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Gene: Tgfb1 (transforming growth factor, beta 1) Rattus norvegicus
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Symbol: Tgfb1
Name: transforming growth factor, beta 1
Description: Exhibits protein N-terminus binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including animal organ development; cellular response to hormone stimulus; and negative regulation of cell population proliferation. Localizes to several cellular components, including the cell surface; extracellular space; and neuronal cell body. Predicted to colocalize with the microvillus. Used to study chronic obstructive pulmonary disease; familial hyperlipidemia; proteinuria; and pulmonary fibrosis. Biomarker of several diseases, including artery disease (multiple); diabetic neuropathy; end stage renal failure; nephrolithiasis; and obesity. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; artery disease (multiple); bone disease (multiple); cystic fibrosis; and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1); PARTICIPATES IN altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; glypican signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-Tetrandrine; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: TGF-beta-1; Tgfb; transforming growth factor beta-1; transforming growth factor beta-1 proprotein; transforming growth factor, beta-1
Orthologs:
Homo sapiens (human) : TGFB1 (transforming growth factor beta 1)  HGNC  Alliance
Mus musculus (house mouse) : Tgfb1 (transforming growth factor, beta 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tgfb1 (transforming growth factor beta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TGFB1 (transforming growth factor beta 1)
Canis lupus familiaris (dog) : B9D2 (B9 domain containing 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgfb1 (transforming growth factor beta 1)
Sus scrofa (pig) : TGFB1 (transforming growth factor beta 1)
more info ...
Allele / Splice: Tgfb1em3Mcwi   Tgfb1em1Mcwi  
Genetic Models: SS-Tgfb1em3Mcwi SS-Tgfb1em1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0182,480,875 - 82,497,196 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0183,742,151 - 83,758,472 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,894,705 - 80,911,020 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1180,972,549 - 80,988,992 (+)NCBI
Celera175,636,001 - 75,652,315 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model