autocrine positive regulator of colon carcinoma U9 cells in vivo as shown by transfection of a TGF beta 1 antisense expression plasmid. Huang F, etal., Cell Growth Differ. 1995 Dec;6(12):1635-42.
86. TGF-beta1-induced Fascin1 promotes cell invasion and metastasis of human 786-0 renal carcinoma cells. Huang W, etal., Acta Histochem. 2016 Mar;118(2):144-51. doi: 10.1016/j.acthis.2015.12.005. Epub 2015 Dec 31.
87. Amniotic fluid transforming growth factor-beta1 and the risk for the development of neonatal bronchopulmonary dysplasia. Ichiba H, etal., Neonatology. 2009;96(3):156-61. Epub 2009 Mar 31.
88. The association of transforming growth factor beta 1 gene polymorphisms with the emphysema phenotype of COPD in Japanese. Ito M, etal., Intern Med. 2008;47(15):1387-94. Epub 2008 Aug 1.
89. Vitamin A and retinoic acid act synergistically to increase lung retinyl esters during normoxia and reduce hyperoxic lung injury in newborn mice. James ML, etal., Pediatr Res. 2010 Jun;67(6):591-7.
90. Mammalian transforming growth factor-betas: Smad signaling and physio-pathological roles. Javelaud D and Mauviel A, Int J Biochem Cell Biol. 2004 Jul;36(7):1161-5.
91. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases Ji YX, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2008 Apr;31(4):264-7.
92. Hypoxia induces transforming growth factor-beta1 gene expression in the pulmonary artery of rats via hypoxia-inducible factor-1alpha. Jiang Y, etal., Acta Biochim Biophys Sin (Shanghai). 2007 Jan;39(1):73-80.
93. High-expression of transforming growth factor beta1 and phosphorylation of extracellular signal-regulated protein kinase in vascular smooth muscle cells from aorta and renal arterioles of spontaneous hypertension rats. Jing L, etal., Clin Exp Hypertens. 2007 Feb;29(2):107-17.
94. [Relationship between transforming growth factor-β1 and interleukin-10 single nucleotide polymorphism and susceptibility of recurrent aphthous ulcer]. Jing Z, etal., Hua Xi Kou Qiang Yi Xue Za Zhi. 2016 Feb;34(1):27-31.
95. TGF-beta 1 variants in chronic beryllium disease and sarcoidosis. Jonth AC, etal., J Immunol. 2007 Sep 15;179(6):4255-62.
96. Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers. Jude EB, etal., Diabet Med. 2002 Jun;19(6):440-7.
97. Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma. Kaiser MF, etal., Blood. 2013 Jul 11;122(2):219-26. doi: 10.1182/blood-2013-03-487884. Epub 2013 May 22.
98. Effect of transforming growth factor-beta1 on acute lung injury caused by paraquat. Kan B, etal., Mol Med Rep. 2014 Apr;9(4):1232-6. doi: 10.3892/mmr.2014.1938. Epub 2014 Feb 7.
99. Pax-8 is essential for regulation of the thyroglobulin gene by transforming growth factor-beta1. Kang HC, etal., Endocrinology 2001 Jan;142(1):267-75.
100. Transforming growth factor beta 1 and its latent form binding protein-1 associate with elastic fibres in human dermis: accumulation in actinic damage and absence in anetoderma. Karonen T, etal., Br J Dermatol. 1997 Jul;137(1):51-8.
101. TGF-beta1, released by myofibroblasts, differentially regulates transcription and function of sodium and potassium channels in adult rat ventricular myocytes. Kaur K, etal., PLoS One. 2013;8(2):e55391. doi: 10.1371/journal.pone.0055391. Epub 2013 Feb 5.
102. X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1). Kaur S, etal., J Biol Chem. 2005 Nov 18;280(46):38599-608. Epub 2005 Sep 12.
103. Divergent expression of liver transforming growth factor superfamily cytokines after successful portoenterostomy in biliary atresia. Kerola A, etal., Surgery. 2019 May;165(5):905-911. doi: 10.1016/j.surg.2018.12.003. Epub 2019 Jan 25.
104. Circulatory levels of T-cell cytokines (interleukin -2, IL-4, IL-17, and transforming growth factor-beta) in patients with vitiligo. Khan R, etal., J Am Acad Dermatol. 2012 Mar;66(3):510-1. doi: 10.1016/j.jaad.2011.07.018.
105. Regulatory T cells and TGF-ß1 in clinically localized renal cell carcinoma: Comparison with age-matched healthy controls. Kim CS, etal., Urol Oncol. 2015 Mar;33(3):113.e19-25. doi: 10.1016/j.urolonc.2014.11.004. Epub 2014 Dec 11.
106. Expression of TGFbeta family in the developing internal ear of rat embryos. Kim HJ, etal., J Korean Med Sci. 2006 Feb;21(1):136-42.
107. Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis. Kim J, etal., J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438. doi: 10.4014/jmb.1910.10055.
108. The TGF-beta1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients. Kim JY, etal., Radiat Oncol. 2009 Nov 27;4:59.
109. Combined effect of IL-10 and TGF-beta1 promoter polymorphisms as a risk factor for aspirin-intolerant asthma and rhinosinusitis. Kim SH, etal., Allergy. 2009 Aug;64(8):1221-5. Epub 2009 Feb 16.
110. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
111. The effects of treatment with antibodies to transforming growth factor beta1 and beta2 following spinal cord damage in the adult rat. King VR, etal., Neuroscience. 2004;126(1):173-83.
112. Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease. Kinoshita A, etal., Nat Genet. 2000 Sep;26(1):19-20.
113. Association of transforming growth factor-beta1 gene polymorphisms with myocardial infarction in patients with angiographically proven coronary heart disease. Koch W, etal., Arterioscler Thromb Vasc Biol. 2006 May;26(5):1114-9. Epub 2006 Mar 16.
114. Elevated plasma transforming growth factor-beta 1 levels in breast cancer patients decrease after surgical removal of the tumor. Kong FM, etal., Ann Surg. 1995 Aug;222(2):155-62.
115. TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling. Konig HG, etal., J Cell Biol. 2005 Mar 28;168(7):1077-86. Epub 2005 Mar 21.
116. Effects of TGF-betas and a specific antagonist on apoptosis of immature rat male germ cells in vitro. Konrad L, etal., Apoptosis. 2006 May;11(5):739-48.
117. Tumor necrosis factor--alpha and transforming growth factor--beta1 polymorphisms in bronchial asthma. Kumar A, etal., Indian J Med Sci. 2008 Aug;62(8):323-30.
118. Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury. Lai CF, etal., Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F581-92. doi: 10.1152/ajprenal.00670.2013. Epub 2014 Jun 11.
119. Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice. Latasa MU, etal., PLoS One. 2010 Dec 29;5(12):e15690. doi: 10.1371/journal.pone.0015690.
120. BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression. Lee MH, etal., J Biol Chem 2003 Sep 5;278(36):34387-94. Epub 2003 Jun 18.
121. Role of the spleen in liver regeneration in relation to transforming growth factor-beta1 and hepatocyte growth factor. Lee SC, etal., J Surg Res. 2015 Jun 15;196(2):270-7. doi: 10.1016/j.jss.2015.02.025. Epub 2015 Feb 19.
122. Reduced endothelial secretion and plasma levels of transforming growth factor-beta1 in patients with hereditary hemorrhagic telangiectasia type 1. Letarte M, etal., Cardiovasc Res. 2005 Oct 1;68(1):155-64.
123. Both high intratumoral microvessel density determined using CD105 antibody and elevated plasma levels of CD105 in colorectal cancer patients correlate with poor prognosis. Li C, etal., Br J Cancer. 2003 May 6;88(9):1424-31.
124. A comparative study of neovascularisation in atherosclerotic plaques using CD31, CD105 and TGF beta 1. Li C, etal., Pathobiology. 2006;73(4):192-7.
125. Customized platelet-rich plasma with transforming growth factor beta1 neutralization antibody to reduce fibrosis in skeletal muscle. Li H, etal., Biomaterials. 2016 May;87:147-56. doi: 10.1016/j.biomaterials.2016.02.017. Epub 2016 Feb 17.
126. Immunolocalization of connective tissue growth factor, transforming growth factor-beta1 and phosphorylated-SMAD2/3 during the postnatal tooth development and formation of junctional epithelium. Li S and Pan Y, Ann Anat. 2018 Mar;216:52-59. doi: 10.1016/j.aanat.2017.10.005. Epub 2017 Nov 22.
127. Immunohistochemical localization of connective tissue growth factor, transforming growth factor-beta1 and phosphorylated-smad2/3 in the developing periodontium of rats. Li S, etal., J Periodontal Res. 2014 Oct;49(5):624-33. doi: 10.1111/jre.12143. Epub 2013 Nov 13.
128. Urocortin ameliorates diabetic nephropathy in obese db/db mice. Li X, etal., Br J Pharmacol. 2008 Jul;154(5):1025-34. Epub 2008 Apr 21.
129. Huang-Lian-Jie-Du-Tang inhibits myocardial remodeling in a rat model of metabolic syndrome. Li X, etal., J Ethnopharmacol. 2008 Sep 26;119(2):259-65. Epub 2008 Jul 25.
130. [Significance of regulatory B cells in nosogenesis of immune thrombocytopenia]. Li X, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2014 Apr;22(2):403-6. doi: 10.7534/j.issn.1009-2137.2014.02.025.
131. The G/G genotype of transforming growth factor beta 1 (TGF-beta1) single nucleotide (+915G/C) polymorphism coincident with other host and environmental factors is associated with irreversible bronchoconstriction in asthmatics. Liebhart J, etal., Int J Immunogenet. 2008 Dec;35(6):417-22.
132. Serum transforming growth factor-beta1 levels and pancreatic cancer risk: a nested case-control study (Japan). Lin Y, etal., Cancer Causes Control. 2006 Oct;17(8):1077-82.
133. Effects of single nucleotide polymorphisms 869 T/C and 915 G/C in the exon 1 locus of transforming growth factor-beta1 gene on chronic obstructive pulmonary disease susceptibility in Chinese. Liu DS, etal., Chin Med J (Engl). 2010 Feb 20;123(4):390-4.
134. Thalidomide attenuates tumor growth and preserves fast-twitch skeletal muscle fibers in cholangiocarcinoma rats. Liu KH, etal., Surgery. 2008 Mar;143(3):375-83. Epub 2007 Dec 21.
135. [Change and significance of Th22 cells in patients with aplastic anemia]. Liu LM, etal., Zhonghua Yi Xue Za Zhi. 2013 May 28;93(20):1537-40.
136. Crosstalk between the activated Slit2-Robo1 pathway and TGF-β1 signalling promotes cardiac fibrosis. Liu Y, etal., ESC Heart Fail. 2021 Feb;8(1):447-460. doi: 10.1002/ehf2.13095. Epub 2020 Nov 24.
137. Ghrelin protects against obesity-induced myocardial injury by regulating the lncRNA H19/miR-29a/IGF-1 signalling axis. Liu Y, etal., Exp Mol Pathol. 2020 Jun;114:104405. doi: 10.1016/j.yexmp.2020.104405. Epub 2020 Feb 19.
138. Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites. Lopez-Casillas F, etal., J Cell Biol. 1994 Feb;124(4):557-68.
139. In situ detection of TGF betas, TGF beta receptor II mRNA and telomerase activity in rat cholangiocarcinogenesis. Lu JP, etal., World J Gastroenterol 2003 Mar;9(3):590-4.
140. Mepacrine inhibits subepithelial fibrosis by reducing the expression of arginase and TGF-beta1 in an extended subacute mouse model of allergic asthma. Mabalirajan U, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Sep;297(3):L411-9. Epub 2009 Jun 19.
141. Inhibition of matrix metalloproteinase on hepatic transforming growth factor beta1 and caspase-3 activation in hemorrhage. Maitra SR, etal., Acad Emerg Med. 2005 Sep;12(9):797-803. doi: 10.1197/j.aem.2005.04.017.
142. Elevated plasma TGF-beta1 levels in patients with chronic obstructive pulmonary disease. Mak JC, etal., Respir Med. 2009 Jul;103(7):1083-9. Epub 2009 Jan 31.
143. Tissue concentration of transforming growth factor beta1 and basic fibroblast growth factor in skin wounds created with a CO2 laser and scalpel: a comparative experimental study, using an animal model of skin resurfacing. Manolis EN, etal., Wound Repair Regen. 2007 Mar-Apr;15(2):252-7.
144. Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma. Mantoni TS, etal., Cancer Biol Ther. 2008 Nov 24;7(11).
145. Serum TGF-beta1 in atopic asthma. Manuyakorn W, etal., Asian Pac J Allergy Immunol. 2008 Dec;26(4):185-9.
146. Transforming growth factor-beta1 supports the rapid morphogenesis of heterotopic endochondral bone initiated by human osteogenic protein-1 via the synergistic upregulation of molecular markers. Matsaba T, etal., Growth Factors 2001;19(2):73-86.
147. Lacrimal gland inflammation is responsible for ocular pathology in TGF-beta 1 null mice. McCartney-Francis NL, etal., Am J Pathol. 1997 Nov;151(5):1281-8.
148. Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice. McMillin M, etal., J Neuroinflammation. 2019 Apr 2;16(1):69. doi: 10.1186/s12974-019-1455-y.
149. Platelet TGF-beta1 contributions to plasma TGF-beta1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload. Meyer A, etal., Blood. 2012 Jan 26;119(4):1064-74. doi: 10.1182/blood-2011-09-377648. Epub 2011 Dec 1.
150. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
151. N-acetylcysteine inhibits RhoA and promotes apoptotic cell clearance during intense lung inflammation. Moon C, etal., Am J Respir Crit Care Med. 2010 Feb 15;181(4):374-87. Epub 2009 Dec 3.
152. Transforming growth factor-beta and inflammation in vascular (type IV) Ehlers-Danlos syndrome. Morissette R, etal., Circ Cardiovasc Genet. 2014 Feb;7(1):80-8. doi: 10.1161/CIRCGENETICS.113.000280. Epub 2014 Jan 6.
153. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Morris DG, etal., Nature 2003 Mar 13;422(6928):169-73.
154. Reduced TGF-beta1 expression and its target genes in human insulinomas. Nabokikh A, etal., Exp Clin Endocrinol Diabetes. 2007 Nov;115(10):674-82.
155. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
156. Immunohistochemical expression of receptor-tyrosine kinase c-kit protein and TGF-beta1 in invasive ductal carcinoma of the pancreas. Nio Y, etal., Anticancer Res. 2005 Sep-Oct;25(5):3523-9.
157. Changes in TGF-beta receptors of rat hepatocytes during primary culture and liver regeneration: increased expression of TGF-beta receptors associated with increased sensitivity to TGF-beta-mediated growth inhibition. Nishikawa Y, etal., J Cell Physiol. 1998 Sep;176(3):612-23.
158. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases Niu RC, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2007 Nov;30(11):851-6.
159. Association of TGFB1 -509 C>T polymorphism with breast cancer: evidence from a meta-analysis involving 23,579 subjects. Niu W, etal., Breast Cancer Res Treat. 2010 Nov;124(1):243-9. doi: 10.1007/s10549-010-0832-0. Epub 2010 Mar 16.
160. Serum concentrations of transforming growth factor beta 1 in patients with psoriasis vulgaris. Nockowski P, etal., Acta Dermatovenerol Croat. 2004;12(1):2-6.
161. Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat. Obaid AA, etal., J Trace Elem Med Biol. 2023 May 24;79:127221. doi: 10.1016/j.jtemb.2023.127221.
162. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
163. The combination of Astragalus membranaceus extract and ligustrazine to improve the inflammation in rats with thrombolytic cerebral ischemia. Pan R, etal., Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419869055. doi: 10.1177/2058738419869055.
164. Left ventricular filling abnormalities and obesity-associated hypertension: relationship with overproduction of circulating transforming growth factor beta1. Parrinello G, etal., J Hum Hypertens. 2005 Jul;19(7):543-50.
165. Transforming growth factor-beta 1 signaling regulates neuroinflammation and apoptosis in mild traumatic brain injury. Patel RK, etal., Brain Behav Immun. 2017 Aug;64:244-258. doi: 10.1016/j.bbi.2017.04.012. Epub 2017 Apr 19.
166. Cellular and molecular events associated with the bone-protecting activity of the noncalcemic vitamin D analog Ro-26-9228 in osteopenic rats. Peleg S, etal., Endocrinology. 2002 May;143(5):1625-36.
167. Effect of transforming growth factor beta-1 in endotoxin-induced uveitis. Peng B, etal., Invest Ophthalmol Vis Sci. 1997 Jan;38(1):257-60.
168. Synergistic heterozygosity for TGFbeta1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension. Phillips JA 3rd, etal., Genet Med. 2008 May;10(5):359-65.
169. Significant expression of endoglin (CD105), TGFbeta-1 and TGFbeta R-2 in the atherosclerotic aorta: an immunohistological study. Piao M and Tokunaga O, J Atheroscler Thromb. 2006 Apr;13(2):82-9.
170. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
171. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
172. Identification of transforming growth factor beta1-driven genetic programs of acute lung fibrosis. Pulichino AM, etal., Am J Respir Cell Mol Biol. 2008 Sep;39(3):324-36. Epub 2008 Apr 10.
173. cDNA cloning by PCR of rat transforming growth factor beta-1. Qian SW, etal., Nucleic Acids Res 1990 May 25;18(10):3059.
174. Altered growth factor expression in the aging penis: the Brown-Norway rat model. Rajasekaran M, etal., J Androl 2002 May-Jun;23(3):393-9.
175. Antioxidant and pro-oxidant effects of oil palm (Elaeis guineensis) leaves extract in experimental diabetic nephropathy: a duration-dependent outcome. Rajavel V, etal., BMC Complement Altern Med. 2013 Sep 29;13(1):242.
176. Steady state levels of transforming growth factor-beta1 and -beta2 mRNA and protein expression are elevated in colonic tumors in vivo irrespective of dietary lipids intervention. Raju J, etal., Int J Cancer 2002 Aug 20;100(6):635-41.
177. Obese state leads to elevated levels of TGF-beta and COX isoforms in platelets of Zucker rats. Raju J, etal., Mol Cell Biochem. 2006 Mar;284(1-2):19-24. Epub 2006 Feb 14.
178. Transforming growth factor-beta stimulates vascular endothelial growth factor production by folliculostellate pituitary cells. Renner U, etal., Endocrinology 2002 Oct;143(10):3759-65.
179. GOA pipeline RGD automated data pipeline
180. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
181. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
182. T-helper 2 cytokines, transforming growth factor beta1, and eosinophil products induce fibrogenesis and alter muscle motility in patients with eosinophilic esophagitis. Rieder F, etal., Gastroenterology. 2014 May;146(5):1266-77.e1-9. doi: 10.1053/j.gastro.2014.01.051. Epub 2014 Jan 28.
183. Prevalence of diabetes mellitus and correlation of urinary transforming growth factor-beta1 with blood hemoglobin A1C in the Atascosa Diabetes Study. Riojas MA, etal., Ethn Dis. 2008 Spring;18(2 Suppl 2):S2-54-9.
184. Heat shock protein 47 as indispensible participant in liver fibrosis: Possible protective effect of lactoferrin. Rizk FH, etal., IUBMB Life. 2018 Aug;70(8):795-805. doi: 10.1002/iub.1884. Epub 2018 Aug 9.
185. Transforming growth factor-beta1 induces collagen synthesis and accumulation via p38 mitogen-activated protein kinase (MAPK) pathway in cultured L(6)E(9) myoblasts. Rodriguez-Barbero A, etal., FEBS Lett 2002 Feb 27;513(2-3):282-8.
186. Mucosal Cytokine Profiles After Induction Therapy With Granulocyte/Monocyte Apheresis in New-onset Inflammatory Colitis. Rolandsdotter H, etal., J Pediatr Gastroenterol Nutr. 2018 Apr;66(4):e103-e107. doi: 10.1097/MPG.0000000000001735.
187. The -509 C/T genotype of TGFbeta1 might contribute to the pathogenesis of benign airway stenosis. Rovo L, etal., Otolaryngol Head Neck Surg. 2010 Mar;142(3):441-3.
188. Therapeutic Effects of Evasin-1, a Chemokine Binding Protein, in Bleomycin-Induced Pulmonary Fibrosis. Russo RC, etal., Am J Respir Cell Mol Biol. 2010 Sep 10.
189. Transforming growth factor- 1 C-509T polymorphism, oxidant stress, and early-onset childhood asthma. Salam MT, etal., Am J Respir Crit Care Med. 2007 Dec 15;176(12):1192-9. Epub 2007 Aug 2.
190. Increased urinary TGF-beta1 and cortical renal GLUT1 and GLUT2 levels: additive effects of hypertension and diabetes. Schaan BD, etal., Nephron Physiol. 2005;100(3):p43-50. Epub 2005 Apr 25.
191. Transforming growth factor beta1 and beta2 (TGFbeta2 / TGFbeta2) profile changes in previously irradiated free flap beds. Schultze-Mosgau S, etal., Head Neck. 2002 Jan;24(1):33-41.
192. Growth factors and interleukin-6 across the lung circulation in pulmonary hypertension. Selimovic N, etal., Eur Respir J. 2009 Sep;34(3):662-8. Epub 2009 Mar 26.
193. Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease. Semitekolou M, etal., J Exp Med. 2009 Aug 3;206(8):1769-85. Epub 2009 Jul 20.
194. Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Shah NM, etal., Cell. 1996 May 3;85(3):331-43.
195. Association of interleukin-2, interleukin-4 and transforming growth factor-beta gene polymorphisms with Behcet's disease. Shahram F, etal., Clin Exp Rheumatol. 2011 May 31.
196. A dual role for TGF-beta1 in the control and persistence of fungal pneumonia. Shao X, etal., J Immunol. 2005 Nov 15;175(10):6757-63.
197. Paclitaxel alleviates liver fibrosis induced by bile duct ligation in rats: Role of TGF-β1, IL-10 and c-Myc. Sharawy MH, etal., Life Sci. 2018 Oct 15;211:245-251. doi: 10.1016/j.lfs.2018.09.037. Epub 2018 Sep 20.
198. Involvement of transforming growth factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells. Sharma K, etal., Am J Physiol Renal Physiol 2003 Dec;285(6):F1258-70.
199. TGF-beta impairs renal autoregulation via generation of ROS. Sharma K, etal., Am J Physiol Renal Physiol. 2005 May;288(5):F1069-77. Epub 2005 Jan 11.
200. Variants in TGFB1, dust mite exposure, and disease severity in children with asthma. Sharma S, etal., Am J Respir Crit Care Med. 2009 Mar 1;179(5):356-62. Epub 2008 Dec 18.
201. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
202. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
203. Effects of Omega-3 Fatty Acids on Erectile Dysfunction in a Rat Model of Atherosclerosis-induced Chronic Pelvic Ischemia. Shim JS, etal., J Korean Med Sci. 2016 Apr;31(4):585-9. doi: 10.3346/jkms.2016.31.4.585. Epub 2016 Feb 22.
204. Oncopreventive effects of theanine and theobromine on dimethylhydrazine-induced colon cancer model. Shojaei-Zarghani S, etal., Biomed Pharmacother. 2021 Feb;134:111140. doi: 10.1016/j.biopha.2020.111140. Epub 2020 Dec 24.
205. Association between Altered Expression and Genetic Variations of Transforming Growth Factor ß-Smad Pathway with Chronic Myeloid Leukemia. Shokeen Y, etal., Int J Hematol Oncol Stem Cell Res. 2018 Jan 1;12(1):14-22.
206. TGF-beta expression during rat pregnancy and activity on decidual cell survival. Shooner C, etal., Reprod Biol Endocrinol. 2005 May 31;3:20.
207. Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Siegel PM, etal., Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8430-5. Epub 2003 Jun 13.
