GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tgfb1 | multiple interactions | EXP | | 6480464 | CTD | Decitabine inhibits the reaction [Cadmium Chloride results in increased expression of TGFB1]; Decitabine inhibits the reaction [TGFB1 protein results in decreased expression of H19 mRNA]; Decitabine inhibits the reaction [TGFB1 protein results in decreased expression of SMAD7 mRNA]; Decitabine inhibits the reaction [TGFB1 protein results in decreased expression of SMAD7 protein]; Decitabine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; Decitabine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Decitabine inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Decitabine inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; Decitabine inhibits the reaction [TGFB1 protein results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [TGFB1 protein results in increased expression of DNMT1 protein]; Decitabine inhibits the reaction [TGFB1 protein results in increased methylation of SMAD7 promoter]; Decitabine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; Decitabine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] | PMID:22457795 PMID:24211420 PMID:27350269 | Tgfb1 | affects expression | ISO | TGFB1 (Homo sapiens) | 6480464 | CTD | Decitabine affects the expression of TGFB1 mRNA | PMID:18320071 | Tgfb1 | increases expression | ISO | TGFB1 (Homo sapiens) | 6480464 | CTD | Decitabine results in increased expression of TGFB1 mRNA; Decitabine results in increased expression of TGFB1 protein | PMID:19234609 | Tgfb1 | multiple interactions | ISO | TGFB1 (Homo sapiens) | 6480464 | CTD | [[Decitabine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein] which results in increased expression of IFNG protein; [[Decitabine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein] which results in increased expression of IL17A protein; [[Decitabine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein] which results in increased expression of IL2 protein; [[Decitabine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein] which results in increased expression of TNF protein; [Decitabine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein | PMID:18567616 | Tgfb1 | multiple interactions | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | [Decitabine co-treated with TGFB1 protein] promotes the reaction [KLF10 protein binds to FOXP3 promoter]; TGFB1 protein promotes the reaction [Decitabine results in increased expression of FOXP3 protein] | PMID:19109157 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |