RGD Reference Report - Role of transforming growth factor-beta superfamily signaling pathways in human disease. - Rat Genome Database

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Role of transforming growth factor-beta superfamily signaling pathways in human disease.

Authors: Gordon, KJ  Blobe, GC 
Citation: Gordon KJ and Blobe GC, Biochim Biophys Acta. 2008 Apr;1782(4):197-228. Epub 2008 Feb 11.
RGD ID: 2299005
Pubmed: PMID:18313409   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbadis.2008.01.006   (Journal Full-text)

Transforming growth factor beta (TGF-beta) superfamily signaling pathways are ubiquitous and essential regulators of cellular processes including proliferation, differentiation, migration, and survival, as well as physiological processes, including embryonic development, angiogenesis, and wound healing. Alterations in these pathways, including either germ-line or somatic mutations or alterations in the expression of members of these signaling pathways often result in human disease. Appropriate regulation of these pathways is required at all levels, particularly at the ligand level, with either a deficiency or an excess of specific TGF-beta superfamily ligands resulting in human disease. TGF-beta superfamily ligands and members of these TGF-beta superfamily signaling pathways also have emerging roles as diagnostic, prognostic or predictive markers for human disease. Ongoing studies will enable targeting of TGF-beta superfamily signaling pathways for the chemoprevention and treatment of human disease.



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Molecular Pathway Annotations    Click to see Annotation Detail View
Objects Annotated

Genes (Rattus norvegicus)
Tgfb1  (transforming growth factor, beta 1)
Tgfbr1  (transforming growth factor, beta receptor 1)
Tgfbr2  (transforming growth factor, beta receptor 2)

Genes (Mus musculus)
Tgfb1  (transforming growth factor, beta 1)
Tgfbr1  (transforming growth factor, beta receptor I)
Tgfbr2  (transforming growth factor, beta receptor II)

Genes (Homo sapiens)
TGFB1  (transforming growth factor beta 1)
TGFBR1  (transforming growth factor beta receptor 1)
TGFBR2  (transforming growth factor beta receptor 2)


Additional Information