208. Transforming growth factor beta 1 promotes cell cycle exit through the cyclin-dependent kinase inhibitor p21 in the developing cerebral cortex. Siegenthaler JA and Miller MW, J Neurosci. 2005 Sep 21;25(38):8627-36.
209. Downregulation of transforming growth factor-beta2 facilitates inflammation in the central nervous system by reciprocal astrocyte/microglia interactions. Siglienti I, etal., J Neuropathol Exp Neurol. 2007 Jan;66(1):47-56.
210. Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma. Silverman ES, etal., Am J Respir Crit Care Med. 2004 Jan 15;169(2):214-9. Epub 2003 Nov 3.
211. Effects of dexamethasone exposure on rat metanephric development: in vitro and in vivo studies. Singh RR, etal., Am J Physiol Renal Physiol. 2007 Aug;293(2):F548-54. Epub 2007 May 30.
212. Formononetin protects against balloon injury‑induced neointima formation in rats by regulating proliferation and migration of vascular smooth muscle cells via the TGF‑β1/Smad3 signaling pathway. Song T, etal., Int J Mol Med. 2018 Oct;42(4):2155-2162. doi: 10.3892/ijmm.2018.3784. Epub 2018 Jul 18.
213. Lesion-associated expression of transforming growth factor-beta-2 in the rat nervous system: evidence for down-regulating the phagocytic activity of microglia and macrophages. Stoll G, etal., Brain Pathol. 2004 Jan;14(1):51-8.
214. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
215. Expression of transforming growth factor-beta-inducible gene-h3 in normal and cyclosporine-treated rat kidney. Sun BK, etal., J Lab Clin Med 2004 Mar;143(3):175-83.
216. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
217. Long noncoding RNA H19 controls DUSP5/ERK1/2 axis in cardiac fibroblast proliferation and fibrosis. Tao H, etal., Cardiovasc Pathol. 2016 Sep-Oct;25(5):381-9. doi: 10.1016/j.carpath.2016.05.005. Epub 2016 Jun 2.
218. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
219. Transforming growth factor beta 1 is implicated in the failure of tamoxifen therapy in human breast cancer. Thompson AM, etal., Br J Cancer. 1991 Apr;63(4):609-14.
220. Transforming growth factor beta 1 as a biomarker for prostate cancer. Thompson TC, etal., J Cell Biochem Suppl. 1992;16H:54-61.
221. Reduced expression of dentin sialophosphoprotein is associated with dysplastic dentin in mice overexpressing transforming growth factor-beta 1 in teeth. Thyagarajan T, etal., J Biol Chem 2001 Apr 6;276(14):11016-20. Epub 2000 Dec 14.
222. [Influence of human bone marrow-derived mesenchymal stem cells on the lung of newborn rats damaged by hyperoxia] Tian ZF, etal., Zhonghua Er Ke Za Zhi. 2008 Jan;46(1):4-8.
223. Differential effects of transforming growth factor-beta1 on cellular proliferation in the developing prostate. Tomlinson DC, etal., Endocrinology. 2004 Sep;145(9):4292-300. Epub 2004 Jun 10.
224. Plasma levels of TGF-beta1 in homeostasis of the inflammation in sickle cell disease. Torres Lde S, etal., Cytokine. 2016 Apr;80:18-25. doi: 10.1016/j.cyto.2016.02.012. Epub 2016 Feb 27.
225. The potential role of TGFbeta1, TGFbeta2 and TGFbeta3 protein expression in colorectal carcinomas. Correlation with classic histopathologic factors and patient survival. Tsamandas AC, etal., Strahlenther Onkol. 2004 Apr;180(4):201-8.
226. Clinical significance of sCD105 in angiogenesis and disease activity in multiple myeloma. Tsirakis G, etal., Eur J Intern Med. 2012 Jun;23(4):368-73. doi: 10.1016/j.ejim.2012.01.012. Epub 2012 Mar 3.
227. T-cell regulation in chronic paranasal sinus disease. Van Bruaene N, etal., J Allergy Clin Immunol. 2008 Jun;121(6):1435-41, 1441.e1-3.
228. Proteoglycan expression in bleomycin lung fibroblasts: role of transforming growth factor-beta(1) and interferon-gamma. Venkatesan N, etal., Am J Physiol Lung Cell Mol Physiol 2002 Oct;283(4):L806-14.
229. Genetic susceptibility of epidermal growth factor +61A>G and transforming growth factor beta1 -509C>T gene polymorphisms with gallbladder cancer. Vishnoi M, etal., Hum Immunol. 2008 Jun;69(6):360-7. Epub 2008 May 6.
230. Mechanical stretch via transforming growth factor-beta1 activates microRNA-208a to regulate hypertrophy in cultured rat cardiac myocytes. Wang BW, etal., J Formos Med Assoc. 2013 Oct;112(10):635-43. doi: 10.1016/j.jfma.2013.01.002. Epub 2013 Feb 4.
231. [A preliminary study on the changes of expression of PDGF-beta, PDGFR-beta, TGF-beta 1, TGFR, bFGF and its relationship with the wound age in wound healing] Wang HJ, etal., Fa Yi Xue Za Zhi. 2001 Nov;17(4):198-201, 204.
232. Cloning and expression of glucocorticoid-induced genes in fetal rat lung fibroblasts. Transforming growth factor-beta 3. Wang J, etal., J Biol Chem 1995 Feb 10;270(6):2722-8.
233. Long Noncoding RNA H19 Promotes Neuroinflammation in Ischemic Stroke by Driving Histone Deacetylase 1-Dependent M1 Microglial Polarization. Wang J, etal., Stroke. 2017 Aug;48(8):2211-2221. doi: 10.1161/STROKEAHA.117.017387. Epub 2017 Jun 19.
234. The impact of 1,25-dihydroxyvitamin D3 on the expression of connective tissue growth factor and transforming growth factor-beta1 in the myocardium of rats with diabetes. Wang L, etal., Diabetes Res Clin Pract. 2014 May;104(2):226-33. doi: 10.1016/j.diabres.2014.01.031. Epub 2014 Feb 14.
235. Nitric oxide and cGMP-dependent protein kinase regulation of glucose-mediated thrombospondin 1-dependent transforming growth factor-beta activation in mesangial cells. Wang S, etal., J Biol Chem 2002 Mar 22;277(12):9880-8. Epub 2002 Jan 9.
236. Silencing CD36 gene expression results in the inhibition of latent-TGF-beta1 activation and suppression of silica-induced lung fibrosis in the rat. Wang X, etal., Respir Res. 2009 May 13;10(1):36.
237. [Effects of salvianolic acid B on expressions of TGF-beta1 and its receptors in liver of rats with dimethylnitrosamine-induced hepatic fibrosis] Wang XN, etal., Zhong Xi Yi Jie He Xue Bao. 2005 Jul;3(4):286-9.
238. Hepatoprotective effects of AdipoRon against d-galactosamine-induced liver injury in mice. Wang Y, etal., Eur J Pharm Sci. 2016 Oct 10;93:123-31. doi: 10.1016/j.ejps.2016.08.017. Epub 2016 Aug 9.
239. Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries. Ward MR, etal., Atherosclerosis. 1998 Apr;137(2):267-75. doi: 10.1016/s0021-9150(97)00275-x.
240. Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats. Wei XH, etal., Microcirculation. 2013 Jan;20(1):17-29. doi: 10.1111/micc.12002.
241. Quantitative monitoring of the mRNA expression pattern of the TGF-beta-isoforms (beta 1, beta 2, beta 3) during transdifferentiation of hepatic stellate cells using a newly developed real-time SYBR Green PCR. Wickert L, etal., Biochem Biophys Res Commun 2002 Jul 12;295(2):330-5.
242. Cell-type-specific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3. Wilkes MC, etal., Mol Cell Biol. 2003 Dec;23(23):8878-89.
243. Antigen presentation by vaginal cells: role of TGFbeta as a mediator of estradiol inhibition of antigen presentation. Wira CR, etal., Endocrinology 2002 Aug;143(8):2872-9.
244. Polymorphism of the TGFB1 gene is not associated with bronchial allergic asthma in a Polish population. Wisniewski A, etal., Hum Immunol. 2009 Feb;70(2):134-8. Epub 2009 Jan 9.
