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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:77733
Term: 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile
Definition: A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Chemical ID: MESH:D014700
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1multiple interactionsEXP 6480464CTDVerapamil inhibits the reaction [[Carbon Tetrachloride co-treated with lard co-treated with Ethanol] results in increased expression of TGFB1 protein]PMID:17223571
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTDVerapamil inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]PMID:34217686
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