245. Existence of a regulatory loop between MCP-1 and TGF-beta in glomerular immune injury. Wolf G, etal., Am J Physiol Renal Physiol 2002 Nov;283(5):F1075-84.
246. Renoprotective effects of carvedilol in hypertensive-stroke prone rats may involve inhibition of TGF beta expression. Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329.
247. Expression of TGF beta1 genes and their receptor types I, II, and III in low- and high-grade malignancy non-Hodgkin's lymphomas. Woszczyk D, etal., Med Sci Monit. 2004 Jan;10(1):CR33-7.
248. Plasma transforming growth factor-beta1 level in patients with severe community-acquired pneumonia and association with disease severity. Wu HP, etal., J Formos Med Assoc. 2009 Jan;108(1):20-7.
249. TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Wyss-Coray T, etal., Nat Med 2001 May;7(5):612-8.
250. Simvastatin ameliorates ventricular remodeling via the TGFbeta1 signaling pathway in rats following myocardial infarction. Xiao X, etal., Mol Med Rep. 2016 Apr 25. doi: 10.3892/mmr.2016.5178.
251. Effect of prenatal tetrandrine administration on transforming growth factor-beta1 level in the lung of nitrofen-induced congenital diaphragmatic hernia rat model. Xu C, etal., J Pediatr Surg. 2009 Aug;44(8):1611-20.
252. TGF-beta signaling alterations and susceptibility to colorectal cancer. Xu Y and Pasche B, Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20.
253. Release of biologically active TGF-beta1 by alveolar epithelial cells results in pulmonary fibrosis. Xu YD, etal., Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L527-39. Epub 2003 Feb 21.
254. Biologic Evaluation of Diabetes and Local Recurrence in Non-Small Cell Lung Cancer. Yang X, etal., Pathol Oncol Res. 2017 Jan;23(1):73-77. doi: 10.1007/s12253-016-0086-1. Epub 2016 Jul 13.
255. Activation of rat alveolar macrophage-derived latent transforming growth factor beta-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36. Yehualaeshet T, etal., Am J Pathol. 1999 Sep;155(3):841-51.
256. Increased plasma levels of cystatin C and transforming growth factor-beta1 in patients with coronary artery ectasia: can there be a potential interaction between cystatin C and transforming growth factor-beta1. Yetkin E, etal., Coron Artery Dis. 2007 May;18(3):211-4.
257. Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells. Yisireyili M, etal., Nagoya J Med Sci. 2017 Nov;79(4):477-486. doi: 10.18999/nagjms.79.4.477.
258. Role of TGF-beta1 in the development of pancreatic fibrosis in Otsuka Long-Evans Tokushima Fatty rats. Yoshikawa H, etal., Am J Physiol Gastrointest Liver Physiol 2002 Mar;282(3):G549-58.
259. Single nucleotide polymorphism at rs1982073:T869C of the TGFbeta 1 gene is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive radiotherapy. Yuan X, etal., J Clin Oncol. 2009 Jul 10;27(20):3370-8. Epub 2009 Apr 20.
260. [Expression of Smad4 and transforming growth factor-beta1, transforming growth factor-beta receptor II in cholangiocarcinoma tissue and its biological significance] Zhang BY, etal., Zhonghua Wai Ke Za Zhi. 2005 Jul 1;43(13):846-9.
261. Regulation of FLRG expression in rat primary astroglial cells and injured brain tissue by transforming growth factor-beta 1 (TGF-beta 1). Zhang G, etal., J Neurosci Res 2003 Apr 1;72(1):33-45.
262. Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway. Zhang L, etal., J Mol Histol. 2020 Feb;51(1):77-87. doi: 10.1007/s10735-020-09859-8. Epub 2020 Feb 17.
263. Role of increased penile expression of transforming growth factor-beta1 and activation of the Smad signaling pathway in erectile dysfunction in streptozotocin-induced diabetic rats. Zhang LW, etal., J Sex Med. 2008 Oct;5(10):2318-29. Epub 2008 Sep 5.
264. Potassium channel changes of peripheral blood T-lymphocytes from Kazakh hypertensive patients in Northwest China and the inhibition effect towards potassium channels by telmisartan. Zhang Q, etal., Kardiol Pol. 2016;74(5):476-488. doi: 10.5603/KP.a2015.0210. Epub 2015 Oct 27.
265. Acute Effects of Transforming Growth Factor-β1 on Neuronal Excitability and Involvement in the Pain of Rats with Chronic Pancreatitis. Zhang X, etal., J Neurogastroenterol Motil. 2016 Apr 30;22(2):333-43. doi: 10.5056/jnm15127.
266. Analysis of serum cytokines in patients with severe acute respiratory syndrome. Zhang Y, etal., Infect Immun. 2004 Aug;72(8):4410-5. doi: 10.1128/IAI.72.8.4410-4415.2004.
267. Effects of aging on growth factors gene and protein expression in the dorsal and ventral lobes of rat prostate. Zhao H, etal., Biochem Biophys Res Commun 2002 Mar 29;292(2):482-91.
268. Transforming growth factor-beta(s) and their receptors in aging rat prostate. Zhao H, etal., Biochem Biophys Res Commun. 2002 Jun 7;294(2):464-9.
269. Reduced MIR130A is involved in primary immune thrombocytopenia via targeting TGFB1 and IL18. Zhao H, etal., Br J Haematol. 2014 Sep;166(5):767-73. doi: 10.1111/bjh.12934. Epub 2014 May 7.
270. Velvet Antler Peptide Prevents Pressure Overload-induced Cardiac Fibrosis via Transforming Growth Factor (TGF)-beta1 Pathway inhibition. Zhao L, etal., Eur J Pharmacol. 2016 Apr 21. pii: S0014-2999(16)30260-6. doi: 10.1016/j.ejphar.2016.04.039.
271. Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation. Zhong W, etal., Oncotarget. 2017 Jun 20;8(25):40486-40500. doi: 10.18632/oncotarget.17119.
272. Açaí (Euterpe oleracea Mart.) attenuates alcohol-induced liver injury in rats by alleviating oxidative stress and inflammatory response. Zhou J, etal., Exp Ther Med. 2018 Jan;15(1):166-172. doi: 10.3892/etm.2017.5427. Epub 2017 Nov 1.
273. High expression of IDO1 and TGF-β1 during recurrence and post infection clearance with Chlamydia trachomatis, are independent of host IFN-γ response. Ziklo N, etal., BMC Infect Dis. 2019 Mar 4;19(1):218. doi: 10.1186/s12879-019-3843-4.
274. Characterization of the TGF-beta1 signaling abnormalities in the Gata1low mouse model of myelofibrosis. Zingariello M, etal., Blood. 2013 Apr 25;121(17):3345-63. doi: 10.1182/blood-2012-06-439661. Epub 2013 Mar 5.
275. Transforming growth factor beta 1 induces cachexia and systemic fibrosis without an antitumor effect in nude mice. Zugmaier G, etal., Cancer Res. 1991 Jul 1;51(13):3590-4.
Additional References at PubMed
PMID:1333888   PMID:1436033   PMID:1821856   PMID:2070682   PMID:2209468   PMID:3470709   PMID:7600998   PMID:7848824   PMID:8009224   PMID:8053900   PMID:8167376   PMID:8421714  
PMID:9008713   PMID:9389648   PMID:9757003   PMID:9770491   PMID:9921650   PMID:9950587   PMID:10092230   PMID:10513816   PMID:10885742   PMID:11157754   PMID:11158066   PMID:11502704  
PMID:11711431   PMID:11799106   PMID:11906205   PMID:11961311   PMID:12021073   PMID:12199527   PMID:12208849   PMID:12484516   PMID:12496370   PMID:12538588   PMID:12646048   PMID:12646629  
PMID:12697724   PMID:12704789   PMID:12712323   PMID:12730080   PMID:12773577   PMID:12794007   PMID:12806594   PMID:12837295   PMID:12865256   PMID:12867422   PMID:12876289   PMID:12893825  
PMID:12937160   PMID:12970361   PMID:12971963   PMID:14514686   PMID:14517293   PMID:14555988   PMID:14575307   PMID:14575314   PMID:14623275   PMID:14623893   PMID:14633629   PMID:14633705  
PMID:14656760   PMID:14670985   PMID:14697288   PMID:14708940   PMID:14717916   PMID:14726452   PMID:14960316   PMID:14967845   PMID:14988498   PMID:15019289   PMID:15040835   PMID:15047629  
PMID:15100250   PMID:15153551   PMID:15184388   PMID:15187003   PMID:15201552   PMID:15219857   PMID:15222754   PMID:15248184   PMID:15251335   PMID:15253713   PMID:15282343   PMID:15316360  
PMID:15334054   PMID:15334678   PMID:15450206   PMID:15451575   PMID:15489334   PMID:15492480   PMID:15550525   PMID:15604101   PMID:15604136   PMID:15652405   PMID:15657445   PMID:15677311  
PMID:15677465   PMID:15702480   PMID:15808558   PMID:15820682   PMID:15964416   PMID:15990875   PMID:15993878   PMID:15994428   PMID:16005428   PMID:16019429   PMID:16020542   PMID:16097048  
PMID:16103255   PMID:16105028   PMID:16115393   PMID:16115399   PMID:16146787   PMID:16182431   PMID:16183734   PMID:16246848   PMID:16362724   PMID:16371439   PMID:16380081   PMID:16449286  
PMID:16458528   PMID:16473861   PMID:16546826   PMID:16549155   PMID:16549518   PMID:16685417   PMID:16690877   PMID:16754747   PMID:16770245   PMID:16778334   PMID:16778384   PMID:16785237  
PMID:16816361   PMID:16935907   PMID:16941024   PMID:16943770   PMID:16944045   PMID:17068209   PMID:17133352   PMID:17158884   PMID:17203207   PMID:17206447   PMID:17215516   PMID:17293613  
PMID:17324121   PMID:17335076   PMID:17374997   PMID:17379848   PMID:17392319   PMID:17396111   PMID:17401695   PMID:17406824   PMID:17438144   PMID:17481928   PMID:17485851   PMID:17530031  
PMID:17541159   PMID:17568773   PMID:17625791   PMID:17629588   PMID:17629604   PMID:17640965   PMID:17664181   PMID:17669238   PMID:17692821   PMID:17721978   PMID:17723189   PMID:17725545  
PMID:17763394   PMID:17765135   PMID:17878231   PMID:17898001   PMID:17916675   PMID:17928287   PMID:17933714   PMID:17938236   PMID:17951031   PMID:17982486   PMID:17999987   PMID:18039789  
PMID:18040277   PMID:18057996   PMID:18071753   PMID:18080134   PMID:18086923   PMID:18090228   PMID:18095586   PMID:18171523   PMID:18184458   PMID:18189272   PMID:18212064   PMID:18256274  
PMID:18266973   PMID:18274641   PMID:18283107   PMID:18300271   PMID:18341643   PMID:18354256   PMID:18356065   PMID:18367662   PMID:18368049   PMID:18375249   PMID:18389287   PMID:18395914  
PMID:18422491   PMID:18428026   PMID:18453574   PMID:18471258   PMID:18472332   PMID:18498113   PMID:18505915   PMID:18538673   PMID:18548003   PMID:18552272   PMID:18555217   PMID:18581202  
PMID:18588859   PMID:18593713   PMID:18597229   PMID:18611337   PMID:18611343   PMID:18614704   PMID:18625725   PMID:18633183   PMID:18679024   PMID:18687224   PMID:18695043   PMID:18705752  
PMID:18722097   PMID:18727865   PMID:18753609   PMID:18758225   PMID:18782534   PMID:18783370   PMID:18790002   PMID:18794329   PMID:18832382   PMID:18835815   PMID:18846337   PMID:18941241  
PMID:18955796   PMID:18983774   PMID:18997793   PMID:19003557   PMID:19023196   PMID:19029909   PMID:19041694   PMID:19056892   PMID:19061498   PMID:19069655   PMID:19098300   PMID:19129258  
PMID:19143766   PMID:19153267   PMID:19161227   PMID:19172096   PMID:19194552   PMID:19197123   PMID:19200954   PMID:19204403   PMID:19207862   PMID:19218122   PMID:19272247   PMID:19291685  
PMID:19304912   PMID:19323784   PMID:19342372   PMID:19342445   PMID:19349682   PMID:19357233   PMID:19366691   PMID:19374881   PMID:19407952   PMID:19426591   PMID:19457680   PMID:19501566  
PMID:19525370   PMID:19570397   PMID:19578009   PMID:19605630   PMID:19645615   PMID:19656380   PMID:19663807   PMID:19668241   PMID:19696167   PMID:19734317   PMID:19736306   PMID:19737467  
PMID:19744530   PMID:19785951   PMID:19788071   PMID:19874817   PMID:19913496   PMID:19926889   PMID:19959709   PMID:20034899   PMID:20039536   PMID:20065510   PMID:20067797   PMID:20089379  
PMID:20104486   PMID:20134202   PMID:20180418   PMID:20182310   PMID:20211260   PMID:20215829   PMID:20221422   PMID:20226149   PMID:20335535   PMID:20375011   PMID:20380796   PMID:20386537  
PMID:20404057   PMID:20417179   PMID:20424484   PMID:20432467   PMID:20463011   PMID:20472273   PMID:20498031   PMID:20501701   PMID:20507850   PMID:20547156   PMID:20573232   PMID:20576680  
PMID:20600816   PMID:20608350   PMID:20613497   PMID:20619281   PMID:20640990   PMID:20653032   PMID:20653044   PMID:20676968   PMID:20684325   PMID:20697373   PMID:20860549   PMID:20873545  
PMID:20874717   PMID:20875417   PMID:20878350   PMID:20926802   PMID:20930066   PMID:20938722   PMID:20952728   PMID:20972576   PMID:20977838   PMID:21038676   PMID:21144460   PMID:21147091  
PMID:21158157   PMID:21168935   PMID:21192306   PMID:21209102   PMID:21245329   PMID:21245484   PMID:21262769   PMID:21336728   PMID:21354908   PMID:21367774   PMID:21390327   PMID:21412780  
PMID:21429339   PMID:21471198   PMID:21505983   PMID:21509626   PMID:21560355   PMID:21567395   PMID:21605584   PMID:21664439   PMID:21674130   PMID:21677751   PMID:21690069   PMID:21718540  
PMID:21739215   PMID:21791611   PMID:21791914   PMID:21841309   PMID:21850315   PMID:21859884   PMID:21868333   PMID:21895415   PMID:21911934   PMID:21931759   PMID:21941776   PMID:21956870  
PMID:21958301   PMID:21984612   PMID:21996044   PMID:22013804   PMID:22020089   PMID:22031849   PMID:22035631   PMID:22041779   PMID:22057676   PMID:22073128   PMID:22094034   PMID:22095944  
PMID:22097314   PMID:22165288   PMID:22166643   PMID:22172122   PMID:22252490   PMID:22258325   PMID:22269326   PMID:22270542   PMID:22285838   PMID:22332556   PMID:22338217   PMID:22371337  
PMID:22384127   PMID:22384214   PMID:22447946   PMID:22451679   PMID:22483454   PMID:22516433   PMID:22551312   PMID:22579701   PMID:22579999   PMID:22613868   PMID:22661380   PMID:22684563  
PMID:22706027   PMID:22714676   PMID:22718393   PMID:22734808   PMID:22735812   PMID:22790384   PMID:22835458   PMID:22851187   PMID:22875344   PMID:22899499   PMID:22911900   PMID:22949406  
PMID:22964152   PMID:23006535   PMID:23009856   PMID:23044204   PMID:23085271   PMID:23089551   PMID:23091366   PMID:23099153   PMID:23110133   PMID:23174757   PMID:23193663   PMID:23270462  
PMID:23271281   PMID:23275087   PMID:23291610   PMID:23306843   PMID:23338707   PMID:23359369   PMID:23403244   PMID:23416528   PMID:23430124   PMID:23471555   PMID:23486522   PMID:23524565  
PMID:23528014   PMID:23547562   PMID:23560091   PMID:23592137   PMID:23832727   PMID:23861879   PMID:23868260   PMID:23871832   PMID:23937416   PMID:23970162   PMID:23979707   PMID:23990681  
PMID:24036265   PMID:24038377   PMID:24103556   PMID:24157151   PMID:24246300   PMID:24290447   PMID:24311432   PMID:24329763   PMID:24338227   PMID:24344329   PMID:24356887   PMID:24379181  
PMID:24461183   PMID:24474615   PMID:24489578   PMID:24530353   PMID:24573206   PMID:24586048   PMID:24591339   PMID:24601883   PMID:24610459   PMID:24634122   PMID:24659892   PMID:24665937  
PMID:24718260   PMID:24721794   PMID:24840640   PMID:25010983   PMID:25031710   PMID:25040634   PMID:25063067   PMID:25065622   PMID:25078775   PMID:25093615   PMID:25100282   PMID:25150141  
PMID:25163461   PMID:25178280   PMID:25185755   PMID:25192797   PMID:25245272   PMID:25310401   PMID:25322725   PMID:25348957   PMID:25359088   PMID:25375034   PMID:25393149   PMID:25422985  
PMID:25446187   PMID:25446530   PMID:25451261   PMID:25451291   PMID:25491150   PMID:25514442   PMID:25538336   PMID:25560248   PMID:25561788   PMID:25633415   PMID:25715398   PMID:25715833  
PMID:25736907   PMID:25740471   PMID:25787292   PMID:25788532   PMID:25857705   PMID:25884585   PMID:25893292   PMID:25923922   PMID:25960249   PMID:25967237   PMID:26016731   PMID:26026059  
PMID:26045739   PMID:26075533   PMID:26082460   PMID:26097534   PMID:26125699   PMID:26169693   PMID:26187065   PMID:26253398   PMID:26256678   PMID:26279426   PMID:26311719   PMID:26340021  
PMID:26341460   PMID:26373045   PMID:26405299   PMID:26493107   PMID:26518453   PMID:26535698   PMID:26566727   PMID:26568079   PMID:26617694   PMID:26617806   PMID:26634652   PMID:26637070  
PMID:26680767   PMID:26687115   PMID:26722423   PMID:26728369   PMID:26729053   PMID:26751072   PMID:26781185   PMID:26788514   PMID:26825317   PMID:26858265   PMID:26869361   PMID:26872211  
PMID:26898453   PMID:26928632   PMID:26934489   PMID:26945889   PMID:26946943   PMID:26954391   PMID:27031437   PMID:27053343   PMID:27072267   PMID:27109695   PMID:27162619   PMID:27217701  
PMID:27247942   PMID:27279449   PMID:27282665   PMID:27297622   PMID:27333806   PMID:27340942   PMID:27345362   PMID:27348628   PMID:27364974   PMID:27379382   PMID:27470217   PMID:27485077  
PMID:27486809   PMID:27492484   PMID:27530924   PMID:27566082   PMID:27567557   PMID:27579669   PMID:27618520   PMID:27633115   PMID:27633729   PMID:27665369   PMID:27693081   PMID:27703278  
PMID:27714812   PMID:27736730   PMID:27756197   PMID:27840939   PMID:27885436   PMID:27927626   PMID:28000380   PMID:28009003   PMID:28039055   PMID:28063381   PMID:28077319   PMID:28091942  
PMID:28092863   PMID:28125630   PMID:28162229   PMID:28193525   PMID:28220578   PMID:28281184   PMID:28303407   PMID:28322466   PMID:28338461   PMID:28350874   PMID:28399671   PMID:28539652  
PMID:28552397   PMID:28566504   PMID:28584818   PMID:28647476   PMID:28658504   PMID:28673338   PMID:28679591   PMID:28688765   PMID:28713909   PMID:28719898   PMID:28737766   PMID:28817810  
PMID:28821620   PMID:28823370   PMID:28837849   PMID:28848997   PMID:28849131   PMID:28943431   PMID:29069575   PMID:29102631   PMID:29104873   PMID:29166374   PMID:29167509   PMID:29200096  
PMID:29215720   PMID:29233682   PMID:29237506   PMID:29334566   PMID:29366910   PMID:29397070   PMID:29402324   PMID:29424488   PMID:29529050   PMID:29537200   PMID:29650971   PMID:29687863  
PMID:29704604   PMID:29746862   PMID:29859189   PMID:29909984   PMID:29921370   PMID:29941815   PMID:30070388   PMID:30132829   PMID:30260287   PMID:30307981   PMID:30317638   PMID:30418079  
PMID:30468668   PMID:30549198   PMID:30711634   PMID:30894415   PMID:30938133   PMID:31078269   PMID:31173168   PMID:31240740   PMID:31247293   PMID:31346987   PMID:31405564   PMID:31411795  
PMID:31434608   PMID:31486510   PMID:31527065   PMID:31576777   PMID:31646592   PMID:31729530   PMID:31766450   PMID:31781338   PMID:31960436   PMID:31975615   PMID:32004504   PMID:32093382  
PMID:32096184   PMID:32097614   PMID:32160810   PMID:32169420   PMID:32258113   PMID:32274619   PMID:32389801   PMID:32416687   PMID:32432762   PMID:32602585   PMID:32633389   PMID:32741046  
PMID:32881898   PMID:32951332   PMID:32965022   PMID:32980902   PMID:33040788   PMID:33098519   PMID:33160814   PMID:33236148   PMID:33243628   PMID:33441166   PMID:33441835   PMID:33448318  
PMID:33469184   PMID:33577025   PMID:33577033   PMID:33754025   PMID:33760134   PMID:33760143   PMID:33771655   PMID:33867340   PMID:33940568   PMID:33992834   PMID:33994866   PMID:34116735  
PMID:34137693   PMID:34175710   PMID:34492249   PMID:34533647   PMID:34665902   PMID:34696976   PMID:34834085   PMID:34929632   PMID:34938805   PMID:35139422   PMID:35167998   PMID:35232222  
PMID:36319684   PMID:36413536   PMID:36495519   PMID:36542225   PMID:36589821   PMID:36631456   PMID:36857632   PMID:36919130   PMID:37030120   PMID:37172885   PMID:37370156   PMID:37389959  
PMID:37433223   PMID:38122948   PMID:38781757   PMID:39168432  


Genomics

Comparative Map Data
Tgfb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,324,312 - 90,340,627 (+)NCBIGRCr8
mRatBN7.2181,196,532 - 81,212,848 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,196,532 - 81,212,847 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,588,717 - 86,605,032 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0195,140,207 - 95,156,569 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,344,513 - 88,360,828 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,480,875 - 82,497,196 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,480,195 - 82,497,199 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,742,151 - 83,758,472 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,894,705 - 80,911,020 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1180,972,549 - 80,988,992 (+)NCBI
Celera175,636,001 - 75,652,315 (+)NCBICelera
Cytogenetic Map1q21NCBI
TGFB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,330,323 - 41,353,922 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1941,301,587 - 41,353,922 (-)EnsemblGRCh38hg38GRCh38
GRCh371941,836,228 - 41,859,827 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,528,491 - 46,551,656 (-)NCBINCBI36Build 36hg18NCBI36
Build 341946,528,658 - 46,551,158NCBI
Celera1938,636,964 - 38,659,992 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1938,268,902 - 38,291,920 (-)NCBIHuRef
CHM1_11941,836,504 - 41,859,495 (-)NCBICHM1_1
T2T-CHM13v2.01944,151,181 - 44,174,790 (-)NCBIT2T-CHM13v2.0
Tgfb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,386,406 - 25,404,503 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,386,427 - 25,404,502 (+)EnsemblGRCm39 Ensembl
GRCm38725,687,002 - 25,705,077 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,687,002 - 25,705,077 (+)EnsemblGRCm38mm10GRCm38
MGSCv37726,472,021 - 26,490,015 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36725,395,762 - 25,413,756 (+)NCBIMGSCv36mm8
Celera720,295,914 - 20,313,908 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.98NCBI
Tgfb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555270,652 - 288,441 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955555274,405 - 288,441 (-)NCBIChiLan1.0ChiLan1.0
TGFB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22047,541,048 - 47,564,105 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11949,409,816 - 49,432,810 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01938,324,009 - 38,347,003 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11946,831,659 - 46,852,973 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,831,659 - 46,852,973 (-)Ensemblpanpan1.1panPan2
B9D2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,621,832 - 112,627,726 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,621,633 - 112,643,885 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,025,951 - 112,032,055 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01113,219,930 - 113,226,035 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,219,701 - 113,241,694 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,781,179 - 112,787,278 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,413,522 - 112,419,614 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,406,803 - 113,412,909 (+)NCBIUU_Cfam_GSD_1.0
Tgfb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,314,010 - 15,330,197 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366613,742,066 - 3,758,272 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366613,742,080 - 3,758,266 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,332,173 - 49,349,046 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,332,169 - 49,348,642 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,127,027 - 45,141,968 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q11-q21NCBI
TGFB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,651,583 - 35,674,387 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl635,648,677 - 35,674,365 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607313,886,646 - 13,908,666 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907161,569 - 176,605 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624907162,567 - 175,696 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tgfb1
102 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:50
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000028051
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat

Markers in Region
PMC307658P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,196,768 - 81,196,853 (+)MAPPERmRatBN7.2
Rnor_6.0182,481,112 - 82,481,196NCBIRnor6.0
Rnor_5.0183,742,388 - 83,742,472UniSTSRnor5.0
RGSC_v3.4180,894,942 - 80,895,026UniSTSRGSC3.4
Celera175,636,238 - 75,636,322UniSTS
Cytogenetic Map1q22UniSTS
RH139885  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,194,907 - 81,195,093 (+)MAPPERmRatBN7.2
Rnor_6.0182,479,244 - 82,479,429NCBIRnor6.0
Rnor_5.0183,740,753 - 83,740,938UniSTSRnor5.0
Celera175,634,392 - 75,634,577UniSTS
RH 3.4 Map1826.0UniSTS
Cytogenetic Map1q22UniSTS
Cytogenetic Map1q21UniSTS
Tgfb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8190,339,729 - 90,340,475 (+)Marker Load Pipeline
mRatBN7.2181,211,950 - 81,212,696 (+)MAPPERmRatBN7.2
Rnor_6.0182,496,299 - 82,497,044NCBIRnor6.0
Rnor_5.0183,757,575 - 83,758,320UniSTSRnor5.0
RGSC_v3.4180,910,123 - 80,910,868UniSTSRGSC3.4
Celera175,651,418 - 75,652,163UniSTS
Cytogenetic Map1q22UniSTS
UniSTS:498452  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,196,799 - 81,196,862 (+)MAPPERmRatBN7.2
Rnor_6.0182,481,143 - 82,481,205NCBIRnor6.0
Rnor_5.0183,742,419 - 83,742,481UniSTSRnor5.0
RGSC_v3.4180,894,973 - 80,895,035UniSTSRGSC3.4
Celera175,636,269 - 75,636,331UniSTS
Cytogenetic Map1q22UniSTS


Genetic Models
This gene Tgfb1 is modified in the following models/strains:
SS-Tgfb1em3Mcwi     SS-Tgfb1em1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000028051   ⟹   ENSRNOP00000028051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl181,196,532 - 81,212,847 (+)Ensembl
Rnor_6.0 Ensembl182,480,195 - 82,497,199 (+)Ensembl
RefSeq Acc Id: NM_021578   ⟹   NP_067589
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,324,312 - 90,340,627 (+)NCBI
mRatBN7.2181,196,532 - 81,212,848 (+)NCBI
Rnor_6.0182,480,875 - 82,497,196 (+)NCBI
Rnor_5.0183,742,151 - 83,758,472 (+)NCBI
RGSC_v3.4180,894,705 - 80,911,020 (+)RGD
Celera175,636,001 - 75,652,315 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_067589 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD20222 (Get FASTA)   NCBI Sequence Viewer  
  AAH76380 (Get FASTA)   NCBI Sequence Viewer  
  AAS55640 (Get FASTA)   NCBI Sequence Viewer  
  CAA36741 (Get FASTA)   NCBI Sequence Viewer  
  EDM07998 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028051
  ENSRNOP00000028051.2
GenBank Protein P17246 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_067589   ⟸   NM_021578
- Peptide Label: precursor
- UniProtKB: Q53YM8 (UniProtKB/Swiss-Prot),   P17246 (UniProtKB/Swiss-Prot),   A6J986 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028051   ⟸   ENSRNOT00000028051
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17246-F1-model_v2 AlphaFold P17246 1-390 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689823
Promoter ID:EPDNEW_R347
Type:multiple initiation site
Name:Tgfb1_1
Description:transforming growth factor, beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R348  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,480,150 - 82,480,210EPDNEW
RGD ID:13689824
Promoter ID:EPDNEW_R348
Type:initiation region
Name:Tgfb1_2
Description:transforming growth factor, beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R347  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,480,654 - 82,480,714EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69051 AgrOrtholog
BioCyc Gene G2FUF-60369 BioCyc
Ensembl Genes ENSRNOG00000020652 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028051 ENTREZGENE
  ENSRNOT00000028051.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
  2.60.120.970 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7107411 IMAGE-MGC_LOAD
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
  TGF-b_propeptide UniProtKB/Swiss-Prot
  TGF-beta UniProtKB/Swiss-Prot
  TGF-beta-rel UniProtKB/Swiss-Prot
  TGFb1 UniProtKB/Swiss-Prot
  TGFb_CS UniProtKB/Swiss-Prot
KEGG Report rno:59086 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93466 IMAGE-MGC_LOAD
NCBI Gene 59086 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot
  TRANSFORMING GROWTH FACTOR BETA-1 PROPROTEIN UniProtKB/Swiss-Prot
Pfam TGF_beta UniProtKB/Swiss-Prot
  TGFb_propeptide UniProtKB/Swiss-Prot
PharmGKB TGFB1 RGD
PhenoGen Tgfb1 PhenoGen
PIRSF TGF-beta UniProtKB/Swiss-Prot
PRINTS TGFBETA UniProtKB/Swiss-Prot
  TGFBETA1 UniProtKB/Swiss-Prot
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot
  TGF_BETA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020652 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
TIGR TC220292
UniProt A6J986 ENTREZGENE, UniProtKB/TrEMBL
  P17246 ENTREZGENE
  Q53YM8 ENTREZGENE
  TGFB1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q53YM8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Tgfb1  transforming growth factor, beta 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutations in human homolog implicated in Camurati-Engelmann hereditary disease 628503
gene_expression expression peaks in fetal lung fibroblasts at day 18 70317
gene_expression lacking in young prostate but present in the epithelium of aging prostate 70812
gene_expression expressed throughout mesenchyme 70317
gene_expression mRNA and protein is expressed in perfused kidneys 628503
gene_expression expressed in anterior pituitary gland 628503
gene_function mitogen 70317
gene_physical_interaction may bind Scya2 during renal scarring 628503
gene_process stimulatory mitogen for fetal lung epithelial cell growth 70317
gene_process stimulates growth of fetal lung epithelial cells at low concentrations and inhibits differentiation at higher concentrations 70317
gene_process involved in regulating extracellular matrix formation 628503
gene_process modulates effects of TSH and growth factors on thyroid gland homeostasis 628503
gene_process suppresses thyroid growth and differentiation 628503
gene_process activates Tgfb receptor mediated signaling pathway involving specific Smad proteins 625677
gene_process growth factor functioning as fundamental regulatory molecule 628521
gene_process inhibits prolactin (PRL) secretion and lactotroph cell proliferation and stimulates vascular endothelial growth factor (Vegf) in pituitary cells 628503
gene_process plays a role in normal immune defense and in accumulation of extracellular matrix macromolecules 628503
gene_process may modulate growth and function of endocrine pituitary cells including intrapituitary vascular permeablility, intergrity and angiogenesis 628503
gene_process induces collagen synthesis via MAPK pathway 1299177
gene_product member of Tgf beta superfamily  
gene_protein 2.5 kDa 628503
gene_regulation expression is increased by the treatment of amiodarone (AM), an iodinated benzofuran derivative and effective antidysrhythmic agent 